HEMATOLOGY 1 (HEMATOPOIESIS 1)

Yves Laure Pimentel · 70問 · 2年前

通報

問題一覧

Total blood volume:

5 to 6 liters or 7 to 8% body weight

Formed elements (45% of the blood):

RBC, WBC, and Platelets

– has Hb for oxygen delivery

RBC

– defense against foreign substances

WBC

– stoppage of bleeding

Platelet

% water

Fluid portion (%)

% proteins, carbs, vitamins, hormones, enzymes, lipids, and salts

serum, has no fibrinogen, has fibrin

Clotted specimen

– plasma, has fibrinogen, has no fibrin

Anticoagulated blood

Clotted specimen –

serum, has no fibrinogen, has fibrin

Anticoagulated blood –

plasma, has fibrinogen, has no fibrin

- Cell renewal, Proliferation, differentiation, and maturation of all functional blood cells.

Hematopoiesis

Bone marrow aka

MEDULLARY MARROW

aka MEDULLARY MARROW

Bone marrow

OUTSIDE THE BONE MARROW

EXTRAMEDULLARY

Primary site of hematopoiesis

Bone marrow

IT HAS TOXIC EFFECT TO BONE MARROW

BENZENE

CONVERSION OF RED TO YELLOW MARROW IS?

RETROGRESSION

REPLACEMENT OF ACTIVE MARROW BY ADIPOCYTES

RETROGRESSION

THIS MARROW IS HIGHER IN CHILDHOOD

RED MARROW

-Hematopoietically active marrow.

Red Marrow (50%)

FLATBONE MOST COMMON FOR BIOPSY ASPIRATION

ILIAC CREST

IT IS SEEN IN URINE WHEN THERE IS CRUSHED SYNDROME IN ADULT

OVAL FAT BODIES

MOST ACCESSIBLE AND SAFEST PROCEDURE IN ILIAC CREST

BIOPSY AND ASPIRATION

Hematopoietically inactive marrow

Yellow Marrow (50%)

WHAT DISEASE WHEN OVAL FAT BODIES ARE SEEN IN BLOOD OR FATS IN BLOOD

LIPIDEMIA

MAIN site of hematopoiesis during the Hepatic phase

Liver

LARGEST secondary lymphoid organ

Spleen

Filters the circulating blood

Spleen

Spleen -Stores ____ of platelet (30%)

1/3

-Stores 1/3 of platelet (30%)

Spleen

MOST POTENT ANTIGEN PRESENTING CELLS

dendritic cells

POIKILOCYTE SEEN IN SPLENECTOMY

SPHEROCYTES

REMOVING OF CELL INCLUSION WITHOUT DESTROYING THE INTEGRITY OF THE MEMBRANE

Pitting

MAIN SITE OF THROMBOPOEITIN PRODUCTION

Liver

REMOVAL OF OLD OR ABNORMAL RBC WHICH KILLED BY MACROPHAGE

Culling

- Play a role in the formation of new lymphocytes from the germinal centers

Lymph Node

-Maturation site of T-lymphocyte

Thymus

Secretes Erythropoietin (EPO) to stimulate erythropoiesis

Kidney

Stem cell HAS CD?

CD34

Self renewing

Stem cell

Foundation of all adult hematopoietic system

Stem cell

Not morphologically Identifiable

Stem cell

Stem cell ARE Not morphologically Identifiable WHAT IS USED TO IDENTIFY?

FLOW CYTOMETRY WITH ANTI CD 34

AUTOSPLENECTOMY: WBC IS?

HIGH

AUTOSPLENECTOMY: PLATELET IS?

HIGH

AUTOSPLENECTOMY: SPHEROCYTE IS?

HIGH

AUTOSPLENECTOMY: WHAT IS THE CELL INCLUSION?

