dis 5

Jef Marc Valencia · 73問 · 2年前

通報

問題一覧

are the largest cell in the bone marroW

MEGAKARYOCYTE

a mechanism by which platelet will deform into fragments for it able to be released in the circulation

PLATELET SHEDDING

Capable of reproduction and proliferation and about 2-3 days

MITOTIC POOL

Maturation pool duration

5-7 DAY

Storage pool duration

11 DAY

Adhere all the endothelial lining that can be formed into marginating pool.

MARGINATING POOL

WBC count pool

CIRCULATING POOL

have receptors for Fc (IgG) and C3 (complement) have same function in recognition of attached RBC.

PHAGOCYTOSIS

Neutrophil function

PHAGOCYTOSIS, KILLING

Step 1 phago

RECOGNITION

Step 2 phago

ENGULFMENT

Step 3 phago

MURAMIDASE

Step 4 phago

KILLING

Step 5 phago

METABOLIZATION

Engulfment happens by protruding its cytoplasm creating a vacuole called

PHAGOSOME

degranulation o Lysosomal degranulation together with the presence of oxygen a chemical reaction takes place, wherein the oxygen will cause the release of potent radicals which are bactericidal.

OXYGEN INDEPENDENT

Does not chemically react with oxygen o respiratory burst H2O2 and (NaCIO/bleach) are produced

OXYGEN DEPENDENT

(normal random, abnormal directional

JOB SYNDROME

(abnormal both random and directional)

LAZY LEUKOCYTE SYNDROME

(abnormal oxygen dependent)

CHRONIC GRANULOCYTIC DISEASE

Form trapsonce they perform their function, will eventually die. When they die, their components like the cytoplasmic and nuclear components will start to disintegrate.

NEUTROPHIL EXTRACELLULAR TRAP

Some of the strands of neutrophils contain contents like

MYELOPEROXIDASE

responsible in secreting other protein like the CD markers, adhesion molecules that will promote the adhesion of neutrophil on cell surfaces or vascular tissues.

SECRETORY GRANULE

Diameter of Acidophil

9-15

Nucleus of acidophil

BILOBED

Growth hormones such as_regulate eosinophil production.

IL3, GM-CSF, IL5

very critical in the maturation as well as when the cell is about to effect its function. In acidophil

IL5

stimulate adrenal glands to produce more adrenal corticosteroid

ADRENOCORTICOTROPIC HORMONE

(increase adrenal function) will also lead to eosinopenia

HYPERADRENALISM

the components of the primary granules including lysophospholipase will form into crystals called

CHARCOT LEYDEN CRYSTAL

is a type of sensitivity reaction wherein one of the manifestations is eosinophilia

LOEFFLER'S SYNDROME

granulated with large nucleus and often indented or bilobed. They both have granules which contains heparin and histamine and involved in hypersensitivity.

BASOPHIL, MAST CELL

true leukocyte;

BASOPHIL

dampen inflammatory and hypersensitivity responses

EOSINOPHIL

Normal WBC count

5000-11500 u/L

As the nuclear component or neutrophils disintegrates, the nucleoproteins from the nucleus/nuclear material and will form into thread like filaments or structure that will serve as the trap called

NEUTROPHIL EXTRACELLULAR TRAP

Decrease eosinophil term

EOSINOPENIA

Where do eosinophils migrates after reaching their half life

SKIN, NASAL MEMBRANE, LUNG, GIT

Charcot-Leyden crystals contain_coming from the cytoplasm of the eosinophils

LYSOPHOSPHOLIPASE

This eosinophil properties caused them to increase

ANTI HELMINTHIC

Chromatin in Basophils

SMUDGED

Size of Basophil

10-16

Immediate precursor of macrophage

MONOCYTE

mediate inflammatory response and immediate hypersensitivity reaction

BASOPHIL

Granules in Basophil Natural Anti-coagulant: Vasoconstriction: Vasodilation: Chemoattractant:

HEPARIN, SEROTONIN, HISTAMINE, ECF-A

This enzyme present in eosinophil that oxidizes histamine

HISTAMINASE

dampen inflammatory and hypersensitivity responses

EOSINOPHIL

Eosinophil is attracted to chemoattractant like

ECF-A

Hallmark of hypersensitivity reaction because of the release of ECF-A during degranulation of basophil and mast cells in response to allergy

EOSINOPHIL

Increase vascular permeability causing smooth muscle contraction

HISTAMINE

Promote T2 lymphocyte differentiation and IgE

IL4, IL13

are connective tissue cells of mesenchymal origin

MAST CELL

Effectors of hypersensitivity

MAST CELL

Granules of Mast cell

SEROTONIN, HISTAMINE, HEPARIN

activated dur8ng first exposure to allergen and be transformed into plasma cells leading (production of antibody

B CELL

Plasma cells will then start producing _against the allergen.

IgE

The primed (attached) IgE and mast cells/basophils will degranulate releasing chemical contents such as

HISTAMINE, CYTOKINE

Monocyte maturation

MONOPOIESIS

3 stages of monopoiesis

MONOBLAST, PROMONOCYTE, MONOCYTE

Large immature cell with deeply basophilic cytoplasm and non-granular. Has a 1-2 nuclei (mitotical active cell)

MONOBLAST

stain marker for primitive myelocytic cells

MYELOPEROXIDASE

Specific Esterase test

ALPHA NAPHTEL CHLOROESTERASE

Non specific esterase test

ALPHA NAPHTEL ACETATE ESTERASE, ALPHA NAPHTEL BUTYRATE ESTERASE

Substrate for the myeloblast is the

CHLOROACETATE

Substrate for the monoblast

ACETATE, BUTYRATE

Stage in Monopoiesis Has a blue-grey cytoplasm - Nucleus is slightly reduced - N/C ration: 3:1 to 2:1 - Actively dividing cell and can divide until 3 more times

PROMONOCYTE

Relative in size, can be between 14-20 um - Nucleus of monocyte is either round, kidney- shaped; with light lobulation; folded; with fine lacy chromatin; has an indentation

MONOCYTE

Ground glass appearance is due to the presence of several_in monocyte

AZUROPHILIC

largest cell in the circulation

MONOCYTE

Lobulation of monocyte

BRAIN LIKE

Chromatin in monocyte

LACED LIKE

smallest of the 5 WBCs

LYMPHOCYTE

nucleus are often round or may have a shallow indentation

LYMPHOCYTE

Chromatin in lymphocyte

COARSE

Life span of monocyte

12-72 HOUR

COMPH Lesson 5

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