Module 4 Part 3

60問 • 1年前

問題一覧

An agonist that produces less than the full effect.

Partial agonist

Two drugs that act on the same tissue or organ through INDEPENDENT receptors resulting in effects in opposite direction is known as:

Physiologic antagonism

A drug was shown to reverse the action of a neurotransmitter. It interacts directly with the neurotransmitter and not at all with the neurotransmitter’s receptor. What type of antagonism is described?

Chemical antagonist

Which of the following describes the action of protamine against heparin?

Chemical antagonism

Which of the following statements is correct?

If 1mg of Drug R produces the same response as 10mg of Drug S, Drug R is more potent than Drug S

The intensity of the pharmacologic action of the drug is most dependent on

Drug concentration at the receptor site

Which of the following would be most likely to cause death to animals?

Toxin D (LD50 = 0.00001 mg/kg)

Receptor is flexible (undergoes conformational change).

Induced Fit theory

Receptor is rigid

Lock and key theory

Receptors must be maximally occupied to provide effect.

Occupancy Theory

Receptors do not need maximum occupancy to provide maximal response

Modified occupancy theory

Response depends on proper stimulus

Rate theory

Defines spare receptors and partial agonist

Modified occupancy theory

Also known Koshland Theory

Induced Fit theory

Also known Fischer Theory

Lock and key theory

Also known Clark’s Theory

Occupancy Theory

Proposed by Ariens and Stephenson

Modified occupancy theory

Also known Paton Theory

Rate theory

Optical resolution of Atropine

Racemic

Optical resolution of Thalidomide

Racemic

Destruction of Salivary Glands

Sjogren Syndrome

DOCs for Sjogren

Pilocarpine

DOCs for Sjogren

Cevimeline

Atonic happens on postpartun and post-operational urinary retention leading to accumulation of unsecreted urine in the bladder. What drug can be use for this conition?

Betanechol

An ALKALOIDAL smoking deterrent

Nicotine

An NON-ALKALOIDAL smoking deterrent

Vareniclin

Full agonist smoking deterrent

Nicotine

Partial agonist smoking deterrent

Varenicline

Diagnosis of bronchial hyper-reactivity

Metacholine

Myasthenia gravis

Severe Muscle Weakness

Diagnosis for Myasthenia gravis

Edrophonium

1st line treatment of Myasthenia gravis

Pyridostigmine

2nd line treatment of Myasthenia gravis

Neostigmine

Diagnosis of bronchial hyper-reactivity

Metacholine

First-line drugs for Alzheimer’s disease

Reversible AChE inhibitors

DOC for atropine poisoning

Physostigmine

Treatment for pesticide poisoning (Organophosphates)

Atropine

Treatment for pesticide poisoning (Organophosphates)

Pralidoxine

MOA of Atroproine for pesticide poisoning (Organophosphates)

Muscarinic blocker

MOA of Pralidoxine for pesticide poisoning (Organophosphates)

Regenerates ACHe

In the treatment for Organphosphate poisoning when should Pralidoxine be given?

Within 24 hours of prior to exposure in the toxicity

Anti-glaucoma that decreases aqueous humor PRODUCTION are:

Beta Blockers, Carbonic anhydrase inhibitors

Anti-glaucoma that increases aqueous humor OUTFLOW are:

PGF2α analogs, Miotics, Non-selective alpha agonist

Anti-glaucoma that decreases aqueous humor PRODUCTION and inreases aqueous humor OUTFLOW :

Alpha-2 agonists

List the Anti glaucoma Beta Blockers

Timolol, Betaxolol

List the Anti glaucoma PGF2α analogs

Latanorost, Bimatoprost

Anti glaucoma that is a Miotic

Pilocarpines

List the Anti glaucoma that is a Non-selective alpha agonist

Dipivefrin

Dipivefrin, a prodrug Anti glaucoma that is a Non-selective alpha agonist upon activating is converted to

Epinephrine

Anti glaucoma that are Carbonic anhydrase inhibitors

-zolamide

List the Anti glaucoma that are alpha 2 agonist

Brimonidine, Apraclonidine

Blocks the uptake of choline

Hemicholinium

Blocks the release of ACh

Botulinum toxin

Stimulates the release of ACh

Latrotoxin

Blocks the receptor of ACh

Atropines

Blocks the storage of AC

Vesamicol

What enzyme is responsible in the synthesis of acetylcholine? __________

Choline acetyl transferase (ChAT)

What enzyme hydrolyzes AC

AchE

ChAT mechanism

Acetylation

AchE mechanism

Hydrolysis

Module 2 Part 1

ユーザ名非公開 · 100問 · 1年前

Module 2 Part 1