outer layer; lines the skull & vertebral canal

NOT FOUND IN NORMAL PLASMA CSF

CSF/ SERUM ALBUMIN Index value of <9=_

Erythrophagocytosis Traumatic Tap

reagent of choice, precipitates albumin and globulin

Lumbar Vertebrae: ADULTS

y-globulin:

CSF bonding (+); Serum banding (-); {IgG index :

Xanthocromia: COLOR Heavy HEMOLYSIS

IF ONLY 1 TUBE: ORDER OF COLLECTION

Brain & spinal cord are lined by

CHEMISTRY EXAMINATION OF CSF ntracranial Hemorrhage

Method of Choice when determining a true CSF specimen:

"Least affected by blood bacteria as a result of the tap procedure

Precipitates proteins using: TCA AND SSA

Endothelial cells have ________to prevent passage of molecules: How many Daltons?

Between _____ Lumbar Vertebrae:

Methemoglobin, hematoma, malanin

Tests are performed on a ? WITHIN?

Intracranial Hemorrhage Causes

D-dimer Test Intracranial Hemorrhage

CSF VOLUME Neonates:

Erythrophagocytosis Intracranial Hemorrhage

Spider web-like/ filamentous inner membrane

TUBE 2 AND PRESERVATIVE

Melastasizing mucin producing adenocarcinoma

Dye-binding index THAT BINDS TO VARIETY OF PROTEINS

LAST TUBE

PHYSICAL EXAMINATION OR APPEARANCE OF CSF: Viscosity:

Bloody = Pathologic:

Damage to BBB (INCREASED OR DECREASED)

CSF bonding (+); Serum banding (-):

USED TO MEASURE BBB INTEGRITY THROUGH CSF/ SERUM ALBUMIN INDEX

Patientis position in lumbar puncture

Dye-binding index THAT IS AUTOMATED

PRODUCTION OF CSF

Slightly Hazy

Decreased protein clearance from fluid (INCREASED OR DECREASED)

CSF/ SERUM ALBUMIN Index value of >0.77

Protein-Error of indicator: LESS INTERFERENCE USES coomassie brilliant blue AND PYROGALLOL RED MOLYBDATE

Lumbar Vertebrae: CHILDREN

Xanthocromic supernatant Intracranial Hemorrhage

infants w/ open fontanels

OILY CAUSES

PHYSICAL EXAMINATION OR APPEARANCE OF CSF: SPECIFIC GRAVITY

PHYSICAL EXAMINATION OR APPEARANCE OF CSF: pH:

Xanthocromia: COLOR conversion of oxyhemoglobin to unconjugated bilirubin ! Other causes: 1 serum bilirubin, (+) carotene, tprotein (>150 mg/dl, melanoma pigment

not an ultrafiltrate of plasma

WBC, RBC. proteins, concentration, INCREASE lipid Microorganisms, Aspirated epidural , fats, rodiogrephic contrast media

Routine method for CSF collection

Reabsorbed by the _______________into the superior sagittal sinus

produce a mechanical barrier to cushion the cushion the brain and spinal cord against trauma trauma * Supply nutrients to the nervous tissue * Remove metabolic waste

D-dimer Test Traumatic Tap

Radiographic Conirast Media

CSF PROTEIN » NORMAL VALUES: Values are higher in infants and older persons

CSF/ SERUM ALBUMIN Index value

VISCOUS ASSO. DISEASE

Supernatant fluid that is left over in every section:

Xanthocromic supernatant Traumatic Tap

PHYSICAL EXAMINATION OR APPEARANCE OF CSF: Pressure:

Meningitis, blockage of CSF circulation in subarachnoid

Meningitis, Hemorrhage (INCREASED OR DECREASED)

CHEMISTRY EXAMINATION OF CSF Traumatic Tap

PHYSICAL EXAMINATION OR APPEARANCE OF CSF: ¥ Color:

Thin membrane lining the surfaces of brain & spinal cord

MS, stimulate immunocompetent cells in CNS, IgG synthesis in CNS

3 parts of meninges

Leakage of fluid from the CNS (INCREASED OR DECREASED)

Neural Tissue Degeneration (INCREASED OR DECREASED)

Clotted CSF DISEASE ASSOCIATED

Serum & CSF banding:

Peliicle FORMATION CAUSES

Traumatic Tap Clot formation

Brown

Increased WBC, proteins, and coagulation factors in CSF

Distribution of blood Traumatic Tap

Bloody =NON Pathologic:

(most abundant) => pre- -albumin (2%) ->a-globulins (haptoglobin, ceruplasmin] OR THE MAJOR CSF PROTEIN

(inflammation in the CNS) w/c is located in y region

Least likely fo contain C cells introduced by the tap procedure

Distribution of blood Intracranial Hemorrhage

MS, Endocrine/ Metabolic disorders (INCREASED OR DECREASED)

CSF VOLUME:

collected in sub-occipital region

200-500 WBC/UL

IT IS USE TO CHECK BBB

Xanthocromia: COLOR--very slight amount of oxynemaoglobin

Adults: CSF VOLUME

used to represent the control and filtration of blood components to the CSF and then to the brain

Flows through _________(Between arachnoid & pia mater)

major B-globulin

(Web-ike peliicle- overnight ref 12-24 hrs)

Increased CSF CAUSES

Traumatic Tap Causes

precipitates albumin, only unless combine with NA2SO4

MOST FREQUENTLY PERFORMED IN CHEMISTRY TEST

PHYSICAL EXAMINATION OR APPEARANCE OF CSF: CLARITY

carbohydrate deficient fransferrin seen in CSF ONLY

Itracranial Hemorrhage Clot formation

Index value of CSF-IgG INDEX