問題一覧
1
Virus attaches to receptors on target cells by
Glycoprotein spikes
2
Receptor for human coronavirus 229E
Amino peptidase N
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Functional receptor for SARS cov
Ace 2
4
Receptor for MERS cov
Dipeptyl peptidase 4, aka CD26
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Alpha coronavirus
229E,NL63
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Mot: Respiratory droplet Present in sweat Urine feces
SARS
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Atypical pneumonia Acute respiratory distress syndrome
SARS
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Strong tropism for non ciliated bronchial epithelial cells
MERS Cov
9
Angiotensin converting enzyme 2 (ACE 2)
MERS Cov
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MERS cov receptor
CD 26
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Create the viral envelope
S,E, and M proteins
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S protein
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HE
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Droplet infection
SARS-COV
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lung is most severely affected
SARS-COV
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Replicate in cytoplasm Budding into ER and Golgi apparatus
Coronaviridae
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Contain the glycoprotein E1 and E2
Virion
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Produce 5-7 mRNA
RNA polymerase
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Natural reservoir: Chinese horse bat
SARS-COV
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Drop of CD4 and CD8 T cell
Lymphopenia
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Required mechanical ventilation
Dry cough, dyspnea
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Infect both upper and lower airway and alveolar epithelial cells
SARS-COV
23
Coronavirus 5 structural proteins
Spike, Envelope, Membrane, Nucleocapsid, Hemagglutinin enterase
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Mers Cov prevention
Avoid exposure to camel, Ingestion of raw camel milk, inadequately cooked meat