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問題一覧
1
Loss of consciousness Adequate muscle relaxation
Anesthesia
2
Reversible loss of consciousness Loss of CNS activity
General Anesthetics
3
Inhalational anesthesia Intravenous anesthesia
General Anesthetics
4
No loss of consciousness Reversible loss of pain sensation
Local Anesthetics
5
Amides Esters
Local Anesthetics
6
MOA: block nerve conduction
Local Anesthetics
7
local anesthetics properties 5
rapid onset ; long duration, non-irritating , no permanent damage, low systemic toxicity, effective
8
(lipophilic/hydrophobic)
aromatic acid
9
hydrophilic
amine group
10
EXCRETION: liver
Local anesthetic
11
Order of disappearance of function 6
Autonomics, Temperature, Pain, Touch, Deep pressure, Motor function
12
Cocaine Chloroprocaine Procaine Tetracaine
esters
13
Lidocaine Dibucaine Bupivacaine Prilocaine Mepivacaine Etidocaine
amides
14
rapid onset, long duration dental practice
Etidocaine
15
First anesthetic used in dentistry vasoconstricting properties
Cocaine
16
Slow onset of arterial spasm 2O to intraarterial basic injection
procaine
17
short acting, fast onset Not very potent
chloroprocaine
18
long acting, potent spinal anesthesia
tetracaine
19
6 LOCAL ANESTHETICS for surface applications
Benzocaine, Tetracaine, Dyclonine , Chlorobutanol, Cocaine, lidocaine/prilocaine
20
3 Role of vasoconstrictors
Reduce toxic effects, Prolong and increase depth of anesthesia, Hemostatic
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stage 1 gen anesthesia
Analgesia
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stage 2 gen anesthesia
Excitement/ Delirium
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Stage 3 general anesthesia
Surgical Anesthesia
24
Stage 4 gen anesthesia
Medullary Paralysis
25
ideal stage for surgery
stage 3 Surgical Anesthesia plane 3 completion ICM paralysis
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stage 3 plane 1
breathing - loss of eye movement
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stage 3 plane 2
initiation of IC muscle paralysis
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Stage 3 plane 3
completion ICM paralysis
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Plane 4 stage 3
diaphragmatic paralysis
30
Inspired anesthetic concentration ( inspired partial pressure ) Alveolar ventilation ( pulmonary ventilation )
From Anesthesia machine to Alveoli
31
Blood:brain partition coefficient Tissue Blood Flow Arterial-to-Venous partial pressure differenc
From Arterial Blood to Brain
32
2 inhalation anesthetics
gaseous, volatile
33
2 gaseous anesthetics
nitrous oxide, cyclopropane
34
Volatile anesthetics 6 Halogenated
Halothane, Isoflurane, Enflurane, Sevoflurane, Methoxyflurane, Desflurane
35
Volatile anesthetics 2 NON Halogenated
Ether, Chloroform
36
Concentration of the anesthetic agent in the inspired gas
Pulmonary phase
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Transfer of anesthetic gases from alveoli to blood
Pulmonary phase
38
Solubility - tissue:blood partition coefficient Tissue Blood Flow
Circulatory or Distribution Phase
39
2 Factors affecting rate of Elimination
Solubility in blood & tissues, Blood flow
40
Flow of anesthetic during elimination:
Tissue/ Brain , Blood, Lungs, Anesthesia machine
41
5 Ideal Characteristics of Inhalational Anesthetics:
Rapid & pleasant induction & recovery, Rapid changes in depth of anesthesia, Adequate relaxation of smooth muscle, Absence of toxic effect, Wide margin of safety
42
5 Adverse Effects
Systemic toxicity, Neural damage, Skeletal muscle, Idiosyncratic reactions, Allergic phenomena
43
6 Techniques of anesthesia
Topical/ Surface application, Local Infiltration, Nerve Block, Spinal or Intrathecal injection, Epidural, Caudal
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5 Properties of desirable L.A.
no permanent damage to nerves, non-irritating to tissues, low systemic toxicity , effective, rapid onset but long duration
45
Injecting under the skin refers to
Intradermal
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involves injection into the caudal or subcaudal canal (a specific part of the epidural space near the tailbone).
Caudal
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Direct injection into tissue
Infiltration
48
Injection of a local anesthetic into the extradural space.
Epidural
49
Injecting of a local anesthetic into the subarachnoid space,
Spinal/ intrathecal
50
Placing a drug on the surface of the skin or a mucous membrane.
Topical
51
Systemic toxicity
52
Neural damage
53
Skeletal muscle
54
Idiosyncratic reactions
55
Allergic phenomena
56
Loss of sensation to pain
Analgesia
57
Mechanism of Action: block nerve conduction
LOCAL ANESTHETICS
58
Local anesthetic
59
Local anes metabolism: ester
plasma and liver
60
Local anes metabolism: esterases
metabolite: PABA
61
Local anes metabolism: amide
Liver
62
Weak anesthetic → obtundent dressing to relieve acute pulpitis postextraction wound pain
chlorobutanol
63
Benzoic acid ester No place in routine dentistry practice
cocaine hci
64
Methemoglobinemia procaine derivative
benzocaine
65
cetacaine ester derivative of p-aminobenzoic acid 10 X more toxic & potent than procaine
tetracaine hci
66
has a ketone moiety tissue irritation on injection Lozenge
dyclonine