TRACE ELEMENT

79問 • 8ヶ月前

問題一覧

Appear in small quantity associated with enzyme or proteins which deficiency impairs a biochemical or functional process: replacement corrects the impairment

TRACE ELEMENT

Specimen of choice for trace elements

ANTI COAGULATED BLOOD

Characteristics of trace elements

LOW CONCENTRATION, UBIQUITOUS

Method of choice for trace elements

AAS

3RD most abundant trace elements important for cellular respiration, DNA and RNA reproduction, cell membrane integrity, sequestration of free radicals

COPPER

Dietary requirement for copper

1.5-3.0 MG/DAY

Highest copper concnetration

LIVER

A-2 globulin copper containing protein

CERULOPLASMIN

What enzyme found in ceruloplasmin

FERROXIDASE

Ceruloplasmin contains copper but not___protein since the copper is not exchangeable

TRANSPORT

Albumin bound which transports copper

TRANSCUPERIN

Albumin boundd which sequesters and stores copper

METALLOTHIONEIN

Copper deficiency is seen in

PREMATURE INFANT, OSTEOPOROSIS, CVD, MENKES DISEASE

Aside from kinky hair, this is also seen in menkes disease

HYPOTONIA

Refers to increased tissue and serum level of copper

COPPER TOXICITY

Acute copper poisoning is c'monly caused by

FUNGICIDE

Genetically determined copper accumulation disease

WILSONS DISEASE

In Wilsons disease, copper accumulates in what tissues

LIVER, BRAIN, CORNEA

Manifestations of wilsons disease

NEUROLOGIC DISORDER, LIVER DYSFUNCTION

Green brown discoloration in the cornea due to wilsons disease

KAYSER FLEISCHER RING

Serum or urine copper is measured via

AAS, COLORIMETRIC METHOD

Ceruloplasmin is measured via

PHOTOMETRIC METHOD, NEPHELOMETRY

Method of choice for copper

AAS

Immunological method determination for copper

NEPHELOMETRY

Reference value for copper male

70-140 UG/DL, 11-22 UMOL/L

Reference value for copper female

80-155 UG/DL, 13-24 UMOL/L

Normal value for ceruloplasmin

23-50 MG/DL

2ND most abundant trace element which is cofactor for >300 enzymes

ZINC

Important in protein and nucleic acid synthesis

ZINC

Essential for the synthesis and action of insulin

ZINC

Zinc containing metalloenzyme

CARBONIC ANHYDRASE, ALKALINE PHOSPHATASE, DNA AND RNA POLYMERASE, CARBOXYPEPTIDASE, ALCOHOL DEHYDROGENASE, SUPEROXIDE DISMUTASE

Zinc is mostly absorbed in the

DUODENUM

Zinc being transferred into the portal blood

METALLOTHIONEIN

Zinc in blood is bound to

ALBUMIN, A-2 MACROGLOBULIN

Contain most of the body's zinc but slowest turnover

MUSCLE, BONE

Where do metallothionein bound zinc found which can be readily mobilized

LIVER

Half life of zinc found in muscles and bones

300 DAY

Half life of metallothionein

2 WEEK

Zinc deficiency is c'mon in what disorders

DIABETES MELLITUS, ALCOHOL ABUSE, MALABSORPTION SYNDROME, LIVER AND KIDNEY DISEASE

Rare autosomal recessive disorder with impaired intestinal absorption and transport of zinc

ACRODERMATITIS ENTEROPATHICA

Factors to consider for zinc laboratory determination

DIURNAL VARIATION, POSTPRANDIAL VARIATION

Serum value is ___to plasma values

>10%

RBC zinc is____to plasma zinc

>10X

Method of choice for zinc in body fluids

FLAME ATOMIC ABSORPTION SPECTROPHOTOMETRY

Reference testing method for zinc serum or plasma

INDUCTIVELY COUPLED PLASMA SPECTROPHOTOMETRY

Reference value for zinc plasma

70-120 UG/DL, 10.7-18.4 UMOL/L

Most abundant trace element

IRON

Iron load in the human body

40-50MG/KG BW

Iron containing proteins

HEMOGLOBIN, COLLAGEN, TYROSINASE, CATECHOLAMINE

Which trace element has effect on cell mediated immunity

IRON

Stored formed of iron

FERRITIN, HEMOSIDERIN

What body tissues iron can be found

MYOGLOBIN, NON HEME ENZYME

Dietary form of iron

FERROUS

Iron absorption is facilitated by

ASCORBIC ACID, REDUCING AGENT, ACID PH

How many percent is dietary iron is being absorbed

5-10%

Glycoprotein that transports iron

TRANSFERRIN

Transferrin is synthesized in the

LIVER

Transferrin has high affinity to

FERRIC ION

Stored form of iron found virtually in all cells which being measured for IDA diagnosis

FERRITIN

Factors that may increased serum ferritin

FEVER, ACUTE INFECTION, RHEUMATOID ARTHRITIS, VIRAL HEPATITIS

Quantitative, specific, sensitive involving invasive procedure measurement for iron

DIRECT

Quantitative measurement for iron includes the following

QUANTITATIVE PHLEBOTOMY, BONE MARROW BIOPSY, LIVER BIOPSY

Indirect measurement for serum iron

COLORIMETRIC METHOD, AAS

measurement for serum transferrin

DIRECT IMMUNOASSAY, TOTAL IRON BINDING CAPACITY

Maximum amount of iron that can bind to serum transferrin

TOTAL IRON BINDING CAPACITY

Ratio of the plasma iron to TIBC

TRANSFERRIN RATIO

Serum ferritin is measured via

IRMA, ELISA, IMMUNOFLUOROMETRIC ASSAY, CHEMILUMINISCENCE ASSAY

Useful marker of body iron stores (pregnancy and neonates) which is sensitive measurement of tissue iron deficiency

SERUM TRANSFERRIN RECEPTOR

Zinc for iron substition in IDA which substition occurs in the Bone Marrow

ZINC PROTOPORPHYRIN

Reagent used to extract ZnPP

ETHYL ACETATE

Method for detecting ZnPP

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

Most advanced stage of iron deficiency

IRON DEFICIENCY ANEMIA

Most c'mon cause of iron overload

HEREDITARY HEMOCHROMATOSIS

Other disease contributing to iron overload

SIDEROBLASTIC ANEMIA, CHRONIC HEPATITIS

Normal value for Total Fe

60-150 UG/DL

Normal value for TIBC

250-400 UG/DL

Normal value for Iron saturation

20-55%

Normal value for ferritin male

15-200 UG/L

Normal value for ferritin Female

12-200 UG/L

COMPH Lesson 5

Jef Marc Valencia · 73問 · 2年前

COMPH Lesson 5