Liver

Jef Marc Valencia · 73問 · 2年前

通報

問題一覧

Weight of kidney in a healthy adult

1.2-1.5 KG

Kidney is located beneath and attached to the_____

DIAPHRAGM

This divides the kidney into two lobes

FALCIFORM LIGAMENT

Kidneys 2 main blood supply

PORTAL VEIN, HEPATIC ARTERY

Kidneys blood supply which carries nutrient rich blood from the digestive tract and it provides__%of the total blood supply to the liver.

PORTAL VEIN, 75

Kidneys blood supply which carries oxygen-rich blood to the liver about __%of the total blood supply to the liver.

HEPATIC ARTERY, 25

Approx., how many mL of blood per minute passes through the kidney

1500

Excretory system of liver begins at the_____

BILE CANALICULI

Main organ of detoxification

LIVER

What synthesis does the kidney perform?

MULTIPLE PLASMA PROTEIN

Liver is the only excretory organ for___

HEME WASTE

Liver is involved in the metabolism of___

BILIRUBIN

Liver is the major site of catabolism of____

HORMONE

The yellow discoloration of the skin, eyes, and mucous membranes most often resulting from the retention of bilirubin

JAUNDICE, ICTERUS

Normal Value of Bilirubin

1.0-1.5 mg/dL

What value of bilirubin when jaundice is noticeable

3.0-5.0 mg/dL

The serum or plasma sample w/ a yellow discoloration due to an elevated bilirubin level.

ICTERUS

Jaundice is commonly classified based on the site of the disorder and these are

PREHEPATIC, HEPATIC, POSTHEPATIC

A major complication caused by accumulation of peritoneal fluid

ASCITES

Accumulation of substances like NH4 which are not metabolized by the liver

HEPATIC FAILURE, ENCEPHALOPATHY

Metabolic abnormalities occur in the presence of ____

CHRONIC LIVER DISEASE

A condition which the kidney do not efficiently perform enzymatic transformation and disposition of drugs

ALTERED DRUG METABOLISM

Hormone imbalance

ENDOCRINE ABNORMALITIES

Liver nutritional and metabolic abnormalities

VITAMIN D DEFICIENCY

The liver efficiently sequesters dimeric IgA and IgG secretes it into the bile.

IMMUNOGLOBULIN ABNORMALITIES

Increased pressure within the portal venous system about (>20mmHg) which increases sinusoidal infiltration, scarring or hepatic vein obstruction causing major complications like HEPATOSPLENOMEGALY, ASCITES, and HEPATORENAL SYNDROME

PORTAL HYPERTENSION

Chronic liver disease produces alterations in Hemostasis and a genralized hemorrhagic tendency

DISORDERED HEMOSTASIS

How many mg of bilirubin metabolize per day

200-300

How many percent of bilirubin derived from the degradation of heme

Erythrocyte precursors are destroyed in the___

Heme-containing proteins

MYOGLOBIN, CYTOCHROME, PEROXIDASE

Total bilirubin of adult in the serum

0.2-1.0 mg/dL

It is conjugated bilirubin tightly bound to albumin

DELTA

Metabolically inactive form of bilirubin

DELTA

It is formed due to prolonged elevation of conjugated bilirubin in biliary obstruction

DELTA

Occurs when the problem causing the jaundice occurs prior to liver metabolism

PREHEPATIC JAUNDICE, UNCONJUGATED HYPERBILIRUBINEMIA

Prehepatic jaundice bilirubin assay

ELEVATED INDIRECT BILIRUBIN

Elevated RBC Destruction

HEPATIC ANEMIA

Occurs when the primary problem causing the jaundice resides in the liver

HEPATIC JAUNDICE, INTRINSIC LIVER DEFECT

The caused of hepatic jaundice which is the failure of bile to flow to the intestine

IMPAIRED BILIRUBIN EXCRETION

Hepatic jaunidce bilirubin assay

ELEVATED DIRECT BILIRUBIN

Results from a genetic mutation in the UGT1A1 gene that produces the enzyme UDPGT

GILBERT'S SYNDROME

Bilirubin transport deficit/Intermittent Unconjugated hyperbilirubinemia

GILBERT'S SYNDROME

This characterized by impaired cellular uptake of bilirubin

GILBERT'S SYNDROME

Chronic nonhemolytic unconjugated hyperbilirubinemia

CRIGLER NAJJAR SYNDROME

CRIGLER NAJJAR SYNDROME that characterizes complete absence of enzymatic bilirubin conjugation

TYPE I

CRIGLER NAJJAR SYNDROME that characterizes mutation causing severe deficiency of UDPGT responsible for bilirubin conjugation

TYPE II

Caused by a deficiency of the canalicular multidrug resistance/multispecific organic anionic transporter protein (MDR2/cMOAT)

DUBIN JOHNSON SYNDROME

Due to a reduction in the concentration or activity or intracellular binding protein such as ligandin

ROTOR SYNDROME

Transport defect that characterizes dark stain sample

DUBIN JOHNSON SYNDROME

Transport disorder which does not show pigmented granules

ROTOR SYNDROME

Physiologic Jaundice mostly found in newborns

UNCONJUGATED HYPERBILIRUBINEMIA

Deposition of bilirubin in the nuclei of brain and nerve cells resulting in cell damage and death in the newborn

KERNICTERUS

An enzyme which serves as one of the last live function to be activated in prenatal life

GLUCURONYL TRANSFERASE

Results from biliary obstructive disease (eg. gallstones and tumors) which may induce clay colored stool

POSTHEPATIC JAUNDICE

Kernicterus/Physiologic jaundice treatment

UV RADIATION, EXCHANGE TRANSCRIPTION

The gene that causes GILBERTS SYNDROME Enzyme produced

URIDINE DIPHOSPHOGLUCOSE GLUCURONYLTRANSFERASE, URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE

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