HOWEL JOLLY BODIES

Give rise to ALL cell lineage MOST VERSATILE

Totipotent hematopoietic stem cell (THSC)

Can develop into any cell type but not into FETUS

Pluripotential or Multipotential stem cell (from pluripotent cell)

Give rise multiple lineages of blood cells

Pluripotential or Multipotential stem cell (from pluripotent cell)

Gives rise to SINGLE lineage of blood cell

Unipotential Stem cell

WHAT ARE THE COMMON LYMPHOID PROGENITOR CELLS

LYMPHOCYTES NATURAL KILLER CELLS DENDRITIC CELLS

DISEASE CAUSE AUTOSPLENECTOMY

SICKLE CELL

WHAT IS THE RECOMMENDED TREATMENT IN AIHA, HS?

SPLENECTOMY

LYMPHOCYTES LEVEL WHEN THERE IS APLASTIC ANEMIA OR BM FAILURE

LESS AFFECTED

MEMBERS OF CMP

LYMPHOCYTES

Also known as Colony Forming Units-Spleen (CFU-S)

Common Myeloid Progenitor (CMP)

Common Myeloid Progenitor (CMP) Also known as

Colony Forming Units-Spleen (CFU-S)

Granulocyte, Erythrocyte, Monocyte, and Megakaryocyte

Common Myeloid Progenitor (CMP)

Also known as Colony forming units-Lymph (CFU-L)

Common Lymphoid Progenitor (CLP)

Also known as Colony forming units-Lymph (CFU-L)

Common Lymphoid Progenitor (CLP)

Site of Hematopoiesis: Mesodermal cells of the yolk sac

Mesoblastic phase

IMMATURE RBC FIRST PRODUCE

Primitive erythroblast

INCREASED WHEN THERE IS HYPOXIA

ERYHTHROPOEITIN

19-20 DAYS TO END: 8-12 WEEKS (3 MONTHS)

Mesoblastic phase

19-20 DAYS TO END: 8-12 WEEKS (3 MONTHS)

Gower I

2 EPSILON + 2 ZETA

Gower I

Gower II

2 EPSILON + 2 ALPHA

Gower II

2 ZETA + 2 GAMMA

Portland

2 ZETA + 2 GAMMA

PORTLAND 2

2 ZETA + 2 BETA

PORTLAND 2

Site of Hematopoiesis: Liver, Spleen, Thymus, Lymph nodes

Hepatic phase

4TH TO 5TH WEEK END: 1-2 WEEKS AFTER BIRTH

Hepatic phase

4TH TO 5TH WEEK END: 1-2 WEEKS AFTER BIRTH

Hepatic phase Hemoglobin:

Hemoglobin F , Hemoglobin A1, Hemoglobin A2

HBF

2 ALPHA + 2 GAMMA

IT IS A MAJOR HEMOGLOBIN THAT RESIST PH AND HAS HIGH O2 AFFINITY

HEMOGLOBIN F

Medullary or Myeloid phase A.Site of Hematopoiesis:

BONE MARROW

Site of Hematopoiesis: BONE MARROW

Medullary or Myeloid phase

THEY HAVE HIGHER RBC COUNT

CHILD

THEY HAVE LOW RBC COUNT

ADULT

CAN ONLY MANIFEST WHEN BIRTH AND CAN ONLY IN 6 MONTHS

BETA THALASSEMIA MAJOR

DISEASE RELATED WHEN THERE IS IMMATURE LYMPHOCYTE

LEUKEMIA

-failure to produce RBC, WBC, and platelets

Aplastic Anemia

bone marrow failure syndrome

Aplastic Anemia

depletion of stem cells

Aplastic Anemia

DECREASE RBC,-> DECREASE O2,-> INCREASE ERYTHROPOIETIN,-> INCREASE RBC CT.-> DECREASE RBC

HEMOLYTIC Anemia

1.Radiation, benzene, heavy metals, and chemotherapy 2.sedative, tranquilizers, Cutting/lubricating oils and chloramphenicol 3.Viral hepatitis, EBV, HIV, autoimmune dse, and PNH

Acquired Aplastic Anemia

NORMAL RBC-> DECREASE O2-> INCREASED ERYTHROPOIETIN, RBC CT. -> INCREASED RBC CT.

