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1
Process which leukocytes are generated from hematopoietic stem cell in the bone marrow
LEUKOPOIESIS
2
Progenitors or lineages of leukopoiesis
COMMON LYMPHOID PROGENITOR, COMMON MYELOID PROGENITOR
3
Lineage wher neutrophils, monocytes, eosinophils, and basophils derived
COMMON MYELOID PROGENITOR, CFU-GEMM
4
Lineage where lymphocytes like Tcell, Bcell and NK cell derived
COMMON LYMPHOID PROGENITOR, CFU-L
5
This refers to the production of granulocytes
GRANULOPOIESIS
6
GRANULOPOIESIS occurs only in
BONE MARROW
7
GRANULOPOIESIS occurs via
MITOSIS
8
Developing WBCs may be divided into what various physiologic compartments/pools
PROLIFERATING, MATURATING/STORAGE, CIRCULATING, MARGINATING
9
Granulopoiesis derived from what progenitor
COMMON MYELOID PROGENITOR
10
This pool is composed of cells actively dividing/mitosis
PROLIFERATING
11
This pool comprises of cell maturing w/o division
MATURATION/STORAGE
12
Maturation/Storage pool is found in
BONE MARROW
13
What pools can be found in the circulation
CIRCULATING, MARGINATING
14
Pool of granulocytes adhere in the endothelial linings of blood vessels
MARGINATING
15
Ratio of granulocytes found in the marginating and circulating pool
50/50
16
What receptor do WBCs are attracted to
CHEMOKINE
17
Most Immature/first identifiable cell in the granulocytic series
MYELOBLAST
18
Myeloblasts stage constitute approx. __of the total nucleated bone marrow cells which stage could lasts approx.___
1%, 15 HOUR
19
Stage of leukopoiesis which constitutes approx. 3% of the nucleated bone marrow cells that could lasts for about 24 hours
PROMYELOCYTE
20
Stage of leukopoiesis which approx. 12% of the proliferative cells exists
MYELOCYTE
21
The last stage of leukopoiesis to undergo mitosis
MYELOCYTE
22
Stage of myelocyte to metamuyelocyte maturation could last for an average of
4.3 DAY
23
larger mye-pro
lagrer
24
Neutrophils remain in the maturation storage phase for how many days
7-10 DAY
25
Eosinophils remain in the maturation storage for how many days
2.5 DAY
26
WBC which remains in the maturation storage for shortest period approx___
BASOPHIL, 12 HOUR
27
Refers to movement of granulocytes from the circulating pool to the peripheral tissues
DIAPEDESIS, EMIGRATION
28
The function of neutrophils in the peripheral tissues
PHAGOCYTOSIS
29
Lifespan of neutrophils in the circulating blood
7-10 HOUR
30
Lifespan of basophils in the circulatingh blood
8.5 HOUR
31
Produced due to damage of degenerated eosinophil seen in body secretions like sputum and stool
CHARCOT LEYDEN CRYSTAL
32
Refers to increased eosinophils in the blood
EOSINOPHILIA
33
Conditions that could induced eosinophiia
PARASITIC INFECTION, ALLERGIC REACTION
34
Stage of granulopoiesis Cytoplasm: Basophilic, Scanty, Non granular
MYELOBLAST
35
Stage of granulopoiesis Cytoplasm: Basophilic and abundant which Primary granules starts to appear
PROMYELOCYTE
36
Stage of granulopoiesis Cytoplasm: Moderate amount w/ few specific granules and Secondary granules starts to appear
MYELOCYTE
37
Stage of granulopoiesis Cytoplasm: Moderate to abundant w/ specific granules
METAMYELOCYTE
38
Stage of granulopoiesis Cytoplasm: Has specific granules
BAND
39
Stage of granulopoiesis Nucleus: Round over slightly oval w/ fine chromatin
MYELOBLAST
40
Stage of granulopoiesis Nucleus: Oval to round w/ slightly coarser chromatin pattern
PROMYELOCYTE
41
Stage of granulopoiesis Nucleus: Oval to round w/ coarse chromatin
MYELOCYTE
42
Stage of granulopoiesis Nucleus: Indented, Kidney Bean shaped w/ coarse and clumped chromatin
METAMYELOCYTE
43
Stage of granulopoiesis Nucleus: Elongated or band shaped w/ coarse and clumped chromatin
BAND
44
Stage of granulopoiesis which last appearance of nucleoli occur
PROMYELOCYTE
45
Number of nucleoli in myelobast
2-5
46
Number of nucleoli in promyelocyte
2-3
47
N/C ratio during myeloblast
4:1
48
N/C ratio during promyelocyte
3:1-2:1
49
What are the mature granulocytes
NEUTROPHIL, EOSINOPHIL, BASOPHIL
50
What day do Blast stage occur
14 DAY
51
Stage when release of mature granulocytes in the peripheral blood
