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40問 • 1年前

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Which of the following is used to detect allergen specific IgE? RIST IEP RAST CRP

RAST

A child has severe hay fever. A total IgE measurement was performed by the Ouchterlony immunodiffusion method. No lines of precipitation appeared on the immunodiffusion plate. The most likely explanation is: a IgE antibodies are not produced in children who have hay fever b hay fever is mediated by the cellular system c IgE is in too low a concentration to be detected by this method d IgA is the antibody commonly produced in people with hay fever

c IgE is in too low a concentration to be detected by this method

Which test is used to evaluate the cellular immune system in a patient? a_ skin test for commonly encountered antigens b determination of isohemagglutinin titer ¢ immunoelectrophoresis of serum d measurement of anti-HBsAg after immunization

a_ skin test for commonly encountered antigens

T cells are incapable of: collaborating with B cells in antibody responses secretion of immunoglobulins secretion of cytokines producing positive skin tests

secretion of immunoglobulins

T lymphocytes are incapable of functioning as: a cytotoxic cells b helper cells c phagocytic cells d regulatory cells

c phagocytic cells

Nonspecific killing of tumor cells is carried out by: cytotoxic T cells helper T cells natural killer cells antibody and complement

natural killer cells

Tumor markers found in the circulation are most frequently measured by: a immunoassays b thin-layer chromatography c high-pressure liquid chromatography d colorimetry

a immunoassays

A patient with a B-cell deficiency will most likely exhibit: decreased phagocytosis increased bacterial infections decreased complement levels increased complement levels

increased bacterial infections

patient with a T-cell deficiency wil! most likely exhibit: increased immune complex formation increased parasitic infections decreased IgE-mediated responses decreased complement levels

increased parasitic infections

Which of the following is an important cellular mediator of immune complex tissue injury? a mast cell b neutrophil c basophil d eosinophil

b neutrophil

hich of the following mediators is released during T-cell activation? immunoglobulins thymosin serotonin cytokines

cytokines

The HLA antibodies used in histocompatibility typing have been obtained from which of the following? multiparous women nonidentical siblings sheep blood rabbit serum

multiparous women

Which of the following terms describes a graft between genetically unidentical individuals belonging to the same species? autograft isograft allograft xenograft

allograft

Incompatibility by which of the following procedures is an absolute contraindication to allotransplantation? a MLC (mixed lymphocyte culture) b HLA typing c Rh typing d ABO grouping

d ABO grouping

Which is a recognized theory of the origin of autoimmunity? a enhanced regulatory T-cell function b diminished helper T-cell activity c production of antibodies that cross-react with tissue components d deficient B-cell activation

c production of antibodies that cross-react with tissue components

C3b and Fc receptors are present on: B lymphocytes monocytes B lymphocytes and monocytes neither B lymphocytes and monocytes

B lymphocytes and monocytes

T lymphocytes that possess the CD8 surface marker mediate which of the following T-cell functions? delayed type hypersensitivity regulatory cytotoxic helper

helper

Delayed hypersensitivity may be induced by: contact sensitivity to inorganic chemicals transfusion reaction anaphylactic reaction bacterial septicemia

contact sensitivity to inorganic chemicals

The most rapid immediate hypersensitivity reaction is associated with: transfusion anaphylaxis contact dermatitis serum sickness

anaphylaxis

The normal controls for a quantitative B lymphocyte assay should have a value of what percentage of total lymphocytes counted? a 21% b 48% c 76% d 89%

a 21%

An immunofluorescence test using reagent antibody directed against the CD3 surface marker would identify which of the following cell types in a sample of human peripheral blood? all mature T lymphocytes T helper lymphocytes only cytotoxic T lymphocytes only T regulatory cells only

all mature T lymphocytes

Refer to the following results for peripheral blood samples: % T lymphocytes patient #1: 85% patient #2: 23% patient #3: 51% patient #4: 82% normal control: 44% The data above indicates: a patient #1 has an abnormally high T lymphocyte count b patient #2 has a normal T lymphocyte count ¢ patients #1 and #3 have normal T lymphocyte counts d_ the normal control is too low and another sample should be selected

the normal control is too low and another sample should be selected

Refer to the following flow cytometric data. absolute WBC: 8,930 total lymphocytes: 30% B lymphocytes: 40% T lymphocytes: 58% Calculate the absolute count for B lymphocytes. a 1,072 b 2,679 c 3,572 d 6,251

a 1,072

A concentrate of lymphocytes can be prepared from peripheral blood by: a density gradient centrifugation b ultracentrifugation c zone electrophoresis d_ freeze fractionation