CHRONIC OBSTRUCTIVE PULMONORAY DISEASE/ HYPOTHYROIDISM CONGESTIVE HEART FAILURE

MOSTLY IN VEGAN/ VEGETARIAN

VIT. B12 DEFICIENCY

HIGH/NORMAL RADIOACTIVITY, PROBLEM IN BRAIN AND BLOOOD

VIT. B12 DEFICIENCY

MOST INSTRINSIC FACTOR, UNDER OF VIT. B12 DEF. ABSENT/ LOW RADIOACTIVITY

PERNICIOUS ANEMIA

MOST COMMON VIT. B12 DEF.

PERNICIOUS ANEMIA

MOST COMMON CAUSE OF PERNICIOUS ANEMIA

AUTOIMMUNE DISEASE

100

HALLAMARK OF MEGALOBLASTIC ANEMIA

HYPERSEGMENTED NEUTROPHILS

other names parasitology

other names parasitology

70問 • 2年前

Yves Laure Pimentel · 111問 · 2年前

PARASITOLOGY

PARASITOLOGY

111問 • 2年前

Yves Laure Pimentel · 64問 · 2年前

HTMLBE

HTMLBE

64問 • 2年前

Yves Laure Pimentel · 61問 · 2年前

CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

CC - 1 LAB. SAFETY, BASIC UNITS, AND CONVERSION FACTOR

61問 • 2年前

Yves Laure Pimentel · 69問 · 2年前

HISTOPATHOLOGY

HISTOPATHOLOGY

69問 • 2年前

CC-2 SPECTROPHOTOMETRY

CC-2 SPECTROPHOTOMETRY

Yves Laure Pimentel · 41問 · 2年前

CC-3 ELECTROPHORESIS

CC-3 ELECTROPHORESIS

41問 • 2年前

Yves Laure Pimentel · 87問 · 2年前

AUBF LAB SAFETY

AUBF LAB SAFETY

87問 • 2年前

CSF 1

CSF 1

Yves Laure Pimentel · 82問 · 2年前

CSF 2

CSF 2

82問 • 2年前

SEMEN 1

SEMEN 1

Yves Laure Pimentel · 7問 · 2年前

SEMEN 2

SEMEN 2

7問 • 2年前

SYNOVIAL FLUID 1

SYNOVIAL FLUID 1

Yves Laure Pimentel · 6問 · 2年前

SYNOVIAL FLUID 2

SYNOVIAL FLUID 2

6問 • 2年前

Yves Laure Pimentel · 25問 · 2年前

SEROUS FLUID

SEROUS FLUID

25問 • 2年前

Yves Laure Pimentel · 44問 · 2年前

PLEURAL FLUID

PLEURAL FLUID

44問 • 2年前

Yves Laure Pimentel · 18問 · 2年前

PERICARDIAL FLUID

PERICARDIAL FLUID

18問 • 2年前

Yves Laure Pimentel · 30問 · 2年前

PERITONEAL FLUID/ ASCITIC FLUID

PERITONEAL FLUID/ ASCITIC FLUID

30問 • 2年前

Yves Laure Pimentel · 92問 · 2年前

AMNIOTIC FLUID

AMNIOTIC FLUID

92問 • 2年前

Yves Laure Pimentel · 80問 · 2年前

FECALYSIS

FECALYSIS

80問 • 2年前

Yves Laure Pimentel · 89問 · 2年前

OTHER BODY FLUIDS

OTHER BODY FLUIDS

89問 • 2年前

Yves Laure Pimentel · 86問 · 2年前

MTLBE- SUHO NOTES

MTLBE- SUHO NOTES

86問 • 2年前

Yves Laure Pimentel · 35問 · 2年前

MTLBE..

MTLBE..

