Week3

Lipid droplets of the cell contain large amounts of cholesterol ester., The acute regulation can be carried out by protein phosphorylation of StAR

3 hydroxysteroid dehydrogenase, 11 hydroxylase, 21 hydroxylase

21 hydroxylase CYP21A2, 3beta HSD

11 hydroxylase, 3 hydroxysteroid dehydrogenase, 17 hydroxylase, 21 hydroxylase

3 bets HSD, 21 hydroxylase, 18 hydroxylase

high level of ACTH, loss of sodium, high level of adrenocortical androgens

high level of adrenocortical androgens, loss of sodium, high level of ACTH

cortisol is a hyperglycemic hormone., the secretion of cortisol peaks at around 8 a.m. each day, the adrenal cortex will atrophy following removal of the anterior pituitary

The AVP can enhance the effect of CRH on the ACTH producing cells.

increase of liver mass, slow wound healing, hypertension

diabetes, muscle weakness, osteoporosis

weight loss, muscle weakness, increased risk for bacteria infection

Plasma K concentration is an important regulator, The Ang2 enhances the aldosterone secretion.

Excess may lead to hypokale,ia

can have mineralcorticoid effect, its level is elevated in Cushing disease, it is bound to proteins in the plasma

the formation of pregnenolone from cholesterol takes place in the mitochondria, the activity of StAR is one of the rate limiting steps of hormone synthesis, the pregnenolone is produced from cholesterol