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9. MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN
50問 • 1年前
  • Yves Laure Pimentel
    • 通報

    問題一覧

  • 1

    what is used to irradiate the donor's cell

    mytomycin C

  • 2

    in lymphotoxicity (microtoxicity) testing what is the indicator of cell dies / dye uptake

    positive

  • 3

    cells are viable/ no dye uptake

    negative

  • 4

    What do you call the antigens that bypass normal antigen processing that causes T cell activation leading to tumor necrosis factor release leading to cardiac arrest

    superantigens

  • 5

    T/F immunogen needs to be degraded for b cell to recognize it presented by the MHC

    False

  • 6

    what class present intracellular

    CLASS I

  • 7

    what class has gene product HLA DP/SB, HLA DQ/DC, HLA DR

    CLASS 2

  • 8

    Gene product is Complement TNF Heat shock protein Steroid enzymes (21 hydroxylase enzyme) C2 , C4, Factor B

    CLASS III

  • 9

    cell that receives class I

    CD8

  • 10

    The most polymorphic system

    MHC

  • 11

    substance that added to vaccine that induces local inflammation

    adjuvants

  • 12

    : discovered an antibody response to circulating WBC

    French Dausset

  • 13

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN Synthesized in

    ROUGH ENDOPLOASMIC RETICULUM

  • 14

    The most POLYMORPHIC system

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

  • 15

    Bring Antigen to the cell surface for recognition by T cells.

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

  • 16

    Pivot to Humoral and Cellular immunity

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

  • 17

    Involved in Transfusion

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

  • 18

    Classes of MHC

    CLASS I CLASS II CLASS III

  • 19

    High= Lymphocytes (T & B cells)

    CLASS I

  • 20

    Low = LIVER, neural cells, muscle cells and sperm

    CLASS I

  • 21

    CLASS I GENE PRODUCTS

    HLA A HLA B HLA C

  • 22

    CLASS II GENE PRODUCTS

    HLA DP/SB HLA DQ/DC HLA DR

  • 23

    Restricted to APC

    CLASS II

  • 24

    CLASS III GENE PRODUCTS

    Complement TNF Heat shock protein Steroid enzymes (21 hydroxylase enzyme) C2, C4, Factor B

  • 25

    THIS ORGAN DOESNT NEED TO HLA TYPE

    LIVER

  • 26

    Restricted to APC IN CLASS II ARE

    BMDM B CELL MONOCYTE DENDRITIC MACROPHAGE

  • 27

    Present INTRACELLULAR antigens

    CLASS I

  • 28

    Present EXTRACELLULAR antigens

    CLASS II

  • 29

    Cytotoxic T cells directed against class I antigens are inhibited by

    CD8 cells

  • 30

    Cytotoxic T cells directed against WHAT class ? antigens are inhibited by CD8 cells;

    CLASS I

  • 31

    Cytotoxic T cells directed against class II antigens are inhibited by ________ cells

    CD4

  • 32

    -Watchdog of viral, tumor, and certain parasite

    MHC 1

  • 33

    Restrict Treg

    CLASS II

  • 34

    – no NEED for MHC presentation

    B cells

  • 35

    – caused by polysaccharide polymers (dextran)

    T-Independent Antigen Triggering

  • 36

    T-Independent Antigen Triggering – caused by polysaccharide polymers (?)

