AUTOIMMUNITY

Jef Marc Valencia · 73問 · 2年前

通報

問題一覧

Selective destruction of the insulin producing b cells of the islets of Langerhans in the pancreas

DM 1

Chronic systemic inflammatory disorder in which joint cartilage ligaments and tendons are destroyed

RHEUMATOID ARTHRITIS

Immune complexes are formed and these lodge in the basement membrane of kidney skin and joints

SYSTEMIC LUPUS ERYTHEMATOSUS

Unregulated secretion of T3 and T4 due to stimulation of TSH receptor by antibody

GRAVES DISEASE

Destruction of the thyroid gland

HASHIMOTOS THYROIDITIS

Destruction of the parietal cells of the stomach mucosa leading to intrinsic factor defieciency

PERNICIOUS ANEMIA

Antibodies involved in DM1

ANTI GLUTAMIC ACID DECARBOXYLASE, ANTI INSULIN ANTIBODY

Antibodies involved in Graves disease

ANTI TSH RECEPTOR ANTIBODY

Antibodies involved in Hashimotos Thyroiditis

ANTI THYROID PEROXIDASE ANTIBODY

Antibodies involved in Pernicious Anemia

ANTI PARIETAL CELL ANTIBODY, ANTI INTRINSIC FACTOR ANTIBODY

Most specific antibody for Systemic Lupus Erythematosus

ANTI dsDNA

HLA associated to RA

HLA DR4

HLA associated in SLE

HLA DR2, HLA DR3

HLA associated in Scleroderma

HLA DR3 WEAK

HLA associated din Sjogrens Syndrome

HLA DR3

Ratio F/M of RA

3:1

Ratio F/M of SLE

10:1

Ratio F/M of MG

4:1

Ratio F/M of Scleroderma

3:1

Ratio F/M of Sjogrens Syndrome

10:1

The only autoimmune disorder c'mon among men

ANKYLOSING SPONDYLITIS

Ankylosing Spondylitis primarily affects the

SACROILIAC JOINT, VERTEBRAL JOINT, LARGE PERIPHERAL JOINT

Causes some of the vertebrae in the spine to fuse inducing stiffness in lower back and hips. May also induced neck pain and fatigue

ANKYLOSING SPONDYLITIS

Antibody involved in Multiple Sclerosis

AUTO REACTIVE T CELL

An autoimmune disease that destroys myelin sheath leading to numerous neurological dysfunctions

MULTIPLE SCLEROSIS

A chronic systemic inflammatory disease primarily involving the joints

RHEUMATOID ARTHRITIS

An IgG auto ab involves in RA

RHEUMATOID FACTOR

Rheumatoid factor attaches to what part of antibody causing pain in joints

FRAGMENT CRYSTALLIZABLE

Refers to advance cases of joint deformities caused by RA

INVASIVE PANNUS

Invasive pannus consists of the following

MACROPHAGE, MAST CELL, FIBROBLAST

These substances are present in synovial fluid in RA cases

ORGANIZED LYMPHOID TISSUE, CD4 T CELL, B CELL, MACROPHAGE

What WBC is increased in synovial fluid due to RA

NEUTROPHIL

A multi organ autoimmune disease in which patients develop autoantibodies to a number of self antigen

SYSTEMIC LUPUS ERYTHEMATOSUS

These substances in serum level drops in cases of SLE

C3, C4

Complement fixing antibodies involved in SLE cases

IGG, IGM

These are major symptoms of SLE

AUTOIMMUNE HEMOLYTIC ANEMIA, THROMBOCYTOPENIA, VASCULITIS, GLOMERULONEPHRITIS, ARTHRITIS

These are the reasons that leads to tissue destruction in SLE

IMMUNE COMPLEX DEPOSITION, SUBSEQUENT COMPLEMENT ACTIVATION

Refers to the butterfly rash in SLE. It is red or purplish and mild scaly

MALAR RASH

Percentage of occurrence of malar rsh in SLE pxt

46-65

Refers to the autoimmune responses directed against self antigens present in many organs and tissues of the body resulting in widespread tissue damage to the host.

ORGAN NON SPECIFIC AUTOIMMUNE DISEASE

Myasthenia Gravis Occurs in

NEUROMUSCULAR JUNCTION

An autoimmune disease which breakdown normal communication between nerves and muscles causing breakdown and fatigue of any muscle

MYASTHENIA GRAVIS

Where do auto abs binds in MG

NICOTINIC RECEPTOR

Ab involves in MG

ANTIBODY AGAINST NICOTINIC RECEPTOR

This organic compound excites nerve cells which is inhibited in MG

ACETYLCHOLINE

These autoimmune disorder which autoantibodies bind to TSH receptor on thyroid

GRAVES DISEASE

Graves disease causes overproduction of thyroid hormone causing

HYPERTHYROIDISM

Other hyperthyroidism, what are the major s/s of graves disease

GRAVE OPTHAMOPATHY, GRAVE DERMOPATHY

Responsible for releasing TRH

HYPOTHALAMUS

This is where the TSH came from

ANTERIOR PITUITARY GLAND

Hormones that may increase in Graves dx

TRIIODOTHYRONINE, THYROXINE

A condition caused by autoimmune responses against beta cells resulting to their destruction

INSULIN DEPENDANT DIABETES

Antibody involved in DM1 which is against the beta cells that migrate to pancreas

SELF REACTIVE CYTOTOXIC T CELL

Autoantibodies to beta cells may activate__ causing destruction to beta cell

COMPLEMENT CASCADE

This cells produces insulin

BETA CELL

3 P's of s/s in DMs

POLYURIA, POLYDIPSIA, POLYPHAGIA

This refers to the enlarged, inflamed, hypofunctioning thyroid

HASHIMOTOS THYROIDITIS

This is caused by the autoantibodies to certain antigens on the membrane kidney glomeruli and lung alveoli resulting in an inflammatory reactions in lungs and kidney

GOODPASTEUR SYNDROME

Refers to bleeding in the lungs due to goodpasteur syndrome

PULMONARY HEMORRHAGE

Specific AB for Goodpasteur syndrome

ANTI GLOMERULAR BASEMENT MEMBRANE ANTIBODY

Refers to the condition which autoantibodies to platelets bind to many of the major platelets membrane glycoproteins

IDIOPATHIC THROMBOCYTOPENIC PURPURA

Major antigens which the platelets autoantibodies bind

GpIIb/IIIa, GpIb/IX

Classic symptoms of Idiopathic Thrombocytopenic Purpura

PETECHIAE, BRUISING, BLEEDING

Procedures of Primary Hemostasis

ADHESION, AGGREGATION, VISCOUS METAMORPHASIS

Components of ADHESION primary hemostasis

Gp Ib, VON WILLEBRAND FACTOR

Components of aggregation primary hemostasis

Gp IIb, Gp IIIa

Procedure of Primary Hemostasis which bind to broken blood vessel

ADHESION

Procedure of Primary Hemostasis which platelets bind together

AGGREGATION

Procedure of Primary Hemostasis which adapt wound size

VISCOUS METAMORPHASIS

A Chronic disease resulting form the non absorption of vit b12

PERNICIOUS ANEMIA

What is being detected in PA diagnostic

IF BLOCKING ANTIBODY

Carrier protein of Vit B12 which is inhibited in PA cases

INTRINSIC FACTOR

What is the basic abnormality of the PA disease

SEVERE ATROPHIC GASTRITIS

Characteristics of RBC in PA

MEGALOBLASTIC

A condition which the autoantibodies bind to antigen on RBCS and lead to the lysis of RBCS

