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TOXICOLOGY

  • Jef Marc Valencia

    • 問題数 72 • 7/13/2025

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  • 1

    Study of drug effects on biological systems

    PHARMACOLOGY

  • 2

    Route of Drug Administration Most C'mon convenient route easily and safe but has slowest onset and risk of intoxication

    ORAL

  • 3

    Route of Drug Administration Drug administration under tongue via oral mucosa Example

    SUBLINGUAL, HYPERTENSIVE

  • 4

    Route of Drug Administration Insertion through rectum via rectal mucosa Example

    RECTAL, LAXATIVE

  • 5

    Route of Drug Administration Fastest but invasive procedure Example

    INTRAVENOUS, ANTIOBIOTICS & ANALGESICS

  • 6

    Route of Drug Administration Injected through muscles

    INTRAMUSCULAR

  • 7

    Route of Drug Administration Injected via skin Example

    SUBCUTANEOUS, INSULIN

  • 8

    Route of Drug Administration Via lungs Example

    INHALATION, SALBUTAMOL

  • 9

    Route of Drug Administration Via skin for localized treatment w/ minimal side effects

    TOPICAL

  • 10

    Route of Drug Administration Via skin like patches

    TRANSDERMAL

  • 11

    Refers to the movement of drug in bloodstream after administration

    ABSORPTION

  • 12

    Refers to the movement of drug in bloodstream to different tissues of the body

    DISTRIBUTION

  • 13

    Refers to the biotransformation conversion of drug into substances to be easily excrete by the body

    METABOLISM

  • 14

    Refers to the elimination of water soluble drug and its metabolites

    EXCRETION

  • 15

    Refers to the steady state removal of drug via urine

    CLEARANCE

  • 16

    Intramuscular administration is usually done in

    GLUTEOUS, DELTOID

  • 17

    Organ responsible for metabolism of drug

    LIVER

  • 18

    Organ responsible for the excretion of drug

    KIDNEY

  • 19

    Drug fate is also known as

    PHARMACOKINETIC

  • 20

    Theory define by pharmacodynamics

    DRUG ACTION, RECEPTOR THEORY

  • 21

    Drugs w/ high affinity binds at ____concentration

    LOW

  • 22

    Strength of drug binding to its receptor or interaction

    AFFINITY

  • 23

    Ability of drug to produce maximal effect activating the receptor to produce physiological response

    EFFICACY

  • 24

    Drug interaction which combined effects is greater than sum like Antibiotics

    SYNERGISM

  • 25

    Drug interaction which combined effects equals the sum of individual effects like Acetaminophen+aspirin

    ADDITION

  • 26

    Drug interaction which one drug enhances the effect of another Clavonalic acid+amoxicillin

    POTENTIATION

  • 27

    Drug interaction which one drug reduces the effect of another Nalaxone antidote to morphine

    ANTAGONISM

  • 28

    Quantitative measurement used by the doctors causing effect to 50% of subjects

    EFFECTIVE DOSE 50

  • 29

    Quantitative measurement causing max affect of 50% to plasma and tissues

    EFFECTIVE CONCENTRATION

  • 30

    Used as safety measure to drug safety

    THERAPEUTIC INDEX

  • 31

    Safety measures used by the Therapeutic Index

    LD50, ED50

  • 32

    Range between therapeutic and lethal doses

    MARGIN OF SAFETY

  • 33

    Study of exogenous chemicals that effect bodily functions harmfully or therapeutically

    TOXICOLOGY

  • 34

    Clinical laboratory function which used by physicians to adjust drug dosages individually

    THERAPEUTIC DRUG MONITORING

  • 35

    Clinical laboratory function determines offending drug, intoxication level, and suggest treatment

    IDENTIFICATION OF DRUG ACUTE INTOXICATION

  • 36

    Clinical laboratory function used in pre employment and medico legal cases

    URINE DRUG TESTING

  • 37

    C'monly used unit to measuring toxins for contaminated water

    PPM

  • 38

    C'monly used unit to measuring metals in food or water

    PPB

  • 39

    C'monly used unit to measuring ultra trace toxins

    PPT

  • 40

    1 CC=1 ML=

    1G

  • 41

    1 LITER WATER=

    1 KG

  • 42

    1 MG/KG=

    1 PPM

  • 43

    Refers to force administration of food

    GAVAGE

  • 44

    Toxicity endpoint causing death

    MORTALITY

  • 45

    Toxicity endpoint causing birth defect or fetal malformation

    TERATOGENICITY

  • 46

    Toxicity endpoint causing cancer or uncontrolled growth of cell

    CARCINOGENICITY

  • 47

    Toxicity endpoint causing DNA mutations or permanent changes

    MUTAGENICITY

  • 48

    Key measurement dose causing death in 50% of test animals

    LETHAL DOSE 50

  • 49

    Key measurement used as median lethal concentration in air/water causing death in 50% of test animals

