問題一覧
1
False about ion trap phenomenon
The equilibrium between the sides of a membrane is determined by the full concentration of the drug
2
Facilitation of the actin of NP muscle relaxants occurs in EXCEPT
use of Achesterase inhibitors
3
Atropine poisoning EXCEPT
Myosis
4
True
Fenoterol is typically applied topically
5
Not true about the undesired effect
It can ce caused when the drug does not bind to the sufficient number of R required to the therapeutic effect
6
True if a drug has zero order kinetics
in case of zero order kinetics elimination speed does not depend on plasma concentration
7
Alpha R inhibitor
Phentolamine
8
Liver may strongly influence the bioavailability of a drug if the way of administration is
oral
9
We consider all of these drug distribution compartments, apart from
Urine
10
It increases the amount of Ach in synaptic cleft
Neostigmine
11
Typical of Prazosin
May cause tachycardia
12
Not characteristic to a pure competitive antagonist?
It reduces the maximal effect of an agonist acting on the same receptor
13
Which used in cardiogenic shock
Dobutamine
14
Which directly inhibits the Ach exocytosis?
Botulinum toxin
15
Scopolamine
motion sickness
16
When Cholinesterase inhibitor be given
Myasthenia gravis
17
Not bind significantly to muscarinic Ach R
Rivastigmine
18
Which most selective for beta receptors?
Dobutamine
19
False
The competitive antagonist is the agonist that shifts dose-response curve to the left
20
False about CNS penetration of drugs
Amino acids cannot cross BBB
21
Which can be used orally?
Ephedrine
22
True
Atropine irritates CNS
23
Not a beta blocker side effect?
tremor
24
Rivastigmine
It is metabolized by Achesterase
25
False
If the potency is higher the efficacy is higher as well
26
In the elimination of NE in synaptic cleft, which one plays a main role
Reuptake mechanism
27
Which is alpha R blocker
Carvedilol
28
Which NOT correct
Adrenaline has a bronchoconstriction effect
29
Not suspended by Neostigmine
Succinylcholine
30
M2 agonist
bradycardia
31
Which compound has vasodilatory effect
Prazosin
32
True for first pass metabolism
The mechanism greatly reduces the bioavailability of drugs
33
Glaucoma treatments, except
Lobeline
34
Typical side effects of clonidine
sedation
35
Not cause dry mouth
Pilocarpine
36
Which nuscle relaxant has the longest action
Pipecuronium
37
True
Baclofen binds to a GPCR
38
Which used orally
Ephedrine
39
Not required by CYP450 reaction
ATP
40
Effects of succinylcholine EXCEPT
hypokalemia
41
Characterized by zero order pharmacokinetics
The metabolism of the compound is independent of plasma concentration
42
Which can cause histamine release?
Tubocurarine
43
Alzheimer disease
Rivastigmine
44
Mechanics of action of baclofen
GABA-B receptor agonism
45
True
Dantrolene inhibits the ryanodine R
46
True for carbachol
Cholinesterase does not degrade it
47
Not a role of beta blockers
Asthma bronchiale
48
Physostigmine
it is metabolized by Achesterase
49
Direct smcs relaxing effect on the vessel.
Isoprenaline
50
False about half life
it linearly related to volume of distribution
51
Treatment for COPD
Ipratropium
52
1-2 drops 1% atropine how long does it take for pupil dilation to disappear completely?
8-10 days
53
Mixture of alpha1 & beta antagonist
Carvedilol
54
Atropine
Causes tachycardia
55
Applicable in HT treatment crisis
Urapidil
56
True
NE not cause high frequency tachycardia
57
TRUE
Phenylephrine can be used for rhinitis
58
Not true for membrane transport of drugs
Are ABC transporters obtaining energy using electrochemical potential difference
59
True
The intrinsic efficacy of a partial agonist is higher than zero
60
True
Carbachol causes bradycardia
61
True
The abosorption of a drug is linear if doubling the dose doubles the absorbed amount
62
Indicated during Fundus eye examination
Cyclopentolate
63
TRUE for Dopamine
has a short half life
64
False about Atropine
its mydriatic effect lasts 2-3 hours long
65
Which fails to enhance the NE concentration in adrenergic synaptic cleft?
Clondine
66
True for Cholinesterase enzyme
Edrophonium is a reversible inhibitor with a short dissociation constant
67
Which phase cannot be missed when drugs are given
Excretion
68
Which enhances NE release
Ephedrine
69
Indication of alpha methyldopa
Preganancy HT
70
Irreversible Cholinesterase inhibitor
Alkyl phosphates
71
False for a competitive antagonist
They have no therapeutic significance
72
Centrally acting cholinolytics
useful in treatment of Parkinson
73
Most common conjugation reactions are
glucuronidation
74
Typical for Isoprenaline :
Relaxes the uterine muscle
75
Not antihypertensive
Phenylephrine
76
How does a reversible competitive antagonist affect the agonist concentration response curve?
It gets pushed to the right
77
In the presence of potent beta receptor agonist pindlol reduces HR, while in the absence of beta-agonist compound increases HR, so pondlol is a
Partial agonist
78
Which muscle relaxant is indicated to a patient who suffers from liver and kidney at the same time?
cisatracurium
79
Which can affect the cholinergic transmission postsynaptically
Ipratropium
80
Which receptor is an ion channel component
NMDA
81
Nichotinic Ach R agonist effect
Carbachol
82
Propranolol may be indicated for
Treatment of hyperthyroidism
83
Selective M3 antagonist
Solifenacin
84
Avoid application with a drug with first pass metabolism
oral
85
Selective alpha1 blocker
Tamsulosin
86
Thyroid R belong to
Cell nuclear R
87
True
Carbachol increases secretions
88
Not characteristic of side effect of alpha blockers
Bradycardia
89
Not true for agonist?
receptor up regulation enhances its maximal effect
90
What to look out for when stopping propranolol in the first place after long term treatment?
The need to do a slow dose reduction
91
Which causes greater chance of bronchi contriction
Propranolol
92
Elimination of a drug is linear then
Elimination is faster at higher plasma concentrations
93
True
Neostigmine enhances peristalsis in the gut
94
Effect of adrenergic neuron paralyzer?
Inhibit the release of NE from AP dependent vesicles
95
Use of reversible Cholinesterase inhibitors in following cases, EXCEPT
Hypertension
96
Parkinson disease
Procyclidine
97
Which drug is used to suspend the action of non-depolarizing muscle relaxants
Neostigmine
98
Which is indicated in organophosphate intoxication?
atropine
99
It is typical of Carvedilol
It reduces BP