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HEMOGLOBIN

  • Jef Marc Valencia

    • 問題数 100 • 10/4/2025

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  • 1

    Components of Hemoglobin

    GLOBIN, HEME, 2,3 BIPHOSPHOGLYCERATE

  • 2

    Composed of 2 sets of 2 different polypeptide chains

    GLOBIN

  • 3

    Heme group are composed of

    4 PROTOPORPHYRIN IX, 4 FERROUS

  • 4

    Globin chains produced only in embryonic stage

    EPSILON, ZETA

  • 5

    Globin chains containing only 141 amino acids

    ALPHA, ZETA

  • 6

    Globin chains containing 146 amino acids

    BETA, DELTA, GAMMA, EPSILON

  • 7

    Globin chains produced only in adult stage

    ALPHA, BETA, DELTA, GAMMA

  • 8

    Globin chain which has unknown numbver of amino acids

    THETA

  • 9

    Consists of a ring of carbon, hydrogen and nitrogen which central atom of divalent ferrous iron

    PROTOPORPHYRIN IX

  • 10

    Protoporphyrin IX is consist also w/ how many what rings aside form carbon rings

    4 PYRROLE RING

  • 11

    Iron state which could bind to oxygen

    FERROUS, FE2++

  • 12

    Iron state which cannot bind to oxygen

    FERRIC, FE3+

  • 13

    Heme production begins and end at

    MITOCHONDRIA

  • 14

    Heme production starts with glycine+succinyl CoA with the action of ALA synthase to produce

    AMINOLEVULENIC ACID

  • 15

    ALA dehydratase converts aminolevulenic acid in the cytosol forming

    PORPHOBILINOGEN

  • 16

    This enzyme converts coproporphyrinogen III into protoporphyrinogen IX

    COPROPORPHYRINOGEN OXIDASE

  • 17

    This stage of heme production awaits for iron to be incorporated

    PROTOPORPHYRIN IX

  • 18

    This enzyme converts protoporphyrin IX into Heme

    FERROCHELATASE, HEME SYNTHASE

  • 19

    Carries ferric into the mitochondria

    TRANSFERRIN

  • 20

    Ferric reduce to ferrous state in the

    CYTOSOL

  • 21

    Component of hemoglobin which decreases affinity of Oxygen to Hemoglobin

    2,3 DIPHOSPHOGLYCERATE

  • 22

    What is the end product of Embden Meyerhof pathway

    LACTATE, PYRUVATE

  • 23

    Pathway which anaerobic glycolysis happens preserve oxygen in hemoglobin

    EMBDEN MEYERHOF PATHWAY

  • 24

    Pathway which 2,3 DPG is produced

    RAPOPORT LUEBERING PATHWAY

  • 25

    Also known as ___ which main product is reduced glutathione

    HEXOSE MONOPHOSPHATE SHUNT, PENTOSE PHOSPHATE PATHWAY

  • 26

    Form of hemoglobin without 2,3 DPG increasing in the affinity of O2

    RELAX FORM

  • 27

    Form of hemoglobin w/ 2,3 DPG that forces O2 out of the hemoglobin

    TENSE FORM

  • 28

    Environment conditions which Tense form of hemoglobin is usually observed

    ALKALINE

  • 29

    These are bridges between the 2,3 DPG and globin chains

    SALT BRIDGE

  • 30

    How many globin, heme and mols of oxygen does 1 hemoglobin holds

    4

  • 31

    Hemoglobin produced in embryonic stages

    GOWER 1, GOWER 2, PORTLAND

  • 32

    Hemoglobin produced in newborn and adults

    FETAL HEMOGLOBIN, HEMOGLOBIN A1, HEMOGLOBIN A2

  • 33

    Components of Gower 1

    2 ZETA, 2 EPSILON

  • 34

    Portland components

    2 ZETA, 2 GAMMA

  • 35

    Components of Gower 2

    2 ALPHA, 2 EPSILON

  • 36

    Fetal hemoglobin components

    2 ALPHA, 2 GAMMA

  • 37

    Hemoglobin A1 components

    2 ALPHA, 2 BETA

  • 38

    Hemoglobin A2 components

    2 ALPHA, 2 DELTA

  • 39

    Embryonic hemoglobins are produced in the first __months after conception

    3

  • 40

    Analoque of Alpha chain

    ZETA CHAIN

  • 41

    Counterpart of the Y, B, and Z

    EPSILON CHAIN

  • 42

    Major Hemoglobin of the fetus and the newborn infant that is acid and alkali resistant

    FETAL HEMOGLOBIN

  • 43

    Test used to measure HbF

    ALKALI DENATURATION, KLEIHAUER BETKE ACID ELUTION

  • 44

    Positive result color for HbF in Sodium hydroxide test

    PINK

  • 45

    Negative result color for HbF

    BROWN

  • 46

    6 months after birth, HbF would less than

    8%

  • 47

    2 years after birth, HbF would less than

    2%

  • 48

    Adult HbF would less than

    1%

  • 49

    Organ that primarily responsible for producing HbF

    LIVER

  • 50

    Organ primarily responsible for producing HbA1

    BONE MARROW

  • 51

    Normal percentage volume for HbA1

    97%

  • 52

    Normal percentage volume for HbA2

    2%, 1.5-3.5%

  • 53

    HbA2 is increased in cases of

    B-THALASSEMIA, HYPERTHYROIDISM, MEGALOBLASTIC ANEMIA

  • 54

    A type of anemia that decreases production of globin chains due to deletion of Beta chain

    B-THALASSEMIA

  • 55

    Normal value of hemoglobin for males

    140-175 G/L

  • 56

    Normal value of hemoglobin for females

    123-153 G/L

  • 57

    Normal value of hemoglobin at birth

    150-200 G/L

  • 58

    Normal RBC formed when the RBCs pass through the alveolar capillaries of the lungs

    OXYHEMOGLOBIN, HBO2

  • 59

    Normal RBC w/ high affinity of oxygen tension and alkaline pH

    OXYHEMOGLOBIN, HBO2

  • 60

    What is the color of Oxyhemoglobin

    BRIGHT RED

  • 61

    Normal reduced form of Hemoglobin w/ acidic pH, and decrease O2 tension, and affinity to Oxygen

    DEOXYHEMOGLOBIN

  • 62

    Carbon Dioxide binds to the free amino group of the hemoglobin to form

    CARBAMINOHEMOGLOBIN

  • 63

    What is the normal color of deoxyhemoglobin

    DARK RED

  • 64

    Abnormal hemoglobin which oxygen molecules bound to heme are replaced by carbon monoxide

    CARBOXYHEMOGLOBIN, HBCO

  • 65

    Element present in carboxyhemoglobin which is 200 times higher affinity to hemoglobin than O2

    CARBON MONOXIDE

  • 66

    Chief sources of Carbon monoxide

    AUTOMOBILE EXHAUST, INDUSTRIAL WASTE, TOBACCO SMOKING

  • 67

    Percentage of endogenous sources of carbon monoxide

    <1%

  • 68

    Abnormal hemoglobin which may cause irreversible tissue changes due to asphyxiation

    CARBOXYHEMOGLOBIN, HBCO

  • 69

    Critical value of Carboxyhemoglobin

    5G/100ML

  • 70

    Percentage of Carboxyhemoglobin which may cause asphyxiation

    >50-70%

  • 71

    Treatment for Carboxyhemoglobin

    PURE OXYGEN ADMINISTRATION, HYPERBARBARIC OXYGEN THERAPY

  • 72

    Absorption wavelength of Carboxyhemoglobin

    576 NM

  • 73

    Rapid test for Carboxyhemoglobin

    SODIUM HYDROXIDE TEST, DILUTION TEST, TANNIC ACID TEST

  • 74

    Reagent used for Sodium Hydroxide Test

    40% SODIUM HYDROXIDE, EDTA BLOOD

  • 75

    Positive result for Sodium Hydroxide test

    RED

  • 76

    Negative result for Sodium Hydroxide test

    BLACK BROWN

  • 77

    How many ml of water is used in Dilution test for Carboxyhemoglobin

    50ML

  • 78

    Positive result for Dilution Test for carboxyhemoglobin

    CHERRY RED

  • 79

    Negative result for Dilution test for Carboxyhemoglobin

    YELLOWISH RED

  • 80

    Positive result for Tannic Acid test for carboxyhemoglobin

    RED PPT

  • 81

    Negative result for Tannic Acid test for Carboxyhemoglobin

    BLACK BROWN DISCOLORATION

  • 82

    Abnormal hemoglobin which iron in the Hb molecule is in the ferric state stead of ferroys state leading to incapacity to bind w/ oxygen

    METHEMOGLOBIN, HEMIGLOBIN, HI

  • 83

    Normal percentage of Methemoglobin

    1.5%

  • 84

    Daily accumulation percentage of Methemoglobin

    0.5-3%

  • 85

    Critical value of Methemoglobin that may leads to cyanosis

    >1.5 G/DL, 10%

  • 86

    Color of methemoglobin

    CHOCOLATE BROWN

  • 87

    Abnormal hemoglobin which has strong affinity with cyanide hemicyanide

    METHEMOGLOBIN

  • 88

    Absorption wavelength of Methemoglobin

    630-635 NM

  • 89

    Mosy Iron in the body must be in __to binds w/ oxygen for transport to lungs and body tissues

    FERROUS

  • 90

    Ferric iron is not able to bind hemoglobin but binds to ___

    TRANSFERRIN

  • 91

    Measures the amount of Ferric iron bound to transferrin

    SERUM IRON

  • 92

    Indirect measurement of transferrin and total amount of iron that transferron can bind when fully saturated

    TOTAL IRON BINDING CAPACITY

  • 93

    Indirect measurement of storage iron in tissues and Bone Marrow

    SERUM FERRITIN

  • 94

    Production of these compounds maintain hemoglobin in the normal reduced state

    DIPHOSPHOPYRIDINE DINUCLEOTIDE, TRIPHOSPHOPYRIDINE NUCLEOTIDE, ASCORBIC ACID

  • 95

    Inherited Enzyme deficiency Condition that causes Methemoglobinemia

    DIAPHORASE DEFICIENCY

  • 96

    Results of various amino acid substitutions in the globin chain that directly affect the heme group

    INHERITED METHEMOGLOBINEMIA

  • 97

    Chemical and therapeutic agents may cause acquired methemoglobinemia

    ANILINE DYE, NO3, NO2, ANTIMALARIAL DRUG, SULFONAMIDE

  • 98

    Therapy for methemoglobinemia

    ASCORBIC ACID, METHYLTHIONIMIUM CL

  • 99

    Abnormal hemoglobin that cannot be revert back to oxyhemoglobin even the use of Cyanmethemoglobin

    SULFHEMOGLOBIN

  • 100

    Oxidant drug that causes Sulfhemoglobin

    PHENACETIN, ACETANILID, SULFONAMIDE

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    問題数 172025/03/18

    CAST-MCQ

    問題数 732025/03/29

    CRYSTALS-MCQ

    問題数 722025/03/30

    Table Uric Acid Vs Cystine

    問題数 102025/03/08

    DIOECIOUS

    問題数 782025/03/22

    RENAL DISORDERS-MCQ

    問題数 642025/03/30

    STONES-MCQ

    問題数 192025/03/30

    Signs and Symptoms and Tables of Renal Disorder

    問題数 422025/04/03

    CHROMOSOME SHITS

    問題数 242025/04/02

    METABOLIC DISORDER-MCQ

    問題数 742025/04/03

    TABULATED METABOLIC DISORDER

    問題数 192025/04/03

    FECAL ANALYSIS-MCQ

    問題数 862025/04/03

    BRISTOL STOOL CHART

    問題数 72025/04/03

    FECALYSIS CHEMICAL EXAMINATION

    問題数 512025/04/03

    BIOLOGICAL PREGNANCY TEST

    問題数 62025/03/31

    SPERM

    問題数 632025/04/22

    SPERM 2

    問題数 692025/04/22

    Fructose test table

    問題数 52025/04/22

    Sperm motility table

    問題数 82025/04/22

    PROTOZOAN

    問題数 812025/04/24

    CSF

    問題数 962025/04/29

    AMOEBA

    問題数 222025/04/29

    MCQ-CHEMICAL EXAMINATION OF URINE PART 2

    問題数 792025/05/03

    PERICARDIAL FLUID

    問題数 662025/05/04

    MCQ-SPERM

    問題数 592025/05/03

    MCQ-SPERM 2

    問題数 882025/05/03

    MCQ-AMNIOTIC FLUID

    問題数 732025/05/08

    HEMOFLAGELLATES

    問題数 682025/05/04

    Sex disorder

    問題数 602025/05/05

    NEMATODES

    問題数 62025/05/06

    MCQ-PERICARDIAL FLUID

    問題数 592025/05/11

    PHASMID NEMATODES

    問題数 52025/05/06

    HOOKWORMS

    問題数 92025/05/06

    MCQ-CSF

    問題数 942025/05/03

    BLOOD AND TISSUE NEMATODE

    問題数 82025/05/06

    PLATYHELMINTHS

    問題数 132025/05/06

    MCQ-CSF2

    問題数 242025/05/03

    TREMATODES

    問題数 72025/05/06

    INTRODUCTION

    問題数 362025/06/10

    INTRODUCTION TABLE

    問題数 412025/06/10

    CLASSFICATION OF ENZYME

    問題数 472025/06/11

    ENZYME VARIANTS

    問題数 412025/06/11

    FACTORS AFFECTING ENZYME ACTIVITY

    問題数 902025/06/12

    INTRODUCTION TO ENZYMOLOGY-MCQ

    問題数 412025/06/26

    CLASS AND VARIANT OF ENZYME-MCQ

    問題数 772025/06/26

    PITUITARY GLAND PART 2

    問題数 52025/07/04

    THYROID GLAND

    問題数 712025/07/04

    PARATHYROID GLAND

    問題数 122025/07/04

    ADRENAL GLAND

    問題数 772025/07/04

    SEX GLANDS

    問題数 352025/07/04

    OTHER GLANDS

    問題数 82025/07/04

    ACID BASE BALANCE

    問題数 512025/07/10

    TRACE ELEMENT

    問題数 792025/07/10

    VITAMINS

    問題数 272025/07/10

    TUMOR MARKERS

    問題数 252025/07/10

    TOXICOLOGY

    問題数 722025/07/13

    DRUG OF ABUSE

    問題数 952025/07/13

    TOXINS

    問題数 572025/07/13

    TDM

    問題数 942025/07/13

    ENDOCRINOLOGY

    問題数 962025/07/16

    ENDROCRINOLOGY PART 2

    問題数 462025/07/16

    FACTORS AFFECTING ENZYME ACTIVITY-MCQ

    問題数 892025/07/17

    ENZYME OF CLINICAL SIGNIFICANCE-MCQ

    問題数 992025/07/17

    ENZYME OF CLINICAL SIGNIFICANCE-MCQ2

    問題数 872025/07/18

    MEDICAL TERMINOLOGIES

    問題数 362025/08/17

    INTRODUCTION TO HEMA 1

    問題数 292025/08/17

    LABORATORY SAFETY

    問題数 232025/08/18

    TERMINOLOGIES

    問題数 512025/08/21

    LABORATORY 1

    問題数 182025/08/22

    LABORATORY 3

    問題数 532025/08/22

    HEMATOPOIESIS

    問題数 622025/08/23

    THEORIES ON BLOOD FORMATION

    問題数 552025/08/30

    ERYTHROPOIESIS

    問題数 462025/08/30

    LEUKOPOIESIS

    問題数 1002025/08/30

    LEUKOPOIESIS II AND MONOPOIESIS

    問題数 422025/09/01

    INTRODUCTION TO MYCOLOGY MCQ

    問題数 322025/09/24

    MYCOLOGY PROPER

    問題数 712025/09/01

    FUNGAL PATHOGENESIS

    問題数 352025/09/01

    CLASSIFICATION OF FUNGI

    問題数 452025/09/06

    SPECIMEN COLLECTION, CULTURE, AND COLONIAL CHARACTERISTICS

    問題数 742025/09/06

    MICROSCOPIC STUDY, CULTURE EXAMINATION, AND PRESERVATION OF FUNGI

    問題数 542025/09/06

    Mind mapping

    問題数 92025/09/07

    INTRODUCTION TO MYCOLOGY MCQ

    問題数 322025/09/13

    MYCOLOGY PROPER MCQ

    問題数 592025/09/13

    FUNGAL PATHOGENESIS MCQ

    問題数 372025/09/13

    CLASSIFICATION OF FUNGI MCQ

    問題数 332025/09/13

    SPECIMEN COLLECTION, CULTURE, AND COLONIAL CHARACTERISTICS MCQ

    問題数 742025/09/13

    MCQ-MICROSCOPIC STUDY, CULTURE EXAMINATION, AND PRESERVATION OF FUNGI

    問題数 532025/09/14

    THE SUPEFICIAL FUNGI

    問題数 342025/09/12

    THE CUTANEOUS FUNGI

    問題数 582025/09/13

    SUBCUTANEOUS FUNGI

    問題数 552025/09/13

    SYSTEMIC FUNGI

    問題数 282025/09/13

    LYMPHOPOIESIS

    問題数 442025/09/07

    MEGAKARYOPOIESIS

    問題数 342025/09/07

    INTRODUCTION TO HEMA1 MCQ

    問題数 452025/09/10

    HEMATOPOIESIS

    問題数 582025/09/14

    THEORIES ON BLOOD FORMATION

    問題数 462025/09/14

    ERYTHROPOIESIS MCQ

    問題数 412025/09/14

    LEUKOPOIESIS MCQ

    問題数 942025/09/10

    LEUKOPOIESIS II AND MONOPOIESIS MCQ

    問題数 392025/09/14

    LYMPHOPOIESIS MCQ

    問題数 392025/09/10

    MEGAKARYOPOIESIS MCQ

    問題数 392025/09/10

    BLOOD COLLECTION

    問題数 352025/09/10

    LABORATORY SAFETY

    問題数 212025/09/17

    LABORATORY 1

    問題数 162025/09/17

    LABORATORY 3

    問題数 472025/09/17

    BLOOD COLLECTION MCQ

    問題数 792025/09/17

    DEMATIACEOUS OPPORTUNISTIC FUNGI

    問題数 522025/09/30

    PENICILLUS

    問題数 212025/10/08

    HYALINE SEPTATE GROUP W/ CONIDIA IN CLUSTER

    問題数 162025/10/08

    HYALINE SEPTATE GROUP W/ CONIDIA BORNE SINGLY

    問題数 122025/10/08

    ZYGOMYCETE/HYALINE SEPTATE GROUP

    問題数 492025/10/08

    YEAST AND YEAST LIKE ORGANISMS

    問題数 722025/10/15

    HEMOCYTOMETRY

    問題数 832025/10/03

    HEMOGLOBIN PART 2

    問題数 262025/10/05

    OXYGEN DISSOCIATION CURVE

    問題数 282025/10/14

    QUANTIFICATION OF HBF

    問題数 762025/10/12

    YEAST AND YEAST LIKE ORGANISMS

    問題数 702025/10/26