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Psychopharm ADHD
20問 • 9ヶ月前
  • Two Clean Queens
    • 通報

    問題一覧

  • 1

    Select the symptom(s) associated with the brain region: dorsal ACC

    Selective attention

  • 2

    Select the symptom(s) associated with the brain region: DLPFC

    Sustained attention/problem solving

  • 3

    Select the symptom(s) associated with the brain region: orbitofrontal cortex

    Impulsive symptoms

  • 4

    Select the symptom(s) associated with the brain region: prefrontal motor cortex

    Hyperactive symptoms

  • 5

    What test will test for sustained attention?

    N-back test

  • 6

    What test will test for selective attention in the dorsal ACC?

    Stroop Test

  • 7

    What part of the brain is associated with frequently interrupting others and fidgeting?

    OFC

  • 8

    What brian regions are associated with disorganization, not finishing tasks, distracted, and makes careless mistakes?

    DLPFC and dorsal ACC

  • 9

    What receptors are associated with alterness, and what are the neurotransmitters involved?

    a2A and D1 receptors, and NE and DA

  • 10

    Increases the incoming signal and allows for increase connections between prefrontal networks through stimulation of alpha 2A receptors

    NE

  • 11

    Decreases the noise and prevents inappropriate connections from taking place through stimulating D1 receptors

    DA

  • 12

    These types of stimulants amplify tonic NE and DA signals

    Slow dose stimulants

  • 13

    These types of stimulants amplify tonic and phasic NE and DA signals

    Pulsatile stimulants

  • 14

    Compare and contrast the mechanisms of amphetamine vs methlyphenidate

    Amphetamine is a competive inhibitor of DAT and VMAT allowing it to be taken up into the vesicles and eventually displaces and dumps DA into the synapse. Methylphenidate basically "freezes" the DAT from taking DA into the terminal but it is not taken up into the terminal via DAT like amphetamines are.

  • 15

    What part of the brain does atomoxetine work and what makes it less likely to be abused?

    Because it works on NET in the PFC and since there are not NETs in the nucleus acumbens this prevents it from being abused

  • 16

    What is the major side effect of atomoxetine and what is its CYP metabolism pathway?

    Liver failure and CYP2D6

  • 17

    -"Multimodal" non-stimulant -Increases NE, 5HT, and DA in the PFC without increasing DA in the NAc -5HT2B Antagonism -5HT2C agonism -NET inhibition -FDA approved for ADHD ages 6-17

    Viloxazine ER

  • 18

    • Can increase heart rate and diastolic blood pressure (20%) • Somnolence (16%) • Possible appetite suppression (5HT2C agonism is MOA of weight loss medication Belviq (locaserin) • No known risk of hepatotoxicity • It is renally eliminated

    Viloxazine

  • 19

    Absorption significantly increased with high fat meal and more selective for alpha-2a receptors than clonidine leading to behavioral improvements.

    Guanfacine

  • 20

    Non-selective alpha-a2 agonist that binds alpha-2a, alpha-2B, alpha-2C, and imidazoline receptors which the ladder can cause sedation and hypotension. It is used off-label for ADHD, conduct disorder, ODD, and Tourette's.

    Clonidine

    • Patho Renal

    Patho Renal

    Two Clean Queens · 100問 · 2年前

    Patho Renal

    Patho Renal

    100問 • 2年前
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    Pathophysiology

    Pathophysiology

    Two Clean Queens · 100問 · 2年前

    Pathophysiology

    Pathophysiology

    100問 • 2年前
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    Patho Immunology

    Patho Immunology

    Two Clean Queens · 34問 · 2年前

    Patho Immunology

    Patho Immunology

    34問 • 2年前
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    Patho Hematology

    Patho Hematology

    Two Clean Queens · 100問 · 2年前

    Patho Hematology

    Patho Hematology

    100問 • 2年前
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    Patho Hematology 2

    Patho Hematology 2

    Two Clean Queens · 76問 · 2年前

    Patho Hematology 2

    Patho Hematology 2

    76問 • 2年前
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    Patho Respiratory

    Patho Respiratory

    Two Clean Queens · 100問 · 2年前

    Patho Respiratory

    Patho Respiratory

    100問 • 2年前
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    Patho Respiratory 2

    Patho Respiratory 2

    Two Clean Queens · 54問 · 2年前

    Patho Respiratory 2

    Patho Respiratory 2

    54問 • 2年前
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    Patho Cardiovascular

    Patho Cardiovascular

    Two Clean Queens · 100問 · 2年前

    Patho Cardiovascular

    Patho Cardiovascular

    100問 • 2年前
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    Patho Cardiovascular 2

    Patho Cardiovascular 2

    Two Clean Queens · 56問 · 2年前

    Patho Cardiovascular 2

    Patho Cardiovascular 2

    56問 • 2年前
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    Patho MSK

    Patho MSK

    Two Clean Queens · 52問 · 2年前

    Patho MSK

    Patho MSK

    52問 • 2年前
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    Patho Acid Base

    Patho Acid Base

    Two Clean Queens · 35問 · 2年前

    Patho Acid Base

    Patho Acid Base

    35問 • 2年前
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    Renal 2

    Renal 2

    Two Clean Queens · 10問 · 2年前

    Renal 2

    Renal 2

    10問 • 2年前
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    Fluid Balance

    Fluid Balance

    Two Clean Queens · 43問 · 2年前

    Fluid Balance

    Fluid Balance

    43問 • 2年前
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    Patho Endocrine

    Patho Endocrine

    Two Clean Queens · 100問 · 2年前

    Patho Endocrine

    Patho Endocrine

    100問 • 2年前
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    Patho Endocrine 2

    Patho Endocrine 2

    Two Clean Queens · 42問 · 2年前

    Patho Endocrine 2

    Patho Endocrine 2

    42問 • 2年前
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    Infections

    Infections

    Two Clean Queens · 58問 · 2年前

    Infections

    Infections

    58問 • 2年前
    Two Clean Queens

    Patho Shock

    Patho Shock

    Two Clean Queens · 31問 · 2年前

    Patho Shock

    Patho Shock

    31問 • 2年前
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    GI

    GI

    Two Clean Queens · 100問 · 2年前

    GI

    GI

    100問 • 2年前
    Two Clean Queens

    GI 2

    GI 2

    Two Clean Queens · 18問 · 2年前

    GI 2

    GI 2

    18問 • 2年前
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    Cancer

    Cancer

    Two Clean Queens · 54問 · 2年前

    Cancer

    Cancer

    54問 • 2年前
    Two Clean Queens

    問題一覧

  • 1

    Select the symptom(s) associated with the brain region: dorsal ACC

    Selective attention

  • 2

    Select the symptom(s) associated with the brain region: DLPFC

    Sustained attention/problem solving

  • 3

    Select the symptom(s) associated with the brain region: orbitofrontal cortex

    Impulsive symptoms

  • 4

    Select the symptom(s) associated with the brain region: prefrontal motor cortex

    Hyperactive symptoms

  • 5

    What test will test for sustained attention?

    N-back test

  • 6

    What test will test for selective attention in the dorsal ACC?

    Stroop Test

  • 7

    What part of the brain is associated with frequently interrupting others and fidgeting?

    OFC

  • 8

    What brian regions are associated with disorganization, not finishing tasks, distracted, and makes careless mistakes?

    DLPFC and dorsal ACC

  • 9

    What receptors are associated with alterness, and what are the neurotransmitters involved?

    a2A and D1 receptors, and NE and DA

  • 10

    Increases the incoming signal and allows for increase connections between prefrontal networks through stimulation of alpha 2A receptors

    NE

  • 11

    Decreases the noise and prevents inappropriate connections from taking place through stimulating D1 receptors

    DA

  • 12

    These types of stimulants amplify tonic NE and DA signals

    Slow dose stimulants

  • 13

    These types of stimulants amplify tonic and phasic NE and DA signals

    Pulsatile stimulants

  • 14

    Compare and contrast the mechanisms of amphetamine vs methlyphenidate

    Amphetamine is a competive inhibitor of DAT and VMAT allowing it to be taken up into the vesicles and eventually displaces and dumps DA into the synapse. Methylphenidate basically "freezes" the DAT from taking DA into the terminal but it is not taken up into the terminal via DAT like amphetamines are.

  • 15

    What part of the brain does atomoxetine work and what makes it less likely to be abused?

    Because it works on NET in the PFC and since there are not NETs in the nucleus acumbens this prevents it from being abused

  • 16

    What is the major side effect of atomoxetine and what is its CYP metabolism pathway?

    Liver failure and CYP2D6

  • 17

    -"Multimodal" non-stimulant -Increases NE, 5HT, and DA in the PFC without increasing DA in the NAc -5HT2B Antagonism -5HT2C agonism -NET inhibition -FDA approved for ADHD ages 6-17

    Viloxazine ER

  • 18

    • Can increase heart rate and diastolic blood pressure (20%) • Somnolence (16%) • Possible appetite suppression (5HT2C agonism is MOA of weight loss medication Belviq (locaserin) • No known risk of hepatotoxicity • It is renally eliminated

    Viloxazine

  • 19

    Absorption significantly increased with high fat meal and more selective for alpha-2a receptors than clonidine leading to behavioral improvements.

    Guanfacine

  • 20

    Non-selective alpha-a2 agonist that binds alpha-2a, alpha-2B, alpha-2C, and imidazoline receptors which the ladder can cause sedation and hypotension. It is used off-label for ADHD, conduct disorder, ODD, and Tourette's.

    Clonidine