    LETHAL CONCENTRATION 50

  • 50

    Unit of measurement used by LD50

    MG/KG

  • 51

    Unit of measurement used by LC50

    MG/L, PPM

  • 52

    Optimal blood sampling time which measures rate of blood administration=rate of elimination

    STEADY STATE

  • 53

    Steady state Optimal blood sampling time is collected ____half lives of regular dosing

    4-5X

  • 54

    Optimal blood sampling time which concentration of drug in bloodstream is measured before the next dose

    TROUGH, PRE DOSE

  • 55

    Optimal blood sampling time used for rate of toxicity

    TROUGH, PRE DOSE

  • 56

    Optimal blood sampling time which measures highest concentration of drug following administration measured after drug is given

    PEAK, POST DOSE

  • 57

    Optimal blood sampling time c'monly used by IV

    PEAK, POST DOSE

  • 58

    How minutes for Optimal blood sampling time of Peak/Post dose post infusion

    30

  • 59

    How minutes for Optimal blood sampling time of Peak/Post dose post injection

    60

  • 60

    Immunologic method measures enzyme activity drug concentration Detects drugs like cocaine, cannabinoids, opiates, barbiturates

    ENZYME MULTIPLIED IMMUNOASSAY TECHNIQUE

  • 61

    Immunologic method Solid-phase assay for drugs like digoxin and digitoxin

    ENZYME LINKED IMMUNOSORBENT ASSAY

  • 62

    Immunologic method Measures fluorescent products like umbelliferone -

    FLUORESCENCE IMMUNOASSAY

  • 63

    Immunologic method Measures drug concentration via radiolabeled drug competition

    RADIOIMMUNOASSAY

  • 64

    Best method for ELISA

    SANDWICH

  • 65

    Product of reaction of Fluorescence Immunoassay

    UMBLIFERONE

  • 66

    Most useful enzymes for EMIT

    MALATE DEHYDROGENASE, GLUCOSE 6 PHOSPHATE DEHYDROGENASE

  • 67

    Chromatographic Methods for drug screening

    THIN LAYER CHROMATOGRAPHY

  • 68

    Chromatographic Methods Quantify serum drug levels, confirm drug identity

    HIGH PERFORMANCE LIQUID CHROMATOGRAPHY, GAS LIQUID CHROMATOGRAPHY

  • 69

    Visible spectrum substance seen in Spectrophotometry

    SALICYLATE

  • 70

    Ultraviolet spectrum Spectrophotometry

    BARBITURATE

  • 71

    Fluorescence substance detected in Spectrophotometry

    QUINIDINE

  • 72

    Also used for tentative drug identification

    SPECTROPHOTOMETRY

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    FACTORS AFFECTING ENZYME ACTIVITY

    問題数 902025/06/12

    INTRODUCTION TO ENZYMOLOGY-MCQ

    問題数 412025/06/26

    CLASS AND VARIANT OF ENZYME-MCQ

    問題数 772025/06/26

    PITUITARY GLAND PART 2

    問題数 52025/07/04

    THYROID GLAND

    問題数 712025/07/04

    PARATHYROID GLAND

    問題数 122025/07/04

    ADRENAL GLAND

    問題数 772025/07/04

    SEX GLANDS

    問題数 352025/07/04

    OTHER GLANDS

    問題数 82025/07/04

    ACID BASE BALANCE

    問題数 512025/07/10

    TRACE ELEMENT

    問題数 792025/07/10

    VITAMINS

    問題数 272025/07/10

    TUMOR MARKERS

    問題数 252025/07/10

    DRUG OF ABUSE

    問題数 952025/07/13

    TOXINS

    問題数 572025/07/13

    TDM

    問題数 942025/07/13

    ENDOCRINOLOGY

    問題数 962025/07/16

    ENDROCRINOLOGY PART 2

    問題数 462025/07/16

    FACTORS AFFECTING ENZYME ACTIVITY-MCQ

    問題数 892025/07/17

    ENZYME OF CLINICAL SIGNIFICANCE-MCQ

    問題数 992025/07/17

    ENZYME OF CLINICAL SIGNIFICANCE-MCQ2

    問題数 872025/07/18

    MEDICAL TERMINOLOGIES

    問題数 362025/08/17

    INTRODUCTION TO HEMA 1

    問題数 292025/08/17

    LABORATORY SAFETY

    問題数 232025/08/18

    TERMINOLOGIES

    問題数 512025/08/21

    LABORATORY 1

    問題数 182025/08/22

    LABORATORY 3

    問題数 532025/08/22

    HEMATOPOIESIS

    問題数 622025/08/23

    THEORIES ON BLOOD FORMATION

    問題数 552025/08/30

    ERYTHROPOIESIS

    問題数 462025/08/30

    LEUKOPOIESIS

    問題数 1002025/08/30

    LEUKOPOIESIS II AND MONOPOIESIS

    問題数 422025/09/01

    INTRODUCTION TO MYCOLOGY MCQ

    問題数 322025/09/24

    MYCOLOGY PROPER

    問題数 712025/09/01

    FUNGAL PATHOGENESIS

    問題数 352025/09/01

    CLASSIFICATION OF FUNGI

    問題数 452025/09/06

    SPECIMEN COLLECTION, CULTURE, AND COLONIAL CHARACTERISTICS

    問題数 742025/09/06

    MICROSCOPIC STUDY, CULTURE EXAMINATION, AND PRESERVATION OF FUNGI

    問題数 542025/09/06

    Mind mapping

    問題数 92025/09/07

    INTRODUCTION TO MYCOLOGY MCQ

    問題数 322025/09/13

    MYCOLOGY PROPER MCQ

    問題数 592025/09/13

    FUNGAL PATHOGENESIS MCQ

    問題数 372025/09/13

    CLASSIFICATION OF FUNGI MCQ

    問題数 332025/09/13

    SPECIMEN COLLECTION, CULTURE, AND COLONIAL CHARACTERISTICS MCQ

    問題数 742025/09/13

    MCQ-MICROSCOPIC STUDY, CULTURE EXAMINATION, AND PRESERVATION OF FUNGI

    問題数 532025/09/14

    THE SUPEFICIAL FUNGI

    問題数 342025/09/12

    THE CUTANEOUS FUNGI

    問題数 582025/09/13

    SUBCUTANEOUS FUNGI

    問題数 552025/09/13

    SYSTEMIC FUNGI

    問題数 282025/09/13

    LYMPHOPOIESIS

    問題数 442025/09/07

    MEGAKARYOPOIESIS

    問題数 342025/09/07

    INTRODUCTION TO HEMA1 MCQ

    問題数 452025/09/10

    HEMATOPOIESIS

    問題数 582025/09/14

    THEORIES ON BLOOD FORMATION

    問題数 462025/09/14

    ERYTHROPOIESIS MCQ

    問題数 412025/09/14

    LEUKOPOIESIS MCQ

    問題数 942025/09/10

    LEUKOPOIESIS II AND MONOPOIESIS MCQ

    問題数 392025/09/14

    LYMPHOPOIESIS MCQ

    問題数 392025/09/10

    MEGAKARYOPOIESIS MCQ

    問題数 392025/09/10

    BLOOD COLLECTION

    問題数 352025/09/10

    LABORATORY SAFETY

    問題数 212025/09/17

    LABORATORY 1

    問題数 162025/09/17

    LABORATORY 3

    問題数 472025/09/17

    BLOOD COLLECTION MCQ

    問題数 792025/09/17

    DEMATIACEOUS OPPORTUNISTIC FUNGI

    問題数 522025/09/30

    PENICILLUS

    問題数 212025/10/08

    HYALINE SEPTATE GROUP W/ CONIDIA IN CLUSTER

    問題数 162025/10/08

    HYALINE SEPTATE GROUP W/ CONIDIA BORNE SINGLY

    問題数 122025/10/08

    ZYGOMYCETE/HYALINE SEPTATE GROUP

    問題数 492025/10/08

    YEAST AND YEAST LIKE ORGANISMS

    問題数 722025/10/15

    HEMOCYTOMETRY

    問題数 832025/10/03

    HEMOGLOBIN

    問題数 1002025/10/04

    HEMOGLOBIN PART 2

    問題数 262025/10/05

    OXYGEN DISSOCIATION CURVE

    問題数 282025/10/14

    QUANTIFICATION OF HBF

    問題数 762025/10/12

    YEAST AND YEAST LIKE ORGANISMS

    問題数 702025/10/26