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6. STAGES IN B-CELL DIFFERENTIATION  PROPIMAP
44問 • 1年前
  • Yves Laure Pimentel
    • 通報

    問題一覧

  • 1

    Earliest B-cell precursor

    Pro – B cells

  • 2

    the earliest B-cell precursor

    CD45R (B220 in mice).

  • 3

    Pro – B cells Rearrangement of Genes that code for the ________ and ________ Chains of Ab

    HEAVY CHAIN AND LIGHT CHAIN

  • 4

    Rearrangement of Genes that code for the HEAVY CHAIN AND LIGHT CHAIN Chains of Ab

    Pro – B cells

  • 5

    Rearrangement of Heavy Chain genes.

    Pro – B cells

  • 6

    Pro – B cells Distinctive markers:

    CD19, CD 45R, CD43, CD 24 and c-Kit, TdT

  • 7

    IT HELPS TO MATURE IGM

    IGD

  • 8

    Differentiation of pro-B cells into pre-B cells occurs upon successful rearrangement of ________-

    HEAVY chain genes

  • 9

    Begins when HC synthesis occus

    Pre – B cells

  • 10

    synthesis of µ chain (first heavy chains synthesized) (IgM) in the cytoplasm

    Pre – B cells

  • 11

    synthesis of µ chain (first heavy chains synthesized) (?) in the cytoplasm

    IgM

  • 12

    Pre – B cells synthesis of ? (first heavy chains synthesized) (IgM) in the cytoplasm

    µ chain

  • 13

    u chain + unusual light chain

    SURROGATE light chain

  • 14

    SURROGATE light chain what stage

    Pre – B cells

  • 15

    CD43, c-Kit, and TdT are GONE in this stage

    Pre – B cells

  • 16

    are GONE in Pre – B cells stage

    CD43, c-Kit, and TdT

  • 17

    Ig LIGHT chain rearranged

    Pre – B cells

  • 18

    Immature B cells MARKERS?

    CD21, CD40 & MHC II

  • 19

    MARKERS: CD21, CD40 & MHC II

    Immature B cells

  • 20

    appearance of complete IGM

    Immature B cells

  • 21

    Immature B cells appearance of complete ___?

    IGM

  • 22

    receptor for a breakdown product of the complement component of C3 (C3d)

    CD21

  • 23

    – important for interaction of B cells with T cells

    CD40 and MHC class II

  • 24

    In the spleen, immature B cells develop into mature cells known as ________ zone B cells

    MARGINAL

  • 25

    In the spleen, THIS CAN develop into mature cells known as MARGINAL zone B cells

    immature B cells

  • 26

    Other ? become follicular B cells, which are found in lymph nodes and other secondary organs.

    immature B cells

  • 27

    Other immature B cells become follicular B cells, which are found in ?

    lymph nodes and other secondary organs.

  • 28

    Other immature B cells become ? which are found in lymph nodes and other secondary organs.

    follicular B cells

  • 29

    PRESENCE OF? These surface immunoglobulins provide the primary activating signal to B cells when contact with antigen takes place

    IGM AND IGD

  • 30

    PROLONGS the life span of mature B cells

    IGD

  • 31

    Antigen-DEPENDENT

    Activated B cells

  • 32

    Activated B cells Antigen-________

    DEPENDENT

  • 33

    -Receptor for IL 2

    CD 25

  • 34

    CD 25 -Receptor for

    IL 2

  • 35

    Give rise to Plasma and Memory cell

    Activated B cells

  • 36

    Activated B cells Give rise to

    Plasma and Memory cell

  • 37

    spherical and ellipsoidal ECCENTRIC nucleus

    Plasma Cells

  • 38

    Function: Antibody production

    Plasma Cells

  • 39

    Plasma Cells Function:

    Antibody production

  • 40

    nondividing

    Plasma Cells

  • 41

    they are similar in appearance to unstimulated B cells, but they remain in an activated state for months or years, ready to respond to the initial antigen.