35問 • 2年前

Yves Laure Pimentel · 19問 · 1年前

CC- CHROMATOGRAPHY

CC- CHROMATOGRAPHY

19問 • 1年前

Yves Laure Pimentel · 14問 · 1年前

CC-OSMOMETRY

CC-OSMOMETRY

14問 • 1年前

Yves Laure Pimentel · 43問 · 1年前

CC-ELECTROCHEMISTRY TECHNIQUES

CC-ELECTROCHEMISTRY TECHNIQUES

43問 • 1年前

Yves Laure Pimentel · 49問 · 2年前

CC- CARBOHYDRATES

CC- CARBOHYDRATES

49問 • 2年前

Yves Laure Pimentel · 97問 · 2年前

CC- DIABETES MELLITUS

CC- DIABETES MELLITUS

97問 • 2年前

Yves Laure Pimentel · 57問 · 2年前

MAJOR LIPOPROTEINS

MAJOR LIPOPROTEINS

57問 • 2年前

Yves Laure Pimentel · 63問 · 2年前

MINOR LIPOPROTEINS

MINOR LIPOPROTEINS

63問 • 2年前

Yves Laure Pimentel · 37問 · 2年前

PROTEINS

PROTEINS

37問 • 2年前

Yves Laure Pimentel · 91問 · 2年前

PLASMA PROTEINS 1

PLASMA PROTEINS 1

91問 • 2年前

Yves Laure Pimentel · 98問 · 2年前

PLASMA PROTEINS 2 (ALPHA 2 REGION)

PLASMA PROTEINS 2 (ALPHA 2 REGION)

98問 • 2年前

Yves Laure Pimentel · 61問 · 2年前

MISCELLANEOUS PROTEINS

MISCELLANEOUS PROTEINS

61問 • 2年前

Liver Function Test 1

Liver Function Test 1

Yves Laure Pimentel · 96問 · 2年前

Liver Function Test 2

Liver Function Test 2

96問 • 2年前

Yves Laure Pimentel · 33問 · 2年前

TUMOR MARKERS

TUMOR MARKERS

33問 • 2年前

Yves Laure Pimentel · 41問 · 2年前

KIDNEY FUNCTION TESTS - NON PROTEIN NITROGEN & CREATININE

KIDNEY FUNCTION TESTS - NON PROTEIN NITROGEN & CREATININE

41問 • 2年前

Yves Laure Pimentel · 17問 · 2年前

GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES

17問 • 2年前

Yves Laure Pimentel · 14問 · 2年前

LIPID STORAGE DISEASES

LIPID STORAGE DISEASES

14問 • 2年前

Yves Laure Pimentel · 71問 · 2年前

PROTEINS

PROTEINS

71問 • 2年前

Yves Laure Pimentel · 7問 · 2年前

QUICK FIRE- ELECTRODES

QUICK FIRE- ELECTRODES

7問 • 2年前

Yves Laure Pimentel · 10問 · 2年前

ELECTROLYTES

ELECTROLYTES

10問 • 2年前

Yves Laure Pimentel · 27問 · 2年前

DRUGS

DRUGS

27問 • 2年前

Yves Laure Pimentel · 12問 · 2年前

TOXIC AGENTS:

TOXIC AGENTS:

12問 • 2年前

Yves Laure Pimentel · 29問 · 2年前

HEMATOLOGY (HEMATOPOIESIS 2)

HEMATOLOGY (HEMATOPOIESIS 2)

