3. NATURAL OR INNATE IMMUNITY

Yves Laure Pimentel · 70問 · 2年前

通報

問題一覧

most important phagocyte

Neutrophil

The regulator of energy that neutralize basophils and mast cells

eosinophils

most potent Antigen presenting cells

Dendritic cells

cell seen when there granulomatous inflammation ex. tuberculosis

Multinucleated Giant Cells

migration of neutrophil from blood to tissues by forming pseudopods squeezing through junctions

Diapedesis

Internal Defense: Cellular what type of immunity?

NATURAL OR INNATE IMMUNITY

- Dominant 1st to arrive then self destruct

Neutrophils

-Cells release nuclear content

NET (Neutrophil Extracellular Trap)

– Increase in allergy and parasitic infection

Eosinophils

Kill parasites

Eosinophils

Homeostatic regulator of INFLAMMATION

Eosinophils

– mediates anaphylaxis

Basophils

larger, longer life span (9 to 18 months), and differ in enzyme content.

Mast cells

TISSUE CELL OR NOT TRUE WBC

Mast cells

Mast cells – larger, longer life span (?), and differ in enzyme conten

9 to 18 months

Functions:  Microbial killing

Monocytes

Functions: Tumorcidal

Monocytes

Functions: Intracellular parasite eradication

Monocytes

Functions: Phagocytosis

Monocytes

Functions: Antigen presentation

Monocytes

– Cytokines that activate macrophage from T cells

IFN-Y and G-CSF

MOST COMMON ENDOTOXIN

LIPOPOLYSACCHARIDE

– TERMINAL stage of mononuclear phagocyte dev’t

Multinucleated Giant Cells

macrophages release ________ during antigen processing

IL1 & IL6

IT releases IL1 & IL6 during antigen processing

macrophages

– deficiency of B-GLUCOSE cerebrosidase

Gaucher’s

– deficiency of sphingomyelinase

Niemann-Pick Disease

Niemann-Pick Disease – deficiency of

sphingomyelinase

TNF a aka

cachetin

cachetin aka

TNF a

- uses tumor cells to assess the KILLING functions of monocytes

Cell-mediated monocytolysis

CELLS in skin and mucous membrane

Langerhan cells

2 Dendritic cells

i. Langerhan cells ii. Interstitial dendritic cells

Their main function is to phagocytose antigen and present it to T-helper cells

Dendritic Cells

Most potent phagocytic cell in the tissue

Dendritic Cells

Rich in MHC Class II molecules

Dendritic Cells

Dendritic Cells Rich in MHC Class ? molecules

Classified according to their tissue location

Dendritic Cells

What kind of dendritic cells?-Heart, lungs, Liver, kidney, and GI tract

Interstitial dendritic cells

other names parasitology

other names parasitology

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