    Memory cells

  • 42

    B CELL SUBSETS

    B1 B2

  • 43

    most common, greater Ag receptor diversity, and response effectively to T cell

    B2

  • 44

    most common, greater Ag receptor diversity, and response effectively to T cell AUTO ANTIBODY

    B1

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    問題一覧

  • 1

    Earliest B-cell precursor

    Pro – B cells

  • 2

    the earliest B-cell precursor

    CD45R (B220 in mice).

  • 3

    Pro – B cells Rearrangement of Genes that code for the ________ and ________ Chains of Ab

    HEAVY CHAIN AND LIGHT CHAIN

  • 4

    Rearrangement of Genes that code for the HEAVY CHAIN AND LIGHT CHAIN Chains of Ab

    Pro – B cells

  • 5

    Rearrangement of Heavy Chain genes.

    Pro – B cells

  • 6

    Pro – B cells Distinctive markers:

    CD19, CD 45R, CD43, CD 24 and c-Kit, TdT

  • 7

    IT HELPS TO MATURE IGM

    IGD

  • 8

    Differentiation of pro-B cells into pre-B cells occurs upon successful rearrangement of ________-

    HEAVY chain genes

  • 9

    Begins when HC synthesis occus

    Pre – B cells

  • 10

    synthesis of µ chain (first heavy chains synthesized) (IgM) in the cytoplasm

    Pre – B cells

  • 11

    synthesis of µ chain (first heavy chains synthesized) (?) in the cytoplasm

    IgM

  • 12

    Pre – B cells synthesis of ? (first heavy chains synthesized) (IgM) in the cytoplasm

    µ chain

  • 13

    u chain + unusual light chain

    SURROGATE light chain

  • 14

    SURROGATE light chain what stage

    Pre – B cells

  • 15

    CD43, c-Kit, and TdT are GONE in this stage

    Pre – B cells

  • 16

    are GONE in Pre – B cells stage

    CD43, c-Kit, and TdT

  • 17

    Ig LIGHT chain rearranged

    Pre – B cells

  • 18

    Immature B cells MARKERS?

    CD21, CD40 & MHC II

  • 19

    MARKERS: CD21, CD40 & MHC II

    Immature B cells

  • 20

    appearance of complete IGM

    Immature B cells

  • 21

    Immature B cells appearance of complete ___?

    IGM

  • 22

    receptor for a breakdown product of the complement component of C3 (C3d)

    CD21

  • 23

    – important for interaction of B cells with T cells

    CD40 and MHC class II

  • 24

    In the spleen, immature B cells develop into mature cells known as ________ zone B cells

    MARGINAL

  • 25

    In the spleen, THIS CAN develop into mature cells known as MARGINAL zone B cells

    immature B cells

  • 26

    Other ? become follicular B cells, which are found in lymph nodes and other secondary organs.

    immature B cells

  • 27

    Other immature B cells become follicular B cells, which are found in ?

    lymph nodes and other secondary organs.

  • 28

    Other immature B cells become ? which are found in lymph nodes and other secondary organs.

    follicular B cells

  • 29

    PRESENCE OF? These surface immunoglobulins provide the primary activating signal to B cells when contact with antigen takes place

    IGM AND IGD

  • 30

    PROLONGS the life span of mature B cells

    IGD

  • 31

    Antigen-DEPENDENT

    Activated B cells

  • 32

    Activated B cells Antigen-________

    DEPENDENT

  • 33

    -Receptor for IL 2

    CD 25

  • 34

    CD 25 -Receptor for

    IL 2

  • 35

    Give rise to Plasma and Memory cell

    Activated B cells

  • 36

    Activated B cells Give rise to

    Plasma and Memory cell

  • 37

    spherical and ellipsoidal ECCENTRIC nucleus

    Plasma Cells

  • 38

    Function: Antibody production

    Plasma Cells

  • 39

    Plasma Cells Function:

    Antibody production

  • 40

    nondividing

    Plasma Cells

  • 41

    they are similar in appearance to unstimulated B cells, but they remain in an activated state for months or years, ready to respond to the initial antigen.

    Memory cells

  • 42

    B CELL SUBSETS

    B1 B2

  • 43

    most common, greater Ag receptor diversity, and response effectively to T cell

    B2

  • 44

    most common, greater Ag receptor diversity, and response effectively to T cell AUTO ANTIBODY

    B1