TREATMENT Soft tissue infections → Surgical debridement and high dose Penicillin - Hyperbaric oxygen therapy (HBOT)- speed up healing of gas gangrene, carbon monoxide poisoning, infections in which tissues are starved for O2 - For food poisoning → Self-limiting → No need for antibiotics > replace fluids by electrolytes

Woolsorters disease

tetanospasmin

3 aerobic sporeforming

Flaccid paralysis

Anaerobic spore forming 4

Metabolic activity of rapidly dividing c. perfringens results to

Food poisoning associated with Chinese fried rice cause by

Food poisoning Eye infection Sepsis

low virulence Opportunistic pathogen

Pulmonary woolsorter's disease Necrotic ulcer with eschar ingestion upper intestinal tract

Antibiotic associated pseudomembranous entercolitis fluroquinolones binary toxin

Treatment pseudo membranous entercolitis

b. Anthracis most immunogenic

c. Botulinum food poisoning is due to

Mechanism of tetanospasmin

lysed by botulinum toxin to cause inhibition of the release of acetylcholine

Persistent back spasm

Passive immunization with human tetanus lg

Active immunization with tetanus toxoid

Produce spores Obligate anaerobes Gram (+) cell wall

Beta hemolysis

Most common and invasive

Cephalic tetanus

Umbilical stump

Wound dibridement Metronidazole passive/active immunization