    dextran

  • 37

    - must be DEGRADED and be presented by MHC

    T cells

  • 38

    Methods of Detecting HLA Antigens

    Lymphotoxicity (microtoxicity) testing Mixed lymphocyte reaction

  • 39

    – IDENTIFIES Class I and Class II HLA Ag

    Lymphotoxicity (microtoxicity) testing

  • 40

    determine class II COMPATIBILITY between donor and recipient

    Mixed lymphocyte reaction

  • 41

    USED TO PREVENT DONOR'S CELL REPLICATION

    MYTOMYCIN C

  • 42

    Irradiated donor’s lymphocytes + Recipient’s lymphocytes =

    PROLIFERATION

  • 43

    COMPATIBLE

    PROLIFERATION

  • 44

    INCOMPATIBLE

    NO PROLIFERATION

  • 45

    NO PROLIFERATION

    INCOMPATIBLE

  • 46

    PROLIFERATION

    COMPATIBLE

  • 47

    – STIMULATOR cell

    Donor’s lymphocytes

  • 48

    Donor’s lymphocytes

    – STIMULATOR cell

  • 49

    – RESPONDER cells

    Recipient’s lymphocytes

  • 50

    Recipient’s lymphocytes

    – RESPONDER cells

    • other names parasitology

    other names parasitology

    Yves Laure Pimentel · 70問 · 2年前

    other names parasitology

    other names parasitology

    70問 • 2年前
    Yves Laure Pimentel

    PARASITOLOGY

    PARASITOLOGY

    Yves Laure Pimentel · 111問 · 2年前

    PARASITOLOGY

    PARASITOLOGY

    111問 • 2年前
    Yves Laure Pimentel

    HTMLBE

    HTMLBE

    Yves Laure Pimentel · 64問 · 2年前

    HTMLBE

    HTMLBE

    64問 • 2年前
    Yves Laure Pimentel

    CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

    CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

    Yves Laure Pimentel · 61問 · 2年前

    CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

    CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

    61問 • 2年前
    Yves Laure Pimentel

    HISTOPATHOLOGY

    HISTOPATHOLOGY

    Yves Laure Pimentel · 69問 · 2年前

    HISTOPATHOLOGY

    HISTOPATHOLOGY

    69問 • 2年前
    Yves Laure Pimentel

    CC-2 SPECTROPHOTOMETRY

    CC-2 SPECTROPHOTOMETRY

    Yves Laure Pimentel · 100問 · 2年前

    CC-2 SPECTROPHOTOMETRY

    CC-2 SPECTROPHOTOMETRY

    100問 • 2年前
    Yves Laure Pimentel

    CC-3 ELECTROPHORESIS

    CC-3 ELECTROPHORESIS

    Yves Laure Pimentel · 41問 · 2年前

    CC-3 ELECTROPHORESIS

    CC-3 ELECTROPHORESIS

    41問 • 2年前
    Yves Laure Pimentel

    AUBF LAB SAFETY

    AUBF LAB SAFETY

    Yves Laure Pimentel · 87問 · 2年前

    AUBF LAB SAFETY

    AUBF LAB SAFETY

    87問 • 2年前
    Yves Laure Pimentel

    CSF 1

    CSF 1

    Yves Laure Pimentel · 100問 · 2年前

    CSF 1

    CSF 1

    100問 • 2年前
    Yves Laure Pimentel

    CSF 2

    CSF 2

    Yves Laure Pimentel · 82問 · 2年前

    CSF 2

    CSF 2

    82問 • 2年前
    Yves Laure Pimentel

    SEMEN 1

    SEMEN 1

    Yves Laure Pimentel · 100問 · 2年前

    SEMEN 1

    SEMEN 1

    100問 • 2年前
    Yves Laure Pimentel

    SEMEN 2

    SEMEN 2

    Yves Laure Pimentel · 7問 · 2年前

    SEMEN 2

    SEMEN 2

    7問 • 2年前
    Yves Laure Pimentel

    SYNOVIAL FLUID 1

    SYNOVIAL FLUID 1

    Yves Laure Pimentel · 100問 · 2年前

    SYNOVIAL FLUID 1

    SYNOVIAL FLUID 1

    100問 • 2年前
    Yves Laure Pimentel

    SYNOVIAL FLUID 2

    SYNOVIAL FLUID 2

    Yves Laure Pimentel · 6問 · 2年前

    SYNOVIAL FLUID 2

    SYNOVIAL FLUID 2

    6問 • 2年前
    Yves Laure Pimentel

    SEROUS FLUID

    SEROUS FLUID

    Yves Laure Pimentel · 25問 · 2年前

    SEROUS FLUID

    SEROUS FLUID

    25問 • 2年前
    Yves Laure Pimentel

    PLEURAL FLUID

    PLEURAL FLUID

    Yves Laure Pimentel · 44問 · 2年前

    PLEURAL FLUID

    PLEURAL FLUID

    44問 • 2年前
    Yves Laure Pimentel

    PERICARDIAL FLUID

    PERICARDIAL FLUID

    Yves Laure Pimentel · 18問 · 2年前

    PERICARDIAL FLUID

    PERICARDIAL FLUID

    18問 • 2年前
    Yves Laure Pimentel

    PERITONEAL FLUID/ ASCITIC FLUID

    PERITONEAL FLUID/ ASCITIC FLUID

    Yves Laure Pimentel · 30問 · 2年前

    PERITONEAL FLUID/ ASCITIC FLUID

    PERITONEAL FLUID/ ASCITIC FLUID

    30問 • 2年前
    Yves Laure Pimentel

    AMNIOTIC FLUID

    AMNIOTIC FLUID

    Yves Laure Pimentel · 92問 · 2年前

    AMNIOTIC FLUID

    AMNIOTIC FLUID

    92問 • 2年前
    Yves Laure Pimentel

    FECALYSIS

    FECALYSIS

    Yves Laure Pimentel · 80問 · 2年前

    FECALYSIS

    FECALYSIS

    80問 • 2年前
    Yves Laure Pimentel

    問題一覧

  • 1

    what is used to irradiate the donor's cell

    mytomycin C

  • 2

    in lymphotoxicity (microtoxicity) testing what is the indicator of cell dies / dye uptake

    positive

  • 3

    cells are viable/ no dye uptake

    negative

  • 4

    What do you call the antigens that bypass normal antigen processing that causes T cell activation leading to tumor necrosis factor release leading to cardiac arrest

    superantigens

  • 5

    T/F immunogen needs to be degraded for b cell to recognize it presented by the MHC

