MAJOR LIPOPROTEINS | 暗記メーカー

暗記メーカー

MAJOR LIPOPROTEINS

57問 • 2年前

Yves Laure Pimentel

問題一覧

1

MAJOR LIPOPROTEINS ARE

Chylomicrons (CM Very Low Density Lipoprotein/Pre-Beta Lipoprotein (VLDL) High density Lipoprotein/Alpha Lipoprotein (HDL)

2

Chylomicrons (CM)______and ______dense._________ TAG TRANSPORT

LARGEST; LEAST; EXOGENOUS/ DIETARY

3

Chylomicrons (CM) Apolipoproteins:

Apo-B 48

4

Chylomicrons (CM) delivers TAG in?

TISSUE AND LIVER

5

Very Low Density Lipoprotein/Pre-Beta Lipoprotein (VLDL) ____________TAG Transport

ENDOGENOUS

6

are secreted into the blood by the liver for metabolism in peripheral tissues.

Very Low Density Lipoprotein/Pre-Beta Lipoprotein (VLDL)

7

Very Low Density Lipoprotein/Pre-Beta Lipoprotein (VLDL) Apolipoproteins:

Apo B-100

8

what VLDL stimulates?

FATS AND CARBOHYDRATES

9

High density Lipoprotein/Alpha Lipoprotein (HDL) synthesized in the ?

INTESTINES and liver cells

10

HDL molecules are RECYCLED? molecules

chylomicron and VLDL

11

High density Lipoprotein/Alpha Lipoprotein (HDL)______and ______dense

SMALLEST AND MOST

12

REVERSE cholesterol Transport

High density Lipoprotein/Alpha Lipoprotein (HDL)

13

HDL maintains the ________of cholesterol

EQUILIBRIUM

14

HDL Apolipoproteins:

Apo A-1

15

Prevents build up of cholesterol in Blood Vessel

ANTI ATHEROGENIC

16

Three Step Procedure: accepted reference method for HDL-C developed at the CDC.

● 1.Ultracentrifugation: ● 2.Heparin Manganese: ● 3.Supernatant Analysis by Abell-Kendall assay

17

Supernatant Analysis by ? WHICH IS FOUND IN THE?

Abell-Kendall assay HDL

18

1.Ultracentrifugation: IS?

TO REMOVE VLDL

19

2.Heparin Manganese: IS?

TO REMOVE LDL

20

HDL Reference value:

40 mg/dL (cutoff level)

21

EXAMPLES OF STEROID HORMONES

CORTISOL ALDOSTERONES

22

<35mg/dL IN HDL

– high risk for CHD

23

– high risk for CHD IN HDL

<35mg/dL

24

≥60 mg/dL IN HDL

high (protective)

25

high (protective) IN HDL

≥60 mg/dL

26

MAJOR cholesterol carrier and transports a large amount of endogenous cholesterol

Low Density Lipoprotein/Beta Lipoprotein (LDL)

27

Low Density Lipoprotein/Beta Lipoprotein (LDL) most __________lipoprotein

ATHEROGENIC

28

Low Density Lipoprotein/Beta Lipoprotein (LDL) .____________cholesterol pathway

FORWARD

29

FORWARD cholesterol pathway

Low Density Lipoprotein/Beta Lipoprotein (LDL) .

30

LDL Apolipoproteins

Apo B-100

31

LDL –C is currently considered the most important value in assessing _________risk

CARDIAC

32

is currently considered the most important value in assessing CARDIAC risk

LDL –C

33

Formula For LDL – Cholesterol (LDL-C) =

TC-HDL-VLDL

34

Friedewald Method (indirect method) METHOD SHORTCUT

TC-HDL-TAG/5 OR 2.175

35

Friedewald Method (indirect method ⇒ indirect, not valid for triglycerides over ____mg/dL)

400

36

Friedewald Method (indirect method) VLDL (mmol/L) =Plasma TAG/?

2.175

37

Friedewald Method (indirect method) VLDL (mg/dL) =Plasma TAG/ ?

5

38

Low Density Lipoprotein/Beta Lipoprotein (LDL) 2 METHODS

Friedewald Method (indirect method) De Long Method (indirect method)

39

De Long Method (indirect method) ⇒ VLDL (mmol/L) = Plasma TAG/?

2.825

40

De Long Method (indirect method ⇒ VLDL (mg/dL) =Plasma TAG/

6.5

41

Reference values <100 mg/dL =

optimal

42

Reference values = optimal

<100 mg/dL

43

Reference values 100 -129 mg/dL =

near/above optimal

44

Reference values = near/above optimal

100 -129 mg/dL

45

Reference values 130-159 mg/dL =

borderline high

46

Reference values = borderline high

130-159 mg/dL

47

Reference values 160-189 mg/dL =

high

48

Reference values = high

160-189 mg/dL

49

Reference values ≥190 mg/dL =

very high

50

Reference values = very high

≥190 mg/dL

51

is the target medications for patient with CHD

LDL-C

52

LDL-C is the target medications for patient with

CHD

53

NCEP (?)

