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12. ANTIBODY
79問 • 1年前
  • Yves Laure Pimentel
    • 通報

    問題一覧

  • 1

    Side –Chain theory STIMULATED BY?

    Paul Ehrlich

  • 2

    theory which Cells have specific receptor for antigen before exposure

    Side –Chain theory

  • 3

    theory for Lock and key

    Side –Chain theory

  • 4

    it laid the foundation for further hypotheses.

    Side –Chain theory

  • 5

    Clonal Selection Discovered by?

    Niels Jerne and Macfarlane Burnet

  • 6

    Niels Jerne and Macfarlane Burnet discovered

    Clonal Selection

  • 7

    what do you call where Each lymphocyte is preprogrammed to prod. 1 type of Ig and specific Ag selects them. 3 to 5 days proliferation

    Clonal Selection

  • 8

    Accounts for most of the basic properties of the adaptive immune system

    Clonal Selection

  • 9

    Constant and variable region have separated genes for coding discovered by

    Dryer and Bennet

  • 10

    Who Discovered that chromosomes contain no intact gene for Ig, only bldg. blocks from w/c gene can be assembled

    Tonegawa

  • 11

    Discoverers -ANTIBODY

    Gerald Edelman and Rodney Porter

  • 12

    ANTIBODY Heavy Chain -CHROMOSOME #

    14

  • 13

    ANTIBODY Light Chains -CHROMOSOME #

    2 and 22

  • 14

    ANTIBODY Light Chains -2 and 22 2 types

    kappa lambda

  • 15

    Sensitive indicator of a monoclonal gammopathy

    Serum Free Light Chain

  • 16

    Serum Free Light Chain Found in

    MULTIPLE MYELOMA

  • 17

    Serum Free Light Chain MEASURED BY rate or endpoint (also heavy chain)

    NEPHELOMETRY

  • 18

    Bence Jones Protein Discoverer:

    Dr.Henry Bence-Jones

  • 19

    Dr.Henry Bence-Jones Discovered?

    Bence Jones Protein

  • 20

    light chains secreted by malignant Plasma cells

    Bence Jones Protein

  • 21

    found in urine of patient with MULTIPLE MYELOMA

    Bence Jones Protein

  • 22

    Bence Jones Protein found in urine of patient with

    MULTIPLE MYELOMA

  • 23

    Bence Jones Precipitate at ? at dissolve at ?

    Precipitate at 60C at dissolve at 80 to 100C

  • 24

    ANTIBODY Location

    Serum portion of the blood, gamma (y) region in electrophoresis

  • 25

    ANTIBODY Functions:

    Complement activation and Opsonization

  • 26

    ANTIBODY Composes:

    Tetrapeptide: 2 heavy chain and 2 light chain

  • 27

    2 heavy chain and 2 light chain

    Tetrapeptide:

  • 28

    ANTIBODY Mostly are ________ charge:

    POSITIVE

  • 29

    ANTIBODY – linking protein

    Cysteine

  • 30

    ANTIBODY – Cleavage with

    Papain and Pepsin

  • 31

    Has NO antigen binding ability

    Fc/Fragment

  • 32

    Fc/Fragment Crystallizable (at ?)

    4C

  • 33

    (at 4C)

    Fc/Fragment Crystallizable

  • 34

    Important in effector function of Ig

    Fc/Fragment Crystallizable

  • 35

    CLEAVE IN TO 2 PARTS

    Pepsin

  • 36

    Pepsin CLEAVE IN TO 2 PARTS?

    1 FC AND 1 FAB

  • 37

    CLEAVED AB INTO 3 PARTS OR FRAGMENTS

    Papain

  • 38

    Papain CLEAVED AB INTO 3 PARTS OR FRAGMENTS?

    1 FC , 2 FAB

  • 39

    complement C1q binding portion

    CH2

  • 40

    Fc/Fragment Crystallizable Represents ? -terminal

    CARBOXY

  • 41

    Location: BETWEEN Ch1 and Ch2

    Hinge Region

  • 42

    Hinge Region Location:

    BETWEEN Ch1 and Ch2

  • 43

    Hinge Region has high content of ________ for FLEXIBILITY

    PROLINE

  • 44

    has high content of PROLINE for FLEXIBILITY

    Hinge Region

  • 45

    Hinge Region Enhance functional activity of _______

    FC

  • 46

    Enhance functional activity of FC

    Hinge Region

  • 47

    fix the complement

    CH1

  • 48

    FC BINDING PORTION

    CH3

  • 49

    Important in effector function of Ig ARE:

    CH1 CH2 CH3

  • 50

    IIMMUNOGLOBULINS IN HINGE REGION

    IgG IgA IgD

  • 51

    BEST IMMUNOGEN

    PROTEIN

  • 52

    MADE FROM AMINO ACID

    PROTEIN

  • 53

    Fab Fragment AKA

    (Fragment antigen-binding)

  • 54

    COMBINING SITE

    Fab Fragment (Fragment antigen-binding)

  • 55

    Fab Fragment (Fragment antigen-binding) ________ acid terminal

    AMINO

  • 56

    AMINO acid terminal

    Fab Fragment (Fragment antigen-binding)

  • 57

    Fab Fragment (Fragment antigen-binding) Fd Fragment

    1 LIGHT CHAIN AND 1/2 HEAVY CHAIN

  • 58

    Fab Fragment (Fragment antigen-binding) IN WHAT FRAGMENT?

