Predominant type of immunoglobulin in humans which has Longest half-life of any immunoglobulin class

IgG is also known as in terms od infection

If the IgG is positive in the laboratory result, it means the person

The most predominant IgG comprising about _% od total IgGs but it has only _disulfide bond

IgG2 _% of total IgGs and has _disulfide bond

IgG3_% of total IgGs and has _disulfide bond

IgG4_% of total IgGs and has _disulfide bond

In case of infection, the arrangement of Igs from highest to lowest is (letters only)

In normal person, the arrangement of Igs from highest to lowest is (letters only)

least effective IgG won’t be able to pass through the placenta

Besg IgG that fixes complement

Decreased level of IgG can be manifested in primary (genetic) or secondary (acquired) Ig deficiencies like

increases of IgG are seen in the following conditions

Star-like appearance Combined with Ag would have crab-like appearance Ig

Has an extra Heavy chain Most primitive, first to appear among infants

IgM is also known as

First Ig the newborns have is

Babies the first that they can produce is

Formed in response to stimulus specifically by gram-negative bacteria

Known as the primary antibody- found in the acute phase infection

First one to appear in phylogeny and the last to leave in senescence and after a primary antigenic stimulus

first test for syphilis

Complement fixation: most efficient in triggering the classical complement pathway

IgM function also as

10-15% serum immunoglobulin which Secretory component provides Mucosal Immunity

Monomeric in serum in IgA

Occurs as a dimer in secretions in IgA

Ig with J chain

Prevent enzymatic degradation

responsible for immunoregulation

control of specific immune response and interactions between the B and T lymphocytes, and also macrophages

Least abundant immunoglobulin in the serum

IgE has a Heat-labile antibodies, originally called as

IgE Binds strongly to a receptor on mast cells and basophils and together with antigen, mediates the release of

Most important functions of IgE

recognizes the IgE attached to parasite to release Major basic protein and Eosinophil Cationic Protein

Best Ig precipitin

These are only effective to parasite when in tissues

IgM reacta on what temperature

IgG reacts on what temp