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13. TYPES OF ANTIBODIES

  • Yves Laure Pimentel

    • 問題数 97 • 1/29/2024

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  • 1

    known as macroglobulin

    IgM

  • 2

    IgM known as

    macroglobulin

  • 3

    Function: Opsonization

    IgM

  • 4

    Function: Agglutination

    IgM

  • 5

    Mercaptoethanol ->IgM = ?

    Five 7S (190,000D)

  • 6

    ? ->IgM = Five 7S (190,000D)

    Mercaptoethanol

  • 7

    Waldenstrom’s macroglobulinemia what Ab

    IgM

  • 8

    Mercaptoethanol ->? = Five 7S (190,000D)

    IgM

  • 9

    IgM def

    Waldenstrom’s macroglobulinemia

  • 10

    Waldenstrom’s macroglobulinemia Type of Antibody

    IgM

  • 11

    Primary response antibody

    IgM

  • 12

    IgE ________ antibody

    REAGIN

  • 13

    – IgM is most efficient

    Complement (CH4) fixation

  • 14

    REAGIN antibody

    IgE

  • 15

    due to large number of binding sites

    Agglutination

  • 16

    Function: Toxin neutralization

    IgM

  • 17

    antibody that participates in Hypersensitivity

    REAGIN antibody

  • 18

    REAGIN antibody -antibody that participates in Hypersensitivity

    IgE

  • 19

    Function: Surface receptor for B cell

    IgM

  • 20

    Function: Complement (CH4) fixation

    IgM

  • 21

    most heat labile

    IgE

  • 22

    release of histamine And heparin.

    IgE

  • 23

    IgE release of

    histamine And heparin.

  • 24

    –Diarrhea, Vomiting, Hives,Hay fever, Anaphylatic shock

    IgE

  • 25

    IgE associated prob

    –Diarrhea, Vomiting, Hives,Hay fever, Anaphylatic shock

  • 26

    Responsible for Type I hypersensitivity and parasitic inf

    IgE

  • 27

    IgE Responsible for

    Type I hypersensitivity and parasitic inf

  • 28

    Triggers acute inflammatory reaction which RECRUIT neutrophils and eosinophils to help destroy invading antigens that have penetrated IgA defenses

    IgE

  • 29

    discovered until 1965 in patient with MM

    IgD

  • 30

    IgD - discovered until 1965 in patient with

    MULTIPLE MYELOMA

  • 31

    Location: surface of immunocompetent B cell

    IgD

  • 32

    IgD Location:

    surface of immunocompetent B cell

  • 33

    Play role in B cell activation, maturation and differentiation.

    IgD

  • 34

    IgD Play role in

    B cell activation, maturation and differentiation.

  • 35

    Found in secretions

    IgA

  • 36

    Secretory component

    IgA

  • 37

    Subtypes: IgA1 and IgA2

    IgA

  • 38

    IgA Subtypes:

    IgA1 and IgA2

  • 39

    Serum:

    MONOMER AND DIMER

  • 40

    Secretion:

    DIMER

  • 41

    IgA1 IS IN

    Serum

  • 42

    IgA2 IN

    MUCOSA

  • 43

    IN MUCOSA

    IgA2

  • 44

    IN SERUM:

    IgA1

  • 45

    PATROL mucosal surface as a first line of defense

    IgA

  • 46

    dse w/c INCREASED IgA

    Laennec’s Cirrhosis

  • 47

    Laennec’s Cirrhosis IS

    INCREASED IgA

  • 48

    most PREDOMINANT immunoglobulin in human and in interstitial fluid.

    IgG

  • 49

    80% of the total immunoglobulin concentration in normal serum

    IgG

  • 50

    IgG - of the total immunoglobulin concentration in normal serum

    80%

  • 51

    IgG - ________ response

    SECONDARY

  • 52

    - SECONDARY response

    IgG

  • 53

    CAN Cross placenta (for fetal immune system) (only Ig that can cross – )

    IgG

  • 54

    Fixing complement (except Ig4)

    IgG

  • 55

    Neutralizing virus and toxins

    IgG

  • 56

    Participate in agglutination and precipitation

    IgG

  • 57

    is better in precipitation than agglutination

    IgG

  • 58

    IgG is better in ? than ?

    precipitation than agglutination

  • 59

    IgG Subtypes

    IgG1 IgG2 IgG3 IgG4

  • 60

    MOST EFFICIENT in CROSSING the placenta

    IgG1

  • 61

    IgG1

    MOST EFFICIENT in CROSSING the placenta

  • 62

    -> LEAST EFFICIENT in crossing the placenta

    IgG2

  • 63

    IgG2 ->

    LEAST EFFICIENT in crossing the placenta

  • 64

    IgG3 -> MOST efficient at binding ________. Largest ________ region

    COMPLEMENT, HINGE

  • 65

    -> MOST efficient at binding COMPLEMENT. Largest HINGE region

    IgG3

  • 66

    IgG3 ->

    MOST efficient at binding COMPLEMENT. Largest HINGE region

  • 67

    -> LEAST EFFICIENT in fixing complement.

    IgG4

  • 68

    IgG4 ->

    LEAST EFFICIENT in fixing complement.

  • 69

    Has J chain

    IgM IgA

  • 70

    Has IgM AND IgA

    J chain

  • 71

    Immunoglobulins Crosses placenta

    IgG

  • 72

    Immunoglobulins Complement Fixation

    IgM IgG except IgG2

  • 73

    IgM Molecular weight

    900,000

  • 74

    IgE Molecular weight

    190,000

  • 75

    IgD Molecular weight

    180,000

  • 76

    IgA Molecular weight

    160,000

  • 77

    IgG Molecular weight

    150,000

  • 78

    Sedimentation coefficient 7S WHAT Immunoglobulins?

    IgD IgA IgG

  • 79

    Sedimentation coefficient IgD

    7S

  • 80

    Sedimentation coefficient IgA

    7S

  • 81

    Sedimentation coefficient IgG

    7S

  • 82

    Sedimentation coefficient IgE

    8S

  • 83

    Sedimentation coefficient IgM

    19S

  • 84

    IgM Subclass

    None

  • 85

    IgE Subclass

    None

  • 86

    IgD Subclass

    None

  • 87

    IgA Subclass

    a1 and a2

  • 88

    IgG Subclass

    y 1, y2,y3,y4

  • 89

    Serum conc (mg/dL) IgM

    120-150

  • 90

    Serum conc (mg/dL) IgE

    0.005

  • 91

    Serum conc (mg/dL) IgD

    1-3

  • 92

    Serum conc (mg/dL) IgA

    70-350

  • 93

    Serum conc (mg/dL) IgG

    800-1600

  • 94

    Serum Half life (days) IgM

    6

  • 95

    Serum Half life (days) IgE

    2-3

  • 96

    Serum Half life (days) IgD

    1-3

  • 97

    Serum Half life (days) IgA

    5