ASPIRIN&amp; ACETANILIDE (PMOC MIDTERM)

Quinn Karylle Fuentes · 28問 · 2年前

通報

問題一覧

The process of synthesizing Aspirin is based on adding or attaching an Acetyl group to a Salicylic acid.

Acetylation

This was used by egyptians as a topical poietes and were generally used for fever and pamamaga

Leaves of willow bark tree

In what century did group doctor named Hippocrates (Father of Medicine), prescribed the leaves as antipyretic (pampababa ng fever), an analgesic for pain, or pain reliever during childbirth

4th century

He Was a vicar in Northern Oxfordshire, submitted reports that details the antipyretic activity or the effect of dried powdered willow bark tree leaves.

Edward stone

Salicylic acid was isolated as a medicine in the 19th Century. However the isolated compound Salicylic acid was known to have a bitter taste and could potentially irritate the stomach. (T/F)

True

He managed to obtain some pure white crystals of a compound, by repeatedly removing impurities from an extract of a willow tree

Buchner, 1828

Buchner called these white crystals as _________ had a bitter taste, but is now used to relieve pain and inflammation.

Salicin

He defined the chemical structure of Salicylic acid and synthesized Acetylsalicylic acid using SODIUM SALICYLATE + ACETYL CHLORIDE.

Charles frederic Gerhardt

Charles Frederic Gerhardt, defined the chemical structure of Salicylic acid and synthesized Acetylsalicylic acid using

Sodium salicylate, Acetyl chloride

who was researching for a non-irritating pain-reliever to ease his father’s rheumatism

Felix hoffman

synthesized the acetyl derivative of salicylic acid in response to his father’s rheumatism and was able to produce a pure and stable form of ASPIRIN.

Felix hoffman

known to be the oldest in the NSAID classification of drugs

Aspirin

The structure of Aspirin was derived from the combination of an

Acetyl group

Salicylic acid can react with Acetic anhydride (with the presence of acetyl group), to facilitate the

Acetylation

It is the process forms Acetylsalicylic acid and Acetic acid.

Acetylation

What is the appearance of Aspirin

Colorless, White crystalline

Melting point of aspirin

135°c, 275 °f

In chemical test Acid hydrolysis with FeCl3

Violet

Chemical test BASIC HYDROLYSIS (with NaOH):

Clear solution.

Tinnitus

Mild intoxication

Hearing loss

Mild intoxication

Dizziness

Mild intoxication

Nausea/vomit

Mild intoxication

Tachypnea

Moderate intoxication

Hyperpyrexia

Moderate intoxication

Diaphoresis

Moderate intoxication

Ataxia

Moderate intoxication

Anxiety

Moderate intoxication

Abnormal mental health status

Severe intoxication

Seizure

Severe intoxication

Acute lung injury

Severe intoxication

Renal failure

Severe intoxication

Cardiac arrhythmia

Severe intoxication

Shock

Severe intoxication

What are the possible antidote/ treatment in aspirin toxicology

Activated charcoal, Sodium bicarbonate, Hemodialysis

What is the three inflammatory mediator of Arachidonic acid

Prostaglandins, Thromboxanes, Prostacyclins

Acetanilide + Hydrochloric acid

Aniline, Acetyl chloride

Acetanilide + Acetic acid

Aniline, Acetic anhydride

Acetyl group can be removed by acid catalyzed hydrolysis

Hydrolysis of acetanilide

Hydrolysis of acetanilide will yield to

para-nitroaniline (C6H6N2O2)., Crystal Formation

The bromination of acetanilide a major product form?

mono-brominated

The bromination of aniline forms a major product of

Tri-brominated

(+) Result: White ppt at the upper and lower layer while clear appearance at the middle layer.

Acetanilide

(+) Result: Yellow slimy substance at the middle junction.

Aniline

used as an inhibitor of peroxides and stabilizer for cellulose ester varnishes.

Acetanilide

Cell structure.

Cell structure.

28問 • 2年前

Quinn Karylle Fuentes · 29問 · 2年前

Electrolytes and non electrolytes

Electrolytes and non electrolytes

29問 • 2年前

Quinn Karylle Fuentes · 38問 · 2年前

POST LAB (EXP 4)

POST LAB (EXP 4)

38問 • 2年前

Density and specific gravity

Density and specific gravity

Quinn Karylle Fuentes · 18問 · 2年前

FORCES OF ATTRACTION

FORCES OF ATTRACTION

18問 • 2年前

Quinn Karylle Fuentes · 63問 · 2年前

Microbial growth

Microbial growth

63問 • 2年前

Quinn Karylle Fuentes · 61問 · 2年前

Introduction.