    False

  • 6

    what class present intracellular

    CLASS I

  • 7

    what class has gene product HLA DP/SB, HLA DQ/DC, HLA DR

    CLASS 2

  • 8

    Gene product is Complement TNF Heat shock protein Steroid enzymes (21 hydroxylase enzyme) C2 , C4, Factor B

    CLASS III

  • 9

    cell that receives class I

    CD8

  • 10

    The most polymorphic system

    MHC

  • 11

    substance that added to vaccine that induces local inflammation

    adjuvants

  • 12

    : discovered an antibody response to circulating WBC

    French Dausset

  • 13

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN Synthesized in

    ROUGH ENDOPLOASMIC RETICULUM

  • 14

    The most POLYMORPHIC system

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

  • 15

    Bring Antigen to the cell surface for recognition by T cells.

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

  • 16

    Pivot to Humoral and Cellular immunity

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

  • 17

    Involved in Transfusion

    MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

  • 18

    Classes of MHC

    CLASS I CLASS II CLASS III

  • 19

    High= Lymphocytes (T & B cells)

    CLASS I

  • 20

    Low = LIVER, neural cells, muscle cells and sperm

    CLASS I

  • 21

    CLASS I GENE PRODUCTS

    HLA A HLA B HLA C

  • 22

    CLASS II GENE PRODUCTS

    HLA DP/SB HLA DQ/DC HLA DR

  • 23

    Restricted to APC

    CLASS II

  • 24

    CLASS III GENE PRODUCTS

    Complement TNF Heat shock protein Steroid enzymes (21 hydroxylase enzyme) C2, C4, Factor B

  • 25

    THIS ORGAN DOESNT NEED TO HLA TYPE

    LIVER

  • 26

    Restricted to APC IN CLASS II ARE

    BMDM B CELL MONOCYTE DENDRITIC MACROPHAGE

  • 27

    Present INTRACELLULAR antigens

    CLASS I

  • 28

    Present EXTRACELLULAR antigens

    CLASS II

  • 29

    Cytotoxic T cells directed against class I antigens are inhibited by

    CD8 cells

  • 30

    Cytotoxic T cells directed against WHAT class ? antigens are inhibited by CD8 cells;

    CLASS I

  • 31

    Cytotoxic T cells directed against class II antigens are inhibited by ________ cells

    CD4

  • 32

    -Watchdog of viral, tumor, and certain parasite

    MHC 1

  • 33

    Restrict Treg

    CLASS II

  • 34

    – no NEED for MHC presentation

    B cells

  • 35

    – caused by polysaccharide polymers (dextran)

    T-Independent Antigen Triggering

  • 36

    T-Independent Antigen Triggering – caused by polysaccharide polymers (?)

    dextran

  • 37

    - must be DEGRADED and be presented by MHC

    T cells

  • 38

    Methods of Detecting HLA Antigens

    Lymphotoxicity (microtoxicity) testing Mixed lymphocyte reaction

  • 39

    – IDENTIFIES Class I and Class II HLA Ag

    Lymphotoxicity (microtoxicity) testing

  • 40

    determine class II COMPATIBILITY between donor and recipient

    Mixed lymphocyte reaction

  • 41

    USED TO PREVENT DONOR'S CELL REPLICATION

    MYTOMYCIN C

  • 42

    Irradiated donor’s lymphocytes + Recipient’s lymphocytes =

    PROLIFERATION

  • 43

    COMPATIBLE

    PROLIFERATION

  • 44

    INCOMPATIBLE

    NO PROLIFERATION

  • 45

    NO PROLIFERATION

    INCOMPATIBLE

  • 46

    PROLIFERATION

    COMPATIBLE

  • 47

    – STIMULATOR cell

    Donor’s lymphocytes

  • 48

    Donor’s lymphocytes

    – STIMULATOR cell

  • 49

    – RESPONDER cells

    Recipient’s lymphocytes

  • 50

    Recipient’s lymphocytes

    – RESPONDER cells