Midterm pp

99問 • 1年前

通報

問題一覧

Which directly inhibits the Ach exocytosis?

Botulinum toxin

In the elimination of NE in synaptic cleft, which one plays a main role

Reuptake mechanism

Effect of adrenergic neuron paralyzer?

Inhibit the release of NE from AP dependent vesicles

True for carbachol

Cholinesterase does not degrade it

True

Carbachol causes bradycardia

True

Carbachol increases secretions

Nichotinic Ach R agonist effect

Carbachol

Glaucoma treatments, except

Lobeline

Not cause dry mouth

Pilocarpine

Irreversible Cholinesterase inhibitor

Alkyl phosphates

Use of reversible Cholinesterase inhibitors in following cases, EXCEPT

Hypertension

When Cholinesterase inhibitor be given

Myasthenia gravis

Alzheimer disease

Rivastigmine

It is metabolized by Achesterase

It increases the amount of Ach in synaptic cleft

Neostigmine

Not suspended by Neostigmine

Succinylcholine

True

Neostigmine enhances peristalsis in the gut

True for Cholinesterase enzyme

Edrophonium is a reversible inhibitor with a short dissociation constant

Not bind significantly to muscarinic Ach R

Rivastigmine

Physostigmine

it is metabolized by Achesterase

Centrally acting cholinolytics

useful in treatment of Parkinson

Selective M3 antagonist

Solifenacin

Treatment for COPD

Ipratropium

M2 agonist

bradycardia

True

NE not cause high frequency tachycardia

Parkinson disease

Procyclidine

Atropine

Causes tachycardia

True

Atropine irritates CNS

Atropine poisoning EXCEPT

Myosis

1-2 drops 1% atropine how long does it take for pupil dilation to disappear completely?

8-10 days

Which is indicated in organophosphate intoxication?

atropine

False about Atropine

its mydriatic effect lasts 2-3 hours long

Scopolamine

motion sickness

Which can be used orally?

Ephedrine

Which most selective for beta receptors?

Dobutamine

Which NOT correct

Adrenaline has a bronchoconstriction effect

Which used in cardiogenic shock

Dobutamine

TRUE for Dopamine

has a short half life

Typical for Isoprenaline :

Relaxes the uterine muscle

Direct smcs relaxing effect on the vessel.

Isoprenaline

TRUE

Phenylephrine can be used for rhinitis

Which used orally

Ephedrine

Which enhances NE release

Ephedrine

Not antihypertensive

Phenylephrine

Indication of alpha methyldopa

Preganancy HT

Which fails to enhance the NE concentration in adrenergic synaptic cleft?

Clondine

Mixture of alpha1 & beta antagonist

Carvedilol

Which is alpha R blocker

Carvedilol

It is typical of Carvedilol

It reduces BP

Which compound has vasodilatory effect

Prazosin

Typical of Prazosin

May cause tachycardia

Applicable in HT treatment crisis

Urapidil

Alpha R inhibitor

Phentolamine

Selective alpha1 blocker

Tamsulosin

Not characteristic of side effect of alpha blockers

Bradycardia

Which causes greater chance of bronchi contriction

Propranolol

Propranolol may be indicated for

Treatment of hyperthyroidism

What to look out for when stopping propranolol in the first place after long term treatment?

The need to do a slow dose reduction

Not a role of beta blockers

Asthma bronchiale

Not a beta blocker side effect?

tremor

Effects of succinylcholine EXCEPT

hypokalemia

Which muscle relaxant is indicated to a patient who suffers from liver and kidney at the same time?

cisatracurium

Which can cause histamine release?

Tubocurarine

Facilitation of the actin of NP muscle relaxants occurs in EXCEPT

use of Achesterase inhibitors

Mechanics of action of baclofen

GABA-B receptor agonism

Which nuscle relaxant has the longest action

Pipecuronium

True

Baclofen binds to a GPCR

Which drug is used to suspend the action of non-depolarizing muscle relaxants

Neostigmine

True

Dantrolene inhibits the ryanodine R

Which receptor is an ion channel component

NMDA

Thyroid R belong to

Cell nuclear R

Not true for agonist?

receptor up regulation enhances its maximal effect

False

The competitive antagonist is the agonist that shifts dose-response curve to the left

In the presence of potent beta receptor agonist pindlol reduces HR, while in the absence of beta-agonist compound increases HR, so pondlol is a

Partial agonist

False for a competitive antagonist

They have no therapeutic significance

How does a reversible competitive antagonist affect the agonist concentration response curve?

It gets pushed to the right

Not characteristic to a pure competitive antagonist?

