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CSF 1
100問 • 2年前
  • Yves Laure Pimentel
    • 通報

    問題一覧

  • 1

    produce a mechanical barrier to cushion the cushion the brain and spinal cord against trauma trauma * Supply nutrients to the nervous tissue * Remove metabolic waste

    CEREBROSPINAL FLUID (CSF)

  • 2

    not an ultrafiltrate of plasma

    CEREBROSPINAL FLUID (CSF)

  • 3

    Brain & spinal cord are lined by

    Meninges

  • 4

    3 parts of meninges

    1. DURA MATER, 2. ARACHNOID MATER, 3.PIA MATER

  • 5

    outer layer; lines the skull & vertebral canal

    DURA MATER

  • 6

    Spider web-like/ filamentous inner membrane

    ARACHNOID

  • 7

    Thin membrane lining the surfaces of brain & spinal cord

    PIA MATER

  • 8

    PRODUCTION OF CSF

    Produced in CHOROID PLEXUS of lumbar ventricles & third & fourth ventricles

  • 9

    Flows through _________(Between arachnoid & pia mater)

    SUBARACHNOID

  • 10

    Reabsorbed by the _______________into the superior sagittal sinus

    ARACHNOID VILLI/ GRANULATION

  • 11

    CSF VOLUME:

    20 ML/PER HOUR

  • 12

    Adults: CSF VOLUME

    40-170 ML/ 90-150 ML

  • 13

    CSF VOLUME Neonates:

    10-60 mL

  • 14

    Endothelial cells have ________to prevent passage of molecules: How many Daltons?

    BLOOD BRAIN BARRIER (BBB): >500 daltons

  • 15

    used to represent the control and filtration of blood components to the CSF and then to the brain

    BLOOD BRAIN BARRIER (BBB)

  • 16

    Increased WBC, proteins, and coagulation factors in CSF

    Meningitis, Multiple Sclerosis

  • 17

    Routine method for CSF collection

    LUMBAR PUNCTURE

  • 18

    Between _____ Lumbar Vertebrae:

    3RD, 4TH, 5TH

  • 19

    Lumbar Vertebrae: ADULTS

    3RD AND 4TH

  • 20

    Lumbar Vertebrae: CHILDREN

    4TH AND 5TH

  • 21

    Patientis position in lumbar puncture

    FETAL POSITION OR LATERAL DECUBITUS POSITION

  • 22

    infants w/ open fontanels

    VENTICULAR PUNCTURE

  • 23

    collected in sub-occipital region

    CISTERIAL PUNCTURE

  • 24

    "Least affected by blood bacteria as a result of the tap procedure

    TUBE 1 CHEMISTRY AND SEROLOGY

  • 25

    TUBE 2 AND PRESERVATIVE

    MICROBIOLOGY, ROOM TEMPERATURE

  • 26

    Least likely fo contain C cells introduced by the tap procedure

    HEMATOLOGY/ CELL COUNT, REF TEMPERATURE; TUBE 3

  • 27

    LAST TUBE

    MICROBIOLOGY

  • 28

    Tests are performed on a ? WITHIN?

    STAT basis: 30 MINS

  • 29

    Supernatant fluid that is left over in every section:

    CHEMISTRY/ SEROLOGY

  • 30

    IF ONLY 1 TUBE: ORDER OF COLLECTION

    MICROBIOLOGY-> HEMATOLOGY-> CHEMISTRY/SEROLOGY

  • 31

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: ¥ Color:

    COLORLESS

  • 32

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: Viscosity:

    Same w/ water

  • 33

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: CLARITY

    Crystal Clear

  • 34

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: SPECIFIC GRAVITY

    1.006-1.008

  • 35

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: pH:

    7.30-7.45

  • 36

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: Pressure:

    50-200 mmH2

  • 37

    Slightly Hazy

    200-500 WBC/UL

  • 38

    200-500 WBC/UL

    Slightly Hazy

  • 39

    WBC, RBC. proteins, concentration, INCREASE lipid Microorganisms, Aspirated epidural , fats, rodiogrephic contrast media

    Turbid/ Milky

  • 40

    Meningitis, blockage of CSF circulation in subarachnoid

    Clotted

  • 41

    Clotted CSF DISEASE ASSOCIATED

    MENINGITIS, FROINS DISEASE

  • 42

    Bloody = Pathologic:

