4. COMPLEMENT SYSTEM

Yves Laure Pimentel · 70問 · 2年前

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Series of serum proteins that are normally present and whose overall function is mediation of inflammation

COMPLEMENT SYSTEM

Measurement of complement components has two major uses in clinical diagnosis:

1. To detect congenital deficiencies 2. To detect Acquired complement deficiencies

- Binds to Fc of IgM and IgG

C1q

Activates C1s

C1r

Cleaves C4 and c2

C1s

Part of C3 convertase

Binds to C4b- forms C3 convertase

Key intermediate in all pathways

Initiates membrane attack complex

Binds to C5b complex

Binds to C5bC6 in MAC

Starts pore formation on membrane

Polymerizes to cause cell lysis

Binds C3b to form C3 convertase C3 Bb

Factor B

Cleaves factor B

Factor D

Stabilizes C3 Convertase

Properdin

Binds to mannose

MBL (Similar to C1q)

Cleaves C4 and C2 in MBL

MASP-2 (Similar to C1s)

Unknown (Helps cleave C4 and C2) IN MBL

MASP-1 (Similar to Cr)

other names parasitology

other names parasitology

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FECALYSIS

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