29問 • 2年前

Yves Laure Pimentel · 25問 · 2年前

hema diseases

hema diseases

25問 • 2年前

Yves Laure Pimentel · 43問 · 2年前

AML

AML

43問 • 2年前

Yves Laure Pimentel · 71問 · 2年前

GLOBIN SYNTHESIS

GLOBIN SYNTHESIS

71問 • 2年前

Yves Laure Pimentel · 31問 · 2年前

HEMATOLOGY REFERENCE RANGES

HEMATOLOGY REFERENCE RANGES

31問 • 2年前

Yves Laure Pimentel · 34問 · 2年前

DISORDERS OF PRIMARY HEMOSTASIS

DISORDERS OF PRIMARY HEMOSTASIS

34問 • 2年前

Yves Laure Pimentel · 37問 · 2年前

PLATELET DISORDERS

PLATELET DISORDERS

37問 • 2年前

CHARACTERISTICS OF CLOTTING FACTORS

CHARACTERISTICS OF CLOTTING FACTORS

Yves Laure Pimentel · 12問 · 2年前

4. CLASSIFICATION OF MACROPHAGE

4. CLASSIFICATION OF MACROPHAGE

12問 • 2年前

Yves Laure Pimentel · 39問 · 2年前

3. NATURAL OR INNATE IMMUNITY

3. NATURAL OR INNATE IMMUNITY

39問 • 2年前

Yves Laure Pimentel · 55問 · 2年前

5. INTERNAL DEFENSE:SOLUBLE FACTORS (ACUTE PHASE REACTANTS)

5. INTERNAL DEFENSE:SOLUBLE FACTORS (ACUTE PHASE REACTANTS)

55問 • 2年前

Yves Laure Pimentel · 37問 · 2年前

6. PHAGOCYTOSIS Chemotaxis

6. PHAGOCYTOSIS Chemotaxis

37問 • 2年前

Yves Laure Pimentel · 44問 · 2年前

8. NATURE OF ANTIGEN

8. NATURE OF ANTIGEN

44問 • 2年前

Yves Laure Pimentel · 50問 · 2年前

9. MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

9. MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

50問 • 2年前

Yves Laure Pimentel · 69問 · 2年前

1. HISTORY

1. HISTORY

69問 • 2年前

Yves Laure Pimentel · 38問 · 2年前

2. TYPES OF IMMUNITY

2. TYPES OF IMMUNITY

38問 • 2年前

Yves Laure Pimentel · 21問 · 2年前

7. PHAGOCYTOSIS Engulfment and Digestion

7. PHAGOCYTOSIS Engulfment and Digestion

21問 • 2年前

Yves Laure Pimentel · 15問 · 2年前

8. PHAGOCYTOSIS EXOCYTOSIS

8. PHAGOCYTOSIS EXOCYTOSIS

15問 • 2年前

Yves Laure Pimentel · 32問 · 2年前

10. DISEASE ASSOCIATED TO HUMAN LEUKOCYTE ANTIGEN (henry)

10. DISEASE ASSOCIATED TO HUMAN LEUKOCYTE ANTIGEN (henry)

32問 • 2年前

Yves Laure Pimentel · 30問 · 2年前

11. TRANSPLANTATION IMMUNOLOGY

11. TRANSPLANTATION IMMUNOLOGY

30問 • 2年前

Yves Laure Pimentel · 38問 · 2年前

2. LYMPHOID ORGANS

2. LYMPHOID ORGANS

38問 • 2年前

Yves Laure Pimentel · 48問 · 2年前

3. CLUSTER OF DIFFERENTIATION

3. CLUSTER OF DIFFERENTIATION

48問 • 2年前

Yves Laure Pimentel · 35問 · 2年前

4. T-CELL DIFFERENTIATION

4. T-CELL DIFFERENTIATION

35問 • 2年前

Yves Laure Pimentel · 18問 · 2年前

5. T CELL IMMUNODEFICIENCIES

5. T CELL IMMUNODEFICIENCIES

18問 • 2年前

Yves Laure Pimentel · 44問 · 2年前

6. STAGES IN B-CELL DIFFERENTIATION  PROPIMAP

6. STAGES IN B-CELL DIFFERENTIATION  PROPIMAP

44問 • 2年前

Yves Laure Pimentel · 23問 · 2年前

7. B CELL IMMUNODEFICIENCIES

7. B CELL IMMUNODEFICIENCIES

23問 • 2年前

