ENZYME VARIANTS

Jef Marc Valencia · 73問 · 2年前

通報

問題一覧

Refers to the different forms of the same enzyme that exist in an organism

ENZYME VARIANT

Structurally distinct forms of an enzyme that catalyzes the same reaction

ISOENZYME, ISOZYME

Isoenzyme are usually____multimeric proteins composed of different combinatios of subunits

MULTICHAINED

Isoenzymes are often differ in

AMINO ACID COMPOSITION, KINETIC PROPERTIES, PHYSICAL PROPERTIES

What is the key features of isoenzymes

FOUND IN SPECIFIC TISSUE, ORGAN, CELL ORGANELLE

Km is also known as

MICHAELIS CONSTANT

Kinetic properties of isoenzymes are measured in

KM, VMAX

Physical properties of isoenzymes are measured in

ELECTROPHORETIC MOBILITY, PH STABILITY

Tissue specificity of LDH-1

HEART

Tissue specificity of LDH-5

LIVER, SKELETAL MUSCLE

Creatine kinase isoenzyme specific to skeletal muscle

CK-MM

Creatine kinase isoenzyme specific to heart

CK-MB

Creatine kinase isoenzyme specific to brain

CK-BB

Enzyme used to differentiate liver Vs bone disease

ALKALINE PHOSPHATASE

Different isoenzyme of alkaline phosphatase

LIVER, BONE, PLACENTAL

Enzyme used to assess pancreatic disorder

AMYLASE

Characteristics of isoenzymes

ELECTROPHORETIC MOBILITY, ION EXCHANGE RESIN MOBILITY, RESPONSE TO SPECIFIC INHIBITOR, RELATIVE SUBSTRATE SPECIFITIES

Characteristics of isoenzyme which differ in net charge and size affecting how they migrate in an electric field

ELECTROPHORETIC MOBILITY

Characteristics of isoenzyme which binds differently due to variation in surface charge, allowing for fractionation and identification

ION EXCHANGE RESIN MOBILITY

Enzymes of similar catalytic activity but are specie specific

HETEROENZYME

Importance of heteroenzyme

COMPARATIVE ENZYMOLOGY, IMMUNOLOGIC STUDY, THERAPEUTIC DEVELOPMENT

Used to differentiate RBC ACP and Prostatic ACP

2% FORMALIN

Which ACP inhibit 2% formalin

RBC ACP

Genetically transmitted enzyme important in defining biochemical characteristics of an individual

ALLOENZYME

Stable and active generally secreted by the liver directly to the plasma

PLASMA SPECIFIC ENZYME

Examples of plasma specific enzyme

COAGULATION ENZYME, COMPLEMENT ENZYME, LIPOPROTEIN LIPASE

Enzymes mostly originated from cells or tissues, and their presence in plasma is typically due to cell injury, secretion, or turnover

NON PLASMA SPECIFIC ENZYME

Secreted into plasma at high rate but also rapidly cleared

ENZYME OF SECRETION

Examples of enzyme of secretion

AMYLASE, LIPASE

Perform metabolic functions inside the cells where they are synthesized and usually released into plasma only when cells are damaged orr undergo necrosis

ENZYME ASSOCIATED WITH CELLULAR METABOLISM

Examples of enzyme associated with cellular metabolism

ALT, AST

Enzymes that are found in only one specific cellular location and involved in cytosolic metabolism such as alkaline phosphatase

UNILOCULAR ENZYME

Enzymes that are distributed in 2 distinct cellular compartments

BILOCULAR ENZYME

Location of unilocular enzyme

CELL SAP

Location of bilocular enzyme

CELL SAP, MITOCHONDRIA

Example of bilocular enzyme

ADENYLATE KINASE

Enzyme kinetics which is unchanges acts as catalyst

ENZYME

Enzyme kinetics which is molecule acted upon

SUBSTRATE

Enzyme kinetics which is temporary intermediate

ENZYME SUBSTRATE COMPLEX

Enzyme kinetics which is transformed substrate

PRODUCT

Enzyme responsible for clot formation

SERINE PROTEASE

COMPH Lesson 5

COMPH Lesson 5

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Discussion 1

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Dis 1

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Researcj Design

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Dis 1 mid

Dis 1 mid

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COMPM LESSON 6-7

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Discussion -2 Six Sigma

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Sigma Levels

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PROTEINS

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PROTEIN 2

PROTEIN 2

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PROTEIN 3

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NPN

NPN

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NPN 2

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Materials management

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Liver

Liver

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LESSON 10

LESSON 10

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hyperlipoproteinemia

hyperlipoproteinemia

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THE SPIROCHETES

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PYOGENIC GRAM POSTIVE

PYOGENIC GRAM POSTIVE

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Introduction

Introduction

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Introduction Page 2

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Introduction pg 3

Introduction pg 3

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NK-Immunity

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meet 2

meet 2

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discussion 3

discussion 3

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dis 1

dis 1

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Immuno vs anti

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Immune 3

Immune 3

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dis 4

dis 4

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dis 5

dis 5

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FIXATIVES

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Long discussion 1

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lactate dehydrogenase

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FIXATIVES-METALLIC

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FIXATIVES-CHROMATE

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Specialized Macrophages

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LYMPHOPOIESIS

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immune 4

immune 4

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Immunoglobulins

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ARTIFACTS

ARTIFACTS

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FIXATIVES QUIZ COPY

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MAJOR HISTOCOMPATIBILITY

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Introduction

Introduction

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OTHERS-FIXATIVES

OTHERS-FIXATIVES

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MEGAKARYOPOLESIS

MEGAKARYOPOLESIS

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DECALCIFICATION

DECALCIFICATION

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DEHYDRATION

DEHYDRATION

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Blood Specimen Collection

Blood Specimen Collection

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CLEARING

CLEARING

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CEARING AGENT

CEARING AGENT

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INTRODUCTION

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Introduction

Introduction

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Methods of Determination

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ASPARTATE AMINOTRANSFERASE

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ALANINE AMINOTRANSFERASE

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ACID PHOSPHATASE

ACID PHOSPHATASE

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