Serum Half life (days) IgE

Found in secretions

REAGIN antibody

IgM known as

Has IgM AND IgA

Function: Toxin neutralization

Responsible for Type I hypersensitivity and parasitic inf

Mercaptoethanol ->? = Five 7S (190,000D)

IgE release of

Location: surface of immunocompetent B cell

- SECONDARY response

Waldenstrom’s macroglobulinemia Type of Antibody

IN MUCOSA

Serum conc (mg/dL) IgD

IgG - ________ response

IgE Molecular weight

antibody that participates in Hypersensitivity

Triggers acute inflammatory reaction which RECRUIT neutrophils and eosinophils to help destroy invading antigens that have penetrated IgA defenses

Sedimentation coefficient IgE

Has J chain

IgD Location:

IgM Subclass

Secretion:

IgD Molecular weight

IgG2 ->

Function: Agglutination

IgG Molecular weight

IgM def

Serum conc (mg/dL) IgE

-> MOST efficient at binding COMPLEMENT. Largest HINGE region

Serum:

Mercaptoethanol ->IgM = ?

IgE Responsible for

discovered until 1965 in patient with MM

? ->IgM = Five 7S (190,000D)

Sedimentation coefficient IgA

Participate in agglutination and precipitation

Serum conc (mg/dL) IgG

Play role in B cell activation, maturation and differentiation.

dse w/c INCREASED IgA

CAN Cross placenta (for fetal immune system) (only Ig that can cross – )

IgG Subtypes

most PREDOMINANT immunoglobulin in human and in interstitial fluid.

IgG Subclass

IgD - discovered until 1965 in patient with

REAGIN antibody -antibody that participates in Hypersensitivity

Immunoglobulins Crosses placenta

IgA Subclass

IgG - of the total immunoglobulin concentration in normal serum

Neutralizing virus and toxins

MOST EFFICIENT in CROSSING the placenta

IgA Molecular weight

release of histamine And heparin.

known as macroglobulin

IgG is better in ? than ?

Function: Complement (CH4) fixation

IgE ________ antibody

IgA1 IS IN

Laennec’s Cirrhosis IS

Primary response antibody

– IgM is most efficient

IgM Molecular weight

Serum conc (mg/dL) IgA

Subtypes: IgA1 and IgA2

due to large number of binding sites

Sedimentation coefficient IgM

IgE associated prob

–Diarrhea, Vomiting, Hives,Hay fever, Anaphylatic shock

IgG3 ->

Serum Half life (days) IgA

-> LEAST EFFICIENT in crossing the placenta

IgD Play role in

Waldenstrom’s macroglobulinemia what Ab

-> LEAST EFFICIENT in fixing complement.

Serum Half life (days) IgD

IgA Subtypes:

Immunoglobulins Complement Fixation

is better in precipitation than agglutination

Function: Opsonization

IN SERUM:

Sedimentation coefficient 7S WHAT Immunoglobulins?

Sedimentation coefficient IgG

Secretory component

Fixing complement (except Ig4)

80% of the total immunoglobulin concentration in normal serum

Serum conc (mg/dL) IgM

IgG3 -> MOST efficient at binding ________. Largest ________ region

Serum Half life (days) IgM

Function: Surface receptor for B cell

IgE Subclass

Sedimentation coefficient IgD

most heat labile

IgG1

IgG4 ->

IgA2 IN

PATROL mucosal surface as a first line of defense

IgD Subclass