    Fd Fragment

  • 59

    2 Regions

    Variable region Constant region

  • 60

    Variable region CONSIST OF

    VARIABLE LIGHT CHAIN AND VARIABLE HEAVY CHAIN

  • 61

    VARIABLE LIGHT CHAIN AND VARIABLE HEAVY CHAIN IS IN WHAT REGION?

    Variable region

  • 62

    CONSTANT HEAVY CHAIN AND CONSTANT LIGHT CHAIN

    Constant region

  • 63

    Constant region CONSISTS OF

    CONSTANT HEAVY CHAIN AND CONSTANT LIGHT CHAIN

  • 64

    1 LIGHT CHAIN AND 1/2 HEAVY CHAIN

    FD FRAGMENT

  • 65

    FD FRAGMENT CONSIST OF

    1 LIGHT CHAIN AND 1/2 HEAVY CHAIN

  • 66

    VARIABLE REGION OF LIGHT CHAIN AND HEAVY CHAIN

    COMBINING SITE

  • 67

    Antibody Variations are (3)

    Isotype Allotype Idiotype

  • 68

    Same heavy chain for each class

    Isotype

  • 69

    Variations in constant region

    Allotype

  • 70

    Variations in variable regions that give individual antibody molecules specificity

    Idiotype

  • 71

    Antibody Phases

    Lag phase Log phase Plateau Decline

  • 72

    Ab catabolism

    Decline

  • 73

    Decline

    Ab catabolism

  • 74

    Ab stabilizes

    Plateau

  • 75

    Plateau

    Ab stabilizes

  • 76

    Log phase –

    Ab increase

  • 77

    – Ab increase

    Log phase

  • 78

    Lag phase –

    No Ab detectable

  • 79

    – No Ab detectable

    Lag phase

    • other names parasitology

    other names parasitology

    Yves Laure Pimentel · 70問 · 2年前

    other names parasitology

    other names parasitology

    70問 • 2年前
    Yves Laure Pimentel

    PARASITOLOGY

    PARASITOLOGY

    Yves Laure Pimentel · 111問 · 2年前

    PARASITOLOGY

    PARASITOLOGY

    111問 • 2年前
    Yves Laure Pimentel

    HTMLBE

    HTMLBE

    Yves Laure Pimentel · 64問 · 2年前

    HTMLBE

    HTMLBE

    64問 • 2年前
    Yves Laure Pimentel

    CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

    CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

    Yves Laure Pimentel · 61問 · 2年前

    CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

    CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

    61問 • 2年前
    Yves Laure Pimentel

    HISTOPATHOLOGY

    HISTOPATHOLOGY

    Yves Laure Pimentel · 69問 · 2年前

    HISTOPATHOLOGY

    HISTOPATHOLOGY

    69問 • 2年前
    Yves Laure Pimentel

    CC-2 SPECTROPHOTOMETRY

    CC-2 SPECTROPHOTOMETRY

    Yves Laure Pimentel · 100問 · 2年前

    CC-2 SPECTROPHOTOMETRY

    CC-2 SPECTROPHOTOMETRY

    100問 • 2年前
    Yves Laure Pimentel

    CC-3 ELECTROPHORESIS

    CC-3 ELECTROPHORESIS

    Yves Laure Pimentel · 41問 · 2年前

    CC-3 ELECTROPHORESIS

    CC-3 ELECTROPHORESIS

    41問 • 2年前
    Yves Laure Pimentel

    AUBF LAB SAFETY

    AUBF LAB SAFETY

    Yves Laure Pimentel · 87問 · 2年前

    AUBF LAB SAFETY

    AUBF LAB SAFETY

    87問 • 2年前
    Yves Laure Pimentel

    CSF 1

    CSF 1

    Yves Laure Pimentel · 100問 · 2年前

    CSF 1

    CSF 1

    100問 • 2年前
    Yves Laure Pimentel

    CSF 2

    CSF 2

    Yves Laure Pimentel · 82問 · 2年前

    CSF 2

    CSF 2

    82問 • 2年前
    Yves Laure Pimentel

    SEMEN 1

    SEMEN 1

    Yves Laure Pimentel · 100問 · 2年前

    SEMEN 1

    SEMEN 1

    100問 • 2年前
    Yves Laure Pimentel

    SEMEN 2

    SEMEN 2

    Yves Laure Pimentel · 7問 · 2年前

    SEMEN 2

    SEMEN 2

    7問 • 2年前