AUTOIMMUNE HEMOLYTIC ANEMIA

Cephalosporins and Dapsone acts as__ in AIHA

HAPTEN

Induces immune system to produce antibodies in AIHA

DRUG RBC ANTIGEN COMPLEX

An AIHA caused by IGG autoantibodies

WARM AUTOIMMUNE HEMOLYTIC ANEMIA

AIHA caused by IGM

COLD AUTOIMMUNE HEMOLYTIC ANEMIA

An AIHA which IGG protein reacts with RBC in colder parts of the body producing complement component binding

PAROXYSMAL COLD HEMOGLOBINURIA

Paroxysmal Cold HEMOGLOBINURIA specific abs

BIPHASIC HEMOLYSIN

Biphasic Hemolysin ___to RBC when cold

BIND

Biphasic Hemolysin ___to RBC when WARM

LYSE

PCH sample must be put in

WARM TEMPERATURE

Organ located in a privilege site

CORNEA

Bacterial species which causes auto anti I cold agglutinins

MYCOPLASMA PNEUMONIAE

Problem of self/non self discrimination

AUTOIMMUNITY

Who described autoimmunituy phenomenon as horror autotoxicus

PAUL EHRLICH

Ehrlich described autoimmunity as__ meaning fear of self poisoning

HORROR AUTOTOXICUS

COMPH Lesson 5

COMPH Lesson 5

73問 • 2年前

Jef Marc Valencia · 42問 · 2年前

Discussion 1

Discussion 1

42問 • 2年前

Jef Marc Valencia · 42問 · 2年前

Dis 1

Dis 1

42問 • 2年前

Jef Marc Valencia · 11問 · 2年前

Shift -Systematic Error

Shift -Systematic Error

11問 • 2年前

Jef Marc Valencia · 8問 · 2年前

LEVEY – JENNINGS CHART

LEVEY – JENNINGS CHART

8問 • 2年前

Jef Marc Valencia · 6問 · 2年前

WESTGARD MULTIRULE CHART

WESTGARD MULTIRULE CHART

6問 • 2年前

Jef Marc Valencia · 5問 · 2年前

Random vs Systematic

Random vs Systematic

5問 • 2年前

Jef Marc Valencia · 48問 · 2年前

Researcj Design

Researcj Design

48問 • 2年前

Jef Marc Valencia · 40問 · 2年前

Dis 1 mid

Dis 1 mid

40問 • 2年前

Jef Marc Valencia · 63問 · 2年前

COMPM LESSON 6-7

COMPM LESSON 6-7

63問 • 2年前

Jef Marc Valencia · 31問 · 2年前

Discussion -2 Six Sigma

Discussion -2 Six Sigma

31問 • 2年前

Jef Marc Valencia · 6問 · 2年前

Sigma Levels

Sigma Levels

6問 • 2年前

Jef Marc Valencia · 46問 · 1年前

COMPH- LESSON 8

COMPH- LESSON 8

46問 • 1年前

Jef Marc Valencia · 81問 · 1年前

Long Discussion ANALYTICAL METHODS & INSTRUMENTATION

Long Discussion ANALYTICAL METHODS & INSTRUMENTATION

81問 • 1年前

Jef Marc Valencia · 9問 · 1年前

WAVELENGTH Color Table

WAVELENGTH Color Table

9問 • 1年前

Jef Marc Valencia · 100問 · 1年前

Quiz Announcement ANALYTICAL METHODS & INSTRUMENTATION

Quiz Announcement ANALYTICAL METHODS & INSTRUMENTATION

100問 • 1年前

Jef Marc Valencia · 18問 · 1年前

QUIz ANNOUNCEMENT part 2

QUIz ANNOUNCEMENT part 2