Introduction.

61問 • 2年前

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Microbial control.

Microbial control.

97問 • 2年前

Quinn Karylle Fuentes · 100問 · 2年前

States of matter

States of matter

100問 • 2年前

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Introduction.

Introduction.

86問 • 2年前

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Drug development.

Drug development.

77問 • 2年前

Quinn Karylle Fuentes · 9問 · 2年前

CGMP

CGMP

9問 • 2年前

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Pharmaceutical ingredients.

Pharmaceutical ingredients.

24問 • 2年前

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Powdered & granules

Powdered & granules

43問 • 2年前

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Capsule.

Capsule.

24問 • 2年前

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Tablets.

Tablets.

23問 • 2年前

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Calculatiom of dose

Calculatiom of dose

3回閲覧 • 66問 • 2年前

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Postlab 5&6

Postlab 5&6

29問 • 2年前

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COLLIGATIVE PROPERTIES.

COLLIGATIVE PROPERTIES.

33問 • 2年前

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SEMI SOLID

SEMI SOLID

69問 • 2年前

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Basic immunology

Basic immunology

60問 • 2年前

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Basic immunology (2)

Basic immunology (2)

62問 • 2年前

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Transdermal

Transdermal

44問 • 2年前

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Distribution.

Distribution.

43問 • 2年前

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Infectious disease.

Infectious disease.

65問 • 2年前

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Infectious diseases (2)

Infectious diseases (2)

79問 • 2年前

Gram positive ( Bacteriology)

Gram positive ( Bacteriology)

All topic. ( Compressed.)

All topic. ( Compressed.)

Quinn Karylle Fuentes · 30問 · 2年前

All topic ( Compressed)

All topic ( Compressed)

30問 • 2年前

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All topics (compressed)

All topics (compressed)

13問 • 2年前

Quinn Karylle Fuentes · 28問 · 2年前

Exercise 6 ; Isotonic solution.

Exercise 6 ; Isotonic solution.

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Exercise 5 : Buffers.

Exercise 5 : Buffers.

16問 • 2年前

Quinn Karylle Fuentes · 26問 · 2年前

Exercise 7 : Factors affecting solubility.

Exercise 7 : Factors affecting solubility.

26問 • 2年前

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Experiment 8: Disintegration.

Experiment 8: Disintegration.

23問 • 2年前

Experiment 9 ; Interfacial phenomenon and surface tension.

Experiment 9 ; Interfacial phenomenon and surface tension.

EXP 9 : Aromatic ammonia spirit.

EXP 9 : Aromatic ammonia spirit.

EXP 10-11 : CAMPHOR WATER AND CINNAMON WATER.

EXP 10-11 : CAMPHOR WATER AND CINNAMON WATER.

Quinn Karylle Fuentes · 20問 · 2年前

EXP 12: ACACIA MUCILAGE

EXP 12: ACACIA MUCILAGE

20問 • 2年前

Quinn Karylle Fuentes · 33問 · 2年前

EXP13&14 : Starch and Barrium sulfate.

EXP13&14 : Starch and Barrium sulfate.

33問 • 2年前

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EXP 15 : Liquid petroleum emulsion 1.0

EXP 15 : Liquid petroleum emulsion 1.0

37問 • 2年前

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EXP 15: Liquid petroleum emulsion 1.1

EXP 15: Liquid petroleum emulsion 1.1

23問 • 2年前

Enterobacteriaceae

Enterobacteriaceae

Quinn Karylle Fuentes · 28問 · 2年前

Enterobacteriaceae.

Enterobacteriaceae.

28問 • 2年前

Quinn Karylle Fuentes · 31問 · 2年前

LIQUID DOSAGE FORM 1.0

LIQUID DOSAGE FORM 1.0

31問 • 2年前

Quinn Karylle Fuentes · 12問 · 2年前

Liquid dosage form

Liquid dosage form

12問 • 2年前

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MICROMERITICS 1.0

MICROMERITICS 1.0

44問 • 2年前

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EXP 7 : ENDOGENOUS AND EXOGENOUS MICROORGANISMS

EXP 7 : ENDOGENOUS AND EXOGENOUS MICROORGANISMS

22問 • 2年前

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EXP 8 : KIRBY-BAUER TECHNIQUE

EXP 8 : KIRBY-BAUER TECHNIQUE

40問 • 2年前

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EXP 9: STAPHYLOCOCCI

EXP 9: STAPHYLOCOCCI

29問 • 2年前

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Drug incompatibilities.

