問題一覧
1
Receptor that stimulates phospholipidase c
gq
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Antiviral drug approved for the treatment of corona virus by the national medical products administration of china
favilavir
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Long acting barbiturate
phenobarbital
4
Process that breaks down drugs into very fine particles
micronization
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Bcs class l
paracetamol, metoprolol, theophylline
6
Antiarrhythmic drug that may cause hypothyroidism
amiodarone
7
Paracetamol toxicity causes depletion of
glutathione
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Frequency of occurence of undesirable effects arising from exposure to a physical or chemical agent
risk
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Ability to cause harm or injury in a guven situation
hazard
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Ability to induce adverse effects
toxicity
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24 hours
acute
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Less than 1 month
subacute
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1-3 months
subchronic
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More than 3 months
chronic
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Secondary to accidental exposure to a drug
poisoning
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Intentional exposure
overdose
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Toxicity associated with any chemical substance
intoxication
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Evidence inferred from a series of events or facts, proves motives
circumstantial evidence
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Evidence obtained from administering the toxic substance into an animal and noting its effect
experimental evidence
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Evidence detected using analysis
chemical evidence
21
Evidende obtained from the examination of organs and tissues of the dead
post mortem evidence
22
Dependent upon the concentration of the drug
first order reaction
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Independent from the concentration of the drug
zero order reaction
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Molecular weight protein that binds to endogenous substances before contributing to the body's immune response
hopten
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A foreign substance that allows the body to create an immune response
antigen
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The immune response created by the body in response to the presence of an antigen
antibody
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Also known as antibodies
immunoglobins
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Refere to efficacy
maximum achievable response
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Lowest dose producing maximum effect
ceiling dose
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Measure of relative safety ( relative- in comparison to other drugs)
therapeutic index
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Degree of changes in dose with changes in response
slope
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Drug concentration needed to just barey produce an effect
maximum toxic concentration
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Bioavailability is greatly affected by
drug absorption
34
Fraction of an administered dose of a drug that reaches the systemic circulation in its active form and is available to produce its intended effect
bioavailability
35
Mineral used for duarrhea that can be chelated by tetracycline
zinc
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Nsaid not effective for gout
tolmetin
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Oral gold compound
auranofin
38
Prostacyclin analog usedfor the management of primary pulmonsry hypertension
epoprostenol
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Pge1 analog for nsaid induced pud
misoprostol
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Pge1 analog for erectile dysfunction
alprostadil
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Pge2 analog for abortion
dinoprostone
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Pge2 analog for glaucoma
latanoprost
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Inhibition of vitamin k dependent clotting factor synthesis
warfarin
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Inhibition of platelet aggregation
antiplatelet
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Inhibition of thrombin
heparin
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Inhibition of p2yl2 receptors
clopidogrel
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Inhibition of fibrinolysis
tranexamic acid
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Inhibition of cyclooxygenase for clotting
aspirin and other cox inhibitors
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Intermediate acting barbiturates
amobarbital, butabarbital
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Irreversible inhibitors of p2yl2 receptors
clopidogrel, ticlopidine
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Aripiprazole is a
antipsychotic
52
Dopamine is metabolized by
mao b
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Nm blockers acts specifically on whuch receptor
nicotinic
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Ritodrine is
tocolytic
55
Process of drug metabolism and excretion
elimination
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Rate limiting facto in the dissolution of drugs
disintegration
57
Sildenafil and nitroglycerin causes
hypotension
58
Low molecular weight heparins
fondaparinux, enoxaparin, dalteparin, tinzaparin
59
Heparins that are safe for pregnant patient
low molecular weight
60
Mixedacting adrenergic antagonist (both alpha and beta blocking)
labetalol, carvedilol
61
Building blocks of rna and dna
nucleic acid
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Vasodilator used for management of hypertensive emergency in pregnancy, and management of chf (combined with ismd)
hydralazine
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Se of hydralazine
systemic lupus, erythematosus
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An acetazolamide used by mountaineers exepriencing dizziness, insomnia, and headache, after quickly reaching the summit
diamox
65
Drugs for oharmacologic stress test
dobutamine, dipyridamole
66
Partial 5ht-1a agonist for anxiety also used in management of acute migraine attacks
buspirone
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5ht-3 antagonist that is an antiemetic also used for management of acute migraine attacks
ondansetron
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5-ht4 agonist used for acute migraine attacks
tegaserod
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B blocker that increases nitric oxide levele
nevibolol
70
Less sedating antihistamines
cetirizine, levocetirizine
71
T3
short acting, more potent
72
T4
long acting, less potent
73
Bcs class ll
carbamazepine, glibenclamide
74
Neurolept analgesia
droperidol, fentanyl
75
Neurolept anesthesia
nitrous oxide, droperidol, fentanyl
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Posses both anti parkinsonian and antiviral activity
amantadine
77
SERM; fertility drug
clomiphene
78
SERM for breast cancer
tamoxifen
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SERM for tamoxefin resistant breast cancer
fulvestrant
80
SERM for osteoporosis
raloxefin
81
BCS class lll
acyclovir, atenolol, cimetidine
82
BCS class lV
furosemide, chlorthalidone
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Weak opioid for pain
tramadol
84
Opioid which exhibits no cardiovascular or biliary effect
mepiridine
85
Opioid used against diarrhea but has lesser or no risk of dependence
loperamide
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Given with atropine to decrease risk of addiction, used to treat diarrhea
diphenoxylate
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Topoisomerase l inhibitor
irenotecan, topotecan
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Topoisomerase ll inhibitor
etoposide, teniposide
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Mitotic inhibitor
vincristine, vinblastine, paclitaxel
90
Reversible adp antiplatelet
ticagrelor
91
5-ht4 agonist for ibs consti type used in management of acute migraine attacks
tegaserod
92
Canivaptan is
vasopressin antagonist
93
Severe withdrawal syndrome that can occur in people who have been heavy drinkers for a long time and abruptly stopped drinking * Hallucinations, disorientation, tremor, fever, sweating
delirium tremens
94
Range of physical and mental health problems that can develop due to chronic heavy alcohol use *Cognitive decline, memory problems, liver damage
alcohol syndrome
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Condition where pre existing hyperthyroidism worsens after exposure to iodine
jod basedow phenomenon
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Rare genetic disorder that affects the skins anility to repair itself from uv damage
xeroderma pigmentosum
97
Non energy requiring Moved along concentration gradient Can be carrier mediated (fascilitated transport)
passive transport
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Energy requiring Move against the concentration gradient Carrier mediated
active transport
99
Storage form of insulin
hexamer
100
Biologically active for of insulin
monomer