6. PHAGOCYTOSIS Chemotaxis

Yves Laure Pimentel · 70問 · 2年前

通報

問題一覧

Toll like receptors discovered in the ?

Fruit fly Drosophila

Disorder which has normal movement but poor directional motility

Job syndrome (Hyperimmunoglobulin E)

what is the toll like receptor if theres a mycobacteria/ lipoprotein

TLR 1

greek word means to prepare for eating

opsonin

what are the 3 most important opsonins

CRP ANTIBODY COMPLEMENT

T/F These are the chemotaxins - Bacterial and viral products complement components coagulation proteins cytokines

True

What is the test used to assess the chemotactic response of neutrophil

Boyden Chamber

(4) important enzymes that are needed for microbial killing

G6PD NADPH OXIDASE SUPEROXIDASE DISMUTASE MYELOPEROXIDASE

central killing of microbes

NADPH OXIDASE

accounts for GREENISH color of the pus

MYELOPEROXIDASE

ingestion of foreign material. Destroys most foreign cells that penetrate

PHAGOCYTOSIS

PHAGOCYTOSIS ORDER

Initiation -> Chemotaxis -> Engulfment and digestion -> Exocytosis

gives signal and acivates neutrophil if theres an invading pathogen

Toll-Like Receptors

Toll-Like Receptors: gram +/ peptidoglycan

TLR 2

Toll-Like Receptors: TLR 2

gram +/ peptidoglycan

Toll-Like Receptors: TLR 4

GRAM (-)/ LIPOPOLYSACCHARIDE

Toll-Like Receptors: GRAM (-)/ LIPOPOLYSACCHARIDE

TLR 4

Toll-Like Receptors: TLR 1

MYCOBACTERIA/ LIPOPROTEIN

Toll-Like Receptors: MYCOBACTERIA/ LIPOPROTEIN

TLR 1

enhance phagocytosis

Opsonins

Action: neutralize surface charge

Opsonins

IT HAS ZETA POTENTIAL

CELLS

CELLS ARE ATTRACTED TO THE SITE OF INFLAMMATION BY CHEMICAL SUBSTANCES SUCH AS SOLUBLE BACTERIAL FACTORS, COMPLEMENT COMPONENTS OR CRP

CHEMOTAXIS

immune cells migrate to the site of inflammation

Chemotaxis

– attracted to the site of injury by the Chemotaxins

Neutrophils

– migrates several hours after SCAVENGE AND CLEAN SITE OF INFLAMMATION

Macrophages

– are chemical messengers that cause cells to migrate in particular direction.

Chemotaxins

– random movement, granulocyte don’t RESPOND to chemotactic factor

Lazy leukocyte

– a chemotaxin deficient

Tufstin deficiency

– def. CYTO skeletal protein actin , poor motiliy or reduced motility

Actin dysfunction

-decrease or absence of specific complement component receptors

CR3 (iC3b receptor) deficiency

defective margination and diapedesis

CR3 (iC3b receptor) deficiency

– CD18 (B2 integrin) deficiency

LAD 1

– absence of Sial- lewis X (CD15) blood group Ag

LAD 2

DELAYED SEPARATION OF UMBILICAL CORD

CR3 (iC3b receptor) deficiency

– Lymphocytes’ chemotactic factors production ability

Migration inhibition

OXIDIZING AGENTS (3)

HYDROXIDE HYDROGEN PEROXIDE HYPOCHLORITE

other names parasitology

other names parasitology

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