GLOBIN SYNTHESIS

Yves Laure Pimentel · 70問 · 2年前

通報

問題一覧

how many globin (polypeptide) chains in globin synsthesis

Four

Quantitative Globin Disorder

Thalassemia

Globin Disorders Qualitative

Hemoglobinopathy

Quantitative production of globin

thalassemia

thalassemia aka

thalassic/ great sea

alpha thalassemia aka

hb bart/ hydrops fetalis syndrome

all 4 alpha genes are deleted (--/--); no normal hemoglobins are produced

alpha thalassemia major

three alpha genes deleted (--/-a)

Hemoglobin H disease

hemoglobin H

4 betw

Hemoglobin H, an unstable hemoglobin is produced

Hemoglobin H disease

inclusion present in Hemoglobin H disease

heinz bodies

% Hb H and the rest is Hb A

30%

Hb H inclusions demonstrated with a supravital stain

brilliant cresyl blue

hemolytic anemia occurs extravascular RBC appearance

Golf ball, Raspberry appearance

2 alpha genes are deleted and are usually asymptomatic

alpha thalassemia Minor/ Trait

Up to 6 % Bart's Hb is present

Alpha thalassemia Minor/ Trait

How many percent Bart's Hb is present in Alpha thalassemia Minor/ Trait

up to 6%

1 alpha gene is deleted

silent carrier

diagnosed only by gene analysis

silent carrier

beta thalassemia major aka

Cooley's anemia

Cooley's anemia aka

Beta thalassemia major

markedly decreased rate of synthesis or absence of both beta chains results in excess alpha chain

Beta thalassemia Major

no hemoglobin A can be produced

Beta thalassemia Major

Beta thalassemia Major ?% Hb F

90%

Hb A1

2 alpha and 2 beta

Hb A2

2 alpha and 2 delta

decrease rate of synthesis of one of the beta chain

beta thalassemia minor/ trait

Hb A is slightly decreased, Hb A2 is slightly increased to compensate

Beta thalassemia Minor/ Trait

Hemoglobinopathies (MCHC)

normocytic, normochromic

structurally abnormal globin chain synthesis due to amino acid substitution

Hemoglobinopathies

both globin chain affected

Homozygous/ Disease conditions

Homozygous/ Disease conditions ex.

Hb SS

Heterozygous/ trait conditions ex.

Hb AS

only one globin chain affected

Heterozygous/ trait conditions

caused when valine replaces glutamic acid at position 6 on both beta chains

Sickle cell disease (Hb SS)

mos common hemoglobinopathy and most severe

Sickle cell disease (Hb SS)

Sickle cell disease (Hb S %)

80%

Sickle cell disease (Hb F %)

20%

caused when Valine replaces glutamic acid at position 6 on one beta chain

Sickle cell trait (Hb AS)

Sickle cell trait (Hb AS) % Hb A

Sickle cell trait (Hb AS) % Hb S are produced

40%

Hemoglobin C disease aka

Hb CC, Bar of gold, clam shell, rod shape

Hemoglobin C disease inclusion

Target cell

caused when lysine replaces glutamic acid at position 6 on both beta chains

Hemoglobin C disease

hexagonal with blunt ends and stain darkly

Hb CC crystals

Hb CC, Bar of gold, clam shell, rod shape

Hb C disease

caused when lysine replaces glutamic acid at position 6 on one beta chains

Hemoglobin C trait

Hemoglobin C trait % Hb A, and % Hb X

60%, 40%

hb severity

Hb SS> Hb SC> Hb CC

S gene from one parent + C gene from one parent

Hemoglobin SC disease

symptoms are less severe than sickle anemia but more severe than Hb C disease

Hemoglobin SC disease

Hemoglobin SC disease % Hb S, and % Hb C

50%, 50%

crystalline fingerlike projection is often straight with parallel sides and blunt, pointed, protruding end

Hb Sc Crystals

Hemoglobin SC disease aka

Washington monument/ pistol shape

Washington monument/ pistol shape aka

Hemoglobin SC disease

caused when lysine replaces glutamic acid position 26 on the beta chain

Hemoglobin E

it migrates with Hb A2 C and O alkaline hemoglobin electrophoresis

Hemoglobin E

caused when glycine replaces glutamic acid at position 121 on beta chain

hemoglobin D (Punjab)

what hb in which both homozygous and heterozygous conditions are asymptomatic

hemoglobin D (Punjab)

Hb D migrates with hb ? and hb? on alkaline hemo electrophoresis

S and G

Hb D migrates with hb S and hb G on

alkaline hb electrophoresis

primary screening procedure used to detect variant hb

Cellulose Acetate Electrophoresis (alkaline ph)

hb is a negative charged molecule

Cellulose Acetate Electrophoresis (alkaline ph)

Cellulose Acetate Electrophoresis (alkaline ph) sample

red cell hemolysate

Cellulose Acetate Electrophoresis (alkaline ph) HB S positive should be confirm with?

