RADBIO 3

18問 • 1年前

通報

問題一覧

this is the law of Radio-sensitivity of Living Tissue varies with maturation

Law of Bergonie & Tribondeau

Physical Factors that affect radio-sensitivity LRPF

> LET > Relative Biologic Effectiveness > Protraction & Fractionation

measure of the rate at which energy is transferred from ionizing radiation to soft tissue

Linear Energy Transfer

As the LET of radiation increases, the ability to produce biologic damage also increases.

Relative Biologic Effectiveness

delivered continuously in lower dose

Protraction

dose delivered at the same dose in equal portions in regular interval

Fractionation

Biological Factors that Affect Radio-sensitivity OARCH

1. Oxygen Enhancement Ratio 2. Age 3. Recovery 4. Chemical Agents 5. Hormesis

ratio of the dose necessary to produce a given effect under anoxic conditions to the dose necessary to produce the same effect under aerobic conditions

Oxygen Enhancement Ratio

Humans are most radiosensitive _____ birth

before

agents that enhance the effect of radiation

Radiosensitizers

protect against the effect, compounds with molecules containing a SULFHYDRYL group ex. CYSTEINE and CYSTEAMINE)

Radioprotectors

biologic responses to low exposures to toxins or other stressors

Hormesis

mathematical relationship between various radiation dose levels and magnitude of the observed response

Radiation dose response

used in radiologic oncology

Hyperbaric/High Pressure Oxygen

_________ x-ray imaging is performed under conditions of ___ oxygenation

1. Diagnostic 2. full

The response is directly proportional to the dose

Linear Dose Relationship

Varied responses are produced from varied dose

Nonlinear dose relationship

LET of the following: 25 MV X-rays 60^Co gamma rays 1 MeV electrons Diagnostic x-rays 10 MeV protons Fast neutrons 5 MeV alpha particles Heavy nuclei

0.2 keV/um 0.3 keV/um 0.3 keV/um 3.0 keV/um 4.0 keV/um 50.0 keV/um 100.0 keV/um 1000.0 keV/um

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RPC L2

RPC L2

RPC L3