Drug incompatibilities.

41問 • 2年前

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Drug compatibilities.

Drug compatibilities.

41問 • 2年前

BACTERIOLOGY 3

BACTERIOLOGY 3

Quinn Karylle Fuentes · 30問 · 2年前

BACTERIOLOGY 3

BACTERIOLOGY 3

30問 • 2年前

SUSPENSION.

SUSPENSION.

Quinn Karylle Fuentes · 40問 · 2年前

Colloidal.

Colloidal.

40問 • 2年前

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BACTERIOLOGY 4 (Rickettsia)

BACTERIOLOGY 4 (Rickettsia)

38問 • 2年前

Quinn Karylle Fuentes · 44問 · 2年前

BACTERIOLOGY.

BACTERIOLOGY.

44問 • 2年前

Quinn Karylle Fuentes · 32問 · 2年前

Emulsion.

Emulsion.

32問 • 2年前

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EMULSION

EMULSION

42問 • 2年前

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MEDICAL RELATED PROBLEMS.

MEDICAL RELATED PROBLEMS.

36問 • 2年前

Quinn Karylle Fuentes · 33問 · 2年前

MEDICATION RELATED PROBLEMS.

MEDICATION RELATED PROBLEMS.

33問 • 2年前

Quinn Karylle Fuentes · 30問 · 2年前

Mycology.

Mycology.

30問 • 2年前

Mycology 2.0

Mycology 2.0

Quinn Karylle Fuentes · 15問 · 2年前

15問 • 2年前

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ppr

ppr

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MEDICAL DEVICES.

MEDICAL DEVICES.

20問 • 2年前

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Pharmacokinetics. (1.0)

Pharmacokinetics. (1.0)

86問 • 2年前

Quinn Karylle Fuentes · 100問 · 2年前

Pharmacokinetics (1.1)

Pharmacokinetics (1.1)

100問 • 2年前

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Pharmacokinetics (1.2)

Pharmacokinetics (1.2)

19問 • 2年前

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Introduction.

Introduction.

17問 • 2年前

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Introduction of biochemistry

Introduction of biochemistry

76問 • 2年前

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Intro medicanal chemistry.

Intro medicanal chemistry.

56問 • 2年前

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Carbohydrates

Carbohydrates

75問 • 2年前

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Carbohydrates 1.1

Carbohydrates 1.1

31問 • 2年前

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Detect and quality variation.

Detect and quality variation.

56問 • 2年前

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INTRODUCTION

INTRODUCTION

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lab (1-2)

lab (1-2)

15問 • 2年前

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lab 1-2

lab 1-2

14問 • 2年前

Pharmaceutical chemistry.

Pharmaceutical chemistry.

Pharmaceutical chemistry 1.1

Pharmaceutical chemistry 1.1

Quinn Karylle Fuentes · 39問 · 2年前

Unit 3.

Unit 3.

39問 • 2年前

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Histamin and kinins

Histamin and kinins

70問 • 2年前

PUD.

PUD.

Quinn Karylle Fuentes · 61問 · 2年前

61問 • 2年前

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Lipids.

Lipids.

67問 • 2年前

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lipids.

lipids.

71問 • 2年前

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LAB ✨

LAB ✨

93問 • 2年前

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Drug discovery.

Drug discovery.

87問 • 2年前

Quinn Karylle Fuentes · 13問 · 2年前

disease of lipids.

disease of lipids.

13問 • 2年前

Quinn Karylle Fuentes · 57問 · 2年前

Intro (identify structure)

Intro (identify structure)

57問 • 2年前

Quinn Karylle Fuentes · 98問 · 2年前

Carbohydrates

Carbohydrates

98問 • 2年前

Quinn Karylle Fuentes · 96問 · 2年前

Dynamic.

Dynamic.

96問 • 2年前

Quinn Karylle Fuentes · 32問 · 2年前

Unit 1

Unit 1

32問 • 2年前