Selective destruction of the insulin producing b cells of the islets of Langerhans in the pancreas

Chronic systemic inflammatory disorder in which joint cartilage ligaments and tendons are destroyed

Immune complexes are formed and these lodge in the basement membrane of kidney skin and joints

Unregulated secretion of T3 and T4 due to stimulation of TSH receptor by antibody

Destruction of the thyroid gland

Destruction of the parietal cells of the stomach mucosa leading to intrinsic factor defieciency

Antibodies involved in DM1

Antibodies involved in Graves disease

Antibodies involved in Hashimotos Thyroiditis

Antibodies involved in Pernicious Anemia

Most specific antibody for Systemic Lupus Erythematosus

HLA associated to RA

HLA associated in SLE

HLA associated in Scleroderma

HLA associated din Sjogrens Syndrome

Ratio F/M of RA

Ratio F/M of SLE

Ratio F/M of MG

Ratio F/M of Scleroderma

Ratio F/M of Sjogrens Syndrome

The only autoimmune disorder c'mon among men

Ankylosing Spondylitis primarily affects the

Causes some of the vertebrae in the spine to fuse inducing stiffness in lower back and hips. May also induced neck pain and fatigue

Antibody involved in Multiple Sclerosis

An autoimmune disease that destroys myelin sheath leading to numerous neurological dysfunctions

A chronic systemic inflammatory disease primarily involving the joints

An IgG auto ab involves in RA

Rheumatoid factor attaches to what part of antibody causing pain in joints

Refers to advance cases of joint deformities caused by RA

Invasive pannus consists of the following

These substances are present in synovial fluid in RA cases

What WBC is increased in synovial fluid due to RA

A multi organ autoimmune disease in which patients develop autoantibodies to a number of self antigen

These substances in serum level drops in cases of SLE

Complement fixing antibodies involved in SLE cases

These are major symptoms of SLE

These are the reasons that leads to tissue destruction in SLE

Refers to the butterfly rash in SLE. It is red or purplish and mild scaly

Percentage of occurrence of malar rsh in SLE pxt

Refers to the autoimmune responses directed against self antigens present in many organs and tissues of the body resulting in widespread tissue damage to the host.

Myasthenia Gravis Occurs in

An autoimmune disease which breakdown normal communication between nerves and muscles causing breakdown and fatigue of any muscle

Where do auto abs binds in MG

Ab involves in MG

This organic compound excites nerve cells which is inhibited in MG

These autoimmune disorder which autoantibodies bind to TSH receptor on thyroid

Graves disease causes overproduction of thyroid hormone causing

Other hyperthyroidism, what are the major s/s of graves disease

Responsible for releasing TRH

This is where the TSH came from

Hormones that may increase in Graves dx

A condition caused by autoimmune responses against beta cells resulting to their destruction

Antibody involved in DM1 which is against the beta cells that migrate to pancreas

Autoantibodies to beta cells may activate__ causing destruction to beta cell

This cells produces insulin

3 P's of s/s in DMs

This refers to the enlarged, inflamed, hypofunctioning thyroid

This is caused by the autoantibodies to certain antigens on the membrane kidney glomeruli and lung alveoli resulting in an inflammatory reactions in lungs and kidney

Refers to bleeding in the lungs due to goodpasteur syndrome

Specific AB for Goodpasteur syndrome

Refers to the condition which autoantibodies to platelets bind to many of the major platelets membrane glycoproteins

Major antigens which the platelets autoantibodies bind

Classic symptoms of Idiopathic Thrombocytopenic Purpura

Procedures of Primary Hemostasis

Components of ADHESION primary hemostasis

Components of aggregation primary hemostasis

Procedure of Primary Hemostasis which bind to broken blood vessel

Procedure of Primary Hemostasis which platelets bind together

Procedure of Primary Hemostasis which adapt wound size

A Chronic disease resulting form the non absorption of vit b12

What is being detected in PA diagnostic

Carrier protein of Vit B12 which is inhibited in PA cases

What is the basic abnormality of the PA disease

Characteristics of RBC in PA

A condition which the autoantibodies bind to antigen on RBCS and lead to the lysis of RBCS

Cephalosporins and Dapsone acts as__ in AIHA

Induces immune system to produce antibodies in AIHA

An AIHA caused by IGG autoantibodies

AIHA caused by IGM

An AIHA which IGG protein reacts with RBC in colder parts of the body producing complement component binding

Paroxysmal Cold HEMOGLOBINURIA specific abs

Biphasic Hemolysin ___to RBC when cold

Biphasic Hemolysin ___to RBC when WARM

PCH sample must be put in

Organ located in a privilege site

Bacterial species which causes auto anti I cold agglutinins

Problem of self/non self discrimination

Who described autoimmunituy phenomenon as horror autotoxicus

Ehrlich described autoimmunity as__ meaning fear of self poisoning