It reduces the maximal effect of an agonist acting on the same receptor

True

The intrinsic efficacy of a partial agonist is higher than zero

False about ion trap phenomenon

The equilibrium between the sides of a membrane is determined by the full concentration of the drug

False

If the potency is higher the efficacy is higher as well

Not true about the undesired effect

It can ce caused when the drug does not bind to the sufficient number of R required to the therapeutic effect

Avoid application with a drug with first pass metabolism

oral

True for first pass metabolism

The mechanism greatly reduces the bioavailability of drugs

Which phase cannot be missed when drugs are given

Excretion

True

The abosorption of a drug is linear if doubling the dose doubles the absorbed amount

False about CNS penetration of drugs

Amino acids cannot cross BBB

Not true for membrane transport of drugs

Are ABC transporters obtaining energy using electrochemical potential difference

We consider all of these drug distribution compartments, apart from

Urine

Liver may strongly influence the bioavailability of a drug if the way of administration is

oral

Most common conjugation reactions are

glucuronidation

Not required by CYP450 reaction

ATP

Elimination of a drug is linear then

Elimination is faster at higher plasma concentrations

Characterized by zero order pharmacokinetics

The metabolism of the compound is independent of plasma concentration

True if a drug has zero order kinetics

in case of zero order kinetics elimination speed does not depend on plasma concentration

False about half life

it linearly related to volume of distribution

Indicated during Fundus eye examination

Cyclopentolate

Which can affect the cholinergic transmission postsynaptically

Ipratropium

True

Fenoterol is typically applied topically

Typical side effects of clonidine

sedation

Week3-4

Week3-4

Weekly2

Weekly2

Weekly2-2

Weekly2-2

Weekly2-3

Weekly2-3

Weekly3

Weekly3

Weekly3-2

Weekly3-2

Weekly3-3

Weekly3-3

Weekly3-4 Viscerosensory

n · 34問 · 2年前

Weekly3-4 Viscerosensory

34問 • 2年前

Week6-skeletal muscle

n · 10問 · 2年前

Week6-skeletal muscle

Week6- Heart

Week6- Heart

Weekly4-1

Weekly4-1

Week9

Week9

⭐️Parameters

⭐️Parameters

DNA

DNA

RNA

RNA

Week11

Week11

Week12

Week12

Week13

Week13

week1

week1

genetics quiz

genetics quiz

genetics mcq

genetics mcq

genetics2

genetics2

Week2

Week2

Immunology final

Immunology final

Week3

Week3

Week3-4 Thyroid

Week3-4 Thyroid

general

general

general2

general2

Week4-body

Week4-body

Week4-Caicium, bone

Week4-Caicium, bone

Week5,6-sexual

Week5,6-sexual

immunology

immunology

Internal Metabolism

Internal Metabolism

cell cycle

cell cycle

mid1?

mid1?

mid2

mid2

Week8

Week8

sensory

sensory

nerve

nerve

genetic3

genetic3

gene4

gene4

Week12

Week12

Week13

Week13

week11

week11

Midterm1-2

Midterm1-2

Mid2-1

Mid2-1

Minimum-mycology

Minimum-mycology

Minimum-virology

Minimum-virology

Minimum-general

Minimum-general

Minimum-systemic

Minimum-systemic

Mid2-2

Mid2-2

Mod2-3

Mod2-3

Minimum-systemic2

Minimum-systemic2

Minimum-parasitology

Minimum-parasitology

問題一覧

Which directly inhibits the Ach exocytosis?

Botulinum toxin

In the elimination of NE in synaptic cleft, which one plays a main role

Reuptake mechanism

Effect of adrenergic neuron paralyzer?

Inhibit the release of NE from AP dependent vesicles

True for carbachol

Cholinesterase does not degrade it

True

Carbachol causes bradycardia

True

Carbachol increases secretions

Nichotinic Ach R agonist effect

Carbachol

Glaucoma treatments, except

Lobeline

Not cause dry mouth

Pilocarpine

Irreversible Cholinesterase inhibitor

Alkyl phosphates

Use of reversible Cholinesterase inhibitors in following cases, EXCEPT

Hypertension

When Cholinesterase inhibitor be given

Myasthenia gravis

Alzheimer disease

Rivastigmine

It is metabolized by Achesterase

It increases the amount of Ach in synaptic cleft

Neostigmine

Not suspended by Neostigmine

Succinylcholine

True

Neostigmine enhances peristalsis in the gut

True for Cholinesterase enzyme

Edrophonium is a reversible inhibitor with a short dissociation constant

Not bind significantly to muscarinic Ach R

Rivastigmine

Physostigmine

it is metabolized by Achesterase

Centrally acting cholinolytics

useful in treatment of Parkinson

Selective M3 antagonist

Solifenacin

Treatment for COPD

Ipratropium

M2 agonist

bradycardia

True

NE not cause high frequency tachycardia

Parkinson disease

Procyclidine

Atropine

Causes tachycardia

True

Atropine irritates CNS

Atropine poisoning EXCEPT

Myosis

1-2 drops 1% atropine how long does it take for pupil dilation to disappear completely?