    INTRACRANIAL HEMORRHAGE (SUBARACHNOID HEMORRHAGE)

  • 43

    Bloody =NON Pathologic:

    TRAUMATIC TAP

  • 44

    Melastasizing mucin producing adenocarcinoma

    VISCOUS

  • 45

    VISCOUS ASSO. DISEASE

    CRYPTOCOCCAL MENINGITIS, ADENOCARCINOMA

  • 46

    Radiographic Conirast Media

    OILY

  • 47

    OILY CAUSES

    Radiographic Contrast Media

  • 48

    (Web-ike peliicle- overnight ref 12-24 hrs)

    Peliicle FORMATION

  • 49

    Peliicle FORMATION CAUSES

    TUBERCULAR MENINGITIS

  • 50

    Xanthocromia: COLOR--very slight amount of oxynemaoglobin

    PINK

  • 51

    Xanthocromia: COLOR Heavy HEMOLYSIS

    ORANGE

  • 52

    Xanthocromia: COLOR conversion of oxyhemoglobin to unconjugated bilirubin ! Other causes: 1 serum bilirubin, (+) carotene, tprotein (>150 mg/dl, melanoma pigment

    YELLOW

  • 53

    Brown

    Methemoglobin, hematoma, malanin

  • 54

    Methemoglobin, hematoma, malanin

    BROWN

  • 55

    Intracranial Hemorrhage Causes

    Haemorhage

  • 56

    Traumatic Tap Causes

    Puncture of blood vessel during procedure

  • 57

    Distribution of blood Intracranial Hemorrhage

    EVEN in all 3 tubes

  • 58

    Distribution of blood Traumatic Tap

    UNEVEN T1>T2>13/ Streaks of blood

  • 59

    Itracranial Hemorrhage Clot formation

    ABSENT

  • 60

    Traumatic Tap Clot formation

    PRESENT

  • 61

    Xanthocromic supernatant Intracranial Hemorrhage

    CLEAR

  • 62

    Xanthocromic supernatant Traumatic Tap

    PRESENT

  • 63

    Erythrophagocytosis Intracranial Hemorrhage

    PRESENT

  • 64

    Erythrophagocytosis Traumatic Tap

    ABSENT

  • 65

    D-dimer Test Intracranial Hemorrhage

    POSITIVE

  • 66

    D-dimer Test Traumatic Tap

    NEGATIVE

  • 67

    CHEMISTRY EXAMINATION OF CSF ntracranial Hemorrhage

    POSTIVE

  • 68

    CHEMISTRY EXAMINATION OF CSF Traumatic Tap

    NEGATIVE

  • 69

    CSF PROTEIN » NORMAL VALUES: Values are higher in infants and older persons

    15-45 MG/DL

  • 70

    MOST FREQUENTLY PERFORMED IN CHEMISTRY TEST

    CSF PROTEIN

  • 71

    (most abundant) => pre- -albumin (2%) ->a-globulins (haptoglobin, ceruplasmin] OR THE MAJOR CSF PROTEIN

    ALBUMIN

  • 72

    major B-globulin

    Transferrin

  • 73

    carbohydrate deficient fransferrin seen in CSF ONLY

    TAU

  • 74

    y-globulin:

    IgG>IgA

  • 75

    NOT FOUND IN NORMAL PLASMA CSF

    BETA LIPOPROTEIN, FIBRINOGEN, IGM

  • 76

    Increased CSF CAUSES

    Meningitis, Hemorrhage

  • 77

    Damage to BBB (INCREASED OR DECREASED)

    INCREASED

  • 78

    Decreased protein clearance from fluid (INCREASED OR DECREASED)

    INCREASED

  • 79

    Neural Tissue Degeneration (INCREASED OR DECREASED)

    INCREASED

  • 80

    Meningitis, Hemorrhage (INCREASED OR DECREASED)

    INCREASED

  • 81

    MS, Endocrine/ Metabolic disorders (INCREASED OR DECREASED)

    INCREASED

  • 82

    Leakage of fluid from the CNS (INCREASED OR DECREASED)

    DECREASED

  • 83

    Precipitates proteins using: TCA AND SSA

    Turbidimetric Method.

