21. INTERFERONS, TNF, TGF, CHEMOKINE

Yves Laure Pimentel · 70問 · 2年前

通報

問題一覧

-interfere viral REPLICATION/NATURAL ANTIBIOTIC

INTERFERONS

Innate: (2 TYPES)

IFN –a .IFN – b

increases MHC I expression

IFN –a

– increases MHC I expression -activates in MS

IFN – b

IFN – b – increases MHC I expression -activates in ?

Adaptive

IFN-y

IFN-y – Major macrophage activator ? antagonist

-IL-4

PRINCIPAL mediator of acute inflammatory response to gram (-) and other microbes. -vasodilator

Tumor Necrosis Factor

gram (-) sepsis

SEPTIC SHOCK

reduced Tx perfusion

LOW BP

uncontrolled bleeding

DIC

inhibitor of IL-1-induced T cell prolif.

Transforming Growth Factor (TGF)

-down regulate inflammation.

Transforming Growth Factor (TGF)

chemotaxis and activates integrin

Chemokine

– monocyte chemoattractant protein 1

MCP -1

MCP -1 –

monocyte chemoattractant protein 1

– neutrophils chemoattractant

CXCL8

CXCL8 –

neutrophils chemoattractant

– cell adhesion that arrest cells (traffic) during physiologic flow

CX3

Chemokine receptor used by HIV as co-HIV for infection of CD4,T lymphocytes and macrophages

CXCR4 & CCR5

BLOCK the virus’s ability to bind to and enter T cells and can delay the progression to full-blown AIDS

SDF1 & RANTES (ligands of CXCR4 and CCR5)

other names parasitology

other names parasitology

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