Week13

GFR/FF, Cinulin/FF

Creatinine is an endogenous substance suitable for the determination of GFR., Gkucose is filtered and completely reabsorbed in normal conditions., Plasma creatinine concentration is inversely proportional to GFR, which has a diagnostic importance., PAH is filtered and further secreted.

Inulin clearance is around 120ml/min., The FF is around 20%., The PAH clearance is around 600-700ml/min., The GFR is around 120ml/min.

Has both afferent and efferent arterioles., filters 20% of the renal plasma flow., renin secreting cells are closely located., is lined by fenestrated endothelium., Contains capillaries which are at a higher hydrostatic pressure than the peritubular capillaries.

basement membrane of the glomerular capillary., Endothelium of the glomerular capillary., Between the foot projections of the podocytes.

the albumin concentration is lower than in the plasma.

it can contain molecules which are smaller than 65 Koda., it’s glucose concentration is the same as in the blood plasma., it contains creatinine

filters 20% of the RPF., contains capillaries which are at a higher hydrostatic p than the the average systemic capillaries.

isosmotic solution, its filtration rate is increased by ANP, the total Ca concentration is about 1.2 mmol/L

its filtration rate is increased by ANP.

for Inulin are normally 120ml/min, it is indicative of secretion if greater than the GFR, it is indicative of reabsorption if less than the GFR, normally zero for glucose

AA constrict in response to increased sympathetic activity., Resistance arteries have a strong autoregulatory function to protect glomerular capillaries from extreme high pressure., TGF equalizes blood supply and GFR if the individual nephrons.

constriction of EA, ANP

ANP

Bayliss effect, Angiotensin 2, Adenosine, macula densa fb

The tubulpglomerular fb equalizes the blood supply of the individual nephrons., AA constrict in response to increased sympathetic activity., AA constrict if NaCl content is increases in the tubular fluid., The preglomerular resistance vessels have a strong autoregulatory function.

Macula densa mediated feedback equalizes blood supply and GFR of the individual nephrons., AA constrict in response to increased sympathetic activity., Resistance arteries have a strong autoregulatory function to protect glomerular capillaries from extreme high pressure.

The renin secretion is activated in response to increased sympathetic activity., Renin secretion is enhanced when NaCl concentration at the macula densa decreases., Renin is produced by granular cells of aa.

Aq1, SGLT2, Na amino acid cotransporter, Carboanhydrase, Na phosphate cotransporter, Na H antiporter

Na H exchanger, SGLT, GLUT, Na phosphate cotransport