問題一覧
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Variations in constant region
Allotype
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ANTIBODY Composes:
Tetrapeptide: 2 heavy chain and 2 light chain
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Bence Jones Protein found in urine of patient with
MULTIPLE MYELOMA
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Constant region CONSISTS OF
CONSTANT HEAVY CHAIN AND CONSTANT LIGHT CHAIN
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what do you call where Each lymphocyte is preprogrammed to prod. 1 type of Ig and specific Ag selects them. 3 to 5 days proliferation
Clonal Selection
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CLEAVED AB INTO 3 PARTS OR FRAGMENTS
Papain
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Sensitive indicator of a monoclonal gammopathy
Serum Free Light Chain
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Lag phase –
No Ab detectable
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Plateau
Ab stabilizes
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Antibody Variations are (3)
Isotype Allotype Idiotype
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Variations in variable regions that give individual antibody molecules specificity
Idiotype
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Location: BETWEEN Ch1 and Ch2
Hinge Region
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Decline
Ab catabolism
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COMBINING SITE
Fab Fragment (Fragment antigen-binding)
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– Ab increase
Log phase
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MADE FROM AMINO ACID
PROTEIN
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Fab Fragment AKA
(Fragment antigen-binding)
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Hinge Region Enhance functional activity of _______
FC
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CONSTANT HEAVY CHAIN AND CONSTANT LIGHT CHAIN
Constant region
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theory which Cells have specific receptor for antigen before exposure
Side –Chain theory
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Fab Fragment (Fragment antigen-binding) ________ acid terminal
AMINO
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Discoverers -ANTIBODY
Gerald Edelman and Rodney Porter
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it laid the foundation for further hypotheses.
Side –Chain theory
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Constant and variable region have separated genes for coding discovered by
Dryer and Bennet
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ANTIBODY – linking protein
Cysteine
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ANTIBODY Light Chains -2 and 22 2 types
kappa lambda
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Hinge Region Location:
BETWEEN Ch1 and Ch2
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Clonal Selection Discovered by?
Niels Jerne and Macfarlane Burnet
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ANTIBODY Mostly are ________ charge:
POSITIVE
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Important in effector function of Ig ARE:
CH1 CH2 CH3
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Serum Free Light Chain MEASURED BY rate or endpoint (also heavy chain)
NEPHELOMETRY
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FC BINDING PORTION
CH3
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Serum Free Light Chain Found in
MULTIPLE MYELOMA
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ANTIBODY Location
Serum portion of the blood, gamma (y) region in electrophoresis
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Fc/Fragment Crystallizable (at ?)
4C
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has high content of PROLINE for FLEXIBILITY
Hinge Region
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Dr.Henry Bence-Jones Discovered?
Bence Jones Protein
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ANTIBODY – Cleavage with
Papain and Pepsin
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Who Discovered that chromosomes contain no intact gene for Ig, only bldg. blocks from w/c gene can be assembled
Tonegawa
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ANTIBODY Heavy Chain -CHROMOSOME #
14
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ANTIBODY Light Chains -CHROMOSOME #
2 and 22
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AMINO acid terminal
Fab Fragment (Fragment antigen-binding)
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ANTIBODY Functions:
Complement activation and Opsonization
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Niels Jerne and Macfarlane Burnet discovered
Clonal Selection
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Ab stabilizes
Plateau
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Enhance functional activity of FC
Hinge Region
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Fab Fragment (Fragment antigen-binding) Fd Fragment
1 LIGHT CHAIN AND 1/2 HEAVY CHAIN
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Accounts for most of the basic properties of the adaptive immune system
Clonal Selection
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light chains secreted by malignant Plasma cells
Bence Jones Protein
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Fc/Fragment Crystallizable Represents ? -terminal
CARBOXY
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VARIABLE LIGHT CHAIN AND VARIABLE HEAVY CHAIN IS IN WHAT REGION?
Variable region
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Hinge Region has high content of ________ for FLEXIBILITY
PROLINE
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Ab catabolism
Decline
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Side –Chain theory STIMULATED BY?
Paul Ehrlich
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(at 4C)
Fc/Fragment Crystallizable
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CLEAVE IN TO 2 PARTS
Pepsin
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Papain CLEAVED AB INTO 3 PARTS OR FRAGMENTS?
1 FC , 2 FAB
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BEST IMMUNOGEN
PROTEIN
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Bence Jones Precipitate at ? at dissolve at ?
Precipitate at 60C at dissolve at 80 to 100C
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Pepsin CLEAVE IN TO 2 PARTS?
1 FC AND 1 FAB
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VARIABLE REGION OF LIGHT CHAIN AND HEAVY CHAIN
COMBINING SITE
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1 LIGHT CHAIN AND 1/2 HEAVY CHAIN
FD FRAGMENT
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Variable region CONSIST OF
VARIABLE LIGHT CHAIN AND VARIABLE HEAVY CHAIN
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2 Regions
Variable region Constant region
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complement C1q binding portion
CH2
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IIMMUNOGLOBULINS IN HINGE REGION
IgG IgA IgD
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– No Ab detectable
Lag phase
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Has NO antigen binding ability
Fc/Fragment
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FD FRAGMENT CONSIST OF
1 LIGHT CHAIN AND 1/2 HEAVY CHAIN
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found in urine of patient with MULTIPLE MYELOMA
Bence Jones Protein
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theory for Lock and key
Side –Chain theory
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2 heavy chain and 2 light chain
Tetrapeptide:
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Same heavy chain for each class
Isotype
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Antibody Phases
Lag phase Log phase Plateau Decline
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fix the complement
CH1
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Log phase –
Ab increase
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Important in effector function of Ig
Fc/Fragment Crystallizable
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Fab Fragment (Fragment antigen-binding) IN WHAT FRAGMENT?
Fd Fragment
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Bence Jones Protein Discoverer:
Dr.Henry Bence-Jones