a density gradient centrifugation

In flow cytometry, labeled cells: scatter the light and absorb fluorescence absorb fluorescence and emit electronic impulses scatter the light and emit fluorescence absorb both fluorescence and light

scatter the light and emit fluorescence

A marked decrease in the CD4 lymphocytes and decrease in the CD4/CD8 ratio: is diagnostic for bacterial septicemia may be seen in most hereditary immunodeficiency disorders is associated with a viral induced immunodeficiency is only seen in patients with advanced disseminated cancer

is associated with a viral induced immunodeficiency

Refer to the following data from a peripheral blood sample: total WBC: 10.0 x 109/uL Differential: neutrophils: 68% lymphocytes: 25% (40% T cells) monocytes: A% eosinophils: 2% basophils: 1% The expected total number of T cells is: a 200 b 1,000 c 2,000 d 2,500

b 1,000

A peripheral blood total leukocyte count is 10.0 x 103/yL. The differential reveals 55% neutrophils, 2% eosinophils, 40% lymphocytes and 3% monocytes. Assuming a lymphocyte recovery of 85%-95%, what is the expected number of T cells in a normal individual? a 750/pL b 2,500/pL © 4,000/pL d 8,000/pL

b 2,500/pL

In laser flow cytometry, applying a voltage potential to sample droplets as they stream past the light beam and using charged deflector plates results in: an emission of red fluorescence from cells labeled with fluorescein isothiocyanate an emission of green fluorescence from cells labeled with rhodamine a 90° light scatter related to cell size the separation of cells into subpopulations based on their charge

the separation of cells into subpopulations based on their charge

What is the immunologic method utilized in the flow cytometer? latex agglutination enzyme linked immunoassay immunofluorescence radioimmunoassay

immunofluorescence

Given the following data: WBC: 5.0 x 10%pL lymphs: 15% CD4: 8% Calculate the absolute CD4: a 40 b 60 c 400 d 750

b 60

Given this hematologic data: WBC: 5.0 x 103/uL lymphs: 15% cD4: 8% Which of the following is the correct interpretation? a CD4% and absolute CD4 normal b consistent with an intact immune system c consistent with a viral infection such as HIV d technical error

c consistent with a viral infection such as HIV

Bone marrow transplant donors and their recipients must be matched for which antigen system(s)? ABO-Rh HLA CD4/CD8 P1^a1

HLA

A 28-year-old man is seen by a physician because of several months of intermittent low back pain. The patient's symptoms are suggestive of ankylosing spondylitis. Which of the following laboratory studies would support this diagnosis? a a decreased synovial fluid CHsp level b low serum CH50 level c positive HLA-B27 antigen test d rheumatoid factor in the synovial fluid

c positive HLA-B27 antigen test

Cells from a patient with hairy cell leukemia have immunologic and functional features of: a mast cells and B lymphocytes b B lymphocytes and T lymphocytes c granulocytes and monocytes d B lymphocytes and monocytes

d B lymphocytes and monocytes

Which T-cell malignancy may retain “helper” activity with regard to immunoglobulin synthesis by B cells? Hodgkin lymphoma acute lymphocytic leukemia (ALL) Sézary syndrome chronic lymphocytic leukemia (CLL)

Sézary syndrome

patient’s abnormal lymphocytes are positive for CD2 antigen, lack C3 receptors, and are negative for surface immunoglobulin. This can be classified as a disorder of: T cells B cells monocytes natural killer cells

T cells

HLA typing of a family yields the following results: On the basis of these genotypes, predict the possibility of ankylosing spondylitis in this percentage Locus A Locus B father (8, 12) (17, 22) mother (7, 12) (13, 27) of their children. a 25% of their children b 50% of their children c 75% of their children d 100%

b 50% of their children

HLA-B8 antigen has been associated with which of the following pairs of diseases? an op ankylosing spondylitis and myasthenia gravis celiac disease and ankylosing spondylitis myasthenia gravis and celiac disease Reiter disease and multiple sclerosis

myasthenia gravis and celiac disease

Which of the following is an important marker for the presence of immature B cells in patients with acute lymphocytic leukemia (ALL)? ans oe terminal deoxynucleotidyl transferase (TdT) adenosine deaminase glucose-6-phosphate dehydrogenase purine nucleoside phosphorylase

terminal deoxynucleotidyl transferase (TdT)

other names parasitology

Yves Laure Pimentel · 70問 · 2年前

other names parasitology