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anti tb week 1
57問 • 1年前
  • Tameyra Stefani Al-Suhairy
    • 通報

    問題一覧

  • 1

    isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin.

    1st line anti tb drugs

  • 2

    can be used to substitute for rifampin if needed (Depending on the reference)

    Rifabutin or rifapentine

  • 3

    classified either as a 1st line of 2nd line drug.

    Streptomycin

  • 4

    – for recurrent infections or cases that exhibit microbial resistance – ethionamide, cycloserine, amikacin, kanamycin, capreomycin, levofloxacin, moxifloxacin, para-aminosalicylic acid, bedaquiline. – Gen. less active & often more toxic than the 1⁰ drugs. – used in combination for active tuberculosis that is drug- resistant.

    2nd line drugs

  • 5

    first line agents

  • 6

    second line agents

  • 7

    • MOA: inhibits synthesis of mycolic acid

    Isoniazid (INH)

  • 8

    most active drug for the treatment of TB

    Isoniazid (INH)

  • 9

    MOA: binds with the β-subunit of bacterial DNA dependent RNA polymerase → inhibit RNA synthesis

    Rifampin (RMP)

  • 10

    Adverse effect: • orange color urine, sweat, tears, sputum, feces

    Rifampin (RMP)

  • 11

    MOA: inhibits mycobacterial arabinosyl transferase (involved in the polymeration of arabino-glycan, an essential component of mycobacterial cell wall barrier) by embCAB oper

    Ethambutol (EMB)

  • 12

    Ethambutol most common; loss of visual acuity; red-green color blindness (dose related)

    retrobulbar neuritis

  • 13

    (-) intracellular organism • MOA: (-) mycobacterial fatty acid synthase I involved in mycolic acid synthesis

    Pyrazinamide (PZA)

  • 14

    MOA: interfere w/ protein synthesis (30s subunit)

    Streptomycin

  • 15

    Most common AE – vertigo and hearing loss

    Streptomycin

  • 16

    rifabutin

  • 17

    rifapentine

  • 18

    Isoniazid (INH)

  • 19

    Rifampin (RMP)

  • 20

    Pyrazinamide (PZA)

  • 21

    Ethambutol (EMB)

  • 22

    3 TREATMENT OF LEPROSY

    sulfones, rifampin, clofazimine

  • 23

    Streptomycin

  • 24

    category 1

  • 25

    category 2

  • 26

    category 3

  • 27

    category 4

  • 28

    acyclovir (zovirax)

  • 29

    vidarabine (vira-a)

  • 30

    amantadine (symmetrel)

  • 31

    ribavirin (virazole)

  • 32

    DIDANOSINE (Videx)

  • 33

    ZALCITABINE (HIVID)

  • 34

    ZIDUVODINE (Retrovir) Or AZT (azidothymidine)

  • 35

    GANCICLOVIR (Cytovene)

  • 36

    FOSCARNET (Foscavir)

  • 37

    AMPHOTERICIN B

  • 38

    CLOTRIMAZOLE (Canesten)

  • 39

    FLUCONAZOLE (Diflucan)

  • 40

    FLUCYTOSINE (Ancobon)

  • 41

    GRISEOFULVIN (Fulvicin)

  • 42

    ITRACONAZOLE (Sporanox)

  • 43

    KETOCONAZOLE (Nizoral)

  • 44

    MICONAZOLE (Monistat)

  • 45

    NYSTATIN (Mycostatin)

  • 46

    4 PROTOZOAL INFECTIONS

    malaria, amebiasis, gardiasis, trichomoniasis

  • 47

    3 HELMINTHIC INFECTIONS

    roundworms, tapeworms, flukes

  • 48

    5 ANTI MALARIAL DRUGS

    CHLOROQUINE, MEFLOQUINE, PRIMAQUINE , PYRIMETHAMINE, QUININE

  • 49

    3 ANTI AMEBIC & OTHER PROTOZOAL AGENTS

    IODOQUINOL, PAROMOMYCIN / DILOXANIDE FUROATE, METRONIDAZOLE

  • 50

    6 ANTI HELMINTHIC AGENTS

    DIETHYLCARBAMAZINE, MEBENDAZOLE, NICLOSAMIDE, PRAZIQUANTEL, PYRANTEL PAMOATE, THIABENDAZOLE

  • 51

    - Drug of choice: trematodes -Adv. Effect: GIT and CNS adverse effects

    PRAZIQUANTEL

  • 52

    - ascariasis, enterobiasis, hookworm infections -Adv. Effect: mild GIT distress

    PYRANTEL PAMOATE

  • 53

    Trichinosis and other roundworm infections - Adv. Effect: GIT distress, allergic reactions

    THIABENDAZOLE

  • 54

    Onchocerciasis, loiasis, filariasis -Adv. Effect: headache, malaise, weakness, loss of appetite

    DIETHYLCARBAMAZINE

  • 55

    Drug of choice for multi-roundworm infestation -Adv. Effect: GIT distress

    MEBENDAZOLE

  • 56

    - Drug of choice: tapeworms -Adv. Effect: GIT distress

    NICLOSAMIDE

  • 57

    1st one of defense 5

    isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin

    • Sporeformers

    Sporeformers

    Tameyra Stefani Al-Suhairy · 44問 · 1年前

    Sporeformers

    Sporeformers

    44問 • 1年前
    Tameyra Stefani Al-Suhairy

    Spirochetes

    Spirochetes

    Tameyra Stefani Al-Suhairy · 46問 · 1年前

    Spirochetes

    Spirochetes

    46問 • 1年前
    Tameyra Stefani Al-Suhairy

    Subcutaneous, Systemic, Opportunistic Mycoses

    Subcutaneous, Systemic, Opportunistic Mycoses

    Tameyra Stefani Al-Suhairy · 75問 · 1年前

    Subcutaneous, Systemic, Opportunistic Mycoses

    Subcutaneous, Systemic, Opportunistic Mycoses

    75問 • 1年前
    Tameyra Stefani Al-Suhairy

    Mycobacteria

    Mycobacteria

    Tameyra Stefani Al-Suhairy · 46問 · 1年前

    Mycobacteria

    Mycobacteria

    46問 • 1年前
    Tameyra Stefani Al-Suhairy

    Bacterial Classification, morphology, utrastructure

    Bacterial Classification, morphology, utrastructure

    Tameyra Stefani Al-Suhairy · 64問 · 1年前

    Bacterial Classification, morphology, utrastructure

    Bacterial Classification, morphology, utrastructure

    64問 • 1年前
    Tameyra Stefani Al-Suhairy

    HIV

    HIV

    Tameyra Stefani Al-Suhairy · 31問 · 1年前

    HIV

    HIV

    31問 • 1年前
    Tameyra Stefani Al-Suhairy

    CORONA

    CORONA

    Tameyra Stefani Al-Suhairy · 24問 · 1年前

    CORONA

    CORONA

    24問 • 1年前
    Tameyra Stefani Al-Suhairy

    PAPILLO

    PAPILLO

    Tameyra Stefani Al-Suhairy · 15問 · 1年前

    PAPILLO

    PAPILLO

    15問 • 1年前
    Tameyra Stefani Al-Suhairy

    ADENO

    ADENO

    Tameyra Stefani Al-Suhairy · 16問 · 1年前

    ADENO

    ADENO

    16問 • 1年前
    Tameyra Stefani Al-Suhairy

    POX

    POX

    Tameyra Stefani Al-Suhairy · 6問 · 1年前

    POX

    POX

    6問 • 1年前
    Tameyra Stefani Al-Suhairy

    PARVO

    PARVO

    Tameyra Stefani Al-Suhairy · 25問 · 1年前

    PARVO

    PARVO

    25問 • 1年前
    Tameyra Stefani Al-Suhairy

    HEPATOTROPHIC

    HEPATOTROPHIC

    Tameyra Stefani Al-Suhairy · 24問 · 1年前

    HEPATOTROPHIC

    HEPATOTROPHIC

    24問 • 1年前
    Tameyra Stefani Al-Suhairy

    PICORNA

    PICORNA

    Tameyra Stefani Al-Suhairy · 25問 · 1年前

    PICORNA

    PICORNA

    25問 • 1年前
    Tameyra Stefani Al-Suhairy

    RABIES

    RABIES

    Tameyra Stefani Al-Suhairy · 26問 · 1年前

    RABIES

    RABIES

    26問 • 1年前
    Tameyra Stefani Al-Suhairy

    PARAMYXO

    PARAMYXO

    Tameyra Stefani Al-Suhairy · 20問 · 1年前

    PARAMYXO

    PARAMYXO

    20問 • 1年前
    Tameyra Stefani Al-Suhairy

    HERPES

    HERPES

    Tameyra Stefani Al-Suhairy · 40問 · 1年前

    HERPES

    HERPES

    40問 • 1年前
    Tameyra Stefani Al-Suhairy

    ORTHO

    ORTHO

    Tameyra Stefani Al-Suhairy · 7問 · 1年前

    ORTHO

    ORTHO

    7問 • 1年前
    Tameyra Stefani Al-Suhairy

    FLAVI

    FLAVI

    Tameyra Stefani Al-Suhairy · 24問 · 1年前

    FLAVI

    FLAVI

    24問 • 1年前
    Tameyra Stefani Al-Suhairy

    TOGA

    TOGA

    Tameyra Stefani Al-Suhairy · 19問 · 1年前

    TOGA

    TOGA

    19問 • 1年前
    Tameyra Stefani Al-Suhairy

    VIRUS STRUCTURE

    VIRUS STRUCTURE

    Tameyra Stefani Al-Suhairy · 16問 · 1年前

    VIRUS STRUCTURE

    VIRUS STRUCTURE

    16問 • 1年前
    Tameyra Stefani Al-Suhairy

    問題一覧

  • 1

    isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin.

    1st line anti tb drugs

  • 2

    can be used to substitute for rifampin if needed (Depending on the reference)

    Rifabutin or rifapentine

  • 3

    classified either as a 1st line of 2nd line drug.

    Streptomycin

  • 4

    – for recurrent infections or cases that exhibit microbial resistance – ethionamide, cycloserine, amikacin, kanamycin, capreomycin, levofloxacin, moxifloxacin, para-aminosalicylic acid, bedaquiline. – Gen. less active & often more toxic than the 1⁰ drugs. – used in combination for active tuberculosis that is drug- resistant.

    2nd line drugs

  • 5

    first line agents

  • 6

    second line agents

  • 7

    • MOA: inhibits synthesis of mycolic acid

    Isoniazid (INH)

  • 8

    most active drug for the treatment of TB

    Isoniazid (INH)

  • 9

    MOA: binds with the β-subunit of bacterial DNA dependent RNA polymerase → inhibit RNA synthesis

    Rifampin (RMP)

  • 10

    Adverse effect: • orange color urine, sweat, tears, sputum, feces

    Rifampin (RMP)

  • 11

    MOA: inhibits mycobacterial arabinosyl transferase (involved in the polymeration of arabino-glycan, an essential component of mycobacterial cell wall barrier) by embCAB oper

    Ethambutol (EMB)

  • 12

    Ethambutol most common; loss of visual acuity; red-green color blindness (dose related)

    retrobulbar neuritis

  • 13

    (-) intracellular organism • MOA: (-) mycobacterial fatty acid synthase I involved in mycolic acid synthesis

    Pyrazinamide (PZA)

  • 14

    MOA: interfere w/ protein synthesis (30s subunit)

    Streptomycin

  • 15

    Most common AE – vertigo and hearing loss

    Streptomycin

  • 16

    rifabutin

  • 17

    rifapentine

  • 18

    Isoniazid (INH)

  • 19

    Rifampin (RMP)

  • 20

    Pyrazinamide (PZA)

  • 21

    Ethambutol (EMB)

  • 22

    3 TREATMENT OF LEPROSY

    sulfones, rifampin, clofazimine

  • 23

    Streptomycin

  • 24

    category 1

  • 25

    category 2

  • 26

    category 3

  • 27

    category 4

  • 28

    acyclovir (zovirax)

  • 29

    vidarabine (vira-a)

  • 30

    amantadine (symmetrel)

  • 31

    ribavirin (virazole)

  • 32

    DIDANOSINE (Videx)

  • 33

    ZALCITABINE (HIVID)

  • 34

    ZIDUVODINE (Retrovir) Or AZT (azidothymidine)

  • 35

    GANCICLOVIR (Cytovene)

  • 36

    FOSCARNET (Foscavir)

  • 37

    AMPHOTERICIN B

  • 38

    CLOTRIMAZOLE (Canesten)

  • 39

    FLUCONAZOLE (Diflucan)

  • 40

    FLUCYTOSINE (Ancobon)

  • 41

    GRISEOFULVIN (Fulvicin)

  • 42

    ITRACONAZOLE (Sporanox)

  • 43

    KETOCONAZOLE (Nizoral)

  • 44

    MICONAZOLE (Monistat)

  • 45

    NYSTATIN (Mycostatin)

  • 46

    4 PROTOZOAL INFECTIONS

    malaria, amebiasis, gardiasis, trichomoniasis

  • 47

    3 HELMINTHIC INFECTIONS

    roundworms, tapeworms, flukes

  • 48

    5 ANTI MALARIAL DRUGS

    CHLOROQUINE, MEFLOQUINE, PRIMAQUINE , PYRIMETHAMINE, QUININE

  • 49

    3 ANTI AMEBIC & OTHER PROTOZOAL AGENTS

    IODOQUINOL, PAROMOMYCIN / DILOXANIDE FUROATE, METRONIDAZOLE

  • 50

    6 ANTI HELMINTHIC AGENTS

    DIETHYLCARBAMAZINE, MEBENDAZOLE, NICLOSAMIDE, PRAZIQUANTEL, PYRANTEL PAMOATE, THIABENDAZOLE

  • 51

    - Drug of choice: trematodes -Adv. Effect: GIT and CNS adverse effects

    PRAZIQUANTEL

  • 52

    - ascariasis, enterobiasis, hookworm infections -Adv. Effect: mild GIT distress

    PYRANTEL PAMOATE

  • 53

    Trichinosis and other roundworm infections - Adv. Effect: GIT distress, allergic reactions

    THIABENDAZOLE

  • 54

    Onchocerciasis, loiasis, filariasis -Adv. Effect: headache, malaise, weakness, loss of appetite

    DIETHYLCARBAMAZINE

  • 55

    Drug of choice for multi-roundworm infestation -Adv. Effect: GIT distress

    MEBENDAZOLE

  • 56

    - Drug of choice: tapeworms -Adv. Effect: GIT distress

    NICLOSAMIDE

  • 57

    1st one of defense 5

    isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin