問題一覧
1
Which directly inhibits the Ach exocytosis?
Botulinum toxin
2
In the elimination of NE in synaptic cleft, which one plays a main role
Reuptake mechanism
3
Effect of adrenergic neuron paralyzer?
Inhibit the release of NE from AP dependent vesicles
4
True for carbachol
Cholinesterase does not degrade it
5
True
Carbachol causes bradycardia
6
True
Carbachol increases secretions
7
Nichotinic Ach R agonist effect
Carbachol
8
Glaucoma treatments, except
Lobeline
9
Not cause dry mouth
Pilocarpine
10
Irreversible Cholinesterase inhibitor
Alkyl phosphates
11
Use of reversible Cholinesterase inhibitors in following cases, EXCEPT
Hypertension
12
When Cholinesterase inhibitor be given
Myasthenia gravis
13
Alzheimer disease
Rivastigmine
14
Rivastigmine
It is metabolized by Achesterase
15
It increases the amount of Ach in synaptic cleft
Neostigmine
16
Not suspended by Neostigmine
Succinylcholine
17
True
Neostigmine enhances peristalsis in the gut
18
True for Cholinesterase enzyme
Edrophonium is a reversible inhibitor with a short dissociation constant
19
Not bind significantly to muscarinic Ach R
Rivastigmine
20
Physostigmine
it is metabolized by Achesterase
21
Centrally acting cholinolytics
useful in treatment of Parkinson
22
Selective M3 antagonist
Solifenacin
23
Treatment for COPD
Ipratropium
24
M2 agonist
bradycardia
25
True
NE not cause high frequency tachycardia
26
Parkinson disease
Procyclidine
27
Atropine
Causes tachycardia
28
True
Atropine irritates CNS
29
Atropine poisoning EXCEPT
Myosis
30
1-2 drops 1% atropine how long does it take for pupil dilation to disappear completely?
8-10 days
31
Which is indicated in organophosphate intoxication?
atropine
32
False about Atropine
its mydriatic effect lasts 2-3 hours long
33
Scopolamine
motion sickness
34
Which can be used orally?
Ephedrine
35
Which most selective for beta receptors?
Dobutamine
36
Which NOT correct
Adrenaline has a bronchoconstriction effect
37
Which used in cardiogenic shock
Dobutamine
38
TRUE for Dopamine
has a short half life
39
Typical for Isoprenaline :
Relaxes the uterine muscle
40
Direct smcs relaxing effect on the vessel.
Isoprenaline
41
TRUE
Phenylephrine can be used for rhinitis
42
Which used orally
Ephedrine
43
Which enhances NE release
Ephedrine
44
Not antihypertensive
Phenylephrine
45
Indication of alpha methyldopa
Preganancy HT
46
Which fails to enhance the NE concentration in adrenergic synaptic cleft?
Clondine
47
Mixture of alpha1 & beta antagonist
Carvedilol
48
Which is alpha R blocker
Carvedilol
49
It is typical of Carvedilol
It reduces BP
50
Which compound has vasodilatory effect
Prazosin
51
Typical of Prazosin
May cause tachycardia
52
Applicable in HT treatment crisis
Urapidil
53
Alpha R inhibitor
Phentolamine
54
Selective alpha1 blocker
Tamsulosin
55
Not characteristic of side effect of alpha blockers
Bradycardia
56
Which causes greater chance of bronchi contriction
Propranolol
57
Propranolol may be indicated for
Treatment of hyperthyroidism
58
What to look out for when stopping propranolol in the first place after long term treatment?
The need to do a slow dose reduction
59
Not a role of beta blockers
Asthma bronchiale
60
Not a beta blocker side effect?
tremor
61
Effects of succinylcholine EXCEPT
hypokalemia
62
Which muscle relaxant is indicated to a patient who suffers from liver and kidney at the same time?
cisatracurium
63
Which can cause histamine release?
Tubocurarine
64
Facilitation of the actin of NP muscle relaxants occurs in EXCEPT
use of Achesterase inhibitors
65
Mechanics of action of baclofen
GABA-B receptor agonism
66
Which nuscle relaxant has the longest action
Pipecuronium
67
True
Baclofen binds to a GPCR
68
Which drug is used to suspend the action of non-depolarizing muscle relaxants
Neostigmine
69
True
Dantrolene inhibits the ryanodine R
70
Which receptor is an ion channel component
NMDA
71
Thyroid R belong to
Cell nuclear R
72
Not true for agonist?
receptor up regulation enhances its maximal effect
73
False
The competitive antagonist is the agonist that shifts dose-response curve to the left
74
In the presence of potent beta receptor agonist pindlol reduces HR, while in the absence of beta-agonist compound increases HR, so pondlol is a
Partial agonist
75
False for a competitive antagonist
They have no therapeutic significance
76
How does a reversible competitive antagonist affect the agonist concentration response curve?
It gets pushed to the right
77
Not characteristic to a pure competitive antagonist?
It reduces the maximal effect of an agonist acting on the same receptor
78
True
The intrinsic efficacy of a partial agonist is higher than zero
79
False about ion trap phenomenon
The equilibrium between the sides of a membrane is determined by the full concentration of the drug
80
False
If the potency is higher the efficacy is higher as well
81
Not true about the undesired effect
It can ce caused when the drug does not bind to the sufficient number of R required to the therapeutic effect
82
Avoid application with a drug with first pass metabolism
oral
83
True for first pass metabolism
The mechanism greatly reduces the bioavailability of drugs
84
Which phase cannot be missed when drugs are given
Excretion
85
True
The abosorption of a drug is linear if doubling the dose doubles the absorbed amount
86
False about CNS penetration of drugs
Amino acids cannot cross BBB
87
Not true for membrane transport of drugs
Are ABC transporters obtaining energy using electrochemical potential difference
88
We consider all of these drug distribution compartments, apart from
Urine
89
Liver may strongly influence the bioavailability of a drug if the way of administration is
oral
90
Most common conjugation reactions are
glucuronidation
91
Not required by CYP450 reaction
ATP
92
Elimination of a drug is linear then
Elimination is faster at higher plasma concentrations
93
Characterized by zero order pharmacokinetics
The metabolism of the compound is independent of plasma concentration
94
True if a drug has zero order kinetics
in case of zero order kinetics elimination speed does not depend on plasma concentration
95
False about half life
it linearly related to volume of distribution
96
Indicated during Fundus eye examination
Cyclopentolate
97
Which can affect the cholinergic transmission postsynaptically
Ipratropium
98
True
Fenoterol is typically applied topically
99
Typical side effects of clonidine
sedation