-Discovered in virally infected cultured cells;

This interference with viral replication in the cells by another virus

An Antiviral; produced by dendritic cells

interferon is Antiviral; produced by ?

what are the Type I IFN:

Major producer: Fibroblast and Epithelial cell

IFN-beta (Fibroblast/Fibroepithelial Interferon) Major producer:

Major producer: NK cells/ Null Cells

IFN-alpha (Leukocyte Interferon) Major producer:

-Produced by virus-induced Leukocyte culture

Type II IFN

what Type of IFN-gamma (Immune Interferon)

-Produced by immulogically stimulated Lymphocyte

IFN-gamma (Immune Interferon) Major Producer:

Stimulates Antigen Presentation by MHC I and MHC II molecules

Type II IFN IFN-gamma (Immune Interferon) Stimulates Antigen Presentation by ?

-For Gram (-) bacteria

Tumor Necrosis Factor -For ? bacteria

-Principal mediator of the acutte inflammatory response to LPS in Gram Negative bacteria

-Produced by Macrophages and NK cells -Action: Local inflammation

TNF-alpha (Cachectin) -Produced by ? -Action: Local inflammation

TNF-alpha (Cachectin) -Produced by Macrophages and NK cells -Action: ?

TNF-alpha (?) -Produced by Macrophages and NK cells -Action: Local inflammation

(Cachectin)

TNF-beta (?)

(Lymphotoxin)

TNF-beta (Lymphotoxin) -Produced by ? -Action: Killing of target cells

TNF-beta (Lymphotoxin) -Produced by T cells (CD4 and CD8) and B cells -Action: ?