8-10 days

Which is indicated in organophosphate intoxication?

atropine

False about Atropine

its mydriatic effect lasts 2-3 hours long

Scopolamine

motion sickness

Which can be used orally?

Ephedrine

Which most selective for beta receptors?

Dobutamine

Which NOT correct

Adrenaline has a bronchoconstriction effect

Which used in cardiogenic shock

Dobutamine

TRUE for Dopamine

has a short half life

Typical for Isoprenaline :

Relaxes the uterine muscle

Direct smcs relaxing effect on the vessel.

Isoprenaline

TRUE

Phenylephrine can be used for rhinitis

Which used orally

Ephedrine

Which enhances NE release

Ephedrine

Not antihypertensive

Phenylephrine

Indication of alpha methyldopa

Preganancy HT

Which fails to enhance the NE concentration in adrenergic synaptic cleft?

Clondine

Mixture of alpha1 & beta antagonist

Carvedilol

Which is alpha R blocker

Carvedilol

It is typical of Carvedilol

It reduces BP

Which compound has vasodilatory effect

Prazosin

Typical of Prazosin

May cause tachycardia

Applicable in HT treatment crisis

Urapidil

Alpha R inhibitor

Phentolamine

Selective alpha1 blocker

Tamsulosin

Not characteristic of side effect of alpha blockers

Bradycardia

Which causes greater chance of bronchi contriction

Propranolol

Propranolol may be indicated for

Treatment of hyperthyroidism

What to look out for when stopping propranolol in the first place after long term treatment?

The need to do a slow dose reduction

Not a role of beta blockers

Asthma bronchiale

Not a beta blocker side effect?

tremor

Effects of succinylcholine EXCEPT

hypokalemia

Which muscle relaxant is indicated to a patient who suffers from liver and kidney at the same time?

cisatracurium

Which can cause histamine release?

Tubocurarine

Facilitation of the actin of NP muscle relaxants occurs in EXCEPT

use of Achesterase inhibitors

Mechanics of action of baclofen

GABA-B receptor agonism

Which nuscle relaxant has the longest action

Pipecuronium

True

Baclofen binds to a GPCR

Which drug is used to suspend the action of non-depolarizing muscle relaxants

Neostigmine

True

Dantrolene inhibits the ryanodine R

Which receptor is an ion channel component

NMDA

Thyroid R belong to

Cell nuclear R

Not true for agonist?

receptor up regulation enhances its maximal effect

False

The competitive antagonist is the agonist that shifts dose-response curve to the left

In the presence of potent beta receptor agonist pindlol reduces HR, while in the absence of beta-agonist compound increases HR, so pondlol is a

Partial agonist

False for a competitive antagonist

They have no therapeutic significance

How does a reversible competitive antagonist affect the agonist concentration response curve?

It gets pushed to the right

Not characteristic to a pure competitive antagonist?

It reduces the maximal effect of an agonist acting on the same receptor

True

The intrinsic efficacy of a partial agonist is higher than zero

False about ion trap phenomenon

The equilibrium between the sides of a membrane is determined by the full concentration of the drug

False

If the potency is higher the efficacy is higher as well

Not true about the undesired effect

It can ce caused when the drug does not bind to the sufficient number of R required to the therapeutic effect

Avoid application with a drug with first pass metabolism

oral

True for first pass metabolism

The mechanism greatly reduces the bioavailability of drugs

Which phase cannot be missed when drugs are given

Excretion

True

The abosorption of a drug is linear if doubling the dose doubles the absorbed amount

False about CNS penetration of drugs

Amino acids cannot cross BBB

Not true for membrane transport of drugs

Are ABC transporters obtaining energy using electrochemical potential difference

We consider all of these drug distribution compartments, apart from

Urine

Liver may strongly influence the bioavailability of a drug if the way of administration is

oral

Most common conjugation reactions are

glucuronidation

Not required by CYP450 reaction

ATP

Elimination of a drug is linear then

Elimination is faster at higher plasma concentrations

Characterized by zero order pharmacokinetics

The metabolism of the compound is independent of plasma concentration

True if a drug has zero order kinetics

in case of zero order kinetics elimination speed does not depend on plasma concentration

False about half life

it linearly related to volume of distribution

Indicated during Fundus eye examination

Cyclopentolate

Which can affect the cholinergic transmission postsynaptically

Ipratropium

True

Fenoterol is typically applied topically

Typical side effects of clonidine

sedation