  • 84

    reagent of choice, precipitates albumin and globulin

    TRICHOLORO ACETIC ACID (TCA)

  • 85

    precipitates albumin, only unless combine with NA2SO4

    SULFOSALICYLIC ACID (SSA)

  • 86

    Protein-Error of indicator: LESS INTERFERENCE USES coomassie brilliant blue AND PYROGALLOL RED MOLYBDATE

    Dye-binding index

  • 87

    Dye-binding index THAT IS AUTOMATED

    PYROGALLOL RED MOLYBDATE

  • 88

    Dye-binding index THAT BINDS TO VARIETY OF PROTEINS

    coomassie brilliant blue

  • 89

    IT IS USE TO CHECK BBB

    PROTEIN FRACTIONS

  • 90

    USED TO MEASURE BBB INTEGRITY THROUGH CSF/ SERUM ALBUMIN INDEX

    CSF/ SERUM ALBUMIN

  • 91

    CSF/ SERUM ALBUMIN Index value of <9=_

    INTACT BBB

  • 92

    MS, stimulate immunocompetent cells in CNS, IgG synthesis in CNS

    CSF- IgG INDEX

  • 93

    CSF/ SERUM ALBUMIN Index value

    <9

  • 94

    Index value of CSF-IgG INDEX

    > 0.77

  • 95

    CSF/ SERUM ALBUMIN Index value of >0.77

    INDICES IgG PRODUCTION WITHIN CNS

  • 96

    (inflammation in the CNS) w/c is located in y region

    OLIGOCLONAL BANDS

  • 97

    Serum & CSF banding:

    Leukemia, Lymphoma, Viral infection (HIV)

  • 98

    CSF bonding (+); Serum banding (-); {IgG index :

    MULTIPLE SCLEROSIS

  • 99

    CSF bonding (+); Serum banding (-):

    MULSTIPLE SCLEROSIS, MENIGITIS, ENCEPHALITIS, NEUROSYPHILIS, GUILLAIN BARE

  • 100

    Method of Choice when determining a true CSF specimen:

    TAU IDENTIFICATION

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    問題一覧

  • 1

    produce a mechanical barrier to cushion the cushion the brain and spinal cord against trauma trauma * Supply nutrients to the nervous tissue * Remove metabolic waste

    CEREBROSPINAL FLUID (CSF)

  • 2

    not an ultrafiltrate of plasma

    CEREBROSPINAL FLUID (CSF)

  • 3

    Brain & spinal cord are lined by

    Meninges

  • 4

    3 parts of meninges

    1. DURA MATER, 2. ARACHNOID MATER, 3.PIA MATER

  • 5

    outer layer; lines the skull & vertebral canal

    DURA MATER

  • 6

    Spider web-like/ filamentous inner membrane

    ARACHNOID

  • 7

    Thin membrane lining the surfaces of brain & spinal cord

    PIA MATER

  • 8

    PRODUCTION OF CSF

    Produced in CHOROID PLEXUS of lumbar ventricles & third & fourth ventricles

  • 9

    Flows through _________(Between arachnoid & pia mater)

    SUBARACHNOID

  • 10

    Reabsorbed by the _______________into the superior sagittal sinus

    ARACHNOID VILLI/ GRANULATION

  • 11

    CSF VOLUME:

    20 ML/PER HOUR

  • 12

    Adults: CSF VOLUME

    40-170 ML/ 90-150 ML

  • 13

    CSF VOLUME Neonates:

    10-60 mL

  • 14

    Endothelial cells have ________to prevent passage of molecules: How many Daltons?

