5. INTERNAL DEFENSE:SOLUBLE FACTORS (ACUTE PHASE REACTANTS)

Yves Laure Pimentel · 70問 · 2年前

通報

問題一覧

major component of Alpha 1 band

Alpha1- antitrypsin

These are natural antibiotics

LYSOZYMES AND INTERFERONS

protect us againts the oxidative property of Ironw because it binds hemoglobin and it has inverse relationship to intravascular hemolysis

Haptoglobin

how many % increases of Acute Phase reactants if there is an inflammation

>25%

stimulus of APR

IL 6

parameter and used to monitor inflammation

C REACTIVE PROTEIN -CRP

non specific form of ab

CRP

indirect measurement of APR and reacts slowly

ESR

major humoral (fluid) component of natural immunity

Complement C3

what is the humoral factor that has enzymatic activity that binds copper; for serum copper measurement

Ceruloplasmin

increase when there is inflammation

Acute phase Reactants

APR production in the

LIVER

It triggers inflammation in APR

EXERCISE

Are cellular factors of immunity that process and "present" antigens to T cell receptor

ANTIGEN PRESENTING CELLS

C-Reactive Protein: increase AT

1000x (100 fold)

C-Reactive Protein hours half life

6-10 hours half life

C-Reactive Protein: Adult:

Adult: <0.05mg/dL

indicator of acute INFLAMMATION

C-Reactive Protein

non specific form of Ab.

C-Reactive Protein

used for DIFFERENTIATION between bacterial and viral infection

C-Reactive Protein

COMPLEMENT ACTIVATOR

Opsonin

C-Reactive Protein Main Substrate: COMMON CONSTITUENT OF MICROBIAL ENZYMES

Phosphocholine

Threshold for High Cardiovascular risk

C-Reactive Protein

Indirect measure of APR

ESR

Direct and quantitative measure of APR

CRP

Reacts SLOWLY

ESR

Reacts RAPIDLY

CRP

Removal of cholesterol (cholesterol-filled macrophages) ? Recycle

Serum Amyloid A

Serum Amyloid A:x?,

1000x

Increase more in bacterial than viral infection

Serum Amyloid A

protease inhibitor (elastase)

Alpha1-antitrypsin

Alpha1-antitrypsin –?x, ? hours

2-5x, 24 hours

Alpha1-antitrypsin DSE

Pulmonary emphysema and Liver Cirrhosis

Clot formation, most abundant coag factor, Increase in coronary artery disease (esp.women)

Fibrinogen

– 20-10x, 24hours

Haptoglobin

– 2-5x, 24 hours

Alpha1-antitrypsin

Haptoglobin – ?x, ? hours

2-10x, 24hours

opsonization and lysis

Complement C3

HAPTOGLOBIN IS INVERSELY PROPORTIONAL TO

INTRAVASCULAR HEMOLYSIS

: 2x, 48-72 hrs -complement activation, opsonin, Ca dependent, recognizes Mannose

Mannose-binding protein

Ceruloplasmin used to monitor WHAT disease

HODGKINS

used to monitor HODGKINS disease

Ceruloplasmin

-associated with HDL cholesterol, and it is thought to play a role in metabolism of cholesterol; by removing cholesterol-filled macrophages at the site of tissue injury, it contributes to the cleaning up of the area.

Serum Amyloid A

Series of serum proteins that are normally present and whose overall function is mediations of inflammation

Complement

-A trimer that acts as opsonin, which is calcium-dependent

Mannose-Binding Protein

- Recognizes foreign carbohydrates from pathogenic microorganisms

Mannose-Binding Protein

Homologous to C1q

Mannose-Binding Protein

-Major component of the alpha-band when serum is electrophoresed

Alpha1-Antitrypsin

General inhibitor of proteases released from leukocytes, especially elastase; deficiency of such results to emphysema

Alpha1-Antitrypsin

-An alpha-2 globulin that primarily binds irreversibly to free hemoglobin released by intravascular hemolysis

Haptoglobin

-Most abundant coagulation factor; cleaved by thrombin to form fibrin clot

Fibrinogen

-Principal copper-transporting protein in human plasma

Ceruloplasmin

Acts as ferroxidase, oxidizing iron from Fe2+ to Fe3+; this may serves as a means of releasing iron from ferritin for binding to transferrin

Ceruloplasmin

Deficiency is associated with wilson's Disease

Ceruloplasmin

Ceruloplasmin Deficiency is associated with

wilson's Disease

other names parasitology

other names parasitology

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