Yves Laure Pimentel · 34問 · 2年前

8. COMBINED T CELL AND B CELL DEFICIENCIES

8. COMBINED T CELL AND B CELL DEFICIENCIES

34問 • 2年前

Yves Laure Pimentel · 12問 · 2年前

9. COMPARISON OF T AND B CELLS

9. COMPARISON OF T AND B CELLS

12問 • 2年前

Yves Laure Pimentel · 16問 · 2年前

10. LABORATORY IDENTIFICATION OF LYMPHOCYTES

10. LABORATORY IDENTIFICATION OF LYMPHOCYTES

16問 • 2年前

Yves Laure Pimentel · 15問 · 2年前

11. NATURAL KILLER CELLS OR THIRD POPULATION CELL

11. NATURAL KILLER CELLS OR THIRD POPULATION CELL

15問 • 2年前

Yves Laure Pimentel · 79問 · 2年前

12. ANTIBODY

12. ANTIBODY

79問 • 2年前

Yves Laure Pimentel · 97問 · 2年前

13. TYPES OF ANTIBODIES

13. TYPES OF ANTIBODIES

97問 • 2年前

Yves Laure Pimentel · 11問 · 2年前

14. MONOCLONAL ANTIBODIES

14. MONOCLONAL ANTIBODIES

11問 • 2年前

Yves Laure Pimentel · 23問 · 2年前

1. INTERLEUKINS

1. INTERLEUKINS

23問 • 2年前

Yves Laure Pimentel · 28問 · 2年前

2. INTERFERONS

2. INTERFERONS

28問 • 2年前

Yves Laure Pimentel · 8問 · 2年前

3. CYTOKINES IN THE INNATE AND ADAPTIVE IMMUNITY

3. CYTOKINES IN THE INNATE AND ADAPTIVE IMMUNITY

8問 • 2年前

Yves Laure Pimentel · 19問 · 2年前

4. COMPLEMENT SYSTEM

4. COMPLEMENT SYSTEM

19問 • 2年前

Yves Laure Pimentel · 76問 · 2年前

15. COMPLEMENT SYSTEM

15. COMPLEMENT SYSTEM

76問 • 2年前

Yves Laure Pimentel · 21問 · 2年前

16. SYSTEM CONTROLS/COMPLEMENT REGULATION

16. SYSTEM CONTROLS/COMPLEMENT REGULATION

21問 • 2年前

Yves Laure Pimentel · 29問 · 2年前

17. COMPLEMENT AND DISEASE STATES

17. COMPLEMENT AND DISEASE STATES

29問 • 2年前

Yves Laure Pimentel · 19問 · 2年前

18. IMMUNOLOGIC ASSAYS OF INDIVIDUAL COMPONENTS (CLASSICAL)

18. IMMUNOLOGIC ASSAYS OF INDIVIDUAL COMPONENTS (CLASSICAL)

19問 • 2年前

Yves Laure Pimentel · 22問 · 2年前

19. CYTOKINES

19. CYTOKINES

22問 • 2年前

Yves Laure Pimentel · 24問 · 2年前

20. INTERLEUKINS

20. INTERLEUKINS

24問 • 2年前

Yves Laure Pimentel · 21問 · 2年前

21. INTERFERONS, TNF, TGF, CHEMOKINE

21. INTERFERONS, TNF, TGF, CHEMOKINE

21問 • 2年前

Yves Laure Pimentel · 54問 · 2年前

1. SERO

1. SERO

54問 • 2年前

Yves Laure Pimentel · 38問 · 2年前

2. PRECIPITATION

2. PRECIPITATION

38問 • 2年前

Yves Laure Pimentel · 17問 · 2年前

3. PASSIVE IMMUNODIFFUSION

3. PASSIVE IMMUNODIFFUSION

17問 • 2年前

Yves Laure Pimentel · 15問 · 2年前

4. OUCHTERLONY

4. OUCHTERLONY

15問 • 2年前

Yves Laure Pimentel · 9問 · 2年前

5. ELECTROPHORETIC TECHNIQUE

5. ELECTROPHORETIC TECHNIQUE

9問 • 2年前

Yves Laure Pimentel · 11問 · 2年前

6. IMMUNOELECTROPHORESIS (DOUBLE DIFFUSION)

6. IMMUNOELECTROPHORESIS (DOUBLE DIFFUSION)

11問 • 2年前

Yves Laure Pimentel · 29問 · 2年前

7. IMMUNOFIXATION ELECTROPHORESIS

7. IMMUNOFIXATION ELECTROPHORESIS

29問 • 2年前