問題一覧
1
Migrates ahead of albumin in the classic electrophoresis of serum or plasma proteins
PRE ALBUMIN
2
PRE-ALBUMIN Transport of thyroid hormones
THYROXINE, TRIIODOTHYRONINE
3
PRE-ALBUMIN Binds with retinol-binding protein to form complex that transports
RETINOL
4
PRE-ALBUMIN is rich in
TRYPTOPHAN, 0.5% CARBOHYDRATE
5
A low pre-albumin level is a sensitive marker o
POOR NUTRITIONAL STATUS
6
Largest plasma protein fraction (52-62%)
ALBUMIN
7
ALBUMIN Synthesized in the _ at a rate that is dependent on protein intake
LIVER
8
Serves as circulating reservoir of amino acids, Regulator of osmotic pressure (fluid balance), and Transport protein because of ease of binding with blood components
ALBUMIN
9
INHIBITOR /MEDIATOR of inflammator processes
NEGATIVE ACUTE PHASE REACTANT
10
Albumin _ in cases of acute inflammatory processes
DECREASES
11
ALBUMIN REFERENCE VALUES
35-50 g/L
12
Hemoconcentration, dehydration W No clinical significance
HYPERALBUMINEMIA
13
Impaired synthesis (1o= liver disease; 2o= diminished protein intake due Malabsorption or malnutrition and Nephrotic syndrome (renal loss)
HYPORALBUMINEMIA
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Heterogenous complex mixture of protein molecules (α1, α2, β and γ fractions)
GLOBULIN
15
Normal A/G ratio:
1.3-3:1
16
GLOBULIN Measurement formula
TOTAL PROTEIN-ALBUMIN
17
Inhibits protease neutrophil elastase to combat infections but destroy alveoli which can lead to emphysema
a-1-ANTITRYPSIN
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a-1-ANTITRYPSIN Prevents self-destruction of tissues by inhibiting
PROTEASE NEUTROPHIL ELASTASE
19
a-1-ANTITRYPSIN increases
INFLAMMATION, PREGNANCY, CONTRACEPTIVE USE
20
Most abundant protein in the fetal serum and Increased in amniotic fluid and maternal serum in neural tube defects (spina bifida)
a-1-FETOPROTEIN
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neural tube defects
SPINA BIFIDA
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a-1-FETOPROTEIN Detectable in the maternal blood up to _ month of pregnancy then peak in the fetus at _ weeks of gestation
7th or 8th, 13
23
a-1-FETOPROTEIN Used as a tumor marker in
HEPATIC, GONADAL CA
24
a-1-FETOPROTEIN decreases in Trisomy
18 and 21
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OROSOMUCOID is also known as
a-1-ACID GLYCOPROTEIN
26
Contains high percentage of CHO and sialic acid (45% CHO + 11-12% Sialic acid) Synthesized both by the liver & by granulocytes and monocytes
OROSOMUCOID
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Inhibits the phagocytic activity of neutrophils & inhibits platelet aggregation May inactivate progesterone
OROSOMUCOID
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OROSOMUCOID Decreased in
NEPHROTIC SYNDROME
29
tetramer (two α and two β chains) synthesized in the hepatocytes, an acute-phase protein
HAPTOGLOBIN
30
Copper-containing protein BUT does NOT transport copper; synthesized in the liver, where 6-8 copper atoms are attached • Acute phase reactant • Imparts a blue color to protein
CERULOPLASMIN
31
Ceruloplasmin Marker of _ measuring _
WILSON'S DISEASE, 0.1 g/L
32
Total copper serum is decrease but Urine copper level is increase
WILSON'S DISEASE
33
Copper deposits in the cornea
KAYSER FLEISCHER RING
34
Orosomucoid contains
45% CHO, 11-12% SIALIC ACID