increase when there is inflammation

: 2x, 48-72 hrs -complement activation, opsonin, Ca dependent, recognizes Mannose

-associated with HDL cholesterol, and it is thought to play a role in metabolism of cholesterol; by removing cholesterol-filled macrophages at the site of tissue injury, it contributes to the cleaning up of the area.

Indirect measure of APR

APR production in the

how many % increases of Acute Phase reactants if there is an inflammation

It triggers inflammation in APR

parameter and used to monitor inflammation

-Major component of the alpha-band when serum is electrophoresed

non specific form of Ab.

used for DIFFERENTIATION between bacterial and viral infection

-Principal copper-transporting protein in human plasma

Haptoglobin – ?x, ? hours

C-Reactive Protein Main Substrate: COMMON CONSTITUENT OF MICROBIAL ENZYMES

C-Reactive Protein: Adult:

C-Reactive Protein: increase AT

Alpha1-antitrypsin DSE

HAPTOGLOBIN IS INVERSELY PROPORTIONAL TO

-An alpha-2 globulin that primarily binds irreversibly to free hemoglobin released by intravascular hemolysis

protease inhibitor (elastase)

Deficiency is associated with wilson's Disease

General inhibitor of proteases released from leukocytes, especially elastase; deficiency of such results to emphysema

indicator of acute INFLAMMATION

Clot formation, most abundant coag factor, Increase in coronary artery disease (esp.women)

Direct and quantitative measure of APR

– 20-10x, 24hours

Are cellular factors of immunity that process and "present" antigens to T cell receptor

Reacts SLOWLY

Alpha1-antitrypsin –?x, ? hours

major humoral (fluid) component of natural immunity

Serum Amyloid A:x?,

opsonization and lysis

-Most abundant coagulation factor; cleaved by thrombin to form fibrin clot

Increase more in bacterial than viral infection

Acts as ferroxidase, oxidizing iron from Fe2+ to Fe3+; this may serves as a means of releasing iron from ferritin for binding to transferrin

– 2-5x, 24 hours

Threshold for High Cardiovascular risk

protect us againts the oxidative property of Ironw because it binds hemoglobin and it has inverse relationship to intravascular hemolysis

Series of serum proteins that are normally present and whose overall function is mediations of inflammation

non specific form of ab

what is the humoral factor that has enzymatic activity that binds copper; for serum copper measurement

major component of Alpha 1 band

Ceruloplasmin used to monitor WHAT disease

indirect measurement of APR and reacts slowly

used to monitor HODGKINS disease

-A trimer that acts as opsonin, which is calcium-dependent

- Recognizes foreign carbohydrates from pathogenic microorganisms

Homologous to C1q

stimulus of APR

Reacts RAPIDLY

Removal of cholesterol (cholesterol-filled macrophages) ? Recycle

These are natural antibiotics

Ceruloplasmin Deficiency is associated with

COMPLEMENT ACTIVATOR

C-Reactive Protein hours half life