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問題一覧
1
Tachyphylaxis
2
An INCORRECT statement about the oral route of drug administration:
It avoids 1st pass metabolism.
3
Pharmacokinetics
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competitive antagonist
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Pharmacodynamic
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subject bias
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Interference
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Graded dose response
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Adverse Drug Reaction:
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physiologic
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Immediate effects
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spare receptors
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Which is a factor that can affect drug absorption
drug solubility
14
Botanicals (herbs & plant extracts)
Alternative health care
15
The apparent space in the body that is able to contain a drug refers to a drug's
Volume of distribution
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Neutral antagonist
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Synergism
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Therapeutic equivalent
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Inverse agonist
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If a drug has a long half-life, it means
The drug is eliminated slower from the body.
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Partial agonists
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Partial agonist
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Additive
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Distribution
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This process of pharmacokinetics refers to making a drug more polar thru biotransformation in order for the drug to be eventually eliminated in the kidneys
metabolism
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Pharmaceutical equivalent
27
The branch of pharmacology that studies the use of drugs in the diagnosis, treatment and prevention of diseases
Pharmacotherapeutics
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Delayed effects
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dimecaprol heavy metals
chemical
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Tolerance
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Absorption
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Full agonist
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Double blind both subject and evaluator
observer bias
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Pharmacodynamics
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This phase of clinical drug evaluation utilizes both healthy subjects as well as those with the disease, in order to determine if the drug works double blind
not sure
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Distribution
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Absorption
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NO hormones corticosteroids sex hormones vit D thyroid hormone
Intracellular receptors for lipid soluble agents
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Pharmacokinetic
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Case report/case series
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growth hormone erythropoietin interferon
cytokine receptor
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insulin growth factor
Ligand regulated transmembrane enzymes
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drug INDUCER means that a drug
When combined with another may decrease its' bioavailability
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Bioavailability
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opioid analgesic antibiotics
G-proteins and 2nd messengers
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Phase l metabolism
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Cumulative effects
48
Metabolism
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Case control
50
This refers to the margin of safety of a drug, and is measured by a drugs' toxic dose over a drugs' effective dose:
Therapeutic index
51
3 Basic parameters of pharmacokinetics:
Volume of distribution, Clearance, t ½ or drug half-life
52
Quantal dose effect response
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Antagonism
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Full agonist
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Intermittent dose:
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Pharmacogenomics
57
Adverse Drug Reaction
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Phase 2 metabolism
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Loading dose
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hypnotic sedative anticonvulsant
Ligand-gated channels
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Absorption
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Maintenance dose
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Displacement
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irreversible
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Kidneys renal disease adjust urine pH to accelerate excretion of the drug
Elimination
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Which is NOT a parameter of pharmacodynamics?
clearance
67
A drug AGONIST is described as:
A drug that binds with a receptor to produce an effect
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Complimentary medicine
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Meta analysis
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Pharmacodynamic
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Cohort
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Controlled trials (randomized)