18問 • 1年前

Jef Marc Valencia · 62問 · 1年前

Electrochem

Electrochem

62問 • 1年前

Jef Marc Valencia · 18問 · 1年前

ELEC TROCH

ELEC TROCH

18問 • 1年前

Jef Marc Valencia · 49問 · 1年前

TRANSCRIPTION

TRANSCRIPTION

49問 • 1年前

LIS

LIS

Jef Marc Valencia · 16問 · 1年前

Carbohydrates

Carbohydrates

16問 • 1年前

DIFFERENT PATHWAYS IN GLUCOSE METABOLISM

DIFFERENT PATHWAYS IN GLUCOSE METABOLISM

III. GLUCOSE MEASUREMENT

III. GLUCOSE MEASUREMENT

Jef Marc Valencia · 7問 · 1年前

Copper Reductions

Copper Reductions

7問 • 1年前

Exp.8

Exp.8

QUIZ 8/9

QUIZ 8/9

Immunology

Immunology

Jef Marc Valencia · 22問 · 1年前

Immunology part 2

Immunology part 2

22問 • 1年前

Immunology 3

Immunology 3

Lesson 4

Lesson 4

Jef Marc Valencia · 26問 · 1年前

PROTEINS

PROTEINS

26問 • 1年前

Jef Marc Valencia · 34問 · 1年前

PROTEIN 2

PROTEIN 2

34問 • 1年前

PROTEIN 3

PROTEIN 3

Jef Marc Valencia · 56問 · 1年前

Serum Albumin Determination

Serum Albumin Determination

56問 • 1年前

Jef Marc Valencia · 14問 · 1年前

CC lec debris

CC lec debris

14問 • 1年前

Jef Marc Valencia · 44問 · 1年前

NPN

NPN

44問 • 1年前

NPN 2

NPN 2

Jef Marc Valencia · 33問 · 1年前

Materials management

Materials management

33問 • 1年前

Jef Marc Valencia · 57問 · 1年前

Liver

Liver

57問 • 1年前

LESSON 10

LESSON 10

Jef Marc Valencia · 25問 · 1年前

hyperlipoproteinemia

hyperlipoproteinemia

25問 • 1年前

Jef Marc Valencia · 24問 · 1年前

OBLIGATE INTRACELLULAR BACTERIA

OBLIGATE INTRACELLULAR BACTERIA

24問 • 1年前

Jef Marc Valencia · 48問 · 1年前

THE SPIROCHETES

THE SPIROCHETES

48問 • 1年前

Jef Marc Valencia · 31問 · 1年前

PYOGENIC GRAM POSTIVE

PYOGENIC GRAM POSTIVE

31問 • 1年前

Jef Marc Valencia · 31問 · 1年前

Introduction

Introduction

31問 • 1年前

Introduction Page 2

Introduction Page 2

Jef Marc Valencia · 31問 · 1年前

Introduction pg 3

Introduction pg 3

31問 • 1年前

Jef Marc Valencia · 32問 · 1年前

Introduction table

Introduction table

32問 • 1年前

Jef Marc Valencia · 14問 · 1年前

Introduction-body

Introduction-body

14問 • 1年前

NK-Immunity

NK-Immunity

Jef Marc Valencia · 45問 · 1年前

meet 2

meet 2

45問 • 1年前

Jef Marc Valencia · 38問 · 1年前

discussion 3

discussion 3

38問 • 1年前

Jef Marc Valencia · 25問 · 1年前

dis 1

dis 1

25問 • 1年前

Immuno vs anti

Immuno vs anti

Jef Marc Valencia · 47問 · 1年前

Immune 3

Immune 3

47問 • 1年前

Jef Marc Valencia · 46問 · 1年前

dis 4

dis 4

46問 • 1年前

Jef Marc Valencia · 12問 · 1年前

TRANSUDATIVE Vs. EXUDATIVE

TRANSUDATIVE Vs. EXUDATIVE

12問 • 1年前

