Psychopharm Impulsivity/Compulsvity/Addiction | 暗記メーカー

暗記メーカー

Psychopharm Impulsivity/Compulsvity/Addiction

7問 • 9ヶ月前

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問題一覧

1

The progression from occasional, impulsive drug use to compulsive and addiction involves?

Both the dysregulation of bottom-up reward circuits and insufficient top-down inhibition of these circuits.

2

Acts on mu receptors or causes release of enkephalin, and acts at presynaptic metabotropic glutamate receptors (mGluRs) and presynaptic voltage-sensitive channels (VSCCs) to inhibit glutamate release and also enhancing GABA by blocking GABAb receptors by direct/indirect action on GABAa receptors.

Alcohol

3

What CYP enzyme may lead to induction (tolerance) of alcohol as well as many other drugs, and help to amplify alcohols effect on those drugs when taken together?

CYP2E1

4

-MOA: Mu receptor blockade interrupts reward pathways in the brain -S/E: Gl upset, headache, dizziness, nervousness, fatigue -Contraindications: Opioid use or opioid withdrawal, severe liver inflammation or cirrhosis

Naltrexone

5

-MOA: Modulate overactive glutamatergic brain activity that occurs after stopping chronic heavy alcohol use -S/E: Diarrhea; nervousness,fatigue, insomnia, depression have been reported with high doses -Contraindications: Severe renal impairment

Acamprosate

6

-MOA: Accumulation of acetaldehyde in the blood produces unpleasant symptoms -S/E: N/V, HTN if taken with alcohol -Contraindications: Patients who recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations; severe myocardial disease or coronary occlusion, and psychosis

Disulfiram

7

Directly causes dopamine release in the nucleus accumbens by binding alpha4-beta2-nicotinic receptors on dopamine neurons in the VTA, and also binds to alpha2-nicotinic neurons on GABA interneurons in the VTA. This disinhibition of GABA allows for more dopamine release.

Nicotine

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Pathophysiology

Pathophysiology

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Pathophysiology

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Patho Immunology

Patho Immunology

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Patho Immunology

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Patho Hematology

Patho Hematology

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Patho Hematology 2

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Patho Respiratory

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Patho Respiratory

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Patho Respiratory 2

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Patho Respiratory 2

Patho Respiratory 2

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Patho Cardiovascular

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Patho Cardiovascular 2

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Patho MSK

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Patho Acid Base

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Patho Acid Base

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Renal 2

Renal 2

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Renal 2

Renal 2

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Fluid Balance

Fluid Balance

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Fluid Balance

Fluid Balance

43問 • 2年前

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Patho Endocrine

Patho Endocrine

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Patho Endocrine

Patho Endocrine

100問 • 2年前

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Patho Endocrine 2

Patho Endocrine 2

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Patho Endocrine 2

Patho Endocrine 2

42問 • 2年前

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Infections

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Infections

Infections

58問 • 2年前

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Patho Shock

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Patho Shock

Patho Shock

31問 • 2年前

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GI

GI

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GI

GI

100問 • 2年前

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GI 2

GI 2

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GI 2

GI 2

18問 • 2年前

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Cancer

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54問 • 2年前

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問題一覧

1

The progression from occasional, impulsive drug use to compulsive and addiction involves?

Both the dysregulation of bottom-up reward circuits and insufficient top-down inhibition of these circuits.

2

Acts on mu receptors or causes release of enkephalin, and acts at presynaptic metabotropic glutamate receptors (mGluRs) and presynaptic voltage-sensitive channels (VSCCs) to inhibit glutamate release and also enhancing GABA by blocking GABAb receptors by direct/indirect action on GABAa receptors.

Alcohol

3

What CYP enzyme may lead to induction (tolerance) of alcohol as well as many other drugs, and help to amplify alcohols effect on those drugs when taken together?

CYP2E1

4

-MOA: Mu receptor blockade interrupts reward pathways in the brain -S/E: Gl upset, headache, dizziness, nervousness, fatigue -Contraindications: Opioid use or opioid withdrawal, severe liver inflammation or cirrhosis

Naltrexone

5

-MOA: Modulate overactive glutamatergic brain activity that occurs after stopping chronic heavy alcohol use -S/E: Diarrhea; nervousness,fatigue, insomnia, depression have been reported with high doses -Contraindications: Severe renal impairment

Acamprosate

6

-MOA: Accumulation of acetaldehyde in the blood produces unpleasant symptoms -S/E: N/V, HTN if taken with alcohol -Contraindications: Patients who recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations; severe myocardial disease or coronary occlusion, and psychosis

Disulfiram

7

Directly causes dopamine release in the nucleus accumbens by binding alpha4-beta2-nicotinic receptors on dopamine neurons in the VTA, and also binds to alpha2-nicotinic neurons on GABA interneurons in the VTA. This disinhibition of GABA allows for more dopamine release.

Nicotine