If drug A is an enzyme inhibitor what will happen to drug b?

The major biotansformation site of drugs in humans is

For conventional oral dosage forms, this is the slowest and rate limiting step in the series of processes of drug distribution

Zero order drugs

Which will concentrate more in breast tissue

In mammary excretion, weak bases will

In mammary excretion, weak acids will

Milk is more ______ than plasma

Milk is more acidic than plasma

Requirement for billiary excretion

Phenomenon in which drugs emptied via bile into the small intestine can be reabsorbed from the intestinal lumen into the SC

Excretion related to volatile substances and gases (niyrous oxide and ethanol)

Primarily ocurs in the procimal tubules by two energy requiring active transport systems

Only _________ forms are reabsorbed in tubular reabsorption

Weak acid is more ______ in the urine

What happens when weak acids are more unionized in the urine

Req for excretion

Neonates have ________ enzyme capacity

Irreversible removal of drugs in the body

________ clearance = ________t50

Toxic metabolite of isoniazid

Non toxic metabolite of isoniazid

Have absent or decreased NAT activities

Enzyme present in acetylation

Dapsone is used in

Use of procainamide

Use of isoniazid

Hydralazine is used as

Most common phase 2 drugs

Enzyme present in glucuronidation

Aspirin + salicyclic acid =

Hydrolysis metabolizes

Reductases causes inactivation of

Dehydrogenases metabolizes

Mao a metabolizes

Mao b metabolizes

Use of glutathion conjugation

Enzyme used in glutathione conjugation

Enzyme used in sulfonation

Drugs that undergoes sulfation

Minor pathway in drug metabolism More important in the synthesis of endogenous compounds

Example of endogenous compounds

Enzyme used in amino acid conjugation

Benzoic acid -> hippuric acid

_____ enzyme= ____ metabolism, ______ plasma concentration which results in ______ activity

Example of enzyme induction

Warfarin + grapefruit juice

1a2

2c9

2d6

3a4