NATIONAL CHOLESTEROL EDUCATION PROGRAM

54

Total cholesterol __% CV

3

55

HDL-C (≥42mg/dL) __%CV

4

56

LDL-C ___% CV

4

57

TAG ___% CV

5

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問題一覧

1

MAJOR LIPOPROTEINS ARE

Chylomicrons (CM Very Low Density Lipoprotein/Pre-Beta Lipoprotein (VLDL) High density Lipoprotein/Alpha Lipoprotein (HDL)

2

Chylomicrons (CM)______and ______dense._________ TAG TRANSPORT

LARGEST; LEAST; EXOGENOUS/ DIETARY

3

Chylomicrons (CM) Apolipoproteins:

Apo-B 48

4

Chylomicrons (CM) delivers TAG in?

TISSUE AND LIVER

5

Very Low Density Lipoprotein/Pre-Beta Lipoprotein (VLDL) ____________TAG Transport

ENDOGENOUS

6

are secreted into the blood by the liver for metabolism in peripheral tissues.

Very Low Density Lipoprotein/Pre-Beta Lipoprotein (VLDL)

7

Very Low Density Lipoprotein/Pre-Beta Lipoprotein (VLDL) Apolipoproteins:

Apo B-100

8

what VLDL stimulates?

FATS AND CARBOHYDRATES

9

High density Lipoprotein/Alpha Lipoprotein (HDL) synthesized in the ?

INTESTINES and liver cells

10

HDL molecules are RECYCLED? molecules

chylomicron and VLDL

11

High density Lipoprotein/Alpha Lipoprotein (HDL)______and ______dense

SMALLEST AND MOST

12

REVERSE cholesterol Transport

High density Lipoprotein/Alpha Lipoprotein (HDL)

13

HDL maintains the ________of cholesterol

EQUILIBRIUM

14

HDL Apolipoproteins:

Apo A-1

15

Prevents build up of cholesterol in Blood Vessel

ANTI ATHEROGENIC

16

Three Step Procedure: accepted reference method for HDL-C developed at the CDC.

● 1.Ultracentrifugation: ● 2.Heparin Manganese: ● 3.Supernatant Analysis by Abell-Kendall assay

17

Supernatant Analysis by ? WHICH IS FOUND IN THE?

Abell-Kendall assay HDL

18

1.Ultracentrifugation: IS?

TO REMOVE VLDL

19

2.Heparin Manganese: IS?

TO REMOVE LDL

20

HDL Reference value:

40 mg/dL (cutoff level)

21

EXAMPLES OF STEROID HORMONES

CORTISOL ALDOSTERONES

22

<35mg/dL IN HDL

– high risk for CHD

23

– high risk for CHD IN HDL

<35mg/dL

24

≥60 mg/dL IN HDL

high (protective)

25

high (protective) IN HDL

≥60 mg/dL

26

MAJOR cholesterol carrier and transports a large amount of endogenous cholesterol

Low Density Lipoprotein/Beta Lipoprotein (LDL)

27

Low Density Lipoprotein/Beta Lipoprotein (LDL) most __________lipoprotein

ATHEROGENIC

28

Low Density Lipoprotein/Beta Lipoprotein (LDL) .____________cholesterol pathway

FORWARD

29

FORWARD cholesterol pathway

Low Density Lipoprotein/Beta Lipoprotein (LDL) .

30

LDL Apolipoproteins

Apo B-100

31

LDL –C is currently considered the most important value in assessing _________risk

CARDIAC

32

is currently considered the most important value in assessing CARDIAC risk

LDL –C

33

Formula For LDL – Cholesterol (LDL-C) =

TC-HDL-VLDL

34

Friedewald Method (indirect method) METHOD SHORTCUT

TC-HDL-TAG/5 OR 2.175

35

Friedewald Method (indirect method ⇒ indirect, not valid for triglycerides over ____mg/dL)

400

36

Friedewald Method (indirect method) VLDL (mmol/L) =Plasma TAG/?

2.175

37

Friedewald Method (indirect method) VLDL (mg/dL) =Plasma TAG/ ?

5

38

Low Density Lipoprotein/Beta Lipoprotein (LDL) 2 METHODS

Friedewald Method (indirect method) De Long Method (indirect method)

39

De Long Method (indirect method) ⇒ VLDL (mmol/L) = Plasma TAG/?

2.825

40

De Long Method (indirect method ⇒ VLDL (mg/dL) =Plasma TAG/

6.5

41

Reference values <100 mg/dL =

optimal

42

Reference values = optimal

<100 mg/dL

43

Reference values 100 -129 mg/dL =

near/above optimal

44

Reference values = near/above optimal

100 -129 mg/dL

45

Reference values 130-159 mg/dL =

borderline high

46

Reference values = borderline high

130-159 mg/dL

47

Reference values 160-189 mg/dL =

high

48

Reference values = high

160-189 mg/dL

49

Reference values ≥190 mg/dL =

very high

50

Reference values = very high

≥190 mg/dL

51

is the target medications for patient with CHD

LDL-C

52

LDL-C is the target medications for patient with

CHD

53

NCEP (?)

NATIONAL CHOLESTEROL EDUCATION PROGRAM

54

Total cholesterol __% CV

3

55

HDL-C (≥42mg/dL) __%CV

4

56

LDL-C ___% CV

4

57

TAG ___% CV

5