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Immune 3

  • Jef Marc Valencia

    • 問題数 47 • 8/28/2024

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  • 1

    Glycoproteins that recognize and bind to a particular antigen with very high specificity

    ANTIBODY

  • 2

    Made in response to exposure to the antigen

    ANTIBODY

  • 3

    antibody binding site

    PARATOPE

  • 4

    at pH 8.6, immunoglobulins appear primarily in the gamma band

    ELECTROPHORESIS

  • 5

    Antibody belong to a group of serum proteins called .

    IMMUNOGLOBULIN

  • 6

    the primarily organ where the antigens are destroyed

    SPLEEN

  • 7

    Occurred once antigen was introduced, it would select the cell with proper receptor, combination would take place and receptors would break off and enter the circulation as antibody molecules New receptors would form in place of those broken off and enter the circulation as antibody molecules

    EHRLICH’S SIDE-CHAIN THEORY, SPECIFIC RECEPTOR

  • 8

    Antibody producing cells are capable of synthesizing a generalized type of antibody and when contact with an antigen occurs, the antigen serves as a mold or template and alters protein synthesis so hat antibody with specific fits is made

    TEMPLATE THEORY, GENERAL RECEPTOR

  • 9

    This now specific antibody enters the circulation, while the antigen remains behind to direct further synthesis or degradation to make more antibodies

    TEMPLATE THEORY, GENERAL RECEPTOR

  • 10

    Template theory proponent

    FELIX HAUROWITZ

  • 11

    Most accepted theory for antibody diversity

    CLONAL SELECTION

  • 12

    Clonal selection theory proponent

    NIELS JERNE, MCFARLANE BURNET

  • 13

    The key premise is that individual lymphocytes are genetically programmed to produce one type of immunoglobulin and that a specific antigen finds or selects those particular cells capable of responding to it, causing toproliferate

    CLONAL SELECTION

  • 14

    pre-committed to produce a specific antibody

    NAIVE B CELL

  • 15

    Immunoglobulin are consists of

    4 POLYPEPTIDE CHAIN

  • 16

    They worked on immunoglobulin G

    GERALD EDELMAN, RODNEY PORTER

  • 17

    A flexible Y-shaped molecule with four protein chains

    MONOMER

  • 18

    2 identical light chains-

    KAPPA, LAMBDA

  • 19

    it will determine the class of immunoglobulin)

    2 IDENTICAL HEAVY CHAIN

  • 20

    Stem of monomer and lower parts of Y arms• Responsible for the type and antigen-antibody reaction that occurs

    CONSTANT REGION

  • 21

    Structure serves as a basis for distinguishing the 5 different classes: IgG, IgA, IgM, IgD and IgE

    CONSTANT REGION

  • 22

    For complement fixation, skin fixation and placental transfer • No capability to bind the antibody

    FRAGMENT CONSTANT REGION

  • 23

    First approximately 110 amino acids at the amino-terminal end • The remaining amino acids can typically be divided up into two or three or more constant regions with very similar constant regions with very similar sequences,

    VARIABLE DOMAIN

  • 24

    H chain IgG

    GAMMA

  • 25

    H chain IgA

    ALPHA

  • 26

    H chain

    EPSILON

  • 27

    H chain IgD

    DELTA

  • 28

    H chain IgM

    MU

  • 29

    Refers to the heavy chain that determine the Ig class

    ISOTYPE

  • 30

    Minor variations of these sequences that are present in some individuals but not others

    ALLOTYPE

  • 31

    The aminoterminal ends of both L and H contain these regions, which are essential to the formation of the antigen- binding site• variable portions of each chain are unique to a specific antibody molecule.

    IDIOTYPE

  • 32

    Possess both constant and variable regions, it is the same for all immunoglobulins

    LIGHT CHAIN

  • 33

    Kappa: contains of the Ig

    65%

  • 34

    Lambda: contains of the Ig

    35%

  • 35

    Ratio of Kappa and Lamba was discovered through

    BENCE JONES PROTEIN

  • 36

    Connect light chains and light chains

    DISULFIDE BOND

  • 37

    Found in between CH1 and CH2 • Has high proline and hydrophobic residue • A.K.A. Flexible region

    HINGE REGION

  • 38

    Causes flexibility in hinge region

    PROLINE

  • 39

    antigen binding site known also as the paratope

    FAB SITE

  • 40

    CH2 and CH3, where B cells, T cells and complement bind to

    FC REGION

  • 41

    mainly done to study the immunoglobulins

    FRAGMENTATION OF MONOMER

  • 42

    Cleaves the Ig above the hinge region

    PAPAIN DIGESTION

  • 43

    Cleaves the Ig below the hinge region

    PEPSIN DIGESTION

  • 44

    Basic Ig structure

    MONOMER

  • 45

    Secretory component/ piece of IgA/ another class of IgA • Prevents the enzymatic degeneration of enzyme among secretions • With J chain

    DIMER

  • 46

    J chain is also known as

    JOINING CHAIN

  • 47

    >2 monomer • IgM- pentamer • 10 valence- 10 binding sites • With J chain

    POLYMER

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    問題数 622025/08/23

    THEORIES ON BLOOD FORMATION

    問題数 552025/08/30

    ERYTHROPOIESIS

    問題数 462025/08/30

    LEUKOPOIESIS

    問題数 1002025/08/30

    LEUKOPOIESIS II AND MONOPOIESIS

    問題数 422025/09/01

    INTRODUCTION TO MYCOLOGY MCQ

    問題数 322025/09/24

    MYCOLOGY PROPER

    問題数 712025/09/01

    FUNGAL PATHOGENESIS

    問題数 352025/09/01

    CLASSIFICATION OF FUNGI

    問題数 452025/09/06

    SPECIMEN COLLECTION, CULTURE, AND COLONIAL CHARACTERISTICS

    問題数 742025/09/06

    MICROSCOPIC STUDY, CULTURE EXAMINATION, AND PRESERVATION OF FUNGI

    問題数 542025/09/06

    Mind mapping

    問題数 92025/09/07

    INTRODUCTION TO MYCOLOGY MCQ

    問題数 322025/09/13

    MYCOLOGY PROPER MCQ

    問題数 592025/09/13

    FUNGAL PATHOGENESIS MCQ

    問題数 372025/09/13

    CLASSIFICATION OF FUNGI MCQ

    問題数 332025/09/13

    SPECIMEN COLLECTION, CULTURE, AND COLONIAL CHARACTERISTICS MCQ

    問題数 742025/09/13

    MCQ-MICROSCOPIC STUDY, CULTURE EXAMINATION, AND PRESERVATION OF FUNGI

    問題数 532025/09/14

    THE SUPEFICIAL FUNGI

    問題数 342025/09/12

    THE CUTANEOUS FUNGI

    問題数 582025/09/13

    SUBCUTANEOUS FUNGI

    問題数 552025/09/13

    SYSTEMIC FUNGI

    問題数 282025/09/13

    LYMPHOPOIESIS

    問題数 442025/09/07

    MEGAKARYOPOIESIS

    問題数 342025/09/07

    INTRODUCTION TO HEMA1 MCQ

    問題数 452025/09/10

    HEMATOPOIESIS

    問題数 582025/09/14

    THEORIES ON BLOOD FORMATION

    問題数 462025/09/14

    ERYTHROPOIESIS MCQ

    問題数 412025/09/14

    LEUKOPOIESIS MCQ

    問題数 942025/09/10

    LEUKOPOIESIS II AND MONOPOIESIS MCQ

    問題数 392025/09/14

    LYMPHOPOIESIS MCQ

    問題数 392025/09/10

    MEGAKARYOPOIESIS MCQ

    問題数 392025/09/10

    BLOOD COLLECTION

    問題数 352025/09/10

    LABORATORY SAFETY

    問題数 212025/09/17

    LABORATORY 1

    問題数 162025/09/17

    LABORATORY 3

    問題数 472025/09/17

    BLOOD COLLECTION MCQ

    問題数 792025/09/17

    DEMATIACEOUS OPPORTUNISTIC FUNGI

    問題数 522025/09/30

    PENICILLUS

    問題数 212025/10/08

    HYALINE SEPTATE GROUP W/ CONIDIA IN CLUSTER

    問題数 162025/10/08

    HYALINE SEPTATE GROUP W/ CONIDIA BORNE SINGLY

    問題数 122025/10/08

    ZYGOMYCETE/HYALINE SEPTATE GROUP

    問題数 492025/10/08

    YEAST AND YEAST LIKE ORGANISMS

    問題数 722025/10/15

    HEMOCYTOMETRY

    問題数 832025/10/03

    HEMOGLOBIN

    問題数 1002025/10/04

    HEMOGLOBIN PART 2

    問題数 262025/10/05

    OXYGEN DISSOCIATION CURVE

    問題数 282025/10/14

    QUANTIFICATION OF HBF

    問題数 762025/10/12

    YEAST AND YEAST LIKE ORGANISMS

    問題数 702025/10/26