Earliest B-cell precursor

the earliest B-cell precursor

Pro – B cells Rearrangement of Genes that code for the ________ and ________ Chains of Ab

Rearrangement of Genes that code for the HEAVY CHAIN AND LIGHT CHAIN Chains of Ab

Rearrangement of Heavy Chain genes.

Pro – B cells Distinctive markers:

IT HELPS TO MATURE IGM

Differentiation of pro-B cells into pre-B cells occurs upon successful rearrangement of ________-

Begins when HC synthesis occus

synthesis of µ chain (first heavy chains synthesized) (IgM) in the cytoplasm

synthesis of µ chain (first heavy chains synthesized) (?) in the cytoplasm

Pre – B cells synthesis of ? (first heavy chains synthesized) (IgM) in the cytoplasm

u chain + unusual light chain

SURROGATE light chain what stage

CD43, c-Kit, and TdT are GONE in this stage

are GONE in Pre – B cells stage

Ig LIGHT chain rearranged

Immature B cells MARKERS?

MARKERS: CD21, CD40 & MHC II

appearance of complete IGM

Immature B cells appearance of complete ___?

receptor for a breakdown product of the complement component of C3 (C3d)

– important for interaction of B cells with T cells

In the spleen, immature B cells develop into mature cells known as ________ zone B cells

In the spleen, THIS CAN develop into mature cells known as MARGINAL zone B cells

Other ? become follicular B cells, which are found in lymph nodes and other secondary organs.

Other immature B cells become follicular B cells, which are found in ?

Other immature B cells become ? which are found in lymph nodes and other secondary organs.

PRESENCE OF? These surface immunoglobulins provide the primary activating signal to B cells when contact with antigen takes place

PROLONGS the life span of mature B cells

Antigen-DEPENDENT

Activated B cells Antigen-________

-Receptor for IL 2

CD 25 -Receptor for

Give rise to Plasma and Memory cell

Activated B cells Give rise to

spherical and ellipsoidal ECCENTRIC nucleus

Function: Antibody production

Plasma Cells Function:

nondividing

they are similar in appearance to unstimulated B cells, but they remain in an activated state for months or years, ready to respond to the initial antigen.

B CELL SUBSETS

most common, greater Ag receptor diversity, and response effectively to T cell

most common, greater Ag receptor diversity, and response effectively to T cell AUTO ANTIBODY