Sickle Cell test

confirmatory for HB

h l electrophoresis

for differentiation of FA hb

Neutral Ph electrophoresis

used ro confirm variant Hb and further differentiates

citrate agar electrophoresis

method of choice when examining newborns for Hb S and C

citrate agar electrophoresis

citrate agar electrophoresis Hb S and C move towards

ANODE

citrate agar electrophoresis Hb Aand F move towards

CATHODE

other names parasitology

other names parasitology

70問 • 2年前

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PARASITOLOGY

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HTMLBE

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HISTOPATHOLOGY

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CC-3 ELECTROPHORESIS

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AUBF LAB SAFETY

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CSF 1

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CSF 2

CSF 2

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SEMEN 1

SEMEN 1

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SEMEN 2

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SYNOVIAL FLUID 1

SYNOVIAL FLUID 1

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SYNOVIAL FLUID 2

SYNOVIAL FLUID 2

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SEROUS FLUID

SEROUS FLUID

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PLEURAL FLUID

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PERICARDIAL FLUID

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PERITONEAL FLUID/ ASCITIC FLUID

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AMNIOTIC FLUID

AMNIOTIC FLUID

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FECALYSIS

FECALYSIS

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OTHER BODY FLUIDS

OTHER BODY FLUIDS

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MTLBE- SUHO NOTES

MTLBE- SUHO NOTES

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MTLBE..

MTLBE..

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CC- CHROMATOGRAPHY

CC- CHROMATOGRAPHY

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CC-OSMOMETRY

CC-OSMOMETRY

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CC-ELECTROCHEMISTRY TECHNIQUES

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CC- CARBOHYDRATES

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CC- DIABETES MELLITUS

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MAJOR LIPOPROTEINS

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MINOR LIPOPROTEINS

MINOR LIPOPROTEINS

63問 • 2年前

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PROTEINS

PROTEINS

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PLASMA PROTEINS 1

PLASMA PROTEINS 1

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PLASMA PROTEINS 2 (ALPHA 2 REGION)

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MISCELLANEOUS PROTEINS

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Liver Function Test 1

Liver Function Test 1

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Liver Function Test 2

Liver Function Test 2

96問 • 2年前

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TUMOR MARKERS

TUMOR MARKERS

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KIDNEY FUNCTION TESTS - NON PROTEIN NITROGEN & CREATININE

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GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES

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LIPID STORAGE DISEASES

LIPID STORAGE DISEASES

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PROTEINS

PROTEINS

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QUICK FIRE- ELECTRODES

QUICK FIRE- ELECTRODES

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ELECTROLYTES

ELECTROLYTES

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DRUGS

DRUGS

27問 • 2年前

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TOXIC AGENTS:

TOXIC AGENTS:

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HEMATOLOGY 1 (HEMATOPOIESIS 1)

HEMATOLOGY 1 (HEMATOPOIESIS 1)

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HEMATOLOGY (HEMATOPOIESIS 2)

HEMATOLOGY (HEMATOPOIESIS 2)

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hema diseases

hema diseases

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AML

AML

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HEMATOLOGY REFERENCE RANGES

HEMATOLOGY REFERENCE RANGES

31問 • 2年前

Yves Laure Pimentel · 34問 · 2年前

DISORDERS OF PRIMARY HEMOSTASIS

DISORDERS OF PRIMARY HEMOSTASIS

34問 • 2年前

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PLATELET DISORDERS

PLATELET DISORDERS

37問 • 2年前

CHARACTERISTICS OF CLOTTING FACTORS

CHARACTERISTICS OF CLOTTING FACTORS

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4. CLASSIFICATION OF MACROPHAGE

4. CLASSIFICATION OF MACROPHAGE

12問 • 2年前

Yves Laure Pimentel · 39問 · 2年前

3. NATURAL OR INNATE IMMUNITY

3. NATURAL OR INNATE IMMUNITY

39問 • 2年前

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5. INTERNAL DEFENSE:SOLUBLE FACTORS (ACUTE PHASE REACTANTS)

5. INTERNAL DEFENSE:SOLUBLE FACTORS (ACUTE PHASE REACTANTS)

55問 • 2年前

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6. PHAGOCYTOSIS Chemotaxis

6. PHAGOCYTOSIS Chemotaxis

37問 • 2年前

Yves Laure Pimentel · 44問 · 2年前

8. NATURE OF ANTIGEN

8. NATURE OF ANTIGEN

44問 • 2年前

Yves Laure Pimentel · 50問 · 2年前

9. MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

9. MAJOR HISTOCOMPATIBILITY COMPLEX/HUMAN LEUKOCYTE ANTIGEN

50問 • 2年前

Yves Laure Pimentel · 69問 · 2年前

1. HISTORY

1. HISTORY

69問 • 2年前

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2. TYPES OF IMMUNITY

2. TYPES OF IMMUNITY

38問 • 2年前

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7. PHAGOCYTOSIS Engulfment and Digestion

7. PHAGOCYTOSIS Engulfment and Digestion

21問 • 2年前

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8. PHAGOCYTOSIS EXOCYTOSIS

8. PHAGOCYTOSIS EXOCYTOSIS

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10. DISEASE ASSOCIATED TO HUMAN LEUKOCYTE ANTIGEN (henry)