BLAST
52
Cell diameter during myeloblast
15-20 UM
53
Cytochemical stain which used to stain specific granules that could be positive in myeloblast stage
SPECIFIC ESTERASE, PEROXIDASE, SUDAN BLACK
54
Stain used for the identification of leukemias
CYTOCHEMICAL
55
Cell diameter of promyelocyte
15-21 UM
56
Non specific granules found in promyelocyte
PRIMARY, AZUROPHILIC
57
Cell diameter of myelocyte
12-18 UM
58
Specific granules are also known as
SECONDARY GRANULE
59
What stage of granulopoiesis which cell diameter starts to decrease
MYELOCYTE
60
Myelocyte stage is also known as
DAWN OF NEUTROPHILIA
61
Metamyelocyte is also known as
JUVENILE CELL
62
Cell diameter of metamyelocyte
10-15 UM
63
Stage of granulopoiesis where tertiary granules starts to form
METAMYELOCYTE
64
Cell diameter of band/stab cell
9-15 UM
65
Other term used to describe the nucleus of band/stab cell
CURVED NEUTROPHIL, SAUSAGE SHAPED
66
Youngest stage of granulopoiesis that could appear in the circulation
BAND, STAB
67
2 stages of mature granulocytes in the blood
BAND FORM, SEGMENTED FORM
68
Mature granulocytes that has a typical elongated nucleus
BAND FORM
69
Mature granulocytes that has a characteristic of multilobed nucleus which separate lobes are attached to each other by a fine thread like filament
SEGMENTED FORM
70
CLSI recommends ___neutrophils should be included in WBC Counting
BAND
71
Fine and stain a blue-pink colour with wright stain
NEUTROPHILIC GRANULE
72
Larger, round and oval shaped granules having an orange and have a glassy or semiopaque texture
EOSINOPHILIC GRANULE
73
Dark blue-black colour and a dense appearance granule
BASOPHILIC GRANULE
74
Granules found in the Basophilic granules
HEPARIN, HISTAMINE, CHONDROITIN SULPHATE
75
Segmented neutrophils is also known as
POLYMORPHONUCLEAR CELL
76
Cell diameter of segmented neutrophil
9-15 UM
77
Cytoplasm apperance of segmented neutrophil
GRAINY, PINK/ROSE-PINK VIOLET GRANULE
78
Number of lobes of segmented neutrophils
3-4 LOBE
79
Condition when neutrophils only exhibits 2 lobes in its nucleus
FAMILIAL PELGER HUET ANOMALY
80
Condition when Segmented neutrophils exhibits hypersegmentation
MEGALOBLASTIC ANEMIA
81
Lifespan of segmented neutrophils
9-10 DAY
82
Which movement of neutrophil is irreversible
MIGRATION
83
Neutrophils is also termed as ___as they die after performing their function
END STAGE CELL
84
What pool and how long do stem cell, myeloblast, promyelocyte, and myelocyte occur in the pool
MITOTIC, 2-3 DAY
85
What pool and how long do metamyelocyte and band occur in the pool
MATURATION, 5-7 DAY
86
What pool and how long do mature neutrophil occur in the pool
STORAGE, 11 DAY
87
Refers to locating, ingesting, and killing invading bacteria
PHAGOCYTOSIS
88
Segmented Neutrophils functions as a defense against infections primarily
BACTERIA
89
Segmented neutrophils has receptors to what portion of IgG
FC PORTION
90
Refers to specific directional motility of neutrophils to chemoattractants via diapedesis
CHEMOTAXIS
91
Refers to random motility of neutrophils to chemoattractants via diapedesis
CHEMOKINESIS
92
These are signals released by cells for neutrophils to respond
CHEMOKINE
93
Enumerate steps of phagocytosis
DIRECTIONAL MOTILITY, RECOGNITION, INGESTION, DEGRANULATION, KILLING
94
This utilizes Superoxide anion and hydrogen peroxide to destroy a bacterial cell wall
RESPIRATORY BURST
95
Produced following the released of the nuclear contents of the neutrophil into the extracellular space which microbes are trapped encountering higher concentrations of antimicrobial proteins
NEUTROPHIL EXTRACELLULAR TRAP
96
Chromatin components of NET
HISTONE, ELASTASE, CATHEPSIN G
97
What cannot be found on the granules of eosinophils
LYSOZYME
98
Granules of eosinophils not containing crystalloids but rich in acid phosphatase
SMALLER ROUND GRANULE
99
Granule of eosinophils which is elliptical, has amorphous matrix which crystals represent the enzyme peroxidase
LARGER CRYSTALLINE GRANULE
100
Cell diameter of eosinophils
9-15 UM
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