7

発癌性

遺伝毒性

癌（腫）

奇形

乳房の

肝細胞の

胃腸の

内皮

内皮異常増殖

前癌性の

血管肉腫

上方調節

The increased incidence of hemangiosarcoma in mice occurred only in organs where this tumour occurs as a relatively common spontaneous finding in the mouse (liver, spleen, uterus etc. )., A study in the mouse demonstrated that vildagliptin inhibits VEGF-induced angiogenes is., Based on these mechanistic data the applicant proposes a mechanism thereby inhibition of VEGF-induced angiogenesis over a long period exerts selection pressure in favour of endothelium that proliferates independently of VEGF and hence increases the likelihood of endothelial neoplasia.

There was a disproportionate increase in hemangiosarcoma involving the liver in treated male mice at ≥ 250 mg/kg/day., In the mouse these was an increased incidence of hemangiosarcomas and mammary carcinoma.