10. DISEASE ASSOCIATED TO HUMAN LEUKOCYTE ANTIGEN (henry)

32問 • 2年前

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11. TRANSPLANTATION IMMUNOLOGY

11. TRANSPLANTATION IMMUNOLOGY

30問 • 2年前

Yves Laure Pimentel · 38問 · 2年前

2. LYMPHOID ORGANS

2. LYMPHOID ORGANS

38問 • 2年前

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3. CLUSTER OF DIFFERENTIATION

3. CLUSTER OF DIFFERENTIATION

48問 • 2年前

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4. T-CELL DIFFERENTIATION

4. T-CELL DIFFERENTIATION

35問 • 2年前

Yves Laure Pimentel · 18問 · 2年前

5. T CELL IMMUNODEFICIENCIES

5. T CELL IMMUNODEFICIENCIES

18問 • 2年前

Yves Laure Pimentel · 44問 · 2年前

6. STAGES IN B-CELL DIFFERENTIATION  PROPIMAP

6. STAGES IN B-CELL DIFFERENTIATION  PROPIMAP

44問 • 2年前

Yves Laure Pimentel · 23問 · 2年前

7. B CELL IMMUNODEFICIENCIES

7. B CELL IMMUNODEFICIENCIES

23問 • 2年前

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8. COMBINED T CELL AND B CELL DEFICIENCIES

8. COMBINED T CELL AND B CELL DEFICIENCIES

34問 • 2年前

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9. COMPARISON OF T AND B CELLS

9. COMPARISON OF T AND B CELLS

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10. LABORATORY IDENTIFICATION OF LYMPHOCYTES

10. LABORATORY IDENTIFICATION OF LYMPHOCYTES

16問 • 2年前

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11. NATURAL KILLER CELLS OR THIRD POPULATION CELL

11. NATURAL KILLER CELLS OR THIRD POPULATION CELL

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12. ANTIBODY

12. ANTIBODY

79問 • 2年前

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13. TYPES OF ANTIBODIES

13. TYPES OF ANTIBODIES

97問 • 2年前

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14. MONOCLONAL ANTIBODIES

14. MONOCLONAL ANTIBODIES

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1. INTERLEUKINS

1. INTERLEUKINS

23問 • 2年前

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2. INTERFERONS

2. INTERFERONS

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3. CYTOKINES IN THE INNATE AND ADAPTIVE IMMUNITY

3. CYTOKINES IN THE INNATE AND ADAPTIVE IMMUNITY

8問 • 2年前

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4. COMPLEMENT SYSTEM

4. COMPLEMENT SYSTEM

19問 • 2年前

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15. COMPLEMENT SYSTEM

15. COMPLEMENT SYSTEM

76問 • 2年前

Yves Laure Pimentel · 21問 · 2年前

16. SYSTEM CONTROLS/COMPLEMENT REGULATION

16. SYSTEM CONTROLS/COMPLEMENT REGULATION

21問 • 2年前

Yves Laure Pimentel · 29問 · 2年前

17. COMPLEMENT AND DISEASE STATES

17. COMPLEMENT AND DISEASE STATES

29問 • 2年前

Yves Laure Pimentel · 19問 · 2年前

18. IMMUNOLOGIC ASSAYS OF INDIVIDUAL COMPONENTS (CLASSICAL)

18. IMMUNOLOGIC ASSAYS OF INDIVIDUAL COMPONENTS (CLASSICAL)

19問 • 2年前

Yves Laure Pimentel · 22問 · 2年前

19. CYTOKINES

19. CYTOKINES

22問 • 2年前

Yves Laure Pimentel · 24問 · 2年前

20. INTERLEUKINS

20. INTERLEUKINS

24問 • 2年前

Yves Laure Pimentel · 21問 · 2年前

21. INTERFERONS, TNF, TGF, CHEMOKINE

21. INTERFERONS, TNF, TGF, CHEMOKINE

21問 • 2年前

Yves Laure Pimentel · 54問 · 2年前

1. SERO

1. SERO

54問 • 2年前

Yves Laure Pimentel · 38問 · 2年前

2. PRECIPITATION

2. PRECIPITATION

38問 • 2年前

Yves Laure Pimentel · 17問 · 2年前

3. PASSIVE IMMUNODIFFUSION

3. PASSIVE IMMUNODIFFUSION

17問 • 2年前

Yves Laure Pimentel · 15問 · 2年前

4. OUCHTERLONY

4. OUCHTERLONY

15問 • 2年前

Yves Laure Pimentel · 9問 · 2年前

5. ELECTROPHORETIC TECHNIQUE

5. ELECTROPHORETIC TECHNIQUE

9問 • 2年前

Yves Laure Pimentel · 11問 · 2年前

6. IMMUNOELECTROPHORESIS (DOUBLE DIFFUSION)

6. IMMUNOELECTROPHORESIS (DOUBLE DIFFUSION)

11問 • 2年前

Yves Laure Pimentel · 29問 · 2年前

7. IMMUNOFIXATION ELECTROPHORESIS

7. IMMUNOFIXATION ELECTROPHORESIS

29問 • 2年前