MODULE 13Gene Therapy

23問 • 1年前

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通報

問題一覧

With the help of this, the causes of genetic disorders were now being traced and defective genes are now detected

molecular biology

treating genetic disorders called__

gene therapy

The initial aim was the correction of inherited genetic diseases.

gene therapy

is when a DNA is introduced into a patient to treat a genetic disease.

gene therapy

A gene that is inserted directly into a cell usually does not function. Instead, a carrier called a ___ is genetically engineered to deliver the gene.

vector

Certain __ are often used as vectors because they can deliver the new gene by infecting the cell.

viruses

____integrate their genetic material including the new gene into a chromosome in the human cell.

retroviruses

___introduce their DNA into the nucleus of the cell, but the DNA is not integrated into a chromosome.

adenoviruses

___can be injected or given intravenously (by IV) directly into a specific tissue in the body, where it is taken up by individual cells.

vector

Types of Gene Therapy:

1. Somatic gene therapy 2. Germline gene therapy

transfer of a section of DNA to any cell of the body that doesn't produce sperm or eggs.

Somatic gene therapy

transfer of a section of DNA to cells that produces sperm or eggs.

Germline gene therapy

Categories of Gene Therapy:

1. Somatic-Cell gene therapy 2. Germ Line gene therapy 3. Somatic cell enhancement 4. 4. Germ line enhancement.

for the cure and prevention of diseases.

Somatic-Cell gene therapy

Example: insertion of a DNA sequence into a person's cell to allow production of an enzyme like adenosine deaminase.

Somatic-Cell gene therapy

🙃🎀💌

Example: Insertion of an adenosine deaminase sequence into early embryo or reproductive cells, which would affect not only the individual but all of his or her offspring.

Example: Insertion of a DNA sequence to improve memory, increase height, or increase intelligence which would affect only the individual.

Somatic cell enhancement.

Example: Insertion of a DNA sequence for enhancement into a blastocyst, sperm or egg, which would affect future generation.

Germ line enhancement

It is designed for diseases caused by loss of function of a gene, introducing extra copies of a normal gene may increase the amount of normal gene product to a level where the normal phenotype is restored.

Gene augmentation therapy.

This is suitable for the treatment of infectious diseases, cancer and inherited diseases caused by the inappropriate gene activity.

Gene inhibition therapy.

The aim is to introduce a gene whose product either: inhibits the expression of another gene or interferes with the activity of the product of another gene.

Gene inhibition therapy.

Genes are directed to the target cells and then expressed so as to cause cell killing.Direct cell killing is possible if the inserted genes are expressed to produce a lethal toxin(suicide gene) or a gene encoding a prodrug is inserted, conferring susceptibility to killing by a subsequently administered drug.

Gene therapy killing of specific cells.

At present, the type of therapy being undertaken is___

somatic gene therapy

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問題一覧

With the help of this, the causes of genetic disorders were now being traced and defective genes are now detected

molecular biology

treating genetic disorders called__

gene therapy

The initial aim was the correction of inherited genetic diseases.

gene therapy

is when a DNA is introduced into a patient to treat a genetic disease.

gene therapy

A gene that is inserted directly into a cell usually does not function. Instead, a carrier called a ___ is genetically engineered to deliver the gene.

vector

Certain __ are often used as vectors because they can deliver the new gene by infecting the cell.

viruses

____integrate their genetic material including the new gene into a chromosome in the human cell.

retroviruses

___introduce their DNA into the nucleus of the cell, but the DNA is not integrated into a chromosome.

adenoviruses

___can be injected or given intravenously (by IV) directly into a specific tissue in the body, where it is taken up by individual cells.

vector

Types of Gene Therapy:

1. Somatic gene therapy 2. Germline gene therapy

transfer of a section of DNA to any cell of the body that doesn't produce sperm or eggs.

Somatic gene therapy

transfer of a section of DNA to cells that produces sperm or eggs.

Germline gene therapy

Categories of Gene Therapy:

1. Somatic-Cell gene therapy 2. Germ Line gene therapy 3. Somatic cell enhancement 4. 4. Germ line enhancement.

for the cure and prevention of diseases.

Somatic-Cell gene therapy

Example: insertion of a DNA sequence into a person's cell to allow production of an enzyme like adenosine deaminase.

Somatic-Cell gene therapy

🙃🎀💌

Example: Insertion of an adenosine deaminase sequence into early embryo or reproductive cells, which would affect not only the individual but all of his or her offspring.

Example: Insertion of a DNA sequence to improve memory, increase height, or increase intelligence which would affect only the individual.

Somatic cell enhancement.

Example: Insertion of a DNA sequence for enhancement into a blastocyst, sperm or egg, which would affect future generation.

Germ line enhancement

Gene augmentation therapy.

This is suitable for the treatment of infectious diseases, cancer and inherited diseases caused by the inappropriate gene activity.

Gene inhibition therapy.

The aim is to introduce a gene whose product either: inhibits the expression of another gene or interferes with the activity of the product of another gene.

Gene inhibition therapy.

Gene therapy killing of specific cells.

At present, the type of therapy being undertaken is___

somatic gene therapy