    Yves Laure Pimentel

    SYNOVIAL FLUID 1

    SYNOVIAL FLUID 1

    Yves Laure Pimentel · 100問 · 2年前

    SYNOVIAL FLUID 1

    SYNOVIAL FLUID 1

    100問 • 2年前
    Yves Laure Pimentel

    SYNOVIAL FLUID 2

    SYNOVIAL FLUID 2

    Yves Laure Pimentel · 6問 · 2年前

    SYNOVIAL FLUID 2

    SYNOVIAL FLUID 2

    6問 • 2年前
    Yves Laure Pimentel

    SEROUS FLUID

    SEROUS FLUID

    Yves Laure Pimentel · 25問 · 2年前

    SEROUS FLUID

    SEROUS FLUID

    25問 • 2年前
    Yves Laure Pimentel

    PLEURAL FLUID

    PLEURAL FLUID

    Yves Laure Pimentel · 44問 · 2年前

    PLEURAL FLUID

    PLEURAL FLUID

    44問 • 2年前
    Yves Laure Pimentel

    PERICARDIAL FLUID

    PERICARDIAL FLUID

    Yves Laure Pimentel · 18問 · 2年前

    PERICARDIAL FLUID

    PERICARDIAL FLUID

    18問 • 2年前
    Yves Laure Pimentel

    PERITONEAL FLUID/ ASCITIC FLUID

    PERITONEAL FLUID/ ASCITIC FLUID

    Yves Laure Pimentel · 30問 · 2年前

    PERITONEAL FLUID/ ASCITIC FLUID

    PERITONEAL FLUID/ ASCITIC FLUID

    30問 • 2年前
    Yves Laure Pimentel

    AMNIOTIC FLUID

    AMNIOTIC FLUID

    Yves Laure Pimentel · 92問 · 2年前

    AMNIOTIC FLUID

    AMNIOTIC FLUID

    92問 • 2年前
    Yves Laure Pimentel

    FECALYSIS

    FECALYSIS

    Yves Laure Pimentel · 80問 · 2年前

    FECALYSIS

    FECALYSIS

    80問 • 2年前
    Yves Laure Pimentel

    問題一覧

  • 1

    Side –Chain theory STIMULATED BY?

    Paul Ehrlich

  • 2

    theory which Cells have specific receptor for antigen before exposure

    Side –Chain theory

  • 3

    theory for Lock and key

    Side –Chain theory

  • 4

    it laid the foundation for further hypotheses.

    Side –Chain theory

  • 5

    Clonal Selection Discovered by?

    Niels Jerne and Macfarlane Burnet

  • 6

    Niels Jerne and Macfarlane Burnet discovered

    Clonal Selection

  • 7

    what do you call where Each lymphocyte is preprogrammed to prod. 1 type of Ig and specific Ag selects them. 3 to 5 days proliferation

    Clonal Selection

  • 8

    Accounts for most of the basic properties of the adaptive immune system

    Clonal Selection

  • 9

    Constant and variable region have separated genes for coding discovered by

    Dryer and Bennet

  • 10

    Who Discovered that chromosomes contain no intact gene for Ig, only bldg. blocks from w/c gene can be assembled

    Tonegawa

  • 11

    Discoverers -ANTIBODY

    Gerald Edelman and Rodney Porter

  • 12

    ANTIBODY Heavy Chain -CHROMOSOME #

    14

  • 13

    ANTIBODY Light Chains -CHROMOSOME #

    2 and 22

  • 14

    ANTIBODY Light Chains -2 and 22 2 types

    kappa lambda

  • 15

    Sensitive indicator of a monoclonal gammopathy

    Serum Free Light Chain

  • 16

    Serum Free Light Chain Found in

    MULTIPLE MYELOMA

  • 17

    Serum Free Light Chain MEASURED BY rate or endpoint (also heavy chain)

    NEPHELOMETRY

  • 18

    Bence Jones Protein Discoverer:

    Dr.Henry Bence-Jones

  • 19

    Dr.Henry Bence-Jones Discovered?

    Bence Jones Protein

  • 20

    light chains secreted by malignant Plasma cells

    Bence Jones Protein

  • 21

    found in urine of patient with MULTIPLE MYELOMA

    Bence Jones Protein

  • 22

    Bence Jones Protein found in urine of patient with

    MULTIPLE MYELOMA

  • 23

    Bence Jones Precipitate at ? at dissolve at ?

