liver
問題一覧
1
Removes harmful substances from the blood, Makes protien and clotting factors, Amonia conversion, Metabolize medication, Vitamin and iron storage, Metabolize glucose, lipid, fat and protein, Produces biles to aid digestion
2
Nodular growth=cirrhosis when liver can’t filter toxins reach the brain and damage the nervous system= encephalopathy fluid retention and peripheral edema
3
Hepatitis, Inherited metabolic disorders, Alcohol, Drugs, NASH non- alcoholic steatohepatitis fatty liver, Immune disorders, Excess vitamin A, Cholestatic disorders
4
Hepatitis
5
Failure of liver cells to regenerate, Progression of nectrotic process (advanced), Often fatal
6
Liver inflammation lasting linger than 6 months, Usually occurs due to HBV or HCV may occur with HBV+ HDV, May lead to cirrhosis and liver cancer
7
Vaccine, Infection control practices
8
Very comprehensive, Travel to another country, Recent ingestion of shellfish, Secual practices with whom/unprotected, Illicit drugs use IV, Body piercing/tattooing, Healthcare worker/child care/correctional facility/ Long term care, Blood/blood products prior to 1992, History of alcohol use, Living conditions
9
Abdominal pain, Changes in skin or sclera yellowing, Changes in color of urine (dark) or stool, Arthralgia (joint, pain) myalgia (muscle pain), Fever, Lethargy, Malaise, N/V, Puritis
10
High carb and calories with moderate amount of fat and protein High protein= ammonia= encephalopathy, Small frequent meals, Highh calorie snacks, Supplemental vitamins, Food preferences
11
Resting the inflamed liver, Alternate periods of rest with activity, Self care and ambulation activities as tolerated
12
Teach pt and caregivers about importance of handwashing, Teach about any isolation precautions, Restrict visitors with active infections, Monitor for development of fever/⬆️WBC& report to physician
13
Anti-emetics very important, Anti virals for HBV&HCV, Integrative therapies, Teach pt to avoid all OTC meds unless
14
Caused by accumulation of fats around the hepatic cells, 2 types non-alcoholic fatty liver disease (NALFD) non-alcoholic steatohepatitis (NASH), Causes: Diabetetes, obesity, elevated lipid profile, genetics
15
Many pts asymptomatic for most part, Diagnostics: Elevated ALT/AST or normal ALT/⬆️ AST, MRI/Ultrasound, Biopsy
16
Weight loss, Glucose control, Lipid lowering agents, Monitor liver function
17
Cirrhosis
18
Extensive irresversible scarring of the liver, Caused by chronic reaction to hepatic inflammation and necrosis, Widespread fibrotic changes lead to change in cellular regulation, Inflammation> destruction of hepatocytes, Tissue becomes modular> nodules block file ducts and blood and lymph flow, Early stage: liver is enlarged, firm and hard, Later stage: liver shrinks in size> ⬇️liver function
19
Usually follows acute viral hepatitis, but may due to industrial chemical hepatotoxins, Massive lose of liver cells, with irregular patterns of regenerating cells, 75% die of complications within five years
20
Chronic alcohol abuse, Also known as Laennec’s or micronudular cirrhosis, Small nodule form as a result of presistence of offending agent, Prognosis depends of presence of complicates and continued abuse
21
Occurs secondary to chronic biliary obstruction or autoimmune disease, Bile flow is ⬇️with concurrent cell damage to hepatocytes around bile ductules, Treatment aim is to relieve mechanical obstruction, Also known as cholestatic
22
Liver is scarred and cellular regulation impaired, Can still perform essential functions, No major symptoms
23
Portal hypertension, Coagulation defects, Ascites and esophageal varices, Jaundice, Portal systemic encephthalopathy> hepatic coma, Hepatorenal syndrome, Spontaneous bacterial pertitonitis
24
Persistent ⬆️in pressure in portal vein, ⬆️ resistance/ obstruction of blood flow through the portal vein and branches, Blood seeks collateral circulation, Backflow of blood to splee causes splenomegaly, Persistant venous dilation: esophagus, stomach, intestines, abdomen, and rectum.
25
Third space shift hypovolemia and edema, Free fluid within peritoneal cavity-Caused by ⬆️hydrostatic pressure from portal HTN- Fluid flows from the vascular system into the abdomen. Distended abdomen!
26
Results from portal HTN, Back up of blood from liver enters esophageal and gastric veins, Varices occur when esophageal veins become distended
27
Life threatening/ Medical emergency, Hematemsis, Melena, Can occur spontaneously with no precipitating symptoms
28
Production of bile in the liver is ⬇️, Prevents the absorption of fat-soluble vitamins (K), Insuffcient quantity of clotting factors produced (susceptible to bleeding and bruising, Genetic disposition primary biliary cirrhosis (PBC)
29
Yellow pigmentation of the sclera, skin and deeper tissues caused by excessive accumulation of bile pigments in blood., Billirubin (bile pigment) a product of RBC breakdown is deposited in the skin and excreted in the urine when present in blood in excessive amounts (hyperbilirubinemia), Total bilirubin 0.3-1.1 mg/dl
30
Develops because the liver cannot metabolize billirubin, ⬆️indirect (unconjugated) and direct (conjugated) bilirubin levels, Excessive circulating bilirubin levels due to impaired uptake of bilirubin from the blood
31
Edema fibrosis or scarring of the hepatic bile channels and bile ducts which interferes with normal bile and bilirubin excretion., Increased direct bilirubin levels
32
Results from impaired bilirubin uptake die to excessive RBC destruction (sickle cell, transfusion reactions), Caused by transfusion reaction, hemolytic anemia, sickle cell crisis, Increased indirect and normal direct levels
33
Exact cause unknown, Cognitive syndrome, Results from liver failure and cirrhosis, Early S/S: sleep disturbances, mood disturbances, mental status changes, speech problems, Later S/S altered LOC, impaired thinking processes, neuromuscular problems
34
High protien diet, Infection, Hypovolemia (⬇️fluid volume), Hypokalemia (⬇️serum K+), Constipation, GI bleeding, Drugs
35
Oliguria (sudden ⬇️ in urinary flow), ⬆️BUN& Creatinine, ⬇️sodium excretion, Increased urine osmoality
36
Very advanced liver disease, Low concentrations of proteins, Symptoms: fever, chills, alterations in comfort (abdomen)
37
Exposure to alcohol and drugs (how much, how often, when, which routes), Needlestick injuries, Sexual history and orientation, Family history of alcoholism or liver disease, Work history (Healthcare, police officer, EMT), History of hepatitis, biliary tract disorders, viral infections, blood transfusions, lipid profile, autoimmune disorders
38
Fatigue, Weight changes, anorexia, N/V, Abdominal tenderness, Jaundice, Dry skin/ rashes, Purpuric lesions (petechiae or echymoses), Asterixes (hand flapping), Warm red palms, Spider angiomas, Ascites, Peripheral edema of extremities, Vitamin deficiencies esp fat soluble (A,D,E,K), Hepatomegaly, Blood in stool or vomit, Amenorrhea, Gynecomastia/ impotence
39
AST, ALT, LDH ⬆️initially, Alkaline phosphatase increased d/t biliary obstruction, Total serum bilirubin ⬆️, Ammonia levels ⬆️, Serum creatinine ⬆️, Total serum albumin ⬇️, PT/INR prolonged, PLT count ⬇️, ⬇️ RBC, HGB,HCT, ⬇️serum sodium, Imaging: Ultrasound of liver, x-ray, MRI-can reveal mass lesions, CAT scan, Liver biopsy, EGD, ERCP
40
Monitor:F&E, I&O, abdominal girth, peripheral edema, Nutrtion therapy: low sodium diet, Vitamin supplements, Drug therapy: Diuretics/K+ replacement, Furosemide (lasix), spirnolactone (aldactone)
41
Endoscopic retrograde cholangiopancreatography, Used to diagnose and treat problems in the liver gallbladder, bile ducts, and pancreas
42
Explain the procedure and answer pt questions, Obtain VS including weight before procedure, Ask pt to void before procedure to prevent injury to bladder!, Position pt in bed with HOB elevated, Measure the drainage record accurately document characteristics, Label and send fluid for lab testing, After catheter removed apply a dressing to the site assess for leakage, Maintian rest per protocol, Take VS and weigh pt after and document
43
S/S: Dyspnea, adventituous lung sounds, Interventions: HOB elevated, feet elevated, weigh pt daily, monitor O2 sat.
44
Drug therapy: Beta blocker propranolol and abx, Endoscopic therapies: ligation of bleeding veins via endoscopic variceal ligation EVL and endoscopic sclerotherapy (EST) injection sclerotherapy, Rescue therapies: balloon tamponade transjugular intrahepatic portal shunt (TIPS)
45
Nutrion: High carb, moderate fat, high protein foods, Restrict opioids sedatives and barbiturates, Medications to reduce ammonia levels LACTULOS, lactilol, Non-absorbable antibiotics- neomycin sulfate or rifaximin
46
Most common injury, Multiple lacerations, simple lacerations, Avulsions (tear),Crush injuries
47
Early signs of hypovolemic shock: hypotension, tachycardia, tachypenia, pallor, diaphoresis, cool clammy skin confusion or other changes in mental status, Hematoma: RUQ pain abdominal pain, abdominal tenderness, guarding, distention, rigidity, Diagnostics: Ultrasound or CT scan
48
Blood products, Massive volume infusion, Srugery
49
Fatal
50
Tumors may be metastatic, Tumor may be hepatocellular
51
EARLY SYMPTOMS: Weight loss/ anorexia, weakness abdominal discomfort RUQ pain, Jaudice, Bleeding, Ascites, Edema
52
⬆️Alpha fetal protein (AFP), Alkaline phosphate a tumor marker, Ultrasound/ CAT scan with contrast
53
Surgical resection/liver transplant, TACE= Transarterial chemoilzation, SIRT= Selected internal radiation therapy, Hepatic artery embolization, Cryotherapy, Chemotherapy, Palliative, End-of-life, Hospice services
54
End stage liver disease, Acute liver failure
55
Severe cardiovascular instability, Sever respiratory disease, Metastatic tumors, Inability to follow instructions regarding self management and drug therapy
56
Graft rejection, Infection, Bleeding
57
2 antibiotics, PPI
58
Antacids, H2 blockers, PPIs
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45問 • 1年前問題一覧
1
Removes harmful substances from the blood, Makes protien and clotting factors, Amonia conversion, Metabolize medication, Vitamin and iron storage, Metabolize glucose, lipid, fat and protein, Produces biles to aid digestion
2
Nodular growth=cirrhosis when liver can’t filter toxins reach the brain and damage the nervous system= encephalopathy fluid retention and peripheral edema
3
Hepatitis, Inherited metabolic disorders, Alcohol, Drugs, NASH non- alcoholic steatohepatitis fatty liver, Immune disorders, Excess vitamin A, Cholestatic disorders
4
Hepatitis
5
Failure of liver cells to regenerate, Progression of nectrotic process (advanced), Often fatal
6
Liver inflammation lasting linger than 6 months, Usually occurs due to HBV or HCV may occur with HBV+ HDV, May lead to cirrhosis and liver cancer
7
Vaccine, Infection control practices
8
Very comprehensive, Travel to another country, Recent ingestion of shellfish, Secual practices with whom/unprotected, Illicit drugs use IV, Body piercing/tattooing, Healthcare worker/child care/correctional facility/ Long term care, Blood/blood products prior to 1992, History of alcohol use, Living conditions
9
Abdominal pain, Changes in skin or sclera yellowing, Changes in color of urine (dark) or stool, Arthralgia (joint, pain) myalgia (muscle pain), Fever, Lethargy, Malaise, N/V, Puritis
10
High carb and calories with moderate amount of fat and protein High protein= ammonia= encephalopathy, Small frequent meals, Highh calorie snacks, Supplemental vitamins, Food preferences
11
Resting the inflamed liver, Alternate periods of rest with activity, Self care and ambulation activities as tolerated
12
Teach pt and caregivers about importance of handwashing, Teach about any isolation precautions, Restrict visitors with active infections, Monitor for development of fever/⬆️WBC& report to physician
13
Anti-emetics very important, Anti virals for HBV&HCV, Integrative therapies, Teach pt to avoid all OTC meds unless
14
Caused by accumulation of fats around the hepatic cells, 2 types non-alcoholic fatty liver disease (NALFD) non-alcoholic steatohepatitis (NASH), Causes: Diabetetes, obesity, elevated lipid profile, genetics
15
Many pts asymptomatic for most part, Diagnostics: Elevated ALT/AST or normal ALT/⬆️ AST, MRI/Ultrasound, Biopsy
16
Weight loss, Glucose control, Lipid lowering agents, Monitor liver function
17
Cirrhosis
18
Extensive irresversible scarring of the liver, Caused by chronic reaction to hepatic inflammation and necrosis, Widespread fibrotic changes lead to change in cellular regulation, Inflammation> destruction of hepatocytes, Tissue becomes modular> nodules block file ducts and blood and lymph flow, Early stage: liver is enlarged, firm and hard, Later stage: liver shrinks in size> ⬇️liver function
19
Usually follows acute viral hepatitis, but may due to industrial chemical hepatotoxins, Massive lose of liver cells, with irregular patterns of regenerating cells, 75% die of complications within five years
20
Chronic alcohol abuse, Also known as Laennec’s or micronudular cirrhosis, Small nodule form as a result of presistence of offending agent, Prognosis depends of presence of complicates and continued abuse
21
Occurs secondary to chronic biliary obstruction or autoimmune disease, Bile flow is ⬇️with concurrent cell damage to hepatocytes around bile ductules, Treatment aim is to relieve mechanical obstruction, Also known as cholestatic
22
Liver is scarred and cellular regulation impaired, Can still perform essential functions, No major symptoms
23
Portal hypertension, Coagulation defects, Ascites and esophageal varices, Jaundice, Portal systemic encephthalopathy> hepatic coma, Hepatorenal syndrome, Spontaneous bacterial pertitonitis
24
Persistent ⬆️in pressure in portal vein, ⬆️ resistance/ obstruction of blood flow through the portal vein and branches, Blood seeks collateral circulation, Backflow of blood to splee causes splenomegaly, Persistant venous dilation: esophagus, stomach, intestines, abdomen, and rectum.
25
Third space shift hypovolemia and edema, Free fluid within peritoneal cavity-Caused by ⬆️hydrostatic pressure from portal HTN- Fluid flows from the vascular system into the abdomen. Distended abdomen!
26
Results from portal HTN, Back up of blood from liver enters esophageal and gastric veins, Varices occur when esophageal veins become distended
27
Life threatening/ Medical emergency, Hematemsis, Melena, Can occur spontaneously with no precipitating symptoms
28
Production of bile in the liver is ⬇️, Prevents the absorption of fat-soluble vitamins (K), Insuffcient quantity of clotting factors produced (susceptible to bleeding and bruising, Genetic disposition primary biliary cirrhosis (PBC)
29
Yellow pigmentation of the sclera, skin and deeper tissues caused by excessive accumulation of bile pigments in blood., Billirubin (bile pigment) a product of RBC breakdown is deposited in the skin and excreted in the urine when present in blood in excessive amounts (hyperbilirubinemia), Total bilirubin 0.3-1.1 mg/dl
30
Develops because the liver cannot metabolize billirubin, ⬆️indirect (unconjugated) and direct (conjugated) bilirubin levels, Excessive circulating bilirubin levels due to impaired uptake of bilirubin from the blood
31
Edema fibrosis or scarring of the hepatic bile channels and bile ducts which interferes with normal bile and bilirubin excretion., Increased direct bilirubin levels
32
Results from impaired bilirubin uptake die to excessive RBC destruction (sickle cell, transfusion reactions), Caused by transfusion reaction, hemolytic anemia, sickle cell crisis, Increased indirect and normal direct levels
33
Exact cause unknown, Cognitive syndrome, Results from liver failure and cirrhosis, Early S/S: sleep disturbances, mood disturbances, mental status changes, speech problems, Later S/S altered LOC, impaired thinking processes, neuromuscular problems
34
High protien diet, Infection, Hypovolemia (⬇️fluid volume), Hypokalemia (⬇️serum K+), Constipation, GI bleeding, Drugs
35
Oliguria (sudden ⬇️ in urinary flow), ⬆️BUN& Creatinine, ⬇️sodium excretion, Increased urine osmoality
36
Very advanced liver disease, Low concentrations of proteins, Symptoms: fever, chills, alterations in comfort (abdomen)
37
Exposure to alcohol and drugs (how much, how often, when, which routes), Needlestick injuries, Sexual history and orientation, Family history of alcoholism or liver disease, Work history (Healthcare, police officer, EMT), History of hepatitis, biliary tract disorders, viral infections, blood transfusions, lipid profile, autoimmune disorders
38
Fatigue, Weight changes, anorexia, N/V, Abdominal tenderness, Jaundice, Dry skin/ rashes, Purpuric lesions (petechiae or echymoses), Asterixes (hand flapping), Warm red palms, Spider angiomas, Ascites, Peripheral edema of extremities, Vitamin deficiencies esp fat soluble (A,D,E,K), Hepatomegaly, Blood in stool or vomit, Amenorrhea, Gynecomastia/ impotence
39
AST, ALT, LDH ⬆️initially, Alkaline phosphatase increased d/t biliary obstruction, Total serum bilirubin ⬆️, Ammonia levels ⬆️, Serum creatinine ⬆️, Total serum albumin ⬇️, PT/INR prolonged, PLT count ⬇️, ⬇️ RBC, HGB,HCT, ⬇️serum sodium, Imaging: Ultrasound of liver, x-ray, MRI-can reveal mass lesions, CAT scan, Liver biopsy, EGD, ERCP
40
Monitor:F&E, I&O, abdominal girth, peripheral edema, Nutrtion therapy: low sodium diet, Vitamin supplements, Drug therapy: Diuretics/K+ replacement, Furosemide (lasix), spirnolactone (aldactone)
41
Endoscopic retrograde cholangiopancreatography, Used to diagnose and treat problems in the liver gallbladder, bile ducts, and pancreas
42
Explain the procedure and answer pt questions, Obtain VS including weight before procedure, Ask pt to void before procedure to prevent injury to bladder!, Position pt in bed with HOB elevated, Measure the drainage record accurately document characteristics, Label and send fluid for lab testing, After catheter removed apply a dressing to the site assess for leakage, Maintian rest per protocol, Take VS and weigh pt after and document
43
S/S: Dyspnea, adventituous lung sounds, Interventions: HOB elevated, feet elevated, weigh pt daily, monitor O2 sat.
44
Drug therapy: Beta blocker propranolol and abx, Endoscopic therapies: ligation of bleeding veins via endoscopic variceal ligation EVL and endoscopic sclerotherapy (EST) injection sclerotherapy, Rescue therapies: balloon tamponade transjugular intrahepatic portal shunt (TIPS)
45
Nutrion: High carb, moderate fat, high protein foods, Restrict opioids sedatives and barbiturates, Medications to reduce ammonia levels LACTULOS, lactilol, Non-absorbable antibiotics- neomycin sulfate or rifaximin
46
Most common injury, Multiple lacerations, simple lacerations, Avulsions (tear),Crush injuries
47
Early signs of hypovolemic shock: hypotension, tachycardia, tachypenia, pallor, diaphoresis, cool clammy skin confusion or other changes in mental status, Hematoma: RUQ pain abdominal pain, abdominal tenderness, guarding, distention, rigidity, Diagnostics: Ultrasound or CT scan
48
Blood products, Massive volume infusion, Srugery
49
Fatal
50
Tumors may be metastatic, Tumor may be hepatocellular
51
EARLY SYMPTOMS: Weight loss/ anorexia, weakness abdominal discomfort RUQ pain, Jaudice, Bleeding, Ascites, Edema
52
⬆️Alpha fetal protein (AFP), Alkaline phosphate a tumor marker, Ultrasound/ CAT scan with contrast
53
Surgical resection/liver transplant, TACE= Transarterial chemoilzation, SIRT= Selected internal radiation therapy, Hepatic artery embolization, Cryotherapy, Chemotherapy, Palliative, End-of-life, Hospice services
54
End stage liver disease, Acute liver failure
55
Severe cardiovascular instability, Sever respiratory disease, Metastatic tumors, Inability to follow instructions regarding self management and drug therapy
56
Graft rejection, Infection, Bleeding
57
2 antibiotics, PPI
58
Antacids, H2 blockers, PPIs