13. TYPES OF ANTIBODIES

Yves Laure Pimentel · 70問 · 2年前

通報

問題一覧

known as macroglobulin

IgM

IgM known as

macroglobulin

Function: Opsonization

IgM

Function: Agglutination

IgM

Mercaptoethanol ->IgM = ?

Five 7S (190,000D)

? ->IgM = Five 7S (190,000D)

Mercaptoethanol

Waldenstrom’s macroglobulinemia what Ab

IgM

Mercaptoethanol ->? = Five 7S (190,000D)

IgM

IgM def

Waldenstrom’s macroglobulinemia

Waldenstrom’s macroglobulinemia Type of Antibody

IgM

Primary response antibody

IgM

IgE ________ antibody

REAGIN

– IgM is most efficient

Complement (CH4) fixation

REAGIN antibody

IgE

due to large number of binding sites

Agglutination

Function: Toxin neutralization

IgM

antibody that participates in Hypersensitivity

REAGIN antibody

REAGIN antibody -antibody that participates in Hypersensitivity

IgE

Function: Surface receptor for B cell

IgM

Function: Complement (CH4) fixation

IgM

most heat labile

IgE

release of histamine And heparin.

IgE

IgE release of

histamine And heparin.

–Diarrhea, Vomiting, Hives,Hay fever, Anaphylatic shock

IgE

IgE associated prob

–Diarrhea, Vomiting, Hives,Hay fever, Anaphylatic shock

Responsible for Type I hypersensitivity and parasitic inf

IgE

IgE Responsible for

Type I hypersensitivity and parasitic inf

Triggers acute inflammatory reaction which RECRUIT neutrophils and eosinophils to help destroy invading antigens that have penetrated IgA defenses

IgE

discovered until 1965 in patient with MM

IgD

IgD - discovered until 1965 in patient with

MULTIPLE MYELOMA

Location: surface of immunocompetent B cell

IgD

IgD Location:

surface of immunocompetent B cell

Play role in B cell activation, maturation and differentiation.

IgD

IgD Play role in

B cell activation, maturation and differentiation.

Found in secretions

IgA

Secretory component

IgA

Subtypes: IgA1 and IgA2

IgA

IgA Subtypes:

IgA1 and IgA2

Serum:

MONOMER AND DIMER

Secretion:

DIMER

IgA1 IS IN

Serum

IgA2 IN

MUCOSA

IN MUCOSA

IgA2

IN SERUM:

IgA1

PATROL mucosal surface as a first line of defense

IgA

dse w/c INCREASED IgA

Laennec’s Cirrhosis

Laennec’s Cirrhosis IS

INCREASED IgA

most PREDOMINANT immunoglobulin in human and in interstitial fluid.

IgG

80% of the total immunoglobulin concentration in normal serum

IgG

IgG - of the total immunoglobulin concentration in normal serum

80%

IgG - ________ response

SECONDARY

- SECONDARY response

IgG

CAN Cross placenta (for fetal immune system) (only Ig that can cross – )

IgG

Fixing complement (except Ig4)

IgG

Neutralizing virus and toxins

IgG

Participate in agglutination and precipitation

IgG

is better in precipitation than agglutination

IgG

IgG is better in ? than ?

precipitation than agglutination

IgG Subtypes

IgG1 IgG2 IgG3 IgG4

MOST EFFICIENT in CROSSING the placenta

IgG1

MOST EFFICIENT in CROSSING the placenta

-> LEAST EFFICIENT in crossing the placenta

IgG2

IgG2 ->

LEAST EFFICIENT in crossing the placenta

IgG3 -> MOST efficient at binding ________. Largest ________ region

COMPLEMENT, HINGE

-> MOST efficient at binding COMPLEMENT. Largest HINGE region

IgG3

IgG3 ->

MOST efficient at binding COMPLEMENT. Largest HINGE region

-> LEAST EFFICIENT in fixing complement.

IgG4

IgG4 ->

LEAST EFFICIENT in fixing complement.

Has J chain

IgM IgA

Has IgM AND IgA

J chain

Immunoglobulins Crosses placenta

IgG

Immunoglobulins Complement Fixation

IgM IgG except IgG2

IgM Molecular weight

900,000

IgE Molecular weight

190,000

IgD Molecular weight

180,000

IgA Molecular weight

160,000

IgG Molecular weight

150,000

Sedimentation coefficient 7S WHAT Immunoglobulins?

IgD IgA IgG

Sedimentation coefficient IgD

Sedimentation coefficient IgA

Sedimentation coefficient IgG

Sedimentation coefficient IgE

Sedimentation coefficient IgM

19S

IgM Subclass

None

IgE Subclass

None

IgD Subclass

None

IgA Subclass

a1 and a2

IgG Subclass

y 1, y2,y3,y4

Serum conc (mg/dL) IgM

120-150

Serum conc (mg/dL) IgE

0.005

Serum conc (mg/dL) IgD

1-3

Serum conc (mg/dL) IgA

70-350

Serum conc (mg/dL) IgG

800-1600

Serum Half life (days) IgM

Serum Half life (days) IgE

2-3

Serum Half life (days) IgD

1-3

Serum Half life (days) IgA

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