it binds to antibody in the presence of carrier protein

T/F age can influence our immune response

T/F Diet can influence our immune response

T/F Genetic predisposition can influence our immune response

this is the shape or configuration recognized by T or B cell

what is the Dalton of the Best immunogen?

in order to called immunogen how many daltons is needed

Factors Influencing the Immune Response

Epitope /determinant site 2 types:

Antigen BINDS WITH ANTIBODY

Immunogen BINDS WITH ANTIBODY

Hapten BINDS WITH ANTIBODY

Evoke Immune response Antigen

Evoke Immune response: Immunogen

Evoke Immune response Hapten

TERM USED FOR AG BIND TO AB

ARE ANTIGENS BUT NOT ALL ANTIGENS ARE THESE

ALL IMMUNOGENS ARE

POISON IVY (CATECHOLS)

HAPTEN POISON

ARE UNIVALENT

-recognized as nonself by an individual’s immune system

Chemical composition and complexity

BLOOD OF HORSE SHOE CRAB

HAS DIRECT RELATIONSHIP IN SIZE OR WEIGHT

– Large dose of immunogen + Memory cells = Nonresponsive

same individual

same species, different individual.

different species, different individual

there’s cross reactivity

Local inflammation -> Increase immune response

increase immune response by producing Local inflammation

killed mycobacteria (0.5mg/mL)  produces granulomas or scar tissue thus it is not used in humans

are the only ones approved for clinical use in the US

smallpox and BCG (mycobacterium bovis)

LIVE VACCINES

= Influenza

Live ATTENUATED =

DEAD

= cholera, typhoid

= Clostridium tetani and diphtheria

TOXOID

poliovirus

MODIFIED VIRUS