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Patho Immunology
34問 • 2年前
  • Two Clean Queens
    • 通報

    問題一覧

  • 1

    Assist activation of CD8, NK, and B-cells

    Helper T-Cells (CD4)

  • 2

    Help prevent autoimmune response

    Regulator T-Cells (CD4)

  • 3

    Binds to antigens surface and destroys infected cell

    Cytotoxic T-Cells (CD8)

  • 4

    Occurs in bone marrow, have antigen binding sites, produces daughter cells that produce plasma cells (Ab factories), and secrete IgM specific to the antigen.

    B-Cell

  • 5

    IgM 7 days after exposure, IgG represents 75% of Abs, levels will gradually decrease.

    Primary B-Cell Response

  • 6

    Subsequent exposure leads to IgG produced quickly in large amounts, levels remain elevated.

    Secondary B-Cell Response

  • 7

    Best complement activating antibody.

    IgM

  • 8

    Best Opsonin Antibody

    IgG

  • 9

    Antibodies Protect Through…

    Neutralization, Agglutination, Precipiation, Opsonization

  • 10

    antibodies block antigen receptors

    Direct Effects

  • 11

    Antibodies responsible for activating innate immunity, complement, phagocytes

    Indirect Effects

  • 12

    Produced after antigen exposure, requires host immune system response, long term memory.

    Acquired Immunity

  • 13

    Antibodies transferred from donor to recipient, no host immune response required, temporary protection.

    Passive Immunity

  • 14

    Has a role in human leukocyte antigen (HLA) and graft rejection after transplant.

    MHC

  • 15

    Most common secretory antibody

    IgA

  • 16

    Lacrimal, Salivary, Bronchial, Breast, GI, GU glands/tissue

    Secretory Immune Response

  • 17

    Small amounts of antibodies move through placenta during…

    1st trimester

  • 18

    when fetal antibodies = maternal antibodies

    37-40 weeks

  • 19

    Leukocytes less lethal and effective, T and B cell production takes 6-8 months.

    Immature Immune System at Birth

  • 20

    Antibodies in breast milk

    IgA, IgG, IgM

  • 21

    Link between chronic illness and chronic inflammation.

    Inflammaging

  • 22

    IgE mediated involves allergies

    Type I

  • 23

    Tissue specific, hemolytic reactions (drugs, hemolytic disease of newborn)

    Type II

  • 24

    Immune complex, gluten allergies, SLE

    Type III

  • 25

    Cell Mediated, transplant rejection

    Type IV

  • 26

    Histamine acts on this receptor to stop degranulation

    H2

  • 27

    Two Types of Histamine Receptors

    H1 (lungs) and H2 (GI)

  • 28

    Individuals have more IgE and mast cell receptors for IgE

    Atopic

  • 29

    multiple exposures needed to build up antibodies to cause hypersensitivity

    Sensitization

  • 30

    Small amounts of antigen over long time period leads to build up of IgG to help suppress IgE

    Desensitization

  • 31

    Lab test ANA, typically deposited in kidneys, vessels, connective tissue, heart, brain.

    SLE

  • 32

    Activates CD4, CD8 and T-lymphocytes

    MHC

  • 33

    Recipient + donor dendritic cells trigger cytokines that activate macrophages and CD8

    Acute Rejection

  • 34

    Ongoing inflammation, damage to endothelial cells of transplant. Antibodies against HLA activate complement and cytotoxins.

    Chronic Rejection

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    問題一覧

  • 1

    Assist activation of CD8, NK, and B-cells

    Helper T-Cells (CD4)

  • 2

    Help prevent autoimmune response

    Regulator T-Cells (CD4)

  • 3

    Binds to antigens surface and destroys infected cell

    Cytotoxic T-Cells (CD8)

  • 4

    Occurs in bone marrow, have antigen binding sites, produces daughter cells that produce plasma cells (Ab factories), and secrete IgM specific to the antigen.

    B-Cell

  • 5

    IgM 7 days after exposure, IgG represents 75% of Abs, levels will gradually decrease.

    Primary B-Cell Response

  • 6

    Subsequent exposure leads to IgG produced quickly in large amounts, levels remain elevated.

    Secondary B-Cell Response

  • 7

    Best complement activating antibody.

    IgM

  • 8

    Best Opsonin Antibody

    IgG

  • 9

    Antibodies Protect Through…

    Neutralization, Agglutination, Precipiation, Opsonization

  • 10

    antibodies block antigen receptors

    Direct Effects

  • 11

    Antibodies responsible for activating innate immunity, complement, phagocytes

    Indirect Effects

  • 12

    Produced after antigen exposure, requires host immune system response, long term memory.

    Acquired Immunity

  • 13

    Antibodies transferred from donor to recipient, no host immune response required, temporary protection.

    Passive Immunity

  • 14

    Has a role in human leukocyte antigen (HLA) and graft rejection after transplant.

    MHC

  • 15

    Most common secretory antibody

    IgA

  • 16

    Lacrimal, Salivary, Bronchial, Breast, GI, GU glands/tissue

    Secretory Immune Response

  • 17

    Small amounts of antibodies move through placenta during…

    1st trimester

  • 18

    when fetal antibodies = maternal antibodies

    37-40 weeks

  • 19

    Leukocytes less lethal and effective, T and B cell production takes 6-8 months.

    Immature Immune System at Birth

  • 20

    Antibodies in breast milk

    IgA, IgG, IgM

  • 21

    Link between chronic illness and chronic inflammation.

    Inflammaging

  • 22

    IgE mediated involves allergies

    Type I

  • 23

    Tissue specific, hemolytic reactions (drugs, hemolytic disease of newborn)

    Type II

  • 24

    Immune complex, gluten allergies, SLE

    Type III

  • 25

    Cell Mediated, transplant rejection

    Type IV

  • 26

    Histamine acts on this receptor to stop degranulation

    H2

  • 27

    Two Types of Histamine Receptors

    H1 (lungs) and H2 (GI)

  • 28

    Individuals have more IgE and mast cell receptors for IgE

    Atopic

  • 29

    multiple exposures needed to build up antibodies to cause hypersensitivity

    Sensitization

  • 30

    Small amounts of antigen over long time period leads to build up of IgG to help suppress IgE

    Desensitization

  • 31

    Lab test ANA, typically deposited in kidneys, vessels, connective tissue, heart, brain.

    SLE

  • 32

    Activates CD4, CD8 and T-lymphocytes

    MHC

  • 33

    Recipient + donor dendritic cells trigger cytokines that activate macrophages and CD8

    Acute Rejection

  • 34

    Ongoing inflammation, damage to endothelial cells of transplant. Antibodies against HLA activate complement and cytotoxins.

    Chronic Rejection