KIDNEY FUNCTION TESTS - NON PROTEIN NITROGEN & CREATININE

Yves Laure Pimentel · 70問 · 2年前

通報

問題一覧

NON PROTEIN NITROGEN

KIDNEY FUNCTION TESTS

Plasma NPN concentration from most concentrated to the last:

UREA (45-50%) >AMINO ACID (25%) >URIC ACID (10%) >CREATININE (5%) >CREATINE (1-2%) > AMMONIA (0.2%)

is an older term

Blood urea nitrogen

MEASURES nitrogen

BUN (Blood Urea Nitrogen)

major END product of protein and amino acid

BUN (Blood Urea Nitrogen)

PRINCIPAL ORGANIC SUBSTANCE IN THE URINE

UREA

First metabolite to elevate in kidney disease

BUN (Blood Urea Nitrogen) Kidney status

For renal function evaluation

BUN (Blood Urea Nitrogen)

Assess hydration status

BUN (Blood Urea Nitrogen)

Determine nitrogen balance

BUN (Blood Urea Nitrogen)

Increased / Decreased BUN Chronic renal disease

Increased

Increased / Decreased BUN Burns

Increased

Increased / Decreased BUN Dehydration

Increased

Increased / Decreased BUN Poor nutrition

Decreased BUN

Increased / Decreased BUN Celiac disease

Decreased BUN

Increased / Decreased BUN Repeated dialysis

Decreased BUN

Increased / Decreased BUN Acute TUBULAR necrosis

Decreased BUN

Increased / Decreased BUN PREGNANCY

Decreased BUN

Increased / Decreased BUN HEPATIC DISEASE OR LIVER PROBLEM

Decreased BUN

TUBE THAT IS NOT USED FOR BUN BEC. IT CAN INHIBIT UREASE

Sodium Fluoride or Sodium citrate

Electrode method = ? is measured

conductivity

= conductivity is measured

Electrode method

- Reference Method

Isotope Dilution Mass Spectrometry

Getting Urea from BUN: _______ xBUN= urea(mg)->

2.14

liver -> arginine, glycine, and methionine -> Creatine ->Muscles ->Creatine phosphate -> phosphoric acid and water loss -> creatinine -> plasma ->kidney

Creatinine

End Product of muscle metabolism

Creatinine

NOT affected by protein diet

Creatinine

Creatinine levels are regulated by ___________excretion.

KIDNEY

Most commonly used to monitor renal func. An INDEX of overall renal func

Creatinine

NOT USED TO DETECT KIDNEY DISEASE BUT FOR MONITORING ONLY

Creatinine

Creatinine eUsed to measure the completeness of _______ urine

24 HOURS

BUN:Crea ratio

10:1-20:1

Difficult to remove by dialysis

Creatinine

Fasting is not required IN Creatinine T/F?

TRUE

UREA NV:

6-20 MG/DL

CREA NV:

0.9-1.3 MG/DL

Creatinine FORMULA

U/C

GLOMERULAR/TUBULAR? <10 IS

TUBULAR

GLOMERULAR/TUBULAR? >20 IS

GLOMERULAR

Creatinine Chemical Methods most frequently used

Jaffe Reaction

Creatinine + Picric acid –alkaline sol’n->red-orange (Creatinine picrate)

Jaffe Reaction

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