Use of procainamide

Hydralazine is used as

Benzoic acid -> hippuric acid

Milk is more acidic than plasma

Irreversible removal of drugs in the body

________ clearance = ________t50

Excretion related to volatile substances and gases (niyrous oxide and ethanol)

Have absent or decreased NAT activities

In mammary excretion, weak acids will

Only _________ forms are reabsorbed in tubular reabsorption

Enzyme used in glutathione conjugation

Warfarin + grapefruit juice

Phenomenon in which drugs emptied via bile into the small intestine can be reabsorbed from the intestinal lumen into the SC

2c9

_____ enzyme= ____ metabolism, ______ plasma concentration which results in ______ activity

If drug A is an enzyme inhibitor what will happen to drug b?

Example of endogenous compounds

Non toxic metabolite of isoniazid

2d6

Example of enzyme induction

Req for excretion

Milk is more ______ than plasma

Drugs that undergoes sulfation

Enzyme present in acetylation

What happens when weak acids are more unionized in the urine

Enzyme used in sulfonation

In mammary excretion, weak bases will

Enzyme used in amino acid conjugation

Use of isoniazid

Aspirin + salicyclic acid =

Hydrolysis metabolizes

Reductases causes inactivation of

Neonates have ________ enzyme capacity

For conventional oral dosage forms, this is the slowest and rate limiting step in the series of processes of drug distribution

Weak acid is more ______ in the urine

Dapsone is used in

Use of glutathion conjugation

Mao b metabolizes

1a2

The major biotansformation site of drugs in humans is

Mao a metabolizes

3a4

Dehydrogenases metabolizes

Which will concentrate more in breast tissue

Primarily ocurs in the procimal tubules by two energy requiring active transport systems

Zero order drugs

Most common phase 2 drugs

Requirement for billiary excretion

Toxic metabolite of isoniazid

Minor pathway in drug metabolism More important in the synthesis of endogenous compounds

Enzyme present in glucuronidation