    Precipitate at 60C at dissolve at 80 to 100C

  • 24

    ANTIBODY Location

    Serum portion of the blood, gamma (y) region in electrophoresis

  • 25

    ANTIBODY Functions:

    Complement activation and Opsonization

  • 26

    ANTIBODY Composes:

    Tetrapeptide: 2 heavy chain and 2 light chain

  • 27

    2 heavy chain and 2 light chain

    Tetrapeptide:

  • 28

    ANTIBODY Mostly are ________ charge:

    POSITIVE

  • 29

    ANTIBODY – linking protein

    Cysteine

  • 30

    ANTIBODY – Cleavage with

    Papain and Pepsin

  • 31

    Has NO antigen binding ability

    Fc/Fragment

  • 32

    Fc/Fragment Crystallizable (at ?)

    4C

  • 33

    (at 4C)

    Fc/Fragment Crystallizable

  • 34

    Important in effector function of Ig

    Fc/Fragment Crystallizable

  • 35

    CLEAVE IN TO 2 PARTS

    Pepsin

  • 36

    Pepsin CLEAVE IN TO 2 PARTS?

    1 FC AND 1 FAB

  • 37

    CLEAVED AB INTO 3 PARTS OR FRAGMENTS

    Papain

  • 38

    Papain CLEAVED AB INTO 3 PARTS OR FRAGMENTS?

    1 FC , 2 FAB

  • 39

    complement C1q binding portion

    CH2

  • 40

    Fc/Fragment Crystallizable Represents ? -terminal

    CARBOXY

  • 41

    Location: BETWEEN Ch1 and Ch2

    Hinge Region

  • 42

    Hinge Region Location:

    BETWEEN Ch1 and Ch2

  • 43

    Hinge Region has high content of ________ for FLEXIBILITY

    PROLINE

  • 44

    has high content of PROLINE for FLEXIBILITY

    Hinge Region

  • 45

    Hinge Region Enhance functional activity of _______

    FC

  • 46

    Enhance functional activity of FC

    Hinge Region

  • 47

    fix the complement

    CH1

  • 48

    FC BINDING PORTION

    CH3

  • 49

    Important in effector function of Ig ARE:

    CH1 CH2 CH3

  • 50

    IIMMUNOGLOBULINS IN HINGE REGION

    IgG IgA IgD

  • 51

    BEST IMMUNOGEN

    PROTEIN

  • 52

    MADE FROM AMINO ACID

    PROTEIN

  • 53

    Fab Fragment AKA

    (Fragment antigen-binding)

  • 54

    COMBINING SITE

    Fab Fragment (Fragment antigen-binding)

  • 55

    Fab Fragment (Fragment antigen-binding) ________ acid terminal

    AMINO

  • 56

    AMINO acid terminal

    Fab Fragment (Fragment antigen-binding)

  • 57

    Fab Fragment (Fragment antigen-binding) Fd Fragment

    1 LIGHT CHAIN AND 1/2 HEAVY CHAIN

  • 58

    Fab Fragment (Fragment antigen-binding) IN WHAT FRAGMENT?

    Fd Fragment

  • 59

    2 Regions

    Variable region Constant region

  • 60

    Variable region CONSIST OF

    VARIABLE LIGHT CHAIN AND VARIABLE HEAVY CHAIN

  • 61

    VARIABLE LIGHT CHAIN AND VARIABLE HEAVY CHAIN IS IN WHAT REGION?

    Variable region

  • 62

    CONSTANT HEAVY CHAIN AND CONSTANT LIGHT CHAIN

    Constant region

  • 63

    Constant region CONSISTS OF

    CONSTANT HEAVY CHAIN AND CONSTANT LIGHT CHAIN

  • 64

    1 LIGHT CHAIN AND 1/2 HEAVY CHAIN

    FD FRAGMENT

  • 65

    FD FRAGMENT CONSIST OF

    1 LIGHT CHAIN AND 1/2 HEAVY CHAIN

  • 66

    VARIABLE REGION OF LIGHT CHAIN AND HEAVY CHAIN

    COMBINING SITE

  • 67

    Antibody Variations are (3)

    Isotype Allotype Idiotype

  • 68

    Same heavy chain for each class

    Isotype

  • 69

    Variations in constant region

    Allotype

  • 70

    Variations in variable regions that give individual antibody molecules specificity

    Idiotype

  • 71

    Antibody Phases

    Lag phase Log phase Plateau Decline

  • 72

    Ab catabolism

    Decline

  • 73

    Decline

    Ab catabolism

  • 74

    Ab stabilizes

    Plateau

  • 75

    Plateau

    Ab stabilizes

  • 76

    Log phase –

    Ab increase

  • 77

    – Ab increase

    Log phase

  • 78

    Lag phase –

    No Ab detectable

  • 79

    – No Ab detectable

    Lag phase