Week9

Increased extracellular K+ concentration., Increased adenosine concentration,, Increased P_CO2.

Increased extracellular H+, Increased extracellular K+, Increased lactate

Increased extracellular H+, Increased extracellular K+, Increased lactate

NO, Endothelin

Catecholamines, Bradykinin, Serotonin

Stimulation of rostro-ventrolateral medulla causes cardiac acceleration., Stimulation of RVLM causes vasoconstriction., The systemic neural control of peripheral blood flow is mediated mainly by the sympathetic nervous system., Stimulation of RVLM causes enhanced myocardial contractility.

plays role in the mechanism of autoregulation of tissue blood flow., is independent of the innervation.

NO, PGI2, Endothelin

Epinephrine, Endothelin, Angiotensin 2, Norepinephrine

Angiotensin 2, Endothelin

NO receptor is a solubule guanylyl cyclase, NO production is upregulated in response to Ach

Angiotensin2, ADH

The release of NO is elevated by increased shear stress., NO production is upregulated in response to Ach., The NO is an endothelium-derived relaxaing factor.

Aortic arch, Carotid sinus

Are important in the rapid, short term regulation of arterial blood pressure.

will result in the decrease of systemic blood pressure., increase depressor nerve activity., increase activity of specific parts of nucleus tractus solitarius (NTS)

Heart rate increases due to this reflex after standing up from lying position., In case of increased BP in the carotid sinus the RVLM becomes inhibited.

The peripheral chemoreceptors are stimulated by decreases in aretrial blood O2 tension., Stimulation of peripheral chemoreceptors increases tone in the capacitance vessels., The peripheral chemoreceptors are sensitive to pH., The peripheral chemoreceptors can be stimulated by significant decreases in arterial blood pressure.

Constritct arteries, Constrict veins

Open upn local extracellular lactate increase, Open upon local pH decrease, Open upon locally elevated extracellular K+

14

4

2

22

27

15