問題一覧
1
Subsequent exposure leads to IgG produced quickly in large amounts, levels remain elevated.
Secondary B-Cell Response
2
multiple exposures needed to build up antibodies to cause hypersensitivity
Sensitization
3
Individuals have more IgE and mast cell receptors for IgE
Atopic
4
Lab test ANA, typically deposited in kidneys, vessels, connective tissue, heart, brain.
SLE
5
Antibodies Protect Through…
Neutralization, Agglutination, Precipiation, Opsonization
6
Cell Mediated, transplant rejection
Type IV
7
Lacrimal, Salivary, Bronchial, Breast, GI, GU glands/tissue
Secretory Immune Response
8
Leukocytes less lethal and effective, T and B cell production takes 6-8 months.
Immature Immune System at Birth
9
Best complement activating antibody.
IgM
10
Histamine acts on this receptor to stop degranulation
H2
11
Antibodies in breast milk
IgA, IgG, IgM
12
Link between chronic illness and chronic inflammation.
Inflammaging
13
Most common secretory antibody
IgA
14
Produced after antigen exposure, requires host immune system response, long term memory.
Acquired Immunity
15
Activates CD4, CD8 and T-lymphocytes
MHC
16
Small amounts of antibodies move through placenta during…
1st trimester
17
Has a role in human leukocyte antigen (HLA) and graft rejection after transplant.
MHC
18
Occurs in bone marrow, have antigen binding sites, produces daughter cells that produce plasma cells (Ab factories), and secrete IgM specific to the antigen.
B-Cell
19
Immune complex, gluten allergies, SLE
Type III
20
Ongoing inflammation, damage to endothelial cells of transplant. Antibodies against HLA activate complement and cytotoxins.
Chronic Rejection
21
Assist activation of CD8, NK, and B-cells
Helper T-Cells (CD4)
22
IgM 7 days after exposure, IgG represents 75% of Abs, levels will gradually decrease.
Primary B-Cell Response
23
antibodies block antigen receptors
Direct Effects
24
Binds to antigens surface and destroys infected cell
Cytotoxic T-Cells (CD8)
25
Antibodies responsible for activating innate immunity, complement, phagocytes
Indirect Effects
26
IgE mediated involves allergies
Type I
27
Tissue specific, hemolytic reactions (drugs, hemolytic disease of newborn)
Type II
28
Small amounts of antigen over long time period leads to build up of IgG to help suppress IgE
Desensitization
29
Two Types of Histamine Receptors
H1 (lungs) and H2 (GI)
30
Help prevent autoimmune response
Regulator T-Cells (CD4)
31
when fetal antibodies = maternal antibodies
37-40 weeks
32
Best Opsonin Antibody
IgG
33
Antibodies transferred from donor to recipient, no host immune response required, temporary protection.
Passive Immunity
34
Recipient + donor dendritic cells trigger cytokines that activate macrophages and CD8
Acute Rejection