    BLOOD BRAIN BARRIER (BBB): >500 daltons

  • 15

    used to represent the control and filtration of blood components to the CSF and then to the brain

    BLOOD BRAIN BARRIER (BBB)

  • 16

    Increased WBC, proteins, and coagulation factors in CSF

    Meningitis, Multiple Sclerosis

  • 17

    Routine method for CSF collection

    LUMBAR PUNCTURE

  • 18

    Between _____ Lumbar Vertebrae:

    3RD, 4TH, 5TH

  • 19

    Lumbar Vertebrae: ADULTS

    3RD AND 4TH

  • 20

    Lumbar Vertebrae: CHILDREN

    4TH AND 5TH

  • 21

    Patientis position in lumbar puncture

    FETAL POSITION OR LATERAL DECUBITUS POSITION

  • 22

    infants w/ open fontanels

    VENTICULAR PUNCTURE

  • 23

    collected in sub-occipital region

    CISTERIAL PUNCTURE

  • 24

    "Least affected by blood bacteria as a result of the tap procedure

    TUBE 1 CHEMISTRY AND SEROLOGY

  • 25

    TUBE 2 AND PRESERVATIVE

    MICROBIOLOGY, ROOM TEMPERATURE

  • 26

    Least likely fo contain C cells introduced by the tap procedure

    HEMATOLOGY/ CELL COUNT, REF TEMPERATURE; TUBE 3

  • 27

    LAST TUBE

    MICROBIOLOGY

  • 28

    Tests are performed on a ? WITHIN?

    STAT basis: 30 MINS

  • 29

    Supernatant fluid that is left over in every section:

    CHEMISTRY/ SEROLOGY

  • 30

    IF ONLY 1 TUBE: ORDER OF COLLECTION

    MICROBIOLOGY-> HEMATOLOGY-> CHEMISTRY/SEROLOGY

  • 31

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: ¥ Color:

    COLORLESS

  • 32

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: Viscosity:

    Same w/ water

  • 33

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: CLARITY

    Crystal Clear

  • 34

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: SPECIFIC GRAVITY

    1.006-1.008

  • 35

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: pH:

    7.30-7.45

  • 36

    PHYSICAL EXAMINATION OR APPEARANCE OF CSF: Pressure:

    50-200 mmH2

  • 37

    Slightly Hazy

    200-500 WBC/UL

  • 38

    200-500 WBC/UL

    Slightly Hazy

  • 39

    WBC, RBC. proteins, concentration, INCREASE lipid Microorganisms, Aspirated epidural , fats, rodiogrephic contrast media

    Turbid/ Milky

  • 40

    Meningitis, blockage of CSF circulation in subarachnoid

    Clotted

  • 41

    Clotted CSF DISEASE ASSOCIATED

    MENINGITIS, FROINS DISEASE

  • 42

    Bloody = Pathologic:

    INTRACRANIAL HEMORRHAGE (SUBARACHNOID HEMORRHAGE)

  • 43

    Bloody =NON Pathologic:

    TRAUMATIC TAP

  • 44

    Melastasizing mucin producing adenocarcinoma

    VISCOUS

  • 45

    VISCOUS ASSO. DISEASE

    CRYPTOCOCCAL MENINGITIS, ADENOCARCINOMA

  • 46

    Radiographic Conirast Media

    OILY

  • 47

    OILY CAUSES

    Radiographic Contrast Media

  • 48

    (Web-ike peliicle- overnight ref 12-24 hrs)

    Peliicle FORMATION

  • 49

    Peliicle FORMATION CAUSES

    TUBERCULAR MENINGITIS

  • 50

    Xanthocromia: COLOR--very slight amount of oxynemaoglobin

    PINK

  • 51

    Xanthocromia: COLOR Heavy HEMOLYSIS

    ORANGE

  • 52

    Xanthocromia: COLOR conversion of oxyhemoglobin to unconjugated bilirubin ! Other causes: 1 serum bilirubin, (+) carotene, tprotein (>150 mg/dl, melanoma pigment

    YELLOW

  • 53

    Brown

    Methemoglobin, hematoma, malanin

  • 54

    Methemoglobin, hematoma, malanin

    BROWN

  • 55

    Intracranial Hemorrhage Causes

    Haemorhage

  • 56

    Traumatic Tap Causes

    Puncture of blood vessel during procedure

  • 57

    Distribution of blood Intracranial Hemorrhage

    EVEN in all 3 tubes

  • 58

    Distribution of blood Traumatic Tap

    UNEVEN T1>T2>13/ Streaks of blood

  • 59

    Itracranial Hemorrhage Clot formation

    ABSENT

  • 60

    Traumatic Tap Clot formation

    PRESENT

  • 61

    Xanthocromic supernatant Intracranial Hemorrhage

    CLEAR

  • 62

    Xanthocromic supernatant Traumatic Tap

    PRESENT

  • 63

    Erythrophagocytosis Intracranial Hemorrhage

    PRESENT

  • 64

    Erythrophagocytosis Traumatic Tap

    ABSENT

  • 65

    D-dimer Test Intracranial Hemorrhage

    POSITIVE

  • 66

    D-dimer Test Traumatic Tap

    NEGATIVE

  • 67

    CHEMISTRY EXAMINATION OF CSF ntracranial Hemorrhage

    POSTIVE

  • 68

    CHEMISTRY EXAMINATION OF CSF Traumatic Tap

    NEGATIVE

  • 69

    CSF PROTEIN » NORMAL VALUES: Values are higher in infants and older persons

    15-45 MG/DL

  • 70

    MOST FREQUENTLY PERFORMED IN CHEMISTRY TEST

    CSF PROTEIN

  • 71

    (most abundant) => pre- -albumin (2%) ->a-globulins (haptoglobin, ceruplasmin] OR THE MAJOR CSF PROTEIN

    ALBUMIN

  • 72

    major B-globulin

    Transferrin

  • 73

    carbohydrate deficient fransferrin seen in CSF ONLY

    TAU

  • 74

    y-globulin:

    IgG>IgA

  • 75

    NOT FOUND IN NORMAL PLASMA CSF

    BETA LIPOPROTEIN, FIBRINOGEN, IGM

  • 76

    Increased CSF CAUSES

    Meningitis, Hemorrhage

  • 77

    Damage to BBB (INCREASED OR DECREASED)

    INCREASED

  • 78

    Decreased protein clearance from fluid (INCREASED OR DECREASED)

    INCREASED

  • 79

    Neural Tissue Degeneration (INCREASED OR DECREASED)

    INCREASED

  • 80

    Meningitis, Hemorrhage (INCREASED OR DECREASED)

    INCREASED

  • 81

    MS, Endocrine/ Metabolic disorders (INCREASED OR DECREASED)

    INCREASED

  • 82

    Leakage of fluid from the CNS (INCREASED OR DECREASED)

    DECREASED

  • 83

    Precipitates proteins using: TCA AND SSA

    Turbidimetric Method.

  • 84

    reagent of choice, precipitates albumin and globulin

    TRICHOLORO ACETIC ACID (TCA)

  • 85

    precipitates albumin, only unless combine with NA2SO4

    SULFOSALICYLIC ACID (SSA)

  • 86

    Protein-Error of indicator: LESS INTERFERENCE USES coomassie brilliant blue AND PYROGALLOL RED MOLYBDATE

    Dye-binding index

  • 87

    Dye-binding index THAT IS AUTOMATED

    PYROGALLOL RED MOLYBDATE

  • 88

    Dye-binding index THAT BINDS TO VARIETY OF PROTEINS

    coomassie brilliant blue

  • 89

    IT IS USE TO CHECK BBB

    PROTEIN FRACTIONS

  • 90

    USED TO MEASURE BBB INTEGRITY THROUGH CSF/ SERUM ALBUMIN INDEX

    CSF/ SERUM ALBUMIN

  • 91

    CSF/ SERUM ALBUMIN Index value of <9=_

    INTACT BBB

  • 92

    MS, stimulate immunocompetent cells in CNS, IgG synthesis in CNS

    CSF- IgG INDEX

  • 93

    CSF/ SERUM ALBUMIN Index value

    <9

  • 94

    Index value of CSF-IgG INDEX

    > 0.77

  • 95

    CSF/ SERUM ALBUMIN Index value of >0.77

    INDICES IgG PRODUCTION WITHIN CNS

  • 96

    (inflammation in the CNS) w/c is located in y region

    OLIGOCLONAL BANDS

  • 97

    Serum & CSF banding:

    Leukemia, Lymphoma, Viral infection (HIV)

  • 98

    CSF bonding (+); Serum banding (-); {IgG index :

    MULTIPLE SCLEROSIS

  • 99

    CSF bonding (+); Serum banding (-):

    MULSTIPLE SCLEROSIS, MENIGITIS, ENCEPHALITIS, NEUROSYPHILIS, GUILLAIN BARE

  • 100

    Method of Choice when determining a true CSF specimen:

    TAU IDENTIFICATION