kinetics

51問 • 1年前

Hannah Angelique Losaria

通報

問題一覧

If drug A is an enzyme inhibitor what will happen to drug b?

inc activity of drug b

The major biotansformation site of drugs in humans is

liver

For conventional oral dosage forms, this is the slowest and rate limiting step in the series of processes of drug distribution

dissolution

Zero order drugs

theophylline, tolbutamine, aspirin, phenytoin, ethanol

Which will concentrate more in breast tissue

weak base

In mammary excretion, weak bases will

diffuse but ion trapped

In mammary excretion, weak acids will

diffuse and redistributed

Milk is more ______ than plasma

acidic

Milk is more acidic than plasma

mammary excretion

Requirement for billiary excretion

lipid soluble, unbound

Phenomenon in which drugs emptied via bile into the small intestine can be reabsorbed from the intestinal lumen into the SC

biliary recycling

Excretion related to volatile substances and gases (niyrous oxide and ethanol)

pulmonary excretion

Primarily ocurs in the procimal tubules by two energy requiring active transport systems

tubular secretion

Only _________ forms are reabsorbed in tubular reabsorption

unionized

Weak acid is more ______ in the urine

unionized

What happens when weak acids are more unionized in the urine

reabsorbed

Req for excretion

hipe

Neonates have ________ enzyme capacity

reduced

Irreversible removal of drugs in the body

drug excretion

________ clearance = ________t50

reduced, higher

Toxic metabolite of isoniazid

hydrazine

Non toxic metabolite of isoniazid

acethyldrazine

Have absent or decreased NAT activities

slow acetylators

Enzyme present in acetylation

n acetyl transferase

Dapsone is used in

leprosy

Use of procainamide

anti arrhythmia

Use of isoniazid

anti tb

Hydralazine is used as

vasodilator

Most common phase 2 drugs

acetaminophen, morphine, nsaids, bilirubin, thyroxine

Enzyme present in glucuronidation

udp glucurunosyl transferase

Aspirin + salicyclic acid =

acetic acid

Hydrolysis metabolizes

esterase, amidase

Reductases causes inactivation of

warfarin

Dehydrogenases metabolizes

alcohols

Mao a metabolizes

serotonin, epinephrine, NE

Mao b metabolizes

dopamine

Use of glutathion conjugation

paracetamol toxicity

Enzyme used in glutathione conjugation

glutathione s transferase

Enzyme used in sulfonation

sulfotransferase

Drugs that undergoes sulfation

acetaminophen, minoxidil

Minor pathway in drug metabolism More important in the synthesis of endogenous compounds

methylation

Example of endogenous compounds

melatonin, epinephrine

Enzyme used in amino acid conjugation

amino acid transferase

Benzoic acid -> hippuric acid

hippurate

_____ enzyme= ____ metabolism, ______ plasma concentration which results in ______ activity

high, high, low, low

Example of enzyme induction

st johns wort

Warfarin + grapefruit juice

severe bleeding

1a2

theophylline, acetaminophen

2c9

phenytoin, warfarin

2d6

many cardiovascular drugs

3a4

60% of drugs in pdr

Amino Acid Structure/Diagram

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ENZYME OF CLINICAL SIGNIFICANCE-MCQ2

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99問 • 1ヶ月前

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89問 • 1ヶ月前

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CLASS AND VARIANT OF ENZYME-MCQ

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Module 3

Module 3

Module 1

Module 1

TOXINS

TOXINS

TOXINS

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ユーザ名非公開 · 41問 · 2ヶ月前

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41問 • 2ヶ月前

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HERSHEY VALERIE BERNARDINO · 100問 · 3ヶ月前

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100問 • 3ヶ月前

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lonic Equilibria

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49問 • 3ヶ月前

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Biochem 2.0

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PHARMA

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Semisolid Preparations Part 2

HERSHEY VALERIE BERNARDINO · 75問 · 4ヶ月前

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75問 • 4ヶ月前

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chapter 2

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問題一覧

If drug A is an enzyme inhibitor what will happen to drug b?

inc activity of drug b

The major biotansformation site of drugs in humans is

liver

For conventional oral dosage forms, this is the slowest and rate limiting step in the series of processes of drug distribution

dissolution

Zero order drugs

theophylline, tolbutamine, aspirin, phenytoin, ethanol

Which will concentrate more in breast tissue

weak base

In mammary excretion, weak bases will

diffuse but ion trapped

In mammary excretion, weak acids will

diffuse and redistributed

Milk is more ______ than plasma

acidic

Milk is more acidic than plasma

mammary excretion

Requirement for billiary excretion

lipid soluble, unbound

Phenomenon in which drugs emptied via bile into the small intestine can be reabsorbed from the intestinal lumen into the SC

biliary recycling

Excretion related to volatile substances and gases (niyrous oxide and ethanol)

pulmonary excretion

Primarily ocurs in the procimal tubules by two energy requiring active transport systems

tubular secretion

Only _________ forms are reabsorbed in tubular reabsorption

unionized

Weak acid is more ______ in the urine

unionized

What happens when weak acids are more unionized in the urine

reabsorbed

Req for excretion

hipe

Neonates have ________ enzyme capacity

reduced

Irreversible removal of drugs in the body

drug excretion

________ clearance = ________t50

reduced, higher

Toxic metabolite of isoniazid

hydrazine

Non toxic metabolite of isoniazid

acethyldrazine

Have absent or decreased NAT activities

slow acetylators

Enzyme present in acetylation

n acetyl transferase

Dapsone is used in

leprosy

Use of procainamide

anti arrhythmia

Use of isoniazid

anti tb

Hydralazine is used as

vasodilator

Most common phase 2 drugs

acetaminophen, morphine, nsaids, bilirubin, thyroxine

Enzyme present in glucuronidation

udp glucurunosyl transferase

Aspirin + salicyclic acid =

acetic acid

Hydrolysis metabolizes

esterase, amidase

Reductases causes inactivation of

warfarin

Dehydrogenases metabolizes

alcohols

Mao a metabolizes

serotonin, epinephrine, NE

Mao b metabolizes

dopamine

Use of glutathion conjugation

paracetamol toxicity

Enzyme used in glutathione conjugation

glutathione s transferase

Enzyme used in sulfonation

sulfotransferase

Drugs that undergoes sulfation

acetaminophen, minoxidil

Minor pathway in drug metabolism More important in the synthesis of endogenous compounds

methylation

Example of endogenous compounds

melatonin, epinephrine

Enzyme used in amino acid conjugation

amino acid transferase

Benzoic acid -> hippuric acid

hippurate

_____ enzyme= ____ metabolism, ______ plasma concentration which results in ______ activity

high, high, low, low

Example of enzyme induction

st johns wort

Warfarin + grapefruit juice

severe bleeding

1a2

theophylline, acetaminophen

2c9

phenytoin, warfarin

2d6

many cardiovascular drugs

3a4

60% of drugs in pdr