Jef Marc Valencia · 75問 · 1年前

dis 5

dis 5

75問 • 1年前

Jef Marc Valencia · 9問 · 1年前

Preserved Tissue Examination Steps by definition

Preserved Tissue Examination Steps by definition

9問 • 1年前

FIXATIVES

FIXATIVES

Jef Marc Valencia · 70問 · 1年前

Long discussion 1

Long discussion 1

70問 • 1年前

Jef Marc Valencia · 10問 · 1年前

ALDEHYDE-FIXATIVES

ALDEHYDE-FIXATIVES

10問 • 1年前

Jef Marc Valencia · 24問 · 1年前

lactate dehydrogenase

lactate dehydrogenase

24問 • 1年前

FIXATIVES-METALLIC

FIXATIVES-METALLIC

Jef Marc Valencia · 5問 · 1年前

FIXATIVES-CHROMATE

FIXATIVES-CHROMATE

5問 • 1年前

Jef Marc Valencia · 10問 · 1年前

Specialized Macrophages

Specialized Macrophages

10問 • 1年前

Jef Marc Valencia · 14問 · 1年前

LYMPHOPOIESIS

LYMPHOPOIESIS

14問 • 1年前

Jef Marc Valencia · 5問 · 1年前

PICRIC ACID-FIXATIVE

PICRIC ACID-FIXATIVE

5問 • 1年前

Jef Marc Valencia · 33問 · 1年前

immune 4

immune 4

33問 • 1年前

FIXATIVES-ALCOHOL

FIXATIVES-ALCOHOL

Jef Marc Valencia · 40問 · 1年前

Immunoglobulins

Immunoglobulins

40問 • 1年前

ARTIFACTS

ARTIFACTS

Jef Marc Valencia · 11問 · 1年前

FIXATIVES QUIZ COPY

FIXATIVES QUIZ COPY

11問 • 1年前

Jef Marc Valencia · 26問 · 1年前

MAJOR HISTOCOMPATIBILITY

MAJOR HISTOCOMPATIBILITY

26問 • 1年前

Jef Marc Valencia · 58問 · 1年前

Introduction

Introduction

58問 • 1年前

Jef Marc Valencia · 5問 · 1年前

OTHERS-FIXATIVES

OTHERS-FIXATIVES

5問 • 1年前

Jef Marc Valencia · 34問 · 1年前

MEGAKARYOPOLESIS

MEGAKARYOPOLESIS

34問 • 1年前

Jef Marc Valencia · 51問 · 1年前

DECALCIFICATION

DECALCIFICATION

51問 • 1年前

Jef Marc Valencia · 64問 · 1年前

DEHYDRATION

DEHYDRATION

64問 • 1年前

Blood Specimen Collection

Blood Specimen Collection

Jef Marc Valencia · 7問 · 1年前

CLEARING

CLEARING

7問 • 1年前

Jef Marc Valencia · 19問 · 1年前

CEARING AGENT

CEARING AGENT

19問 • 1年前

Jef Marc Valencia · 27問 · 1年前

INTRODUCTION

INTRODUCTION

27問 • 1年前

Jef Marc Valencia · 51問 · 1年前

Introduction

Introduction

51問 • 1年前

Jef Marc Valencia · 12問 · 1年前

Methods of Determination

Methods of Determination

12問 • 1年前

Jef Marc Valencia · 11問 · 1年前

ASPARTATE AMINOTRANSFERASE

ASPARTATE AMINOTRANSFERASE

11問 • 1年前

Jef Marc Valencia · 15問 · 1年前

ALANINE AMINOTRANSFERASE

ALANINE AMINOTRANSFERASE

15問 • 1年前

Jef Marc Valencia · 34問 · 1年前

Creatinine Kinase

Creatinine Kinase

34問 • 1年前

Jef Marc Valencia · 27問 · 1年前

LACTATE DEHYDROGENASE

LACTATE DEHYDROGENASE

27問 • 1年前

Jef Marc Valencia · 41問 · 1年前

ACID PHOSPHATASE

ACID PHOSPHATASE

41問 • 1年前