PROTEINS

Yves Laure Pimentel · 70問 · 2年前

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-Confirms a specimen if it is really CSF

Prealbumin/Transthyretin

-Serves as an indicator of nutritional status

Prealbumin/Transthyretin

-Transports Retinol (Vit. A) and Thyroxine (T4)

Prealbumin/Transthyretin

Prealbumin/Transthyretin -Transports ? and

Retinol (Vit. A) and Thyroxine (T4)

-Major protease inhibitor (Neutralize trypsin-like enzymes used to combat infections but can destroy alveoli)

α1-antitrypsin

-Most abundant protein in the α1 globulin band

α1-antitrypsin

α1-antitrypsin Increased:

Inflammation, Pregnancy and Contraceptive use

α1-antitrypsin Decreased:

Pulmonary Emphysema, Juvenile Cirrhosis

-Most abundant protein in the fetal serum

α1-fetoprotein

-Increased in adult serum: Hepatic and Gonadal (Testicular) cancer

α1-fetoprotein

α1-fetoprotein -Increased in adult serum: ? and ?

Hepatic and Gonadal (Testicular) cancer

-Only protein that is negatively charged even in acidic solution

α1- acid glycoprotein/ orosomucoid

-Greatest affinity to progesterone; Binds quinidine drugs

α1- acid glycoprotein/ orosomucoid

α1- acid glycoprotein/ orosomucoid -Greatest affinity to ?; Binds quinidine drugs

progesterone

α1- acid glycoprotein/ orosomucoid -Greatest affinity to progesterone; Binds ?

quinidine drugs

-Major transporter of PS

α1-antichymotrypsin

Increased: Alzheimer’s disease

α1-antichymotrypsin

α1-antichymotrypsin Increased:

Alzheimer’s disease

-Transporter of cholecalciferol (Vit. D)

Group-specific component (Gc) globulin

-Migrates between α1 and α2 globulin

Group-specific component (Gc) globulin

-Transports free hemoglobin

Haptoglobin

Alpha-2 globulins

Haptoglobin

-Marker of intravascular hemolysis

Haptoglobin

-Copper binding protein

Ceruloplasmin

-Marker for Wilson’s disease

Ceruloplasmin

Ceruloplasmin -Marker for

Wilson’s disease

-The enzyme present in highest circulating concentration

Ceruloplasmin

-a ferroxidase essential for iron conversion to ferric state for transferring binding

Ceruloplasmin

-Largest major nonimmunoglobulin protein in plasma

. α2-macroglobulin

-Increased in nephrosis

. α2-macroglobulin

. α2-macroglobulin -Increased in

nephrosis

-Major component of beta globulin fraction

Transferrin (Siderophilin)

-Transport iron to its storage sites

Transferrin (Siderophilin)

-Increased: Hemochromatosis, Decreased IDA

Transferrin (Siderophilin)

Transferrin (Siderophilin) -Increased: ?, Decreased IDA

Hemochromatosis

Transferrin (Siderophilin) -Increased: Hemochromatosis, Decreased

IDA

-Binds heme released in hemoglobin degradation

Hemopexin

- Helps in diagnosing early hemolysis

Hemopexin

-Measure clearance of normal molecules that are not bound to protein and are freely filtered by the glomeruli and neither reabsorbed nor secreted by the tubules

c. β2 microglobulin

-Light chain component of the major human leukocyte antigen (MHC Class I)

β2 microglobulin

β2 microglobulin -Light chain component of the

major human leukocyte antigen (MHC Class I)

-Most abundant coagulation factor

Fibrinogen

-Distinct band between β and ϒ globulin

Fibrinogen

Fibrinogen -Distinct band between ?

β and ϒ globulin

-Natural defense mechanism against infection

Complement

-C3 is the most abundant form in the serum

Complement

- is the most abundant form in the serum

-Binds to C-polysaccharide of Pneumococcus

C-reactive protein

-No. 1 APR

C-reactive protein

-Normal/ abnormal? to have undetected CRP in normal individua

Normal

C-reactive protein -Binds to ?

C-polysaccharide of Pneumococcus

- synthesized by plasma cells

Immunoglobulins

globulins in IgG

Gamma globulins

-- most abundant Gamma globulins

IgG

Gamma globulins -- found in secretions

IgA-

Gamma globulins -- first antibody to appear

IgM

Gamma globulins -- present on the surface of B cells

-IgD-

Gamma globulins -- allergic and anaphylactic reactions

IgE

-Screening test for AMI

Myoglobin

-Small heme protein found in skeletal and cardiac muscle

Myoglobin

-Higher affinity for oxygen than hemoglobin

Myoglobin

-Nephrotoxin

Myoglobin

-Earliest cardiac marker

Myoglobin

-Assessment of early and late AMI

Troponin T

-Sensitive marker for unstable angina

Troponin T

Troponin T -Sensitive marker for unstable ?

angina

Also elevated in renal and skeletal diseases

Troponin T

-Only found on the myocardium ( Highly specific for AMI)

Troponin I

-Not a marker for late AMI

Troponin I

-Marker for CHF

B-type Natriuretic Peptide

Spx: Heparinized plasma

B-type Natriuretic Peptide

other names parasitology

other names parasitology

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