Immune 3

Jef Marc Valencia · 73問 · 2年前

通報

問題一覧

Glycoproteins that recognize and bind to a particular antigen with very high specificity

ANTIBODY

Made in response to exposure to the antigen

ANTIBODY

antibody binding site

PARATOPE

at pH 8.6, immunoglobulins appear primarily in the gamma band

ELECTROPHORESIS

Antibody belong to a group of serum proteins called .

IMMUNOGLOBULIN

the primarily organ where the antigens are destroyed

SPLEEN

Occurred once antigen was introduced, it would select the cell with proper receptor, combination would take place and receptors would break off and enter the circulation as antibody molecules New receptors would form in place of those broken off and enter the circulation as antibody molecules

EHRLICH’S SIDE-CHAIN THEORY, SPECIFIC RECEPTOR

Antibody producing cells are capable of synthesizing a generalized type of antibody and when contact with an antigen occurs, the antigen serves as a mold or template and alters protein synthesis so hat antibody with specific fits is made

TEMPLATE THEORY, GENERAL RECEPTOR

This now specific antibody enters the circulation, while the antigen remains behind to direct further synthesis or degradation to make more antibodies

TEMPLATE THEORY, GENERAL RECEPTOR

Template theory proponent

FELIX HAUROWITZ

Most accepted theory for antibody diversity

CLONAL SELECTION

Clonal selection theory proponent

NIELS JERNE, MCFARLANE BURNET

The key premise is that individual lymphocytes are genetically programmed to produce one type of immunoglobulin and that a specific antigen finds or selects those particular cells capable of responding to it, causing toproliferate

CLONAL SELECTION

pre-committed to produce a specific antibody

NAIVE B CELL

Immunoglobulin are consists of

4 POLYPEPTIDE CHAIN

They worked on immunoglobulin G

GERALD EDELMAN, RODNEY PORTER

A flexible Y-shaped molecule with four protein chains

MONOMER

2 identical light chains-

KAPPA, LAMBDA

it will determine the class of immunoglobulin)

2 IDENTICAL HEAVY CHAIN

Stem of monomer and lower parts of Y arms• Responsible for the type and antigen-antibody reaction that occurs

CONSTANT REGION

Structure serves as a basis for distinguishing the 5 different classes: IgG, IgA, IgM, IgD and IgE

CONSTANT REGION

For complement fixation, skin fixation and placental transfer • No capability to bind the antibody

FRAGMENT CONSTANT REGION

First approximately 110 amino acids at the amino-terminal end • The remaining amino acids can typically be divided up into two or three or more constant regions with very similar constant regions with very similar sequences,

VARIABLE DOMAIN

H chain IgG

GAMMA

H chain IgA

ALPHA

H chain

EPSILON

H chain IgD

DELTA

H chain IgM

Refers to the heavy chain that determine the Ig class

ISOTYPE

Minor variations of these sequences that are present in some individuals but not others

ALLOTYPE

The aminoterminal ends of both L and H contain these regions, which are essential to the formation of the antigen- binding site• variable portions of each chain are unique to a specific antibody molecule.

IDIOTYPE

Possess both constant and variable regions, it is the same for all immunoglobulins

LIGHT CHAIN

Kappa: contains of the Ig

65%

Lambda: contains of the Ig

35%

Ratio of Kappa and Lamba was discovered through

BENCE JONES PROTEIN

Connect light chains and light chains

DISULFIDE BOND

Found in between CH1 and CH2 • Has high proline and hydrophobic residue • A.K.A. Flexible region

HINGE REGION

Causes flexibility in hinge region

PROLINE

antigen binding site known also as the paratope

FAB SITE

CH2 and CH3, where B cells, T cells and complement bind to

FC REGION

mainly done to study the immunoglobulins

FRAGMENTATION OF MONOMER

Cleaves the Ig above the hinge region

PAPAIN DIGESTION

Cleaves the Ig below the hinge region

PEPSIN DIGESTION

Basic Ig structure

MONOMER

Secretory component/ piece of IgA/ another class of IgA • Prevents the enzymatic degeneration of enzyme among secretions • With J chain

DIMER

J chain is also known as

JOINING CHAIN

>2 monomer • IgM- pentamer • 10 valence- 10 binding sites • With J chain

POLYMER

COMPH Lesson 5

COMPH Lesson 5

73問 • 2年前

Jef Marc Valencia · 42問 · 2年前

Discussion 1

Discussion 1

42問 • 2年前

Jef Marc Valencia · 42問 · 2年前

Dis 1

Dis 1

42問 • 2年前

Jef Marc Valencia · 11問 · 2年前

Shift -Systematic Error

Shift -Systematic Error

11問 • 2年前

Jef Marc Valencia · 8問 · 2年前

LEVEY – JENNINGS CHART

LEVEY – JENNINGS CHART

8問 • 2年前

Jef Marc Valencia · 6問 · 2年前

WESTGARD MULTIRULE CHART

WESTGARD MULTIRULE CHART

6問 • 2年前

Jef Marc Valencia · 5問 · 2年前

Random vs Systematic

Random vs Systematic

5問 • 2年前

Jef Marc Valencia · 48問 · 2年前

Researcj Design

Researcj Design

48問 • 2年前

Jef Marc Valencia · 40問 · 2年前

Dis 1 mid

Dis 1 mid

40問 • 2年前

Jef Marc Valencia · 63問 · 2年前

COMPM LESSON 6-7

COMPM LESSON 6-7

63問 • 2年前

Jef Marc Valencia · 31問 · 2年前

Discussion -2 Six Sigma

Discussion -2 Six Sigma

31問 • 2年前

Jef Marc Valencia · 6問 · 2年前

Sigma Levels

Sigma Levels

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Jef Marc Valencia · 46問 · 2年前

COMPH- LESSON 8

COMPH- LESSON 8

46問 • 2年前

Jef Marc Valencia · 81問 · 1年前

Long Discussion ANALYTICAL METHODS & INSTRUMENTATION

Long Discussion ANALYTICAL METHODS & INSTRUMENTATION

81問 • 1年前

Jef Marc Valencia · 9問 · 1年前

WAVELENGTH Color Table

WAVELENGTH Color Table

9問 • 1年前

Jef Marc Valencia · 100問 · 1年前

Quiz Announcement ANALYTICAL METHODS & INSTRUMENTATION

Quiz Announcement ANALYTICAL METHODS & INSTRUMENTATION

100問 • 1年前

Jef Marc Valencia · 18問 · 1年前

QUIz ANNOUNCEMENT part 2

QUIz ANNOUNCEMENT part 2

18問 • 1年前

Jef Marc Valencia · 62問 · 1年前

Electrochem

Electrochem

62問 • 1年前

Jef Marc Valencia · 18問 · 1年前

ELEC TROCH

ELEC TROCH

18問 • 1年前

Jef Marc Valencia · 49問 · 1年前

TRANSCRIPTION

TRANSCRIPTION

49問 • 1年前

LIS

LIS

Jef Marc Valencia · 16問 · 1年前

Carbohydrates

Carbohydrates

16問 • 1年前

DIFFERENT PATHWAYS IN GLUCOSE METABOLISM

DIFFERENT PATHWAYS IN GLUCOSE METABOLISM

III. GLUCOSE MEASUREMENT

III. GLUCOSE MEASUREMENT

Jef Marc Valencia · 7問 · 1年前

Copper Reductions

Copper Reductions

7問 • 1年前

Exp.8

Exp.8

QUIZ 8/9

QUIZ 8/9

Immunology

Immunology

Jef Marc Valencia · 22問 · 1年前

Immunology part 2

Immunology part 2

22問 • 1年前

Immunology 3

Immunology 3

Lesson 4

Lesson 4

Jef Marc Valencia · 26問 · 1年前

PROTEINS

PROTEINS

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Jef Marc Valencia · 34問 · 1年前

PROTEIN 2

PROTEIN 2

34問 • 1年前

PROTEIN 3

PROTEIN 3

Jef Marc Valencia · 56問 · 1年前

Serum Albumin Determination

Serum Albumin Determination

56問 • 1年前

Jef Marc Valencia · 14問 · 1年前

CC lec debris

CC lec debris

14問 • 1年前

Jef Marc Valencia · 44問 · 1年前

NPN

NPN

44問 • 1年前

NPN 2

NPN 2

Jef Marc Valencia · 33問 · 1年前

Materials management

Materials management

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Jef Marc Valencia · 57問 · 1年前

Liver

Liver

57問 • 1年前

LESSON 10

LESSON 10

Jef Marc Valencia · 25問 · 1年前

hyperlipoproteinemia

hyperlipoproteinemia

25問 • 1年前

Jef Marc Valencia · 24問 · 1年前

OBLIGATE INTRACELLULAR BACTERIA

OBLIGATE INTRACELLULAR BACTERIA

24問 • 1年前

Jef Marc Valencia · 48問 · 1年前

THE SPIROCHETES

THE SPIROCHETES

48問 • 1年前

Jef Marc Valencia · 31問 · 1年前

PYOGENIC GRAM POSTIVE

PYOGENIC GRAM POSTIVE

31問 • 1年前

Jef Marc Valencia · 31問 · 1年前

Introduction

Introduction

31問 • 1年前

Introduction Page 2

Introduction Page 2

Jef Marc Valencia · 31問 · 1年前

Introduction pg 3

Introduction pg 3

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Jef Marc Valencia · 32問 · 1年前

Introduction table

Introduction table

32問 • 1年前

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Introduction-body

Introduction-body

14問 • 1年前

NK-Immunity

NK-Immunity

Jef Marc Valencia · 45問 · 1年前

meet 2

meet 2

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Jef Marc Valencia · 38問 · 1年前

discussion 3

discussion 3

38問 • 1年前

Jef Marc Valencia · 25問 · 1年前

dis 1

dis 1

25問 • 1年前

Immuno vs anti

Immuno vs anti

Jef Marc Valencia · 46問 · 1年前

dis 4

dis 4

46問 • 1年前

Jef Marc Valencia · 12問 · 1年前

TRANSUDATIVE Vs. EXUDATIVE

TRANSUDATIVE Vs. EXUDATIVE

12問 • 1年前

Jef Marc Valencia · 75問 · 1年前

dis 5

dis 5

75問 • 1年前

Jef Marc Valencia · 9問 · 1年前

Preserved Tissue Examination Steps by definition

Preserved Tissue Examination Steps by definition

9問 • 1年前

FIXATIVES

FIXATIVES

Jef Marc Valencia · 70問 · 1年前

Long discussion 1

Long discussion 1

70問 • 1年前

Jef Marc Valencia · 10問 · 1年前

ALDEHYDE-FIXATIVES

ALDEHYDE-FIXATIVES

10問 • 1年前

Jef Marc Valencia · 24問 · 1年前

lactate dehydrogenase

lactate dehydrogenase

24問 • 1年前

FIXATIVES-METALLIC

FIXATIVES-METALLIC

Jef Marc Valencia · 5問 · 1年前

FIXATIVES-CHROMATE

FIXATIVES-CHROMATE

5問 • 1年前

Jef Marc Valencia · 10問 · 1年前

Specialized Macrophages

Specialized Macrophages

10問 • 1年前

Jef Marc Valencia · 14問 · 1年前

LYMPHOPOIESIS

LYMPHOPOIESIS

14問 • 1年前

Jef Marc Valencia · 5問 · 1年前

PICRIC ACID-FIXATIVE

PICRIC ACID-FIXATIVE

5問 • 1年前

Jef Marc Valencia · 33問 · 1年前

immune 4

immune 4

33問 • 1年前

FIXATIVES-ALCOHOL

FIXATIVES-ALCOHOL

Jef Marc Valencia · 40問 · 1年前

Immunoglobulins

Immunoglobulins

40問 • 1年前

ARTIFACTS

ARTIFACTS

Jef Marc Valencia · 11問 · 1年前

FIXATIVES QUIZ COPY

FIXATIVES QUIZ COPY

11問 • 1年前

Jef Marc Valencia · 26問 · 1年前

MAJOR HISTOCOMPATIBILITY

MAJOR HISTOCOMPATIBILITY

26問 • 1年前

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Introduction

Introduction

58問 • 1年前

Jef Marc Valencia · 5問 · 1年前

OTHERS-FIXATIVES

OTHERS-FIXATIVES

5問 • 1年前

Jef Marc Valencia · 34問 · 1年前

MEGAKARYOPOLESIS

MEGAKARYOPOLESIS

34問 • 1年前

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DECALCIFICATION

DECALCIFICATION

51問 • 1年前

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DEHYDRATION

DEHYDRATION

64問 • 1年前

Blood Specimen Collection

Blood Specimen Collection

Jef Marc Valencia · 7問 · 1年前

CLEARING

CLEARING

7問 • 1年前

Jef Marc Valencia · 19問 · 1年前

CEARING AGENT

CEARING AGENT

19問 • 1年前

Jef Marc Valencia · 27問 · 1年前

INTRODUCTION

INTRODUCTION

27問 • 1年前

Jef Marc Valencia · 51問 · 1年前

Introduction

Introduction

51問 • 1年前

Jef Marc Valencia · 12問 · 1年前

Methods of Determination

Methods of Determination

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Jef Marc Valencia · 11問 · 1年前

ASPARTATE AMINOTRANSFERASE

ASPARTATE AMINOTRANSFERASE

11問 • 1年前

Jef Marc Valencia · 15問 · 1年前

ALANINE AMINOTRANSFERASE

ALANINE AMINOTRANSFERASE

15問 • 1年前

Jef Marc Valencia · 34問 · 1年前

Creatinine Kinase

Creatinine Kinase

34問 • 1年前

Jef Marc Valencia · 27問 · 1年前

LACTATE DEHYDROGENASE

LACTATE DEHYDROGENASE

27問 • 1年前

Jef Marc Valencia · 41問 · 1年前

ACID PHOSPHATASE

ACID PHOSPHATASE

41問 • 1年前