CSF

Jef Marc Valencia · 73問 · 2年前

通報

問題一覧

A major fluid of the body

CEREBROSPINAL FLUID

3 layers of the meninges

DURA MATER, ARACHNOID MATER, PIA MATER

Tough outermost layer lining the skull and vertebral canal

DURA MATER

Middle spiderweblike filamentous membrane

ARACHNOID MATER

Thin delicate innermost membrane closely adhering to the brain and spinal cord surfaces

PIA MATER

Space between the arachnoid and pia mater containing CSF

SUBARACHNOID SPACE

CSF is primarily produced by the

CHOROID PLEXUS

Choroid plexus are located in what part of Brain ventricles

LATERAL, 3RD, 4TH

How many CSF is produced per hour by adults

20 ML

Total volume of csf in adults

90-150 ML

Total volume of csf in neonates

10-60 ML

Function as one way valves preventing reflux which reabsorbed CSF into bloodstream

ARACHNOID GRANULATION, VILLAE

Formed by tight junctions in the choroid plexus endothelial cells restricting passange of many substances in the brain

BLOOD BRAIN BARRIER

Choroid plexus forms CSF by

SELECTIVE FILTRATION, ACTIVE SECRETION FROM PLASMA

Done in neonates w/ open fontanels

VENTRICULAR CANNULATION

Done in case of lumbar puncture failure

CISTERNAL PUNCTURE

Cisternal puncture are collected from the

SUBOCCIPITAL REGION

It is the pool of CSF collection are the cerebral medulla area

CISTERNA MAGNA

Cisterna magna is also known as

CEREBRAL MEDULLARY CISTERN

Trajectory of needle during Cisternal puncture

UPWARD, FORWARD

Risk of Cisternal puncure causing paralysis or in cases death

MEDULLA OBLONGATA

Most c'mon method for CSF collection

LUMBAR TAP, LUMBAR PUNCTURE

Advaantage of lumbar tap

CHEMOTHERAPY

Risk of Lumbar tap

10% PATIENT SUFFER HEADACHE

Medications that should be avoided prior to CSF collection

ASPIRIN, WARFARIN

Site of collection for adult lumbar tap

3RD OR 4TH LUMBAR INTERSPACE

Site of collection for children lumbar tap

4TH OR 5TH LUMBAR INTERSPACE

Antiseptic used for lumbar tap

POVIDONE IODINE

This indicates that the spinal needle penetrates Dura mater

POP

CSF presssure is measured using___ before aspiration

MANOMETER

Normal CSF pressure in lateral position

50-180 MMHG

How many percent of CSF total of 20 ml total volume

15%

How many ml of csf is collected if normal pressure of csf is not obtain

2 ML

How many minutes does csf collection takes

15-30 MINS

Normal CSF pressure after collection

<10-30 MMHG

CSF order of draw lab sections

CHEMISTRY AND SEROLOGIC TEST, MICROBIAL TEST, MICROSCOPIC EXAMINATION

Order of draw for low volume

MICROBIAL TEST, HEMATOLOGY TEST, CHEMISTRY AND IMMUNOLOGIC TEST

Normal color of CSF

COLORLESS

Normal transparency of CSF

CLEAR, TRANSPARENT

Normal viscosity of CSF

WATER

Normal Specific gravity of CSF

1.006-1.008

Dtermination of chemical composition that is regulated by BBB

CHEMICAL EXAMINATION

Mostly frequently performed chemical test on CSF

PROTEIN

Normal of protein fpr 6 mos.- adults

15-45 MG/DL

Normal value of CSF protein in newborn

75-150 MG/DL

Normal value of CSF protein in >60 yrs old

>60 MG/DL

Major protein in the CSF

ALBUMIN

2nd protein in the CSF

PREALBUMIN

Alpha globulins of CSF

HAPTOGLOBIN, CERULOPLASMIN

Protein not normaly found in proteins

IGM, FIBRINOGEN BETA LIPOPROTEIN

Clinical significance of presence of protein in the CSF

MENINGITIS, HEMORRHAGE

Quantitative test for proteinsin in CSF

TURBIDIMETRIC, DYE BINDING, ELECTROPHORESIS

Incorporated w/ automated machines which uses precipitating agents

TURBIDIMETRIC

Reagent of choice for turbidimetric method that precipitates albumin and globulins

TRICHLOROACETIC ACID

Precipitates albumin only unless Sodium sulfate is added

SULFOSALICYLIC ACID

A test for CSF Protein determination which based on the principle pf protein error of indicators

DYE BINDING

Dyes uses in dye binding method

COOMASSIE BRILIANT BLUE, PONCEAU S

Most frequent method for CSF protein determination and TAU identification

ELECTROPHORESIS

What is being detected in the Electrophoresis method of CSF protein determination

OLIGOCLONAL BAND

Enter CSF by selective transport across BBB

GLUCOSE

Normal value of CSF glucose in adults

60-70% OF PLASMA GLUCOSE

Normal value of CSF glucose in Neonates

80% OF PLASMA GLUCOSE

How many hours is plasma sample should be withdrawn prior to spinal tap

2 HOUR

Aids in the diagnosis and management of meningitis and also to evaluate antibiotic therapy

LACTATE

Value of CSF Lactate indication viral meningitis

<25 MG/DL

Value of CSF Lactate indication tubercular and fungal meningitis

>25 MG/DL

Value of CSF Lactate indication bacterial meningitis

>35 MG/DL

Produce from ammonia and alpha ghetto glutarate by the brain cells which witch serves to remove the toxic metabolic waste product ammonia from the cns

GLUTAMINE

Normal concentration glutamine csf

8-18 MG/DL

Level of glutamine csf which indicates disturbance consciousness

>35 MG/DL

Disease which 75% of the diagnosed children are positive for csf glutamine

REYS SYNDROME

Aids in the diagnosis of meningitis

LACTATE DEHYDROGENASE

Volume of ckbb in post cardiac arrest indicating poor prognosis

>17 MG/DL

Volume of ckbB indicating recovery from cardiac arrest after resuscitatioB

<17 MG/DL

Duration of incubation for the material meningitis csf

24 HOUR

Duration of tubercular meningitis for csf microculture

6 WEEK

The sensitivity of micro csf culture

80-90%

Mediums used for culture in csf microbio

THIOGLYCOLATE BROTH, CHOCOLATE AGAR

Routinely perform on csf from all suspected cases of meningitis

GRAM STAINING

This bacteria has a starburst pattern

CRYPTOCOCCUS NEOFORMAN

Perform when tubercular meningitis is suspected

ACID FAST, FLUORESCENT ANTIBODY STAIN

It detects the presence of thickly encapsulated cryptococcus neoformance

INDIA INK

The positive result for india ink

LARGE ROUND YEAST WITH HALO

This is more sensitive method in the detection of cryptococcus neoformance in serum and csf

REVERSE LATEX AGGLUTINATION

Serologic test for micro csf used in combination with hematology and clinical chemistry result

BACTERIAL ANTIGEN TEST

Diagnosis of meningitis caused by gram-negative organisms

LIMULUS LYSATE TEST

The reagent use in limulus lysate test

AMEBOCYTE OF HORSEHOW CRAB

The positive result of limulus lysate test

BLUE

Perform for the diagnosis of neurosyphilis

VENEREAL DISEASE RESEARCH LABORATORY

Sensitive and specific syphilis diagnosis

FLUORESCENT TREPONEMAL ANTIBODY ABSORPTION

Refers to the increased amount of wbcs in body fluid

PLEOCYTOSIS

This is performed when there is a traumatic tap

RBC COUNT

What is the diluent used for the total cell count in csf

NORMAL SALINE SOLUTION

Lactate dehydrogenase isoenzyme which may indicates brain tissue destruction

LD1, LD2

Lactate dehydrogenase isoenzyme which indicates viral meningitis

LD2, LD3

Lactate dehydrogenase isoenzyme which may indicate bacterial meningitis

LD4, LD